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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:apigenin
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Accession:CHEBI:18388 term browser browse the term
Definition:A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Synonyms:related_synonym: 2-(p-hydroxyphenyl)-5,7-dihydroxychromone;   4',5,7-Trihydroxyflavone;   5,7-Dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4-benzopyrone;   5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one;   C.I. Natural Yellow 1;   Formula=C15H10O5;   InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H;   InChIKey=KZNIFHPLKGYRTM-UHFFFAOYSA-N;   SMILES=Oc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1;   chamomile;   spigenin;   versulin
 alt_id: CHEBI:12084;   CHEBI:22588;   CHEBI:2768
 xref: Beilstein:262620;   CAS:520-36-5;   HMDB:HMDB0002124;   KEGG:C01477;   KNApSAcK:C00003817;   LINCS:LSM-5206;   LIPID_MAPS_instance:LMPK12110005
 xref_mesh: MESH:D047310
 xref: MetaCyc:CPD-431;   PDBeChem:AGI;   PMID:23304222;   PMID:23344191;   PMID:23354402;   PMID:23359392;   PMID:28166217;   Reaxys:262620;   Wikipedia:Apigenin
 cyclic_relationship: is_conjugate_acid_of CHEBI:58470


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apigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin multiple interactions EXP Apigenin inhibits the reaction [Cadmium Chloride results in increased expression of A2M protein] CTD PMID:15618353 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity
multiple interactions		 ISO Apigenin results in decreased activity of ABCC1 protein
[Glutathione co-treated with Apigenin] affects the reaction [ABCC1 protein results in increased uptake of estradiol-17 beta-glucuronide]; Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]; Apigenin promotes the reaction [ABCC1 protein results in increased uptake of Glutathione]; Glutathione promotes the reaction [Apigenin inhibits the reaction [ABCC1 protein results in increased uptake of Leukotriene C4]]		 CTD PMID:11306701 PMID:12485947 PMID:15670588 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114 		JBrowse link
G Ache acetylcholinesterase multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in increased activity of ACHE protein] CTD PMID:28389404 NCBI chr12:19,406,133...19,413,713
Ensembl chr12:19,407,360...19,413,651 		JBrowse link
G Acsl4 acyl-CoA synthetase long-chain family member 4 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of ACSL4 protein] CTD PMID:35500696 NCBI chr  X:105,942,794...106,006,573
Ensembl chr  X:105,942,799...106,006,427 		JBrowse link
G Afg3l2 AFG3 like matrix AAA peptidase subunit 2 increases expression ISO Apigenin results in increased expression of AFG3L2 mRNA CTD PMID:22359648 NCBI chr18:60,954,268...60,999,110
Ensembl chr18:60,954,268...60,999,110 		JBrowse link
G Afp alpha-fetoprotein affects binding EXP Apigenin binds to AFP protein CTD PMID:23013281 PMID:25349334 NCBI chr14:17,573,412...17,591,476
Ensembl chr14:17,573,412...17,591,480 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO Apigenin binds to and results in increased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]
Apigenin binds to and results in decreased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]		 CTD PMID:14644660 PMID:17869316 PMID:20450880 PMID:29584932 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Aip aryl-hydrocarbon receptor-interacting protein multiple interactions ISO Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]] CTD PMID:20450880 NCBI chr 1:201,408,002...201,419,220
Ensembl chr 1:201,407,288...201,419,122 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases expression		 ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein
Apigenin results in decreased expression of AKT1 protein		 CTD PMID:15947208 PMID:19885610 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 multiple interactions ISO
EXP		 [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of APAF1 protein
Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 mRNA]		 CTD PMID:24070738 PMID:30107153 NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540 		JBrowse link
G Ar androgen receptor multiple interactions ISO Apigenin inhibits the reaction [[6-fluorotestosterone co-treated with Norgestrel] binds to and results in increased activity of AR protein] CTD PMID:33049310 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925 		JBrowse link
G Arhgap29 Rho GTPase activating protein 29 increases expression ISO Apigenin results in increased expression of ARHGAP29 mRNA CTD PMID:22359648 NCBI chr 2:210,060,036...210,132,572
Ensembl chr 2:210,071,199...210,132,028 		JBrowse link
G Arnt aryl hydrocarbon receptor nuclear translocator multiple interactions ISO Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]
Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein]		 CTD PMID:20450880 NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580 		JBrowse link
G Atf6 activating transcription factor 6 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of ATF6 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of ATF6 protein] CTD PMID:20493918 NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177 		JBrowse link
G Atg7 autophagy related 7 multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of ATG7 protein]; Glutathione inhibits the reaction [Apigenin results in increased expression of ATG7 protein] CTD PMID:29247770 NCBI chr 4:147,718,663...147,925,656
Ensembl chr 4:147,718,752...147,925,593 		JBrowse link
G B3galt5 Beta-1,3-galactosyltransferase 5 increases expression ISO Apigenin results in increased expression of B3GALT5 protein CTD PMID:22906706 NCBI chr11:35,584,273...35,630,922
Ensembl chr11:35,585,220...35,630,917 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator decreases expression
multiple interactions		 EXP
ISO		 Apigenin results in decreased expression of BAX protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of BAX protein; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of BAX protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of BAX protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of BAX protein]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of BAX protein		 CTD PMID:24070738 PMID:24144774 PMID:25557508 PMID:30107153 PMID:30152906 More... NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
decreases response to substance		 ISO
EXP		 Apigenin results in decreased expression of BCL2 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of BCL2 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of BCL2 protein]; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
[Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein
BCL2 protein results in decreased susceptibility to Apigenin		 CTD PMID:15486995 PMID:24070738 PMID:25557508 PMID:29247770 PMID:30107153 More... NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
multiple interactions		 EXP Apigenin results in decreased expression of BCL2L1 protein
Apigenin inhibits the reaction [Isoproterenol results in decreased expression of BCL2L1 protein]		 CTD PMID:24144774 PMID:30152906 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Bdnf brain-derived neurotrophic factor multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of BDNF mRNA] CTD PMID:28389404 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615 		JBrowse link
G Becn1 beclin 1 multiple interactions
increases expression		 ISO Apigenin promotes the reaction [Fluorouracil results in increased expression of BECN1 protein]; Fluorouracil promotes the reaction [Apigenin results in increased expression of BECN1 protein] CTD PMID:28025107 NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression EXP Apigenin results in increased expression of BID protein CTD PMID:24144774 NCBI chr 4:154,113,198...154,136,353
Ensembl chr 4:154,113,198...154,134,720 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 multiple interactions ISO [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein CTD PMID:29247770 NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732 		JBrowse link
G Birc3 baculoviral IAP repeat-containing 3 increases cleavage
multiple interactions		 ISO Apigenin results in increased cleavage of BIRC3 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein		 CTD PMID:15486995 PMID:29247770 NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802 		JBrowse link
G Bnip3l BCL2 interacting protein 3 like increases expression ISO Apigenin results in increased expression of BNIP3L mRNA CTD PMID:22359648 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803 		JBrowse link
G Casp1 caspase 1 multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of CASP1 protein modified form] CTD PMID:29960001 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp12 caspase 12 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP12 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP12 protein] CTD PMID:20493918 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
increases cleavage		 ISO
EXP		 [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]
Apigenin results in increased activity of CASP3 protein
Apigenin results in increased cleavage of CASP3 protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP3 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP3 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP3 protein]
Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein]		 CTD PMID:15486995 PMID:17132221 PMID:19397994 PMID:19647729 PMID:19885610 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casp7 caspase 7 increases cleavage
increases activity		 ISO Apigenin results in increased cleavage of CASP7 protein
Apigenin results in increased activity of CASP7 protein		 CTD PMID:15486995 PMID:19647729 NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729 		JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
increases activity		 ISO
EXP		 Apigenin results in increased cleavage of CASP8 protein
[TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein
Apigenin results in increased activity of CASP8 protein
Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP8 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP8 protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP8 protein]		 CTD PMID:15486995 PMID:24144774 PMID:29247770 PMID:30152906 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542 		JBrowse link
G Casp9 caspase 9 increases cleavage
increases activity
multiple interactions		 ISO
EXP		 Apigenin results in increased cleavage of CASP9 protein
Apigenin results in increased activity of CASP9 protein
Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP9 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP9 protein]
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of and results in increased cleavage of CASP9 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP9 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP9 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]
[Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 mRNA; [Polylactic Acid-Polyglycolic Acid Copolymer co-treated with Apigenin] results in increased expression of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein		 CTD PMID:15486995 PMID:19397994 PMID:24070738 PMID:25557508 PMID:28025107 More... NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626 		JBrowse link
G Cat catalase decreases expression
multiple interactions
increases activity
increases expression
decreases response to substance		 ISO
EXP		 Apigenin results in decreased expression of CAT mRNA
Apigenin inhibits the reaction [Isoproterenol results in decreased activity of CAT protein]; Apigenin inhibits the reaction [Rotenone results in decreased activity of CAT protein]
Apigenin results in increased activity of CAT protein
Apigenin results in increased expression of CAT mRNA
CAT protein results in decreased susceptibility to Apigenin		 CTD PMID:21756884 PMID:22359648 PMID:28389404 PMID:30152906 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccn5 cellular communication network factor 5 increases expression
multiple interactions		 ISO Apigenin results in increased expression of CCN5 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]		 CTD PMID:23384675 NCBI chr 3:152,491,247...152,502,639
Ensembl chr 3:152,491,220...152,502,636 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO Apigenin results in decreased expression of CCNB1 mRNA; Apigenin results in decreased expression of CCNB1 protein CTD PMID:19397994 PMID:26961604 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Cd40 CD40 molecule multiple interactions ISO Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] CTD PMID:16601352 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO Apigenin results in decreased expression of CDC25C protein CTD PMID:26961604 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 multiple interactions
