GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Casp3 | increases activity | EXP | | 6480464 | CTD | Apigenin results in increased activity of CASP3 protein | PMID:24144774 | Casp3 | multiple interactions | EXP | | 6480464 | CTD | (2-isopropyl-5-methylcyclohexyl) diphenylphosphine oxide inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; [Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of CASP3 mRNA]; Apigenin inhibits the reaction [Isoproterenol results in increased expression of CASP3 protein]; Apigenin inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]; Apigenin inhibits the reaction [Methylmercury Compounds results in increased expression of CASP3 protein]; Apigenin promotes the reaction [hydroxygenkwanin results in increased activity of CASP3 protein]; HIF1A protein inhibits the reaction [[Apigenin co-treated with Oxygen deficiency] results in increased expression of CASP3 protein modified form]; hydroxygenkwanin promotes the reaction [Apigenin results in increased activity of CASP3 protein] | PMID:24144774 PMID:25557508 PMID:30107153 PMID:30152906 PMID:31930969 PMID:35373622 | Casp3 | increases activity | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Apigenin results in increased activity of CASP3 protein | PMID:28025107 | Casp3 | increases activity | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Apigenin results in increased activity of CASP3 protein | PMID:17132221 PMID:19647729 PMID:24148603 | Casp3 | increases cleavage | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | Apigenin results in increased cleavage of CASP3 protein | PMID:15486995 PMID:19397994 PMID:24148603 | Casp3 | multiple interactions | ISO | Casp3 (Mus musculus) | 6480464 | CTD | Apigenin inhibits the reaction [Brefeldin A results in increased activity of CASP3 protein]; Apigenin inhibits the reaction [Thapsigargin results in increased activity of CASP3 protein]; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein]; Fluorouracil promotes the reaction [Apigenin results in increased activity of CASP3 protein] | PMID:20493918 PMID:28025107 | Casp3 | multiple interactions | ISO | CASP3 (Homo sapiens) | 6480464 | CTD | [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 mRNA; [polylactic acid-polyglycolic acid copolymer co-treated with Apigenin] results in increased expression of CASP3 protein; [TNFSF10 protein results in increased susceptibility to Apigenin] which results in increased cleavage of CASP3 protein; Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein] | PMID:19885610 PMID:24070738 PMID:29247770 | | ||||||||||||||||||||||
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