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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tetramethylpyrazine
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Accession:CHEBI:133246 term browser browse the term
Definition:A member of the class of pyrazines that is pyrazine in which all four hydrogens have been replaced by methyl groups. An alkaloid extracted from Chuanxiong (Ligusticum wallichii).
Synonyms:related_synonym: 2,3,5,6,-tetramethyl-1,4-pyrazine;   2,3,5,6-tetramethylpyrazine;   FEMA 3237;   FEMA No. 3237;   Formula=C8H12N2;   InChI=1S/C8H12N2/c1-5-6(2)10-8(4)7(3)9-5/h1-4H3;   InChIKey=FINHMKGKINIASC-UHFFFAOYSA-N;   SMILES=C=1(N=C(C(=NC1C)C)C)C;   TMP;   liqustrazine
 xref: CAS:1124-11-4;   HMDB:HMDB0036584
 xref_mesh: MESH:C017953
 xref: MetaCyc:CPD-15901;   PMID:11583735;   PMID:18790005;   PMID:21456940;   PMID:23253813;   PMID:23563941;   PMID:2413290;   PMID:24333010;   PMID:25841319;   PMID:26275042;   PMID:26404762;   PMID:27179035;   PMID:27389185;   PMID:27391608;   PMID:27431939;   PMID:27607420;   PMID:27610159;   PMID:27717875;   Reaxys:113100;   Wikipedia:Tetramethylpyrazine


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tetramethylpyrazine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO tetramethylpyrazine results in increased expression of ABCA1 protein CTD PMID:28034800 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP [huperzine A co-treated with tetramethylpyrazine] results in decreased activity of ACHE protein CTD PMID:20624417 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions
decreases expression		 EXP
ISO		 tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of ACTA2 mRNA]
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]
tetramethylpyrazine results in decreased expression of ACTA2 mRNA; tetramethylpyrazine results in decreased expression of ACTA2 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of ACTA2 protein]		 CTD PMID:23022513 PMID:27477297 PMID:27837167 PMID:30744607 NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of AKT1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased phosphorylation of AKT1 protein] CTD PMID:30744607 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apoc3 apolipoprotein C3 decreases expression ISO tetramethylpyrazine results in decreased expression of APOC3 mRNA CTD PMID:15520497 NCBI chr 8:46,531,478...46,533,658
Ensembl chr 8:46,531,478...46,533,583 		JBrowse link
G Asic3 acid sensing ion channel subunit 3 increases expression ISO tetramethylpyrazine results in increased expression of ASIC3 mRNA CTD PMID:15520497 NCBI chr 4:10,760,509...10,764,987
Ensembl chr 4:10,760,597...10,764,643 		JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression ISO tetramethylpyrazine results in increased expression of ATP2A2 mRNA CTD PMID:15520497 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of BAX protein] CTD PMID:26404762 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP tetramethylpyrazine inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2 protein] CTD PMID:21586279 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP
ISO		 tetramethylpyrazine inhibits the reaction [Gentamicins results in decreased expression of BCL2L1 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of BCL2L1 protein]		 CTD PMID:17132701 PMID:26404762 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Becn1 beclin 1 multiple interactions ISO tetramethylpyrazine affects the reaction [Paraquat affects the expression of BECN1 protein]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of BECN1 mRNA] CTD PMID:30744607 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP3 protein]
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]		 CTD PMID:17132701 PMID:32135237 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp8 caspase 8 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP8 protein]; tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]] CTD PMID:17132701 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP
ISO		 tetramethylpyrazine inhibits the reaction [Gentamicins results in increased activity of CASP9 protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in decreased expression of CASP9 protein]		 CTD PMID:17132701 PMID:26404762 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase increases activity
multiple interactions		 ISO tetramethylpyrazine results in increased activity of CAT protein
DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]		 CTD PMID:28034800 PMID:32135237 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccn2 cellular communication network factor 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of CCN2 protein] CTD PMID:30744607 NCBI chr 1:20,802,199...20,805,315
Ensembl chr 1:20,802,199...20,805,734 		JBrowse link
G Cftr CF transmembrane conductance regulator multiple interactions
increases activity		 ISO
EXP		 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein]; RMI 12330A inhibits the reaction [tetramethylpyrazine results in increased activity of CFTR protein] CTD PMID:15763242 PMID:16015685 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Clu clusterin multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of CLU protein] CTD PMID:24200859 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions
decreases expression		 EXP
ISO		 tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of COL1A1 mRNA]
tetramethylpyrazine results in decreased expression of COL1A1 mRNA; tetramethylpyrazine results in decreased expression of COL1A1 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]		 CTD PMID:23022513 PMID:27477297 PMID:27837167 NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624 		JBrowse link
G Col3a1 collagen type III alpha 1 chain multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein] CTD PMID:27477297 NCBI chr 9:47,374,611...47,410,547
Ensembl chr 9:47,374,593...47,410,547 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions
decreases expression		 ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of CTNNB1 protein]
