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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2582
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Esr2
Name: estrogen receptor 2
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Esr2affects bindingISOESR2 (Homo sapiens)6480464CTDApigenin binds to ESR2 proteinPMID:12224631
Esr2increases activityISOESR2 (Homo sapiens)6480464CTDApigenin results in increased activity of ESR2 proteinPMID:16118406 PMID:16860978 PMID:17132221
Esr2multiple interactionsISOESR2 (Homo sapiens)6480464CTDApigenin binds to and results in increased activity of ESR2 protein; Apigenin inhibits the reaction [Estradiol binds to ESR2 protein]PMID:33049310 PMID:9751507
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