decreases expression		 ISO Apigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein
Apigenin results in decreased expression of CDK1 protein		 CTD PMID:11322924 PMID:26872304 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdkal1 CDK5 regulatory subunit associated protein 1-like 1 increases expression ISO Apigenin results in increased expression of CDKAL1 mRNA CTD PMID:22359648 NCBI chr17:34,718,701...35,271,276
Ensembl chr17:34,718,687...35,407,524 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO
EXP		 Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein]; TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin results in increased expression of CDKN1A mRNA
Apigenin results in increased expression of CDKN1A mRNA; Apigenin results in increased expression of CDKN1A protein		 CTD PMID:11790449 PMID:16023288 PMID:19397994 PMID:26872304 PMID:31201582 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cdkn2c cyclin-dependent kinase inhibitor 2C increases expression ISO Apigenin results in increased expression of CDKN2C mRNA CTD PMID:18331776 NCBI chr 5:124,411,123...124,416,278
Ensembl chr 5:124,411,124...124,416,278 		JBrowse link
G Cebpb CCAAT/enhancer binding protein beta decreases expression ISO Apigenin results in decreased expression of CEBPB mRNA CTD PMID:18359623 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473 		JBrowse link
G Ces1d carboxylesterase 1D decreases activity EXP Apigenin results in decreased activity of CES1 protein CTD PMID:37353134 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035 		JBrowse link
G Cftr CF transmembrane conductance regulator increases activity
affects localization		 ISO Apigenin results in increased activity of CFTR protein; Apigenin results in increased activity of CFTR protein mutant form
Apigenin affects the localization of CFTR protein mutant form		 CTD PMID:15191910 PMID:15277574 NCBI chr 4:46,561,269...46,728,759
Ensembl chr 4:46,560,885...46,728,756 		JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex multiple interactions EXP Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of CHUK protein] CTD PMID:25935278 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065 		JBrowse link
G Ckm creatine kinase, M-type multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of CKM protein] CTD PMID:25557508 NCBI chr 1:79,061,390...79,071,721
Ensembl chr 1:79,061,456...79,071,720 		JBrowse link
G Clca1 chloride channel accessory 1 decreases expression ISO Apigenin results in decreased expression of CLCA1 mRNA CTD PMID:22359648 NCBI chr 2:233,938,677...233,964,369
Ensembl chr 2:233,938,677...233,964,369 		JBrowse link
G Cox17 cytochrome c oxidase copper chaperone COX17 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of COX17 protein] CTD PMID:30107153 NCBI chr11:62,400,733...62,406,507 JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 increases expression
multiple interactions		 ISO Apigenin results in increased expression of CXCL12 mRNA
ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]		 CTD PMID:23384675 PMID:28396216 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168 		JBrowse link
G Cycs cytochrome c, somatic affects localization
multiple interactions		 ISO
EXP		 Apigenin affects the localization of CYCS protein
(2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]
[polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] affects the localization of CYCS protein		 CTD PMID:15486995 PMID:24070738 PMID:30152906 PMID:31930969 NCBI chr 4:79,651,894...79,653,994
Ensembl chr 4:79,651,378...79,654,054
Ensembl chr18:79,651,378...79,654,054 		JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Apigenin results in decreased expression of CYP11A1 mRNA CTD PMID:31201582 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338 		JBrowse link
G Cyp11b2 cytochrome P450, family 11, subfamily b, polypeptide 2 decreases expression ISO Apigenin results in decreased expression of CYP11B1 mRNA CTD PMID:22172629 NCBI chr 7:106,838,590...106,845,004
Ensembl chr 7:106,838,590...106,845,004 		JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] CTD PMID:23370353 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573 		JBrowse link
G Cyp19a1 cytochrome P450, family 19, subfamily a, polypeptide 1 decreases activity
decreases expression		 ISO Apigenin results in decreased activity of CYP19A1 protein
Apigenin results in decreased expression of CYP19A1 mRNA		 CTD PMID:10403137 PMID:15319488 PMID:16023337 PMID:16965912 NCBI chr 8:54,552,978...54,580,375
Ensembl chr 8:54,553,165...54,580,758 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity
increases expression		 ISO Apigenin binds to and results in decreased activity of CYP1A1 protein; Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
Apigenin results in decreased activity of CYP1A1 protein
Apigenin results in increased expression of CYP1A1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1A1 mRNA]; Apigenin promotes the reaction [beta-Naphthoflavone results in increased activity of CYP1A1 protein]		 CTD PMID:11454723 PMID:11752233 PMID:16271822 PMID:17012224 PMID:17090139 More... NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO Apigenin results in decreased activity of CYP1A2 protein CTD PMID:20806393 PMID:21053930 PMID:29753067 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
increases expression
multiple interactions
increases chemical synthesis		 ISO Apigenin results in decreased activity of CYP1B1 protein
Apigenin results in increased expression of CYP1B1 mRNA
Apigenin affects the reaction [beta-Naphthoflavone results in increased expression of CYP1B1 mRNA]
CYP1B1 protein results in increased chemical synthesis of Apigenin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin; Apigenin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:16271822 PMID:19666078 PMID:20930378 PMID:21053930 PMID:21482471 More... NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
decreases activity		 ISO Apigenin inhibits the reaction [Alcohols results in increased expression of CYP2E1 protein]
Apigenin results in decreased activity of CYP2E1 protein		 CTD PMID:28803762 PMID:29753067 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity		 ISO Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
Apigenin results in decreased activity of CYP3A4 protein		 CTD PMID:21053930 PMID:29753067 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of DDIT3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of DDIT3 protein] CTD PMID:20493918 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dgat1 diacylglycerol O-acyltransferase 1 multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of DGAT1 protein] CTD PMID:28803762 NCBI chr 7:108,223,860...108,235,413
Ensembl chr 7:108,218,524...108,234,299 		JBrowse link
G Dhrs11 dehydrogenase/reductase 11 decreases activity ISO Apigenin results in decreased activity of DHRS11 protein CTD PMID:30926317 NCBI chr10:69,698,214...69,708,294
Ensembl chr10:69,698,214...69,708,295 		JBrowse link
G Drd2 dopamine receptor D2 multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of DRD2 protein] CTD PMID:28389404 NCBI chr 8:49,708,927...49,772,876
Ensembl chr 8:49,708,927...49,772,875 		JBrowse link
G Duox1 dual oxidase 1 decreases expression ISO Apigenin results in decreased expression of DUOX1 mRNA CTD PMID:22359648 NCBI chr 3:109,260,526...109,295,588
Ensembl chr 3:109,262,397...109,295,563 		JBrowse link
G Eif5b eukaryotic translation initiation factor 5B increases expression ISO Apigenin results in increased expression of EIF5B mRNA CTD PMID:22359648 NCBI chr 9:40,222,769...40,277,482
Ensembl chr 9:40,222,898...40,277,482 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:20153296 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Epo erythropoietin increases expression ISO Apigenin results in increased expression of EPO mRNA CTD PMID:37348668 NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946 		JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 multiple interactions ISO [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein CTD PMID:19885610 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078 		JBrowse link
G Ern1 endoplasmic reticulum to nucleus signaling 1 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased phosphorylation of ERN1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased phosphorylation of ERN1 protein] CTD PMID:20493918 NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029 		JBrowse link
G Erp29 endoplasmic reticulum protein 29 increases expression ISO Apigenin results in increased expression of ERP29 mRNA CTD PMID:22359648 NCBI chr12:35,089,698...35,095,952
Ensembl chr12:35,089,707...35,096,376 		JBrowse link
G Esr1 estrogen receptor 1 multiple interactions
increases phosphorylation
increases activity
decreases expression
affects binding		 ISO
EXP		 Apigenin binds to and results in increased activity of ESR1 protein; Apigenin inhibits the reaction [Estradiol binds to ESR1 protein]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CCN5 mRNA]; ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA]
Apigenin results in increased phosphorylation of ESR1 protein
Apigenin results in increased activity of ESR1 protein
Apigenin results in decreased expression of ESR1 protein
Apigenin binds to ESR1 protein		 CTD PMID:14579009 PMID:16118406 PMID:16541309 PMID:16860978 PMID:17323972 More... NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 multiple interactions
affects binding
increases activity		 ISO Apigenin binds to and results in increased activity of ESR2 protein; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein]
Apigenin binds to ESR2 protein
Apigenin results in increased activity of ESR2 protein		 CTD PMID:9751507 PMID:12224631 PMID:16118406 PMID:16860978 PMID:17132221 More... NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F2 coagulation factor II, thrombin multiple interactions ISO Apigenin inhibits the reaction [F2 protein results in increased localization of Calcium] CTD PMID:19814731 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fas Fas cell surface death receptor decreases expression
multiple interactions		 ISO
EXP		 Apigenin results in decreased expression of FAS mRNA
Apigenin inhibits the reaction [Isoproterenol results in increased expression of FAS protein]		 CTD PMID:18359623 PMID:30152906 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of FASN protein] CTD PMID:28803762 NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261 		JBrowse link
G Fbp1 fructose-bisphosphatase 1 decreases expression ISO Apigenin results in decreased expression of FBP1 mRNA CTD PMID:18331776 NCBI chr17:2,207,271...2,230,076
Ensembl chr17:2,208,031...2,230,071 		JBrowse link
G Fgf2 fibroblast growth factor 2 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA] CTD PMID:26800359 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Fn1 fibronectin 1 increases expression ISO Apigenin results in increased expression of FN1 protein CTD PMID:26408079 NCBI chr 9:73,196,044...73,264,695
Ensembl chr 9:73,196,044...73,264,678 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of FOS protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] CTD PMID:15322261 PMID:22634262 NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036 		JBrowse link
G Frmd4a FERM domain containing 4A increases expression ISO Apigenin results in increased expression of FRMD4A mRNA CTD PMID:22359648 NCBI chr17:73,667,787...74,258,487
Ensembl chr17:73,667,789...74,258,687 		JBrowse link
G Fth1 ferritin heavy chain 1 increases expression
multiple interactions		 ISO Apigenin results in increased expression of FTH1 mRNA; Apigenin results in increased expression of FTH1 protein
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTH1 protein]		 CTD PMID:35500696 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424 		JBrowse link
G Ftl1 ferritin light chain 1 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of FTL mRNA] CTD PMID:35500696 NCBI chr 1:95,936,387...95,938,234
Ensembl chr 1:95,936,387...95,939,725
Ensembl chr10:95,936,387...95,939,725 		JBrowse link
G Gata3 GATA binding protein 3 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in increased expression of GATA3 protein] CTD PMID:36350155 NCBI chr17:68,643,760...68,666,000
