Gene: Mcl1 (MCL1, BCL2 family apoptosis regulator) Rattus norvegicus
Symbol: Mcl1
Name: MCL1, BCL2 family apoptosis regulator
Description: ENCODES a protein that exhibits BH domain binding; protein dimerization activity; protein heterodimerization activity; INVOLVED IN negative regulation of apoptotic process; apoptotic mitochondrial changes (ortholog); extrinsic apoptotic signaling pathway in absence of ligand (ortholog); PARTICIPATES IN intrinsic apoptotic pathway; hypoxia inducible factor pathway; interleukin-6 signaling pathway; ASSOCIATED WITH Barrett Esophagus (ortholog); Leishmaniasis (ortholog); Lung Neoplasms (ortholog); FOUND IN Bcl-2 family protein complex (ortholog); cytoplasm (ortholog); cytosol (ortholog); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene
Type: protein-coding
Also known as: BCL2 family apoptosis regulator; induced myeloid leukemia cell differentiation protein Mcl-1 homolog; myeloid cell leukemia 1; myeloid cell leukemia sequence 1
Homo sapiens (human) : MCL1 (MCL1, BCL2 family apoptosis regulator)  HGNC  AGR
Mus musculus (house mouse) : Mcl1 (myeloid cell leukemia sequence 1)  MGI  AGR
Chinchilla lanigera (long-tailed chinchilla) : Mcl1 (MCL1, BCL2 family apoptosis regulator)
Pan paniscus (bonobo/pygmy chimpanzee) : MCL1 (MCL1, BCL2 family apoptosis regulator)
Canis lupus familiaris (dog) : MCL1 (MCL1, BCL2 family apoptosis regulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcl1 (MCL1, BCL2 family apoptosis regulator)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
NCBI Annotation Information: Annotation category: partial on reference assembly
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02197,786,212 - 197,788,992 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.02217,273,158 - 217,275,930 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2175,749,995 - 175,752,956 (+)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
More on Mcl1
AGR Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 620525
Created: 2002-08-06
Species: Rattus norvegicus
Last Modified: 2017-10-03
Status: ACTIVE