Tp53 (tumor protein p53) - Rat Genome Database

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Gene: Tp53 (tumor protein p53) Rattus norvegicus
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Symbol: Tp53
Name: tumor protein p53
RGD ID: 3889
Description: Enables several functions, including MDM2/MDM4 family protein binding activity; transmembrane transporter binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including cellular response to polyamine macromolecule; regulation of apoptotic process; and regulation of macromolecule biosynthetic process. Located in PML body and chromatin. Part of RNA polymerase II transcription regulator complex. Used to study disease of cellular proliferation (multiple); oral mucosa leukoplakia; and traumatic brain injury. Biomarker of several diseases, including bronchopulmonary dysplasia; gastrointestinal system cancer (multiple); ischemia; oral mucosa leukoplakia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53); PARTICIPATES IN altered p53 signaling pathway; endometrial cancer pathway; non-small cell lung carcinoma pathway; INTERACTS WITH (+)-catechin; (+)-dexrazoxane; (+)-schisandrin B.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: cellular tumor antigen p53; MGC112612; p53; transformation related protein 53; Trp53; tumor protein p53 (Li-Fraumeni syndrome); tumor suppressor p53
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Tp53-ps1   Tp53-ps3  
Allele / Splice: Tp53em3Mcwi ; Tp53m1Kyo ; Tp53tm1(EGFP-Pac)Qly ; Tp53em1Sage
Genetic Models: SD-Tp53em3Mcwi ; SD-Tp53em1Sage ; STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc ; F344-Tp53m1Kyo
Is Marker For: Strains:   STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc   F344-Tp53m1Kyo  
Candidate Gene For: Hcar1
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,798,851 - 54,810,299 (+)EnsemblGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,454,375 - 53,465,803 (+)NCBICelera
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Cytogenetic Map10q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Acute Erythroleukemia  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
acute megakaryocytic leukemia  (ISO)
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
adenoid cystic carcinoma  (ISO)
adenoma  (ISO)
Adrenal Cortex Neoplasms  (ISO)
Adrenal Gland Neoplasms  (ISO)
adrenocortical carcinoma  (ISO)
adult T-cell leukemia/lymphoma  (ISO)
Alzheimer's disease  (ISO)
amyotrophic lateral sclerosis  (ISO)
anaplastic astrocytoma  (ISO)
anaplastic thyroid carcinoma  (ISO)
angiosarcoma  (ISO)
Animal Disease Models  (ISO)
Arsenic Poisoning  (ISO)
atherosclerosis  (ISO)
atypical teratoid rhabdoid tumor  (ISO)
autosomal recessive dyskeratosis congenita 3  (ISO)
B-Cell Chronic Lymphocytic Leukemia  (ISO)
B-lymphoblastic leukemia/lymphoma  (ISO)
Balkan nephropathy  (ISO)
basal cell carcinoma  (ISO)
bone development disease  (ISO)
Bone Marrow Failure Syndrome 5  (ISO)
Bone Marrow Neoplasms  (ISO)
bone osteosarcoma  (ISO)
brain ischemia  (ISO)
Brain Neoplasms  (ISO)
breast adenocarcinoma  (ISO)
breast cancer  (ISO,ISS)
Breast Cancer, Familial  (ISO)
breast carcinoma  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (IMP)
bronchopulmonary dysplasia  (IEP)
Calcification of Aortic Valve  (ISO)
calcinosis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
Cardiotoxicity  (ISO)
carotid artery disease  (ISO)
cataract  (ISO)
Cecal Neoplasms  (ISO)
Central Nervous System Neoplasms  (ISO)
cervical adenocarcinoma  (ISO)
cervical cancer  (ISO)
cervical squamous cell carcinoma  (ISO)
CHARGE syndrome  (ISS)
Chemotherapy-Induced Febrile Neutropenia  (ISO)
