Lrrc26 (leucine rich repeat containing 26) - Rat Genome Database

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Gene: Lrrc26 (leucine rich repeat containing 26) Rattus norvegicus
Analyze
Symbol: Lrrc26
Name: leucine rich repeat containing 26
RGD ID: 1308398
Description: Predicted to enable potassium channel activator activity; transmembrane transporter binding activity; and voltage-gated potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Orthologous to human LRRC26 (leucine rich repeat containing 26); INTERACTS WITH bisphenol A; cadmium dichloride; Cuprizon.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: BK channel auxiliary gamma subunit LRRC26; BK channel auxilliary gamma subunit LRRC26; leucine-rich repeat-containing protein 26; LOC311803; RGD1308398; similar to hypothetical protein MGC37548
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,500,517 - 28,501,843 (+)NCBIGRCr8
mRatBN7.238,102,361 - 8,103,687 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,102,361 - 8,103,687 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,206,881 - 11,208,207 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,793,111 - 19,794,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,982,954 - 17,984,280 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,506,426 - 2,507,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,426 - 2,507,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,487,839 - 2,489,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,452,457 - 3,453,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,452,456 - 3,453,783 (+)NCBI
Celera32,928,903 - 2,930,229 (+)NCBICelera
Cytogenetic Map3p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. GOA pipeline RGD automated data pipeline
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:19199708   PMID:20613726   PMID:22547800   PMID:24906643  


Genomics

Comparative Map Data
Lrrc26
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8328,500,517 - 28,501,843 (+)NCBIGRCr8
mRatBN7.238,102,361 - 8,103,687 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl38,102,361 - 8,103,687 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx311,206,881 - 11,208,207 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0319,793,111 - 19,794,437 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0317,982,954 - 17,984,280 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.032,506,426 - 2,507,752 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl32,506,426 - 2,507,752 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.032,487,839 - 2,489,165 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.433,452,457 - 3,453,783 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.133,452,456 - 3,453,783 (+)NCBI
Celera32,928,903 - 2,930,229 (+)NCBICelera
Cytogenetic Map3p13NCBI
LRRC26
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh389137,168,758 - 137,170,051 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl9137,168,758 - 137,170,051 (-)EnsemblGRCh38hg38GRCh38
GRCh379140,063,210 - 140,064,503 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 369139,183,031 - 139,184,312 (-)NCBINCBI36Build 36hg18NCBI36
Celera9110,577,036 - 110,578,146 (-)NCBICelera
Cytogenetic Map9q34.3NCBI
HuRef9109,523,227 - 109,524,508 (-)NCBIHuRef
CHM1_19140,211,899 - 140,213,180 (-)NCBICHM1_1
T2T-CHM13v2.09149,406,438 - 149,407,731 (-)NCBIT2T-CHM13v2.0
Lrrc26
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39225,179,923 - 25,181,205 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl225,179,927 - 25,181,192 (+)EnsemblGRCm39 Ensembl
GRCm38225,289,911 - 25,291,193 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl225,289,915 - 25,291,180 (+)EnsemblGRCm38mm10GRCm38
MGSCv37225,145,431 - 25,146,713 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36225,111,956 - 25,113,185 (+)NCBIMGSCv36mm8
Celera225,017,421 - 25,018,703 (+)NCBICelera
Cytogenetic Map2A3NCBI
cM Map217.14NCBI
Lrrc26
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555135,178,631 - 5,180,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555135,178,631 - 5,180,462 (-)NCBIChiLan1.0ChiLan1.0
LRRC26
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2112,227,500 - 2,230,362 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan192,230,299 - 2,232,695 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v09108,228,889 - 108,230,178 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.19137,198,298 - 137,199,602 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl9137,198,298 - 137,199,602 (-)Ensemblpanpan1.1panPan2
LRRC26
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1948,490,172 - 48,492,141 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl948,490,995 - 48,492,031 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha947,681,002 - 47,682,961 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0949,355,847 - 49,357,806 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1948,132,258 - 48,134,217 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0948,431,069 - 48,433,028 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0948,478,228 - 48,480,187 (+)NCBIUU_Cfam_GSD_1.0
Lrrc26
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947202,560,725 - 202,562,707 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936669813,111 - 814,220 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936669813,097 - 814,264 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRRC26
(Sus scrofa - pig)
No map positions available.
LRRC26
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1121,018,560 - 1,020,556 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl121,019,263 - 1,020,460 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660584,284,701 - 4,285,976 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lrrc26
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624760774,137 - 777,095 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Lrrc26
1 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:69
Count of miRNA genes:58
Interacting mature miRNAs:58
Transcripts:ENSRNOT00000015242
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
70202Alc19Alcohol consumption QTL 192.5drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)3127494778Rat
631679Cm10Cardiac mass QTL 107.340.0001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3131158234Rat
631831Alc8Alcohol consumption QTL 82.7consumption behavior trait (VT:0002069)calculated ethanol drink intake rate (CMO:0001615)3133230976Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)diastolic blood pressure (CMO:0000005)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)3133278763Rat
61468Bp15Blood pressure QTL 154.4blood pressure trait (VT:0000183)pulse pressure (CMO:0000292)3133278763Rat
631545Bp85Blood pressure QTL 853.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3133278763Rat
4889966Bss95Bone structure and strength QTL 954.4tibia area (VT:1000281)tibia-fibula cross-sectional area (CMO:0001718)3136847613Rat
2312664Scl62Serum cholesterol level QTL 620.05blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)3138710544Rat
631568Bp92Blood pressure QTL 922.20.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3139874793Rat
2290452Scl56Serum cholesterol level QTL 562.26blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)3191609953Rat
1358185Ept6Estrogen-induced pituitary tumorigenesis QTL 66.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat
2292615Ept17Estrogen-induced pituitary tumorigenesis QTL 176.7pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)3653764510778823Rat