Ensembl chr17:68,643,873...68,665,391 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit increases expression
multiple interactions		 ISO
EXP		 Apigenin results in increased expression of GCLC mRNA
[Apigenin results in increased expression of GCLC mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of GCLC mRNA; Apigenin results in increased expression of GCLC protein		 CTD PMID:11864778 PMID:22864849 NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544 		JBrowse link
G Gclm glutamate cysteine ligase, modifier subunit increases expression
multiple interactions		 EXP Apigenin results in increased expression of GCLM mRNA; Apigenin results in increased expression of GCLM protein
[Apigenin results in increased expression of GCLM mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide		 CTD PMID:22864849 NCBI chr 2:210,347,482...210,367,537
Ensembl chr 2:210,347,482...210,367,535 		JBrowse link
G Gdnf glial cell derived neurotrophic factor multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of GDNF mRNA] CTD PMID:28389404 NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209 		JBrowse link
G Gli1 GLI family zinc finger 1 decreases expression ISO Apigenin results in decreased expression of GLI1 mRNA; Apigenin results in decreased expression of GLI1 protein CTD PMID:20395211 NCBI chr 7:63,156,926...63,169,579
Ensembl chr 7:63,156,926...63,169,251 		JBrowse link
G Gpx1 glutathione peroxidase 1 increases expression ISO Apigenin results in increased expression of GPX1 mRNA CTD PMID:22359648 NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024 		JBrowse link
G Gpx4 glutathione peroxidase 4 increases expression
multiple interactions
affects binding		 ISO Apigenin results in increased expression of GPX4 mRNA; Apigenin results in increased expression of GPX4 protein
Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of GPX4 protein]
Apigenin binds to GPX4 protein		 CTD PMID:35500696 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982 		JBrowse link
G Greb1 growth regulating estrogen receptor binding 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Apigenin results in increased expression of GREB1 mRNA] CTD PMID:33405908 NCBI chr 6:39,440,522...39,562,364
Ensembl chr 6:39,440,504...39,581,633 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Rotenone results in decreased activity of GSR protein]
Apigenin inhibits the reaction [Alcohols results in decreased expression of GSR protein]		 CTD PMID:28389404 PMID:28803762 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661 		JBrowse link
G Gypa glycophorin A increases expression ISO Apigenin results in increased expression of GYPA protein CTD PMID:25058688 NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822 		JBrowse link
G Hbegf heparin-binding EGF-like growth factor multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of HBEGF mRNA] CTD PMID:26800359 NCBI chr18:28,106,284...28,116,167
Ensembl chr18:28,105,760...28,116,441 		JBrowse link
G Hexa hexosaminidase subunit alpha multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased secretion of HEXA protein]
Apigenin inhibits the reaction [p-Methoxy-N-methylphenethylamine results in increased secretion of HEXA protein]		 CTD PMID:36350155 NCBI chr 8:59,936,526...59,961,654
Ensembl chr 8:59,936,660...59,962,013 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression
increases expression
multiple interactions
decreases activity		 ISO
EXP		 Apigenin results in decreased expression of HIF1A protein
Apigenin results in increased expression of HIF1A mRNA; Apigenin results in increased expression of HIF1A protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP9 protein modified form]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CYCS protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of BAX protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of BCL2 protein]]
Apigenin results in decreased activity of HIF1A protein
[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein; Apigenin inhibits the reaction [Oxygen deficiency promotes the reaction [HIF1A protein binds to EP300 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in increased activity of HIF1A protein]; Apigenin results in decreased degradation of and results in increased expression of HIF1A protein modified form; benzyloxycarbonylleucyl-leucyl-leucine aldehyde affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]; Cycloheximide affects the reaction [[Apigenin co-treated with Oxygen deficiency] affects the expression of HIF1A protein]		 CTD PMID:15947208 PMID:19958256 PMID:20153296 PMID:31930969 PMID:35513012 More... NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions ISO Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of HMGB1 protein]] CTD PMID:36055550 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression
decreases expression		 ISO
EXP		 Apigenin inhibits the reaction [Hemin results in increased activity of HMOX1 protein]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; Apigenin inhibits the reaction [Hemin results in increased expression of HMOX1 protein]
[Apigenin results in increased expression of HMOX1 mRNA] which results in decreased susceptibility to tert-Butylhydroperoxide
Apigenin results in increased expression of HMOX1 mRNA; Apigenin results in increased expression of HMOX1 protein
Apigenin results in decreased expression of HMOX1 protein		 CTD PMID:16109301 PMID:22864849 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hsd17b7 hydroxysteroid (17-beta) dehydrogenase 7 decreases expression EXP Apigenin results in decreased expression of HSD17B7 mRNA CTD PMID:31201582 NCBI chr13:82,170,079...82,190,018
Ensembl chr13:82,173,179...82,190,017 		JBrowse link
G Hsd3b2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 multiple interactions ISO Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] CTD PMID:23370353 NCBI chr 2:186,095,897...186,105,354
Ensembl chr 2:186,095,897...186,101,852 		JBrowse link
G Hsp90b1 heat shock protein 90 beta family member 1 multiple interactions ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSP90B1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSP90B1 protein] CTD PMID:20493918 NCBI chr 7:21,110,431...21,124,762
Ensembl chr 7:21,110,457...21,124,788 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A decreases expression ISO Apigenin results in decreased expression of HSPA1A mRNA CTD PMID:22359648 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B affects expression ISO Apigenin affects the expression of HSPA1B mRNA CTD PMID:22359648 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Hspa1l heat shock protein family A (Hsp70) member 1 like decreases expression ISO Apigenin results in decreased expression of HSPA1L mRNA CTD PMID:22359648 NCBI chr20:3,848,843...3,855,571
Ensembl chr20:3,848,843...3,855,571 		JBrowse link
G Hspa2 heat shock protein family A (Hsp70) member 2 decreases expression ISO Apigenin results in decreased expression of HSPA2 mRNA CTD PMID:22359648 NCBI chr 6:95,128,504...95,131,281
Ensembl chr 6:95,128,350...95,131,287 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions
decreases expression		 ISO Apigenin inhibits the reaction [Brefeldin A results in increased expression of HSPA5 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 protein]
Apigenin results in decreased expression of HSPA5 mRNA		 CTD PMID:20493918 PMID:22359648 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 decreases expression ISO Apigenin results in decreased expression of HSPA8 mRNA; Apigenin results in decreased expression of HSPA8 protein CTD PMID:22359648 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259 		JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] CTD PMID:15113938 PMID:15322261 PMID:16987811 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Idh3a isocitrate dehydrogenase (NAD(+)) 3 catalytic subunit alpha decreases expression ISO Apigenin results in decreased expression of IDH3A mRNA CTD PMID:22359648 NCBI chr 8:54,971,694...54,991,085
Ensembl chr 8:54,971,740...54,991,084 		JBrowse link
G Ifng interferon gamma multiple interactions EXP
ISO		 Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]
Apigenin inhibits the reaction [Ovalbumin results in decreased secretion of IFNG protein]		 CTD PMID:18090225 PMID:36350155 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin results in decreased expression of and results in decreased activity of IKBKB protein; Apigenin results in decreased phosphorylation of and results in decreased activity of IKBKB protein; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of IKBKB protein]
Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of IKBKB protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]		 CTD PMID:24148603 PMID:25557508 PMID:25935278 PMID:36350155 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250 		JBrowse link
G Il10 interleukin 10 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL10 mRNA]
Apigenin inhibits the reaction [nickel chloride results in increased expression of IL10 protein]		 CTD PMID:16934226 PMID:30016632 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il12b interleukin 12B multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B protein]] CTD PMID:28673093 NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903 		JBrowse link
G Il13 interleukin 13 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL13 protein] CTD PMID:36350155 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Adenosine Triphosphate results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL1B mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Poly dA-dT results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin inhibits the reaction [Uric Acid results in increased expression of and results in increased cleavage of and results in increased secretion of IL1B protein]; Apigenin promotes the reaction [Antigens, Bacterial results in increased cleavage of and results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of IL1B protein]		 CTD PMID:15985724 PMID:18090225 PMID:24134915 PMID:25557508 PMID:25935278 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il33 interleukin 33 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of IL33 mRNA]; Apigenin inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of IL33 mRNA] CTD PMID:37545493 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Il4 interleukin 4 decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of IL4 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL4 protein]
Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL4 protein]		 CTD PMID:16343431 PMID:36350155 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750 		JBrowse link
G Il5 interleukin 5 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased secretion of IL5 protein] CTD PMID:36350155 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]
Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [IL1B protein results in increased secretion of IL6 protein]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of IL6 mRNA]]; Apigenin inhibits the reaction [nickel chloride results in increased expression of IL6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]		 CTD PMID:24134915 PMID:25557508 PMID:25935278 PMID:28389404 PMID:30016632 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Ins1 insulin 1 multiple interactions EXP
ISO		 Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in decreased secretion of INS1 protein]
Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Apigenin inhibits the reaction [INS1 protein results in increased uptake of Deoxyglucose]		 CTD PMID:18090225 PMID:18591783 NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] CTD PMID:15322261 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Kcna5 potassium voltage-gated channel subfamily A member 5 multiple interactions EXP (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]]; Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]; HIF1A protein inhibits the reaction [Apigenin inhibits the reaction [Oxygen deficiency results in decreased expression of KCNA5 protein]] CTD PMID:31930969 NCBI chr 4:159,354,689...159,358,173
Ensembl chr 4:159,350,097...159,357,697 		JBrowse link
G Kdm3a lysine demethylase 3A increases expression ISO Apigenin results in increased expression of KDM3A mRNA CTD PMID:22359648 NCBI chr 4:103,630,907...103,675,073
Ensembl chr 4:103,630,908...103,675,073 		JBrowse link
G Kdr kinase insert domain receptor multiple interactions ISO [Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of KDR protein CTD PMID:35513012 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Lamb2 laminin subunit beta 2 increases expression ISO Apigenin results in increased expression of LAMB2 protein CTD PMID:26408079 NCBI chr 8:109,178,367...109,190,552