cholangiocarcinoma  (ISO)
cholesteatoma of middle ear  (ISO)
choroid plexus carcinoma  (ISO)
choroid plexus papilloma  (ISO)
Chromosome 17 Deletion  (ISO)
chronic lymphocytic leukemia  (ISO)
chronic obstructive pulmonary disease  (ISO)
clear cell adenocarcinoma  (ISO)
clear cell renal cell carcinoma  (ISO)
colon carcinoma  (ISO)
Colon Diverticulum  (ISO)
Colonic Neoplasms  (ISO)
colorectal adenocarcinoma  (ISO)
colorectal cancer  (IEP,ISO)
colorectal carcinoma  (ISO)
Colorectal Neoplasms  (ISO)
congenital fibrosarcoma  (ISO)
congenital merosin-deficient muscular dystrophy 1A  (ISO)
congestive heart failure  (ISO)
coronary artery disease  (ISO)
coronary restenosis  (ISO)
Craniofacial Abnormalities  (ISO)
demyelinating disease  (ISO)
Diabetic Nephropathies  (IEP)
Diamond-Blackfan anemia  (ISO)
diffuse large B-cell lymphoma  (ISO,ISS)
diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype  (ISO)
DiGeorge syndrome  (ISO)
dilated cardiomyopathy  (IEP)
disease of cellular proliferation  (IMP,ISO)
Disease Progression  (ISO)
Drug-induced Neutropenia  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Ductal Carcinoma  (ISO)
ductal carcinoma in situ  (ISO)
dyskeratosis congenita  (ISS)
Emphysema  (ISO)
endometrial adenocarcinoma  (ISO)
endometrial cancer  (ISS)
endometrial carcinoma  (IMP,ISO)
Endometrial Intraepithelial Neoplasia  (ISO)
Endometrial Neoplasms  (ISO)
esophageal cancer  (ISO)
esophageal carcinoma  (ISO)
Esophageal Neoplasms  (IEP,ISO)
esophagus adenocarcinoma  (ISO)
esophagus squamous cell carcinoma  (ISO)
Experimental Diabetes Mellitus  (IEP,ISO)
Experimental Liver Neoplasms  (ISO)
Experimental Mammary Neoplasms  (IEP,ISO)
Experimental Neoplasms  (ISO)
Eye Neoplasms  (ISO)
familial melanoma  (ISO)
Familial Pancreatic Carcinoma  (ISO)
Female Infertility  (ISO)
gallbladder cancer  (ISO)
Gallbladder Neoplasms  (ISO)
gastric adenocarcinoma  (ISO)
glioblastoma  (ISO,ISS)
graft-versus-host disease  (ISO)
Graves' disease  (ISO)
head and neck squamous cell carcinoma  (ISO)
hematologic cancer  (ISO)
hepatoblastoma  (ISO)
hepatocellular carcinoma  (IEP,ISO)
Hereditary Adrenocortical Carcinoma  (ISO)
hereditary breast ovarian cancer syndrome  (ISO)
Hereditary Neoplastic Syndromes  (ISO)
high grade glioma  (ISO)
hypertension  (ISO)
hypertrophic cardiomyopathy  (ISO)
Hypogonadism and Testicular Atrophy  (IMP)
ischemia  (IEP,ISO)
Kaposi's sarcoma  (ISO)
keratosis  (ISO)
Leber hereditary optic neuropathy  (ISO)
leukemia  (ISO)
Li-Fraumeni syndrome  (ISO,ISS)
Li-Fraumeni syndrome 1  (ISO)
Li-Fraumeni-Like Syndrome  (ISO)
Lip Neoplasms  (ISO)
Liver Neoplasms  (ISO)
low tension glaucoma  (ISO)
lung adenocarcinoma  (ISO)
Lung Neoplasms  (IMP,ISO)
lung non-small cell carcinoma  (ISO)
lung sarcomatoid carcinoma  (ISO)
lung small cell carcinoma  (ISO)
lung squamous cell carcinoma  (ISO)
Lymphatic Metastasis  (ISO)
lymphoma  (ISO)
male infertility  (ISO)
malignant astrocytoma  (ISO)
malignant mesothelioma  (ISO)
marginal zone lymphoma  (ISO)
medulloblastoma  (ISO)
melanoma  (ISO)
meninges sarcoma  (IMP)
Mesothelioma  (ISO)
mismatch repair cancer syndrome  (ISO)
mitochondrial metabolism disease  (ISO)
Mouth Neoplasms  (IEP,ISO)
multiple myeloma  (ISO)
myelodysplastic syndrome  (ISO)
myelofibrosis  (ISO)
myeloid leukemia associated with Down Syndrome  (ISO)
myeloid neoplasm  (ISO)
myocardial infarction  (ISO)
Myocardial Reperfusion Injury  (IEP)
nasal cavity cancer  (ISO)
Nasopharyngeal Neoplasms  (ISO)
nasopharynx carcinoma  (ISO)
Neoplasm Metastasis  (IMP,ISO)
Neoplastic Cell Transformation  (ISO)
nephroblastoma  (ISO)
