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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 2074
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ahr
Name: aryl hydrocarbon receptor
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ahrmultiple interactionsISOAhr (Mus musculus)6480464CTDApigenin binds to and results in increased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin inhibits the reaction [AHR protein binds to AIP protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ARNT protein]]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein]; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased localization of AHR protein]PMID:14644660 PMID:17869316 PMID:20450880
Ahrmultiple interactionsISOAHR (Homo sapiens)6480464CTDApigenin binds to and results in decreased activity of AHR protein; Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein]PMID:20450880 PMID:29584932
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