Ensembl chr 8:109,178,409...109,190,549 		JBrowse link
G Lep leptin increases expression ISO Apigenin results in increased expression of LEP mRNA; Apigenin results in increased expression of LEP protein CTD PMID:18359623 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Lmbr1l limb development membrane protein 1-like increases expression ISO Apigenin results in increased expression of LMBR1L mRNA CTD PMID:22359648 NCBI chr 7:130,061,136...130,078,101
Ensembl chr 7:130,061,136...130,076,381 		JBrowse link
G Lpcat3 lysophosphatidylcholine acyltransferase 3 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of LPCAT3 mRNA] CTD PMID:35500696 NCBI chr 4:157,468,397...157,509,889
Ensembl chr 4:157,468,290...157,509,880 		JBrowse link
G Lrrc26 leucine rich repeat containing 26 increases expression ISO Apigenin results in increased expression of LRRC26 mRNA CTD PMID:22359648 NCBI chr 3:8,102,361...8,103,687
Ensembl chr 3:8,102,361...8,103,687 		JBrowse link
G Ltbp1 latent transforming growth factor beta binding protein 1 decreases expression ISO Apigenin results in decreased expression of LTBP1 mRNA CTD PMID:22359648 NCBI chr 6:20,029,629...20,425,339
Ensembl chr 6:20,029,629...20,425,349 		JBrowse link
G Ltf lactotransferrin increases expression EXP Apigenin results in increased expression of LTF protein CTD PMID:24487097 NCBI chr 8:110,999,948...111,022,795
Ensembl chr 8:110,999,948...111,022,795 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases expression		 ISO Acetylcysteine inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form]; Glutathione inhibits the reaction [Apigenin results in increased expression of MAP1LC3B protein modified form] CTD PMID:29247770 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation
increases activity		 ISO
EXP		 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin results in increased phosphorylation of and results in increased activity of MAPK1 protein
Apigenin results in decreased phosphorylation of MAPK1 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]
Apigenin results in increased activity of MAPK1 protein		 CTD PMID:15322261 PMID:19647729 PMID:22864849 PMID:25557508 PMID:27468969 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO
EXP		 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein]; [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein; Apigenin results in increased phosphorylation of and results in increased activity of MAPK3 protein
Apigenin results in decreased phosphorylation of MAPK3 protein
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]		 CTD PMID:19647729 PMID:25557508 PMID:27468969 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK8 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of MAPK8 protein] CTD PMID:25557508 PMID:35373622 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK9 protein] CTD PMID:25557508 NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of MCL1 mRNA
Apigenin promotes the reaction [Fluorouracil results in decreased expression of MCL1 mRNA]; Fluorouracil promotes the reaction [Apigenin results in decreased expression of MCL1 mRNA]		 CTD PMID:28025107 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303 		JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase decreases phosphorylation ISO Apigenin results in decreased phosphorylation of MET protein CTD PMID:27468969 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876 		JBrowse link
G Mib1 MIB E3 ubiquitin protein ligase 1 increases expression ISO Apigenin results in increased expression of MIB1 mRNA CTD PMID:22359648 NCBI chr18:1,802,519...1,926,988
Ensembl chr18:1,802,519...1,920,689 		JBrowse link
G Mmp1 matrix metallopeptidase 1 decreases expression ISO Apigenin results in decreased expression of MMP1 mRNA; Apigenin results in decreased expression of MMP1 protein CTD PMID:21112745 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO Apigenin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:26408079 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions ISO Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] CTD PMID:22634262 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Mpg N-methylpurine-DNA glycosylase multiple interactions EXP Apigenin inhibits the reaction [Methylmercury Compounds results in decreased expression of MPG protein] CTD PMID:35373622 NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520 		JBrowse link
G Mt-atp6 mitochondrially encoded ATP synthase membrane subunit 6 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP6 protein] CTD PMID:30107153 NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
NCBI chr MT:7,919...8,599
Ensembl chr MT:7,919...8,599 		JBrowse link
G Mt-atp8 mitochondrially encoded ATP synthase membrane subunit 8 multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 mRNA]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of ATP8 protein] CTD PMID:30107153 NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
NCBI chr MT:7,758...7,961
Ensembl chr MT:7,758...7,961 		JBrowse link
G Mybl1 MYB proto-oncogene like 1 multiple interactions
increases expression		 ISO Fulvestrant inhibits the reaction [Apigenin results in increased expression of MYBL1 mRNA] CTD PMID:33405908 NCBI chr 5:9,582,905...9,618,179
Ensembl chr 5:9,582,934...9,618,183 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of MYD88 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased expression of MYD88 protein]		 CTD PMID:36055550 PMID:36350155 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nanog Nanog homeobox decreases expression ISO Apigenin results in decreased expression of NANOG protein CTD PMID:27468969 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116 		JBrowse link
G Ndufa4 Ndufa4, mitochondrial complex associated multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of NDUFA4 mRNA] CTD PMID:30107153 NCBI chr 4:40,002,216...40,009,384
Ensembl chr 4:40,002,216...40,023,920 		JBrowse link
G Neo1 neogenin 1 increases expression ISO Apigenin results in increased expression of NEO1 mRNA CTD PMID:22359648 NCBI chr 8:59,273,860...59,426,486
Ensembl chr 8:59,275,569...59,430,348 		JBrowse link
G Nfat5 nuclear factor of activated T-cells 5 multiple interactions ISO Apigenin inhibits the reaction [Sodium Chloride results in increased expression of NFAT5 mRNA] CTD PMID:26800359 NCBI chr19:35,199,737...35,286,675
Ensembl chr19:35,199,016...35,286,675 		JBrowse link
G Nfe2 nuclear factor, erythroid 2 decreases expression EXP Apigenin results in decreased expression of NFE2 mRNA CTD PMID:31201582 NCBI chr 7:134,382,758...134,395,364
Ensembl chr 7:134,382,761...134,390,108 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions EXP Apigenin affects the localization of and results in increased activity of NFE2L2 protein CTD PMID:22864849 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 multiple interactions
affects localization		 EXP
ISO		 Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]
Apigenin affects the localization of NFKB1 protein
Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]		 CTD PMID:18090225 PMID:24148603 PMID:28389404 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NFKB2 protein] CTD PMID:25557508 NCBI chr 1:245,164,586...245,173,225
Ensembl chr 1:245,165,950...245,173,213 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions
affects degradation		 ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Apigenin affects the degradation of NFKBIA protein
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in decreased expression of NFKBIA protein]
Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]; Apigenin inhibits the reaction [Ovalbumin results in increased phosphorylation of NFKBIA protein]		 CTD PMID:15322261 PMID:16934226 PMID:18090225 PMID:24148603 PMID:25557508 More... NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Nfkbib NFKB inhibitor beta multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] CTD PMID:15322261 NCBI chr 1:84,046,292...84,053,862
Ensembl chr 1:84,046,295...84,053,862 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of NLRP3 protein]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of NLRP3 protein]] CTD PMID:36055550 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of NOS2 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NOS2 mRNA]		 CTD PMID:11343698 PMID:12512693 PMID:16934226 PMID:18090225 PMID:28389404 More... NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 multiple interactions ISO Apigenin inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] CTD PMID:25257666 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions		 ISO Apigenin results in increased activity of NR1I2 protein
Apigenin binds to and results in increased activity of NR1I2 protein		 CTD PMID:25455453 PMID:33049310 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Nsdhl NAD(P) dependent steroid dehydrogenase-like decreases expression EXP Apigenin results in decreased expression of NSDHL mRNA CTD PMID:31201582 NCBI chr  X:150,775,034...150,807,161
Ensembl chr  X:150,775,080...150,807,142 		JBrowse link
G P2rx7 purinergic receptor P2X 7 multiple interactions EXP Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of P2RX7 protein] CTD PMID:25935278 NCBI chr12:33,889,709...33,934,168
Ensembl chr12:33,879,745...33,934,619 		JBrowse link
G Pank2 pantothenate kinase 2 decreases expression ISO Apigenin results in decreased expression of PANK2 mRNA CTD PMID:22359648 NCBI chr 3:118,483,382...118,519,551
Ensembl chr 3:118,483,444...118,518,320 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage		 ISO Apigenin inhibits the reaction [Brefeldin A results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased cleavage of PARP1 protein]
[Apigenin co-treated with 3-(4-methylphenylsulfonyl)-2-propenenitrile] results in increased cleavage of PARP1 protein; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased cleavage of PARP1 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein
Apigenin results in increased cleavage of PARP1 protein		 CTD PMID:20493918 PMID:22155090 PMID:24070738 PMID:24148603 PMID:29247770 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO Apigenin promotes the reaction [CDKN1A protein binds to PCNA protein] CTD PMID:26872304 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta multiple interactions ISO [Apigenin co-treated with Oxygen deficiency] affects the phosphorylation of PDGFRB protein CTD PMID:35513012 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pgr progesterone receptor affects binding
multiple interactions		 ISO Apigenin binds to PGR protein
Apigenin inhibits the reaction [Progesterone binds to PGR protein]		 CTD PMID:14579009 NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO Apigenin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pkmyt1 protein kinase, membrane associated tyrosine/threonine 1 decreases expression ISO Apigenin results in decreased expression of PKMYT1 mRNA CTD PMID:22359648 NCBI chr10:12,748,221...12,758,995
Ensembl chr10:12,748,237...12,758,995 		JBrowse link
G Polr2h RNA polymerase II, I and III subunit H increases expression ISO Apigenin results in increased expression of POLR2H mRNA CTD PMID:22359648 NCBI chr11:80,192,017...80,197,468
Ensembl chr11:80,192,032...80,197,515
Ensembl chr10:80,192,032...80,197,515 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 decreases expression ISO Apigenin results in decreased expression of POU5F1 protein CTD PMID:22906706 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in decreased expression of PPARA protein] CTD PMID:28803762 NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
decreases expression		 ISO Apigenin binds to and results in increased activity of PPARG protein; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin results in decreased expression of PPARG mRNA		 CTD PMID:11343698 PMID:18359623 PMID:33049310 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Prkaa1 protein kinase AMP-activated catalytic subunit alpha 1 multiple interactions ISO Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] CTD PMID:16873680 NCBI chr 2:54,240,298...54,275,978
Ensembl chr 2:54,240,137...54,275,978 		JBrowse link
G Prom1 prominin 1 decreases expression ISO Apigenin results in decreased expression of PROM1 protein CTD PMID:27468969 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527 		JBrowse link