Nerve Sheath Neoplasms  (ISO)
nervous system disease  (ISO)
neuroblastoma  (ISO)
non-Hodgkin lymphoma  (ISO)
Odontogenic Myxoma  (ISO)
Oral Lichen Planus  (ISO)
oral mucosa leukoplakia  (IEP,IMP,ISO)
oral squamous cell carcinoma  (ISO)
oral submucous fibrosis  (ISO)
Oropharyngeal Neoplasms  (ISO)
osteosarcoma  (IMP,ISO,ISS)
ovarian cancer  (ISO)
ovarian carcinoma  (ISO)
Ovarian Neoplasms  (ISO)
ovarian small cell carcinoma  (ISO)
ovary serous adenocarcinoma  (ISO)
pancreatic cancer  (ISO)
pancreatic carcinoma  (ISO)
pancreatic ductal carcinoma  (ISO)
pancreatic intraductal papillary-mucinous neoplasm  (ISO)
papillary thyroid carcinoma  (ISO)
paranasal sinus benign neoplasm  (ISO)
Parasitic Liver Diseases  (ISO)
Pediatric Adrenocortical Carcinoma  (ISO)
Penile Neoplasms  (ISO)
Phyllodes Tumor  (ISO)
pleomorphic xanthoastrocytoma  (ISO)
Pleural Effusion  (ISO)
Polyploidy  (ISO)
pre-malignant neoplasm  (IEP,ISO)
Premature Aging  (ISO)
primary cutaneous T-cell non-Hodgkin lymphoma  (ISO)
primary open angle glaucoma  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
Prostate Cancer, Hereditary, 1  (ISO)
Prostatic Neoplasms  (ISO)
psoriasis  (ISO)
pterygium  (ISO)
pulmonary hypertension  (ISO)
renal cell carcinoma  (ISO)
Reperfusion Injury  (IEP)
rhabdomyosarcoma  (ISO)
SAPHO syndrome  (ISO)
sarcoma  (IMP,ISO)
schizophrenia  (ISO)
serous cystadenocarcinoma  (ISO)
Sezary's disease  (ISO)
skin melanoma  (ISO)
Skin Neoplasms  (ISO)
small cell carcinoma  (ISO)
Spinal Cord Injuries  (IEP)
spondyloarthropathy  (ISO)
squamous cell carcinoma  (ISO)
stomach cancer  (ISO)
Stomach Neoplasms  (ISO)
T-cell non-Hodgkin lymphoma  (ISO)
thymoma  (ISO)
Thymus Neoplasms  (ISO)
Thyroid Neoplasms  (ISO)
Tongue Neoplasms  (IEP,IMP,ISO)
tongue squamous cell carcinoma  (IEP)
transitional cell carcinoma  (ISO)
traumatic brain injury  (IMP)
Trigeminal Nerve Injuries  (IEP)
ulcerative colitis  (ISO)
urinary bladder cancer  (ISO)
Urinary Bladder Neoplasm  (ISO)
Urogenital Neoplasms  (ISO)
Urologic Neoplasms  (ISO)
vascular dementia  (IEP)
Vulvar Lichen Sclerosus  (ISO)
Vulvar Neoplasms  (IEP,ISO)
xeroderma pigmentosum  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-(S)-ar-turmerone  (ISO)
(+)-artemisinin  (ISO)
(+)-catechin  (EXP,ISO)
(+)-dexrazoxane  (EXP,ISO)
(+)-epicatechin-3-O-gallate  (ISO)
(+)-schisandrin B  (EXP,ISO)
(-)-alpha-phellandrene  (ISO)
(-)-anisomycin  (EXP)
(-)-citrinin  (EXP,ISO)
(-)-epigallocatechin 3-gallate  (EXP,ISO)
(-)-noscapine  (ISO)
(1->4)-beta-D-glucan  (ISO)
(1S)-bornane-2,3-dione  (ISO)
(20R)-protopanaxadiol  (ISO)
(6aR,11aS,11bR)-10-acetyl-11-hydroxy-7,7-dimethyl-2,6,6a,7,11a,11b-hexahydro-9H-pyrrolo[1',2':2,3]isoindolo[4,5,6-cd]indol-9-one  (ISO)
(9E,11E)-octadecadienoic acid  (ISO)
(aminomethyl)phosphonic acid  (ISO)
(R)-adrenaline  (ISO)
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(R,R,R)-alpha-tocopherol  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
(S)-ropivacaine  (EXP)
(Z)-3-butylidenephthalide  (ISO)
(Z)-ligustilide  (ISO)
1'-acetoxychavicol acetate  (ISO)
1,1'-azobis(N,N-dimethylformamide)  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3-Dinitropyrene  (ISO)
1,4-benzoquinone  (ISO)
1,4-dithiothreitol  (ISO)
1,8-Dinitropyrene  (ISO)
1-[(2,3,4-trimethoxyphenyl)methyl]piperazine  (ISO)
1-hydroxy-1-norresistomycin  (ISO)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (ISO)
1-methylphenanthrene  (EXP)
1-naphthyl isothiocyanate  (EXP)
1-nitropyrene  (EXP,ISO)
11-deoxycorticosterone  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (ISO)
19-Nor-17alpha-pregn-5(10)-en-20-yne-3alpha,17beta-diol  (EXP)