Markers in Region
RH144153  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.238,101,712 - 8,101,892 (+)MAPPERmRatBN7.2
Rnor_6.032,505,778 - 2,505,957NCBIRnor6.0
Rnor_5.032,487,191 - 2,487,370UniSTSRnor5.0
RGSC_v3.433,451,809 - 3,451,988UniSTSRGSC3.4
Celera32,928,255 - 2,928,434UniSTS
Cytogenetic Map3p13UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system reproductive system respiratory system appendage
High
Medium
Low 3 4 5
Below cutoff 4 3 2 1 1 7 12 9 1

Sequence


RefSeq Acc Id: ENSRNOT00000015242   ⟹   ENSRNOP00000015242
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl38,102,361 - 8,103,687 (+)Ensembl
Rnor_6.0 Ensembl32,506,426 - 2,507,752 (+)Ensembl
RefSeq Acc Id: NM_001014053   ⟹   NP_001014075
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8328,500,517 - 28,501,843 (+)NCBI
mRatBN7.238,102,361 - 8,103,687 (+)NCBI
Rnor_6.032,506,426 - 2,507,752 (+)NCBI
Rnor_5.032,487,839 - 2,489,165 (+)NCBI
RGSC_v3.433,452,457 - 3,453,783 (+)RGD
Celera32,928,903 - 2,930,229 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_001014075 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH61729 (Get FASTA)   NCBI Sequence Viewer  
  EDL93615 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015242
  ENSRNOP00000015242.2
  ENSRNOP00055000682
  ENSRNOP00060045345
  ENSRNOP00065035400
GenBank Protein Q6P7C4 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_001014075   ⟸   NM_001014053
- Peptide Label: precursor
- UniProtKB: Q6P7C4 (UniProtKB/Swiss-Prot),   A6JT32 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000015242   ⟸   ENSRNOT00000015242
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P7C4-F1-model_v2 AlphaFold Q6P7C4 1-334 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691869
Promoter ID:EPDNEW_R2394
Type:initiation region
Name:Lrrc26_1
Description:leucine rich repeat containing 26
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.032,506,454 - 2,506,514EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:1308398 AgrOrtholog
BioCyc Gene G2FUF-50463 BioCyc
Ensembl Genes ENSRNOG00000011457 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00055000503 UniProtKB/Swiss-Prot
  ENSRNOG00060031655 UniProtKB/Swiss-Prot
  ENSRNOG00065025115 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015242 ENTREZGENE
  ENSRNOT00000015242.4 UniProtKB/Swiss-Prot
  ENSRNOT00055000868 UniProtKB/Swiss-Prot
  ENSRNOT00060054847 UniProtKB/Swiss-Prot
  ENSRNOT00065043204 UniProtKB/Swiss-Prot
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:5598709 IMAGE-MGC_LOAD
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311803 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:72588 IMAGE-MGC_LOAD
NCBI Gene 311803 ENTREZGENE
PANTHER GH08155P UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LEUCINE-RICH REPEAT-CONTAINING PROTEIN 26 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Lrrc26 PhenoGen
PROSITE LRR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011457 RatGTEx
  ENSRNOG00055000503 RatGTEx
  ENSRNOG00060031655 RatGTEx
  ENSRNOG00065025115 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A6JT32 ENTREZGENE, UniProtKB/TrEMBL
  LRC26_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-26 Lrrc26  leucine rich repeat containing 26  RGD1308398  similar to hypothetical protein MGC37548  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-06 RGD1308398  similar to hypothetical protein MGC37548  RGD1308398_predicted  similar to hypothetical protein MGC37548 (predicted)  Symbol and Name updated 1559027 APPROVED
2005-01-20 RGD1308398_predicted  similar to hypothetical protein MGC37548 (predicted)  LOC311803_predicted    Symbol and Name status set to approved 1331353 APPROVED
2005-01-12 LOC311803_predicted  similar to hypothetical protein MGC37548 (predicted)      Symbol and Name status set to provisional 70820 PROVISIONAL