G Prpsap1 phosphoribosyl pyrophosphate synthetase-associated protein 1 increases expression ISO Apigenin results in increased expression of PRPSAP1 mRNA CTD PMID:22359648 NCBI chr10:101,701,094...101,750,753
Ensembl chr10:101,701,096...101,750,751 		JBrowse link
G Psca prostate stem cell antigen decreases expression ISO Apigenin results in decreased expression of PSCA mRNA CTD PMID:18331776 NCBI chr 7:106,598,203...106,603,114
Ensembl chr 7:106,595,284...106,609,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases expression		 ISO
EXP		 Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 mRNA]; Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PTGS2 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; PPARG protein affects the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]
Apigenin results in decreased expression of PTGS2 protein
Apigenin inhibits the reaction [Isoproterenol results in increased expression of PTGS2 protein]
Apigenin affects the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]		 CTD PMID:11343698 PMID:16552572 PMID:30152906 PMID:35500696 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Ptk2b protein tyrosine kinase 2 beta multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of PTK2B protein] CTD PMID:29960001 NCBI chr15:40,360,722...40,481,235
Ensembl chr15:40,360,723...40,481,282 		JBrowse link
G Pycard PYD and CARD domain containing multiple interactions ISO Apigenin inhibits the reaction [Uric Acid promotes the reaction [PYCARD protein binds to PYCARD protein]] CTD PMID:29960001 NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955 		JBrowse link
G Ranbp10 RAN binding protein 10 increases expression ISO Apigenin results in increased expression of RANBP10 mRNA CTD PMID:22359648 NCBI chr19:33,656,046...33,716,864
Ensembl chr19:33,656,046...33,717,033 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit increases expression
multiple interactions
affects localization		 ISO
EXP		 Apigenin results in increased expression of RELA protein
Apigenin inhibits the reaction [Alcohols results in increased expression of RELA protein]
Apigenin affects the localization of RELA protein
Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]
Apigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of RELA protein]; Apigenin inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]		 CTD PMID:15090468 PMID:15113938 PMID:18090225 PMID:22634262 PMID:24148603 More... NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Rnase3 ribonuclease A family member 3 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased secretion of RNASE3 protein] CTD PMID:36350155 NCBI chr15:24,511,894...24,512,764
Ensembl chr15:24,511,891...24,512,790 		JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases expression ISO Apigenin results in decreased expression of RPS6KB1 protein CTD PMID:15947208 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908 		JBrowse link
G S1pr1 sphingosine-1-phosphate receptor 1 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR1 protein] CTD PMID:25557508 NCBI chr 2:203,624,752...203,629,110
Ensembl chr 2:203,621,587...203,629,681 		JBrowse link
G S1pr2 sphingosine-1-phosphate receptor 2 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR2 protein] CTD PMID:25557508 NCBI chr 8:19,503,276...19,514,169
Ensembl chr 8:19,502,627...19,523,574 		JBrowse link
G S1pr3 sphingosine-1-phosphate receptor 3 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of S1PR3 protein] CTD PMID:25557508 NCBI chr17:13,781,050...13,794,408
Ensembl chr17:13,781,050...13,794,505 		JBrowse link
G Sdha succinate dehydrogenase complex flavoprotein subunit A multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of SDHA mRNA] CTD PMID:30107153 NCBI chr 1:28,935,965...28,960,936
Ensembl chr 1:28,940,164...28,961,535 		JBrowse link
G Sele selectin E multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] CTD PMID:15113938 PMID:16987811 NCBI chr13:76,402,841...76,412,741
Ensembl chr13:76,403,304...76,412,741 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases expression ISO Apigenin results in increased expression of SF3B2 mRNA CTD PMID:22359648 NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759 		JBrowse link
G Shbg sex hormone binding globulin affects binding ISO Apigenin binds to SHBG protein CTD PMID:25349334 NCBI chr10:54,332,939...54,350,409
Ensembl chr10:54,332,941...54,351,057 		JBrowse link
G Slain2 SLAIN motif family, member 2 increases expression ISO Apigenin results in increased expression of SLAIN2 mRNA CTD PMID:22359648 NCBI chr14:35,236,034...35,314,186
Ensembl chr14:35,236,041...35,304,678 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [Apigenin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions
decreases expression		 ISO Apigenin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]
Apigenin results in decreased expression of SLC2A1 mRNA; Apigenin results in decreased expression of SLC2A1 protein		 CTD PMID:36870413 PMID:37437745 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slc2a3 solute carrier family 2 member 3 multiple interactions
decreases expression		 ISO [Apigenin co-treated with Oxygen deficiency] results in decreased expression of SLC2A3 mRNA
Apigenin results in decreased expression of SLC2A3 mRNA; Apigenin results in decreased expression of SLC2A3 protein		 CTD PMID:20153296 PMID:37437745 NCBI chr 4:155,960,944...156,026,000
Ensembl chr 4:155,960,946...156,025,472 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 multiple interactions ISO Apigenin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein] CTD PMID:18591783 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Slc3a2 solute carrier family 3 member 2 multiple interactions
decreases expression		 ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC3A2 mRNA]
Apigenin results in decreased expression of SLC3A2 mRNA		 CTD PMID:35500696 NCBI chr 1:205,604,468...205,618,931
Ensembl chr 1:205,604,468...205,618,931 		JBrowse link
G Slc5a1 solute carrier family 5 member 1 multiple interactions ISO Apigenin analog inhibits the reaction [SLC5A1 protein results in increased uptake of methylglucoside] CTD PMID:17495124 NCBI chr14:77,553,990...77,618,589
Ensembl chr14:77,553,843...77,618,547 		JBrowse link
G Slc7a11 solute carrier family 7 member 11 multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in decreased expression of SLC7A11 mRNA] CTD PMID:35500696 NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 multiple interactions ISO Apigenin inhibits the reaction [SLCO1B3 protein results in increased import of Sulfobromophthalein] CTD PMID:22394605 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981 		JBrowse link
G Slf2 SMC5-SMC6 complex localization factor 2 decreases expression ISO Apigenin results in decreased expression of SLF2 mRNA CTD PMID:22359648 NCBI chr 1:243,782,786...243,845,418
Ensembl chr 1:243,782,246...243,845,250 		JBrowse link
G Snca synuclein alpha multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in increased expression of SNCA protein] CTD PMID:28389404 NCBI chr 4:89,696,420...89,797,240
Ensembl chr 4:89,696,420...89,796,262 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 increases expression ISO Apigenin results in increased expression of SOCS3 mRNA CTD PMID:23782265 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 decreases expression ISO Apigenin results in decreased expression of SOD1 mRNA; Apigenin results in decreased expression of SOD1 protein CTD PMID:22359648 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Apigenin results in decreased expression of SOX2 protein CTD PMID:27468969 NCBI chr 2:117,536,929...117,539,340
Ensembl chr 2:117,536,929...117,539,338 		JBrowse link
G Sphk1 sphingosine kinase 1 multiple interactions EXP Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of SPHK1 protein] CTD PMID:25557508 NCBI chr10:101,758,567...101,764,240
Ensembl chr10:101,758,711...101,764,240 		JBrowse link
G Sptbn1 spectrin, beta, non-erythrocytic 1 increases expression ISO Apigenin results in increased expression of SPTBN1 mRNA CTD PMID:22359648 NCBI chr14:103,841,713...104,016,900
Ensembl chr14:103,842,684...104,008,507 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO Apigenin inhibits the reaction [Alcohols results in increased expression of SREBF1 protein] CTD PMID:28803762 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation
multiple interactions		 ISO Apigenin results in decreased phosphorylation of STAT3 protein
Apigenin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of STAT3 protein]		 CTD PMID:20153296 PMID:27468969 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Sult1a1 sulfotransferase family 1A member 1 increases sulfation ISO SULT1A1 protein SNP results in increased sulfation of Apigenin CTD PMID:17293380 NCBI chr 1:181,272,022...181,276,750
Ensembl chr 1:181,272,023...181,275,562 		JBrowse link
G Sult1e1 sulfotransferase family 1E member 1 multiple interactions ISO Apigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] CTD PMID:22414680 NCBI chr14:20,422,324...20,439,562
Ensembl chr14:20,422,324...20,439,275 		JBrowse link
G Syk spleen associated tyrosine kinase multiple interactions ISO Apigenin inhibits the reaction [Uric Acid results in increased phosphorylation of SYK protein] CTD PMID:29960001 NCBI chr17:12,604,615...12,678,437
Ensembl chr17:12,604,619...12,661,410 		JBrowse link
G Tbx21 T-box transcription factor 21 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 mRNA]; Apigenin inhibits the reaction [Ovalbumin results in decreased expression of TBX21 protein] CTD PMID:36350155 NCBI chr10:82,082,322...82,098,831
Ensembl chr10:82,082,322...82,098,831 		JBrowse link
G Tecr trans-2,3-enoyl-CoA reductase increases expression ISO Apigenin results in increased expression of TECR mRNA CTD PMID:22359648 NCBI chr19:24,526,700...24,568,168
Ensembl chr19:24,541,615...24,568,168 		JBrowse link
G Tfpt TCF3 fusion partner decreases expression ISO Apigenin results in decreased expression of TFPT mRNA CTD PMID:22359648 NCBI chr 1:65,587,633...65,597,407
Ensembl chr 1:65,582,359...65,611,689 		JBrowse link
G Tfrc transferrin receptor multiple interactions ISO Apigenin inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TFRC protein] CTD PMID:35500696 NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257 		JBrowse link
G Th tyrosine hydroxylase multiple interactions EXP Apigenin inhibits the reaction [Rotenone results in decreased expression of TH protein] CTD PMID:28389404 NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767 		JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Apigenin binds to and results in increased activity of THRA protein CTD PMID:33049310 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936 		JBrowse link
G Thrb thyroid hormone receptor beta multiple interactions ISO Apigenin binds to and results in increased activity of THRB protein CTD PMID:33049310 NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein]]
Apigenin inhibits the reaction [Ovalbumin results in increased expression of TLR4 protein]		 CTD PMID:36350155 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression EXP Apigenin results in decreased expression of TM7SF2 mRNA CTD PMID:31201582 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270 		JBrowse link
G Tnf tumor necrosis factor multiple interactions
increases expression		 ISO
EXP		 Apigenin analog inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin analog inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Acrolein promotes the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides promotes the reaction [Acrolein results in increased expression of TNF mRNA]]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [nickel chloride results in increased expression of TNF protein]; Apigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein]; Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]]; Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein]; Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased activity of IKBKB protein]; Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]
Apigenin inhibits the reaction [Freund's Adjuvant results in increased expression of TNF protein]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of TNF protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of TNF protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of TNF mRNA]; Apigenin promotes the reaction [hydroxygenkwanin results in increased expression of TNF protein]; hydroxygenkwanin promotes the reaction [Apigenin results in increased expression of TNF protein]