tetramethylpyrazine results in decreased expression of CTNNB1 mRNA; tetramethylpyrazine results in decreased expression of CTNNB1 protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]		 CTD PMID:24961358 PMID:27477297 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 increases expression ISO tetramethylpyrazine results in increased expression of CYP11B1 mRNA CTD PMID:15520497 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Ddah2 DDAH family member 2, ADMA-independent multiple interactions ISO DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased abundance of Nitric Oxide]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased activity of CAT protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Malondialdehyde]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of N,N-dimethylarginine]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased abundance of Reactive Oxygen Species]]; DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in increased expression of CASP3 protein modified form]]; tetramethylpyrazine inhibits the reaction [[Iron-Dextran Complex results in decreased expression of DDAH2 protein] which results in increased abundance of N,N-dimethylarginine]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased expression of DDAH2 protein] CTD PMID:32135237 NCBI chr20:3,761,460...3,764,718
Ensembl chr20:3,761,465...3,764,511 		JBrowse link
G Egfr epidermal growth factor receptor multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein] CTD PMID:27477297 NCBI chr14:91,176,979...91,349,722
Ensembl chr14:91,177,067...91,344,382 		JBrowse link
G Fn1 fibronectin 1 multiple interactions
decreases expression		 EXP
ISO		 tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of FN1 mRNA]
NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]
tetramethylpyrazine results in decreased expression of FN1 mRNA; tetramethylpyrazine results in decreased expression of FN1 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]		 CTD PMID:23022513 PMID:27477297 PMID:27837167 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP [tetramethylpyrazine affects the expression of FOS mRNA] which results in decreased susceptibility to Methylnitrosourea CTD PMID:16268501 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO tetramethylpyrazine analog results in increased expression of GCLC mRNA; tetramethylpyrazine analog results in increased expression of GCLC protein
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]		 CTD PMID:25056784 PMID:27477297 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein] CTD PMID:27477297 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gli1 GLI family zinc finger 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of GLI1 protein] CTD PMID:30744607 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in decreased activity of GSR protein] CTD PMID:24200859 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Havcr1 hepatitis A virus cellular receptor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Cadmium Chloride results in increased expression of HAVCR1 protein] CTD PMID:24200859 NCBI chr10:31,118,667...31,151,730
Ensembl chr10:31,119,088...31,151,698 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein] CTD PMID:27837167 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmox1 heme oxygenase 1 increases expression
multiple interactions		 ISO tetramethylpyrazine analog results in increased expression of HMOX1 mRNA; tetramethylpyrazine analog results in increased expression of HMOX1 protein; tetramethylpyrazine results in increased expression of HMOX1 mRNA
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of HMOX1 protein]; tetramethylpyrazine results in increased expression of and results in increased activity of HMOX1 protein		 CTD PMID:18842672 PMID:25056784 PMID:26404762 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Ifng interferon gamma multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein] CTD PMID:27477297 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein] CTD PMID:27477297 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions EXP
ISO		 [tetramethylpyrazine affects the expression of JUN mRNA] which results in decreased susceptibility to Methylnitrosourea
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of JUN protein modified form]		 CTD PMID:16268501 PMID:26404762 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein] CTD PMID:26404762 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein] CTD PMID:26404762 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK8 protein] CTD PMID:26404762 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK9 protein] CTD PMID:26404762 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mir193a microRNA 193a multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of MIR193A mRNA] CTD PMID:30744607 NCBI chr10:64,672,343...64,672,454
Ensembl chr10:64,672,343...64,672,454 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MMP9 protein] CTD PMID:30744607 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of MPO protein] CTD PMID:22200888 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of MTOR mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of MTOR protein] CTD PMID:30744607 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions
increases response to substance
increases expression
affects response to substance		 ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of ACTA2 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of COL1A1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of CTNNB1 protein]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 mRNA]; NFE2L2 protein promotes the reaction [tetramethylpyrazine results in decreased expression of FN1 protein]; tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of NFE2L2 protein]
NFE2L2 protein results in increased susceptibility to tetramethylpyrazine
tetramethylpyrazine analog results in increased expression of NFE2L2 protein; tetramethylpyrazine results in increased expression of NFE2L2 mRNA; tetramethylpyrazine results in increased expression of NFE2L2 protein
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of ACTA2 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of COL1A1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of FN1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of HIF1A protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLC protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of GCLM protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of COL3A1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of CTNNB1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of EGFR protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of FN1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IFNG protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of IL6 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Paraquat results in decreased expression of NFE2L2 protein]