1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one  (ISO)
1H-pyrazole  (ISO)
2'-Hydroxy-2,3,5'-trimethoxychalcone  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2',5,5'-Tetrachlorobenzidine  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2'-dithiodiethanol  (ISO)
2,2,2-tetramine  (ISO)
2,2-bis(hydroxymethyl)-1-azabicyclo[2.2.2]octan-3-one  (ISO)
2,3,4,6-tetrachlorophenol  (ISO)
2,3,5,6-tetrachlorophenol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,4'-trichlorobiphenyl  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP,ISO)
2,4-D  (EXP,ISO)
2,4-dibromophenol  (ISO)
2,4-dinitrotoluene  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2,6-dichloroindophenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP,ISO)
2-amino-4,6-dinitrotoluene  (ISO)
2-deoxy-D-glucose  (ISO)
2-Hydroxy-6-(8,11,14-pentadecatrienyl)benzoic acid  (ISO)
2-methoxyethanol  (EXP)
2-naphthylamine  (ISO)
2-nitropropane  (ISO)
2-nitrotoluene  (ISO)
2-pyridylethylamine  (ISO)
2-tert-butylhydroquinone  (EXP,ISO)
25-hydroxycholesterol  (ISO)
3',4',7-trihydroxyisoflavone  (ISO)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (EXP,ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP,ISO)
3,3',5,5'-tetraiodothyroacetic acid  (EXP,ISO)
3,3'-Dichlorobenzidine  (ISO)
3,3'-diindolylmethane  (ISO)
3,4,8-Trimethyl-1H,2H,3H-imidazo[4,5-F]quinoxalin-2-imine  (ISO)
3,6-diaminoacridine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-aminobenzamide  (ISO)
3-BROMO-7-NITROINDAZOLE  (ISO)
3-bromopyruvic acid  (ISO)
3-Chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-hydroxybutyric acid  (ISO)
3-iodoprop-2-yn-1-yl butylcarbamate  (ISO)
3-methyladenine  (ISO)
3-methylcholanthrene  (EXP,ISO)
3-methylfuran  (EXP)
3-Nitrobenzanthrone  (ISO)
3-Nitrofluoranthene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-epidoxorubicin  (ISO)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (ISO)
4-amino-2,6-dinitrotoluene  (EXP)
4-Aminobenzamide  (ISO)
4-aminofolic acid  (ISO)
4-chloroaniline  (ISO)
4-hydroperoxycyclophosphamide  (ISO)
4-hydroxy-3-[4-(2-hydroxyphenyl)phenyl]-6-oxo-7H-thieno[2,3-b]pyridine-5-carbonitrile  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-methylumbelliferone  (ISO)
4-Nerolidylcatechol  (ISO)
4-nitrophenol  (ISO)
4-nitroquinoline N-oxide  (EXP,ISO)
4-nonylphenol  (EXP,ISO)
4-phenylbutyric acid  (EXP)
4-tert-Octylphenol  (EXP,ISO)
5'-S-methyl-5'-thioadenosine  (ISO)
5,6,7,8-tetrahydrobiopterin  (ISO)
5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole  (ISO)
5-(2-chloroethyl)-4-methylthiazole  (EXP)
5-aminolevulinic acid  (ISO)
5-aza-2'-deoxycytidine  (EXP,ISO)
5-azacytidine  (EXP,ISO)
5-chloro-7-iodoquinolin-8-ol  (ISO)
5-fluorouracil  (EXP,ISO)
5-Geranyloxy-7-methoxycoumarin  (ISO)
5-methoxypsoralen  (ISO)
6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide  (EXP,ISO)
6-O-methylguanine  (ISO)
6-oxocampestanol  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP,ISO)
7,8-diacetoxy-4-methylcoumarin  (ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
7-amino-4-hydroxy-2-naphthalenesulfonic acid  (ISO)
7-ketocholesterol  (EXP)
7-nitroindazole  (EXP)
8-Br-cAMP  (ISO)
8-bromo-3',5'-cyclic GMP  (EXP)
9,10-phenanthroquinone  (ISO)
9,11,13-octadecatrienoic acid  (ISO)
9-aminoacridine  (ISO)
9-Methoxycamptothecin  (ISO)
ABT-737  (ISO)
acetamide  (EXP)
acetamiprid  (ISO)
acetic acid  (ISO)
acetylsalicylic acid  (ISO)
aconitine  (EXP)
acridine orange  (ISO)
acridine orange free base  (ISO)
acrolein  (EXP,ISO)
acrylamide  (EXP,ISO)
acrylonitrile  (ISO)
actinomycin D  (ISO)
adavosertib  (ISO)
adefovir pivoxil  (ISO)
aflatoxin B1