Apigenin inhibits the reaction [Alcohols results in increased expression of TNF protein]; Apigenin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]		 CTD PMID:15113938 PMID:15322261 PMID:15985724 PMID:16987811 PMID:24144774 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tnfsf10 TNF superfamily member 10 multiple interactions
increases response to substance		 ISO [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BCL2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC2 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in decreased expression of BIRC3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP8 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP9 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of PARP1 protein CTD PMID:29247770 NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
affects activity
increases expression		 ISO TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein]
Apigenin affects the activity of TP53 protein
Apigenin results in increased expression of TP53 protein		 CTD PMID:11790449 PMID:16023288 PMID:35435491 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53i3 tumor protein p53 inducible protein 3 increases expression ISO Apigenin results in increased expression of TP53I3 mRNA; Apigenin results in increased expression of TP53I3 protein CTD PMID:19397994 NCBI chr 6:27,818,327...27,825,753 JBrowse link
G Tp63 tumor protein p63 increases expression ISO Apigenin results in increased expression of TP63 protein CTD PMID:19397994 NCBI chr11:74,838,858...75,049,764
Ensembl chr11:74,838,859...75,049,398 		JBrowse link
G Tp73 tumor protein p73 increases expression ISO Apigenin results in increased expression of TP73 protein CTD PMID:19397994 NCBI chr 5:164,621,377...164,703,958
Ensembl chr 5:164,621,377...164,681,128 		JBrowse link
G Traf6 TNF receptor associated factor 6 multiple interactions ISO Apigenin inhibits the reaction [Ovalbumin results in increased expression of TRAF6 protein]
Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]; TLR4 protein inhibits the reaction [Apigenin inhibits the reaction [Lipopolysaccharides results in increased expression of TRAF6 protein]]		 CTD PMID:36350155 NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507 		JBrowse link
G Tubb5 tubulin, beta 5 class I increases expression ISO Apigenin results in increased expression of TUBB5 mRNA CTD PMID:22359648 NCBI chr20:2,912,779...2,916,928
Ensembl chr20:2,912,778...2,916,940 		JBrowse link
G Tyr tyrosinase increases expression ISO Apigenin results in increased expression of TYR mRNA CTD PMID:21071833 NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression
increases glucuronidation
multiple interactions		 ISO Apigenin results in increased expression of UGT1A1 mRNA
UGT1A1 protein results in increased glucuronidation of Apigenin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA]; [sulforaphane co-treated with Apigenin] results in increased expression of UGT1A1 mRNA		 CTD PMID:14557274 PMID:15090468 PMID:29584932 PMID:31621310 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 increases glucuronidation ISO UGT1A9 protein results in increased glucuronidation of Apigenin CTD PMID:14557274 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b15 UDP glucuronosyltransferase family 2 member B15 increases metabolic processing EXP UGT2B15 protein results in increased metabolism of Apigenin CTD PMID:7574722 NCBI chr14:20,768,015...20,783,599
Ensembl chr14:20,768,015...20,783,589 		JBrowse link
G Uqcrq ubiquinol-cytochrome c reductase, complex III subunit VII multiple interactions EXP Apigenin inhibits the reaction [alpha-Chlorohydrin results in decreased expression of UQCRQ mRNA] CTD PMID:30107153 NCBI chr10:37,585,864...37,589,328
Ensembl chr10:37,586,888...37,589,169 		JBrowse link
G Usp48 ubiquitin specific peptidase 48 increases expression ISO Apigenin results in increased expression of USP48 mRNA CTD PMID:22359648 NCBI chr 5:149,800,189...149,867,838
Ensembl chr 5:149,800,179...149,867,719 		JBrowse link
G Utrn utrophin increases expression ISO Apigenin results in increased expression of UTRN mRNA CTD PMID:22028826 NCBI chr 1:6,720,854...7,224,313
Ensembl chr 1:6,722,594...7,224,313 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions ISO Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA]; Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] CTD PMID:15113938 PMID:16987811 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 ISO Apigenin results in decreased expression of VEGFA mRNA; Apigenin results in decreased expression of VEGFA protein
[Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA mRNA; [Apigenin co-treated with Oxygen deficiency] affects the expression of VEGFA protein; Apigenin inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; Apigenin inhibits the reaction [Oxygen deficiency results in increased secretion of VEGFA protein]		 CTD PMID:15947208 PMID:20153296 PMID:35513012 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Zcrb1 zinc finger CCHC-type and RNA binding motif containing 1 increases expression ISO Apigenin results in increased expression of ZCRB1 mRNA CTD PMID:22359648 NCBI chr 7:124,525,227...124,538,564
Ensembl chr 7:124,524,870...124,571,261 		JBrowse link
G Zfp110 zinc finger protein 110 increases expression ISO Apigenin results in increased expression of ZFP110 mRNA CTD PMID:22359648 NCBI chr 1:73,445,303...73,461,112
Ensembl chr 1:73,445,336...73,461,086 		JBrowse link
5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 decreases expression ISO acacetin results in decreased expression of CCNB1 protein CTD PMID:36740148 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172 		JBrowse link
G Ccne1 cyclin E1 decreases expression ISO acacetin results in decreased expression of CCNE1 protein CTD PMID:36740148 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO acacetin results in decreased expression of CDC25C protein CTD PMID:36740148 NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 decreases expression ISO acacetin results in decreased expression of CDK1 protein CTD PMID:36740148 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO acacetin results in decreased expression of CDK2 protein CTD PMID:36740148 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO acacetin results in increased expression of CDKN1A protein CTD PMID:36740148 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Chek1 checkpoint kinase 1 increases expression ISO acacetin results in increased expression of CHK1 protein CTD PMID:36740148 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO
EXP		 acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:32738202 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2B1 protein CTD PMID:32738202 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP acacetin results in decreased activity of CYP2C11 protein CTD PMID:32738202 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2E1 protein CTD PMID:32738202 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
multiple interactions
increases expression		 EXP
ISO		 acacetin results in decreased activity of CYP3A2 protein
acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]
acacetin results in increased expression of CYP3A4 mRNA		 CTD PMID:21053930 PMID:29933105 PMID:32738202 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Fadd Fas associated via death domain decreases expression ISO acacetin results in decreased expression of FADD protein CTD PMID:36740148 NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
increases phosphorylation		 ISO Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein] CTD PMID:36740148 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation
multiple interactions		 ISO acacetin results in increased phosphorylation of MAPK3 protein
Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein]		 CTD PMID:36740148 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
multiple interactions		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]		 CTD PMID:25455453 PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases expression ISO acacetin results in increased expression of PARP1 protein CTD PMID:36740148 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 increases expression ISO acacetin results in increased expression of RIPK1 protein CTD PMID:36740148 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Ripk3 receptor-interacting serine-threonine kinase 3 increases expression ISO acacetin results in increased expression of RIPK3 protein CTD PMID:36740148 NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
apigenin 7-O-beta-D-glucoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Gypa glycophorin A increases expression ISO apigetrin results in increased expression of GYPA protein CTD PMID:25058688 NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822 		JBrowse link
genkwanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp1 caspase 1 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 protein] CTD PMID:34481870 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]] CTD PMID:34481870 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity		 ISO CYP1A1 protein results in increased metabolism of genkwanin
genkwanin results in decreased activity of CYP1A1 protein		 CTD PMID:19666078 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of genkwanin CTD PMID:19666078 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of genkwanin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin		 CTD PMID:19666078 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]] CTD PMID:34481870 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]] CTD PMID:34481870 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]] CTD PMID:34481870 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] CTD PMID:34481870 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]] CTD PMID:34481870 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] CTD PMID:34481870 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] CTD PMID:34481870 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
hinokiflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator increases expression ISO hinokiflavone results in increased expression of BAX protein CTD PMID:30575109 PMID:32252563 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO hinokiflavone results in decreased expression of BCL2 protein CTD PMID:30575109 PMID:32252563 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 increases expression
increases cleavage		 ISO hinokiflavone results in increased expression of CASP3 protein
hinokiflavone results in increased cleavage of CASP3 protein		 CTD PMID:30575109 PMID:32252563 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G F3 coagulation factor III, tissue factor multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein]; hinokiflavone inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 2:209,827,061...209,838,666
Ensembl chr 2:209,826,959...209,838,668 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO hinokiflavone inhibits the reaction [IL1B protein results in increased secretion of F3 protein] CTD PMID:8882428 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] CTD PMID:29673161 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein] CTD PMID:29673161 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein] CTD PMID:29673161 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO hinokiflavone results in decreased expression of MMP2 mRNA; hinokiflavone results in decreased expression of MMP2 protein CTD PMID:29635122 PMID:30575109 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO hinokiflavone results in decreased expression of MMP9 protein
hinokiflavone results in decreased expression of MMP9 mRNA; hinokiflavone results in decreased expression of MMP9 protein		 CTD PMID:29635122 PMID:30575109 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:29673161 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Prpf40a pre-mRNA processing factor 40 homolog A increases sumoylation ISO hinokiflavone results in increased sumoylation of PRPF40A protein CTD PMID:28884683 NCBI chr 3:37,625,585...37,689,859
Ensembl chr 3:37,627,690...37,690,886 		JBrowse link
G Ptgds prostaglandin D2 synthase affects binding ISO hinokiflavone binds to PTGDS protein CTD PMID:26456343 NCBI chr 3:8,281,899...8,284,833
Ensembl chr 3:8,281,899...8,284,833 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:29673161 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] CTD PMID:29673161 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Senp1 SUMO specific peptidase 1 decreases activity ISO hinokiflavone results in decreased activity of SENP1 protein CTD PMID:28884683 NCBI chr 7:129,163,173...129,226,766