NFE2L2 affects the susceptibility to tetramethylpyrazine		 CTD PMID:25056784 PMID:26404762 PMID:27477297 PMID:27837167 PMID:30744607 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP
ISO		 tetramethylpyrazine inhibits the reaction [Methylnitrosourea results in increased expression of NFKBIA protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in decreased expression of NFKBIA protein]		 CTD PMID:15960898 PMID:27477297 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of NLRP3 protein] CTD PMID:27477297 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 increases expression
multiple interactions		 EXP
ISO		 tetramethylpyrazine results in increased expression of NOS2 mRNA
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of NOS2 mRNA]		 CTD PMID:15528953 PMID:22200888 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO DDAH2 promotes the reaction [tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein]]; tetramethylpyrazine inhibits the reaction [Iron-Dextran Complex results in decreased phosphorylation of NOS3 protein] CTD PMID:32135237 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO tetramethylpyrazine results in increased expression of NR1H3 mRNA CTD PMID:28034800 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased cleavage of PARP1 protein] CTD PMID:26404762 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions EXP
ISO		 tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]
NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]		 CTD PMID:23022513 PMID:27477297 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in decreased expression of PPARA protein] CTD PMID:27837167 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression
multiple interactions		 EXP
ISO		 tetramethylpyrazine results in increased expression of PPARG protein
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PPARG protein]
tetramethylpyrazine results in increased expression of PPARG mRNA		 CTD PMID:22200888 PMID:23022513 PMID:28034800 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]
tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of PTGS2 mRNA]		 CTD PMID:22200888 PMID:24961358 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of RELA protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of RELA mRNA]
tetramethylpyrazine promotes the reaction [Methylnitrosourea affects the localization of RELA protein]
tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of RELA protein modified form]		 CTD PMID:15960898 PMID:22200888 PMID:24961358 PMID:27837167 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Shh sonic hedgehog signaling molecule multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SHH protein] CTD PMID:30744607 NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased phosphorylation of SMAD2 protein] CTD PMID:30744607 NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323 		JBrowse link
G Smo smoothened, frizzled class receptor multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO mRNA]; tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of SMO protein] CTD PMID:30744607 NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]]; NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 mRNA]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of SREBF1 protein] CTD PMID:27837167 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srrt serrate, RNA effector molecule multiple interactions ISO tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of SRRT protein] CTD PMID:26404762 NCBI chr12:19,392,578...19,406,098
Ensembl chr12:19,392,625...19,406,095 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of TGFB1 protein] CTD PMID:30744607 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847 		JBrowse link
G Tgfbr1 transforming growth factor, beta receptor 1 multiple interactions ISO NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 mRNA]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TGFBR1 protein] CTD PMID:27477297 NCBI chr 5:61,653,773...61,710,777
Ensembl chr 5:61,653,233...61,710,777 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions EXP tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of TIMP1 protein] CTD PMID:23022513 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 tetramethylpyrazine inhibits the reaction [sodium arsenite results in increased expression of TNF protein]
tetramethylpyrazine inhibits the reaction [TNF protein promotes the reaction [Gentamicins results in increased expression of CASP8 protein]]
NFE2L2 affects the reaction [tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]]; NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]]; tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Ethanol results in increased expression of TNF protein]; tetramethylpyrazine inhibits the reaction [Oxazolone results in increased expression of TNF mRNA]		 CTD PMID:17132701 PMID:22200888 PMID:24961358 PMID:27477297 PMID:27837167 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO tetramethylpyrazine inhibits the reaction [Paraquat results in increased expression of VEGFA protein] CTD PMID:30744607 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19808
    role 19784
      biological role 19782
        inhibitor 18877
          apoptosis inhibitor 7136
            tetramethylpyrazine 66
Path 2
Term Annotations click to browse term
  CHEBI ontology 19808
    subatomic particle 19806
      composite particle 19806
        hadron 19806
          baryon 19806
            nucleon 19806
              atomic nucleus 19806
                atom 19806
                  main group element atom 19756
                    p-block element atom 19756
                      carbon group element atom 19705
                        carbon atom 19702
                          organic molecular entity 19702
                            organic molecule 19655
                              organic cyclic compound 19468
                                organic heterocyclic compound 18848
                                  organic heteromonocyclic compound 17773
                                    diazines 13204
                                      pyrazines 1085
                                        tetramethylpyrazine 66
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