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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 70498
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Nfkb1
Name: nuclear factor kappa B subunit 1
Acc ID: CHEBI:18388
Term: apigenin
Definition: A trihydroxyflavone that is flavone substituted by hydroxy groups at positions 4', 5 and 7. It induces autophagy in leukaemia cells.
Chemical ID: MESH:D047310
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Nfkb1multiple interactionsEXP 6480464CTDApigenin inhibits the reaction [[IL1B protein co-treated with IFNG protein] affects the localization of and results in increased activity of NFKB1 protein]; Apigenin inhibits the reaction [Rotenone results in increased expression of NFKB1 mRNA]PMID:18090225 PMID:28389404
Nfkb1affects localizationISONFKB1 (Homo sapiens)6480464CTDApigenin affects the localization of NFKB1 proteinPMID:24148603
Nfkb1multiple interactionsISONFKB1 (Homo sapiens)6480464CTDApigenin inhibits the reaction [TNF protein affects the localization of NFKB1 protein]PMID:24148603
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