Ensembl chr 7:129,165,774...129,221,598 		JBrowse link
G Sf3a2 splicing factor 3A subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3A2 protein CTD PMID:28884683 NCBI chr 7:8,909,507...8,916,104
Ensembl chr 7:8,909,507...8,915,530 		JBrowse link
G Sf3b1 splicing factor 3b, subunit 1 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B1 protein CTD PMID:28884683 NCBI chr 9:56,492,403...56,532,300
Ensembl chr 9:56,492,403...56,532,300 		JBrowse link
G Sf3b2 splicing factor 3b, subunit 2 increases sumoylation ISO hinokiflavone results in increased sumoylation of SF3B2 protein CTD PMID:28884683 NCBI chr 1:202,570,423...202,590,774
Ensembl chr 1:202,570,423...202,590,759 		JBrowse link
G Snrpd2 small nuclear ribonucleoprotein D2 polypeptide increases sumoylation ISO hinokiflavone results in increased sumoylation of SNRPD2 protein CTD PMID:28884683 NCBI chr 1:78,798,377...78,801,227
Ensembl chr 1:78,798,377...78,803,351 		JBrowse link
G Sumo1 small ubiquitin-like modifier 1 increases localization ISO hinokiflavone results in increased localization of SUMO1 protein CTD PMID:28884683 NCBI chr 9:61,078,790...61,108,697
Ensembl chr 9:61,077,435...61,108,761 		JBrowse link
G Sumo2 small ubiquitin-like modifier 2 increases localization ISO hinokiflavone results in increased localization of SUMO2 protein CTD PMID:28884683 NCBI chr10:100,771,941...100,784,503
Ensembl chr10:100,686,797...100,784,513 		JBrowse link
G Sumo3 small ubiquitin-like modifier 3 increases localization ISO hinokiflavone results in increased localization of SUMO3 protein CTD PMID:28884683 NCBI chr20:11,010,140...11,020,850
Ensembl chr20:11,007,148...11,020,877
Ensembl chr20:11,007,148...11,020,877 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO hinokiflavone results in increased expression of TIMP2 mRNA; hinokiflavone results in increased expression of TIMP2 protein CTD PMID:30575109 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO hinokiflavone inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:29673161 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G U2surp U2 snRNP-associated SURP domain containing increases sumoylation ISO hinokiflavone results in increased sumoylation of U2SURP protein CTD PMID:28884683 NCBI chr 8:96,018,932...96,075,795
Ensembl chr 8:96,022,957...96,075,691 		JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775 		JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum RGD PMID:29575334 RGD:149735333 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Slc2a1 solute carrier family 2 member 1 multiple interactions ISO hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] CTD PMID:36870413 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416 		JBrowse link
G Slco1c1 solute carrier organic anion transporter family, member 1c1 decreases activity
multiple interactions		 EXP hispidulin results in decreased activity of SLCO1B1 protein
[hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate		 CTD PMID:32259555 NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289 		JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,172,208...1,227,400
Ensembl chr  X:1,172,208...1,227,396 		JBrowse link
isoscutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing increases expression ISO isoscutellarein results in increased expression of ADIPOQ protein CTD PMID:30445784 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Lep leptin decreases expression ISO isoscutellarein results in decreased expression of LEP protein CTD PMID:30445784 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262 		JBrowse link
G Rbp4 retinol binding protein 4 decreases expression ISO isoscutellarein results in decreased expression of RBP4 protein CTD PMID:30445784 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Slc2a4 solute carrier family 2 member 4 increases expression ISO isoscutellarein results in increased expression of SLC2A4 protein CTD PMID:30445784 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565 		JBrowse link
G Tnf tumor necrosis factor decreases expression ISO isoscutellarein results in decreased expression of TNF protein CTD PMID:30445784 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
isovitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO isovitexin inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; isovitexin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions EXP [isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin results in increased expression of and results in increased activity of AHR protein CTD PMID:37263555 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO isovitexin results in decreased expression of CDK2 mRNA; isovitexin results in decreased expression of CDK2 protein CTD PMID:37939611 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO isovitexin results in increased expression of CDKN1A mRNA; isovitexin results in increased expression of CDKN1A protein CTD PMID:37939611 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases expression
multiple interactions		 EXP isovitexin results in increased expression of CYP1A1 protein
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin results in increased expression of CYP1A1 protein]; [isovitexin results in increased expression of and results in increased activity of AHR protein] which results in increased expression of CYP1A1 protein		 CTD PMID:37263555 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of IL1B protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]		 CTD PMID:37263555 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein] CTD PMID:37263555 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Mpo myeloperoxidase multiple interactions ISO isovitexin inhibits the reaction [Dextran Sulfate results in increased activity of MPO protein] CTD PMID:37263555 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein] CTD PMID:37263555 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941 		JBrowse link
G Ocln occludin multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein] CTD PMID:37263555 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein] CTD PMID:37263555 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein] CTD PMID:37263555 NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 isovitexin inhibits the reaction [Dextran Sulfate results in increased expression of TNF protein]
2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of NFKBIA protein]]; 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [isovitexin inhibits the reaction [TNF protein results in increased expression of RELA protein]]; isovitexin inhibits the reaction [TNF protein results in decreased expression of AHR protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of OCLN protein]; isovitexin inhibits the reaction [TNF protein results in decreased expression of TJP1 protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL1B protein]; isovitexin inhibits the reaction [TNF protein results in increased expression of IL6 protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]; isovitexin inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]		 CTD PMID:37263555 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO isovitexin results in increased expression of TP53 mRNA; isovitexin results in increased expression of TP53 protein CTD PMID:37939611 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
pectolinarigenin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Atm ATM serine/threonine kinase increases phosphorylation
multiple interactions		 ISO pectolinarigenin results in increased phosphorylation of ATM protein
TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein]		 CTD PMID:37393350 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A multiple interactions
increases expression		 ISO TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein] CTD PMID:37393350 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585 		JBrowse link
G H2ax H2A.X variant histone increases expression
multiple interactions		 ISO pectolinarigenin results in increased expression of H2AX protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]		 CTD PMID:37393350 NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239 		JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta multiple interactions
increases lipidation		 ISO Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein] CTD PMID:37393350 NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO pectolinarigenin results in decreased expression of MKI67 protein CTD PMID:37393350 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Sqstm1 sequestosome 1 increases expression
multiple interactions		 ISO pectolinarigenin results in increased expression of SQSTM1 protein
Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]		 CTD PMID:37393350 NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673 		JBrowse link
G Top2a DNA topoisomerase II alpha multiple interactions ISO pectolinarigenin binds to and results in increased expression of TOP2A protein; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of CDKN1A protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of H2AX protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; TOP2A protein affects the reaction [pectolinarigenin results in increased phosphorylation of ATM protein] CTD PMID:37393350 NCBI chr10:83,945,731...83,976,874
Ensembl chr10:83,945,735...83,976,874 		JBrowse link
G Tp53 tumor protein p53 increases expression
multiple interactions		 ISO pectolinarigenin results in increased expression of TP53 protein
TOP2A protein affects the reaction [pectolinarigenin results in increased expression of TP53 protein]		 CTD PMID:37393350 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Tp53bp1 tumor protein p53 binding protein 1 increases expression ISO pectolinarigenin results in increased expression of TP53BP1 protein CTD PMID:37393350 NCBI chr 3:108,166,574...108,270,229
Ensembl chr 3:108,169,980...108,269,822 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases glucuronidation
affects binding		 ISO UGT1A1 protein results in increased glucuronidation of pectolinarigenin
pectolinarigenin binds to UGT1A1 protein		 CTD PMID:37797876 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a2 UDP glucuronosyltransferase 1 family, polypeptide A2 affects binding
increases glucuronidation		 ISO pectolinarigenin binds to UGT1A3 protein
UGT1A3 protein results in increased glucuronidation of pectolinarigenin		 CTD PMID:37797876 NCBI chr 9:88,791,216...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt1a9 UDP glucuronosyltransferase family 1 member A9 affects binding
increases glucuronidation		 ISO pectolinarigenin binds to UGT1A9 protein
UGT1A9 protein results in increased glucuronidation of pectolinarigenin		 CTD PMID:37797876 NCBI chr 9:88,696,981...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
G Ugt2b1 UDP glucuronosyltransferase 2 family, polypeptide B1 increases glucuronidation ISO UGT2B17 protein results in increased glucuronidation of pectolinarigenin CTD PMID:37797876 NCBI chr14:21,024,035...21,035,784
Ensembl chr14:21,024,006...21,035,986 		JBrowse link
schaftoside term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO schaftoside inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin] CTD PMID:34217736 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
scutellarein term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions		 ISO scutellarein results in decreased activity of CYP1A1 protein
CYP1A1 protein affects the metabolism of scutellarein
[CYP1A1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 PMID:21482471 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 affects metabolic processing ISO CYP1A2 protein affects the metabolism of scutellarein CTD PMID:19666078 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity
affects metabolic processing
multiple interactions		 ISO scutellarein results in decreased activity of CYP1B1 protein
CYP1B1 protein affects the metabolism of scutellarein
[CYP1B1 protein affects the metabolism of scutellarein] which results in increased chemical synthesis of 6-hydroxyluteolin		 CTD PMID:19666078 PMID:21482471 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
scutellarin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G App amyloid beta precursor protein multiple interactions EXP scutellarin inhibits the reaction [APP protein binds to APP protein] CTD PMID:17323972 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP scutellarin inhibits the reaction [cobaltous chloride results in decreased expression of BCL2L1 mRNA] CTD PMID:18442013 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479 		JBrowse link
G Casp1 caspase 1 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of CASP1 mRNA] CTD PMID:37081038 NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 scutellarin inhibits the reaction [cobaltous chloride results in increased activity of CASP3 protein]
scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased cleavage of CASP3 protein]		 CTD PMID:18442013 PMID:36252740 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ep300 E1A binding protein p300 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]] CTD PMID:25192544 NCBI chr 7:113,108,476...113,178,529
Ensembl chr 7:113,106,247...113,136,088
Ensembl chr 7:113,106,247...113,136,088 		JBrowse link
G Fgf2 fibroblast growth factor 2 decreases expression EXP scutellarin results in decreased expression of FGF2 protein CTD PMID:16297343 NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221 		JBrowse link
G Gsdmd gasdermin D multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of GSDMD protein] CTD PMID:37081038 NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions
decreases expression		 ISO benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; epoxomicin inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; epoxomicin inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; MG 262 inhibits the reaction [scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]]; MG 262 inhibits the reaction [scutellarin results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose co-treated with Cycloheximide] results in decreased expression of HIF1A protein]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] promotes the reaction [HIF1A protein binds to EP300 protein]]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of and results in decreased ubiquitination of HIF1A protein]; scutellarin promotes the reaction [Cycloheximide inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of HIF1A protein]] CTD PMID:25192544 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261 		JBrowse link
G Il18 interleukin 18 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of IL18 protein] CTD PMID:37081038 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of JUN protein] CTD PMID:36252740 NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656 		JBrowse link
G Map2k4 mitogen activated protein kinase kinase 4 multiple interactions ISO scutellarin inhibits the reaction [Zearalenone results in increased expression of MAP2K4 protein] CTD PMID:36252740 NCBI chr10:50,343,227...50,447,956
Ensembl chr10:50,344,915...50,447,993 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of MKI67 protein] CTD PMID:25192544 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762 		JBrowse link
G Nlrp3 NLR family, pyrin domain containing 3 multiple interactions EXP scutellarin inhibits the reaction [Streptozocin results in increased expression of NLRP3 protein] CTD PMID:37081038 NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811 		JBrowse link
G Nos2 nitric oxide synthase 2 decreases expression EXP scutellarin results in decreased expression of NOS2 protein CTD PMID:16297343 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 increases expression EXP scutellarin results in increased expression of NOS3 protein CTD PMID:16297343 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions ISO scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of PCNA protein] CTD PMID:25192544 NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995 		JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO scutellarin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599 		JBrowse link
G Pla2g2a phospholipase A2 group IIA affects activity ISO scutellarin affects the activity of PLA2G2A protein CTD PMID:8190018 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Ripk1 receptor interacting serine/threonine kinase 1 multiple interactions ISO scutellarin affects the reaction [RIPK1 protein affects the reaction [Zearalenone results in increased cleavage of CASP3 protein]]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 mRNA]; scutellarin inhibits the reaction [Zearalenone results in increased expression of RIPK1 protein] CTD PMID:36252740 NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824 		JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression
multiple interactions		 EXP
ISO		 scutellarin results in decreased expression of VEGFA protein
scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA mRNA]; scutellarin inhibits the reaction [[cobaltous chloride co-treated with Glucose] results in increased expression of VEGFA protein]		 CTD PMID:16297343 PMID:25192544 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
vitexin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 increases expression ISO vitexin results in increased expression of ABCA1 mRNA CTD PMID:29545167 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Apoe apolipoprotein E increases expression ISO vitexin results in increased expression of APOE mRNA CTD PMID:29545167 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G App amyloid beta precursor protein multiple interactions
decreases expression		 ISO vitexin inhibits the reaction [APP protein modified form results in decreased abundance of Glutathione]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA]; vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Malondialdehyde]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Nitrogen Species]; vitexin inhibits the reaction [APP protein modified form results in increased abundance of Reactive Oxygen Species]; vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein]; vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA]; vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA]
vitexin results in decreased expression of APP mRNA; vitexin results in decreased expression of APP protein		 CTD PMID:29545167 PMID:32926499 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of BAX protein] CTD PMID:29545167 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of BCL2 protein] CTD PMID:29545167 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein] CTD PMID:29545167 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of DDIT3 mRNA] CTD PMID:29545167 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201 		JBrowse link
G Dhcr24 24-dehydrocholesterol reductase increases expression ISO vitexin results in increased expression of DHCR24 mRNA CTD PMID:29545167 NCBI chr 5:121,344,552...121,371,124
Ensembl chr 5:121,344,575...121,371,137 		JBrowse link
G Fshb follicle stimulating hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of FSHB protein] CTD PMID:30365938 NCBI chr 3:93,548,560...93,552,370
Ensembl chr 3:93,548,560...93,552,370 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HMOX1 mRNA] CTD PMID:29545167 NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of HSPA5 mRNA] CTD PMID:29545167 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891 		JBrowse link
G Lhb luteinizing hormone subunit beta multiple interactions ISO vitexin inhibits the reaction [Streptozocin results in decreased expression of LHB protein] CTD PMID:30365938 NCBI chr 1:95,898,269...95,901,973
Ensembl chr 1:95,900,984...95,901,972
Ensembl chr 1:95,900,984...95,901,972 		JBrowse link
G Nfe2l2 NFE2 like bZIP transcription factor 2 multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in decreased expression of NFE2L2 mRNA] CTD PMID:29545167 NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 increases expression ISO vitexin results in increased expression of NR1H3 mRNA CTD PMID:29545167 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Ppid peptidylprolyl isomerase D multiple interactions ISO vitexin inhibits the reaction [APP protein modified form results in increased expression of PPID mRNA] CTD PMID:29545167 NCBI chr 2:164,727,803...164,740,168
Ensembl chr 2:164,727,779...164,740,221 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19841
    role 19817
      biological role 19815
        biochemical role 19529
          metabolite 19515
            apigenin 292
              3-methoxyapigenin 0
              5,7-dihydroxy-4'-methoxyflavone + 22
              6,8-di-C-alpha-L-arabinosylapigenin 0
              6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)apigenin 0
              6-C-D-Xylopyranosyl-8-C-L-arabinopyranosylapigenin 0
              6-C-L-arabinopyranosyl-8-C-D-xylopyranosylapigenin 0
              7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin 0
              8-C-glucopyranosyl-6-C-xylopyranosylapigenin 0
              apigenin 7,4'-dimethyl ether 0
              apigenin 7-O-beta-D-glucoside 1
              apigenin 7-O-beta-L-glucoside 0
              apigenin 7-O-neohesperidoside 0
              apigenin C-pentoside 0
              apigenin-7-O-gentiobioside 0
              apiin + 0
              genkwanin 12
              hinokiflavone 26
              isoschaftoside 0
              isoscutellarein + 5
              isovitexin + 14
              neoschaftoside 0
              ochnaflavone 0
              schaftoside 1
              scutellarein + 45
              swertisin 0
              vitexin + 15
Path 2
Term Annotations click to browse term
  CHEBI ontology 19841
    subatomic particle 19839
      composite particle 19839
        hadron 19839
          baryon 19839
            nucleon 19839
              atomic nucleus 19839
                atom 19839
                  main group element atom 19789
                    p-block element atom 19789
                      carbon group element atom 19737
                        carbon atom 19733
                          organic molecular entity 19733
                            organic molecule 19686
                              organic cyclic compound 19498
                                organic heterocyclic compound 18876
                                  oxacycle 17888
                                    benzopyran 11957
                                      1-benzopyran 11709
                                        flavonoid 7192
                                          anthoxanthin 4541
                                            flavones 4541
                                              hydroxyflavone 4519
                                                trihydroxyflavone 429
                                                  apigenin 292
                                                    3-methoxyapigenin 0
                                                    5,7-dihydroxy-4'-methoxyflavone + 22
                                                    6,8-di-C-alpha-L-arabinosylapigenin 0
                                                    6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)apigenin 0
                                                    6-C-D-Xylopyranosyl-8-C-L-arabinopyranosylapigenin 0
                                                    6-C-L-arabinopyranosyl-8-C-D-xylopyranosylapigenin 0
                                                    7-O-[beta-D-arabinopyranosyl-(1->6)-beta-D-glucosyl]apigenin 0
                                                    8-C-glucopyranosyl-6-C-xylopyranosylapigenin 0
                                                    apigenin 7,4'-dimethyl ether 0
                                                    apigenin 7-O-beta-D-glucoside 1
                                                    apigenin 7-O-beta-L-glucoside 0
                                                    apigenin 7-O-neohesperidoside 0
                                                    apigenin C-pentoside 0
                                                    apigenin-7-O-gentiobioside 0
                                                    apiin + 0
                                                    genkwanin 12
                                                    hinokiflavone 26
                                                    isoschaftoside 0
                                                    isoscutellarein + 5
                                                    isovitexin + 14
                                                    neoschaftoside 0
                                                    ochnaflavone 0
                                                    schaftoside 1
                                                    scutellarein + 45
                                                    swertisin 0
                                                    vitexin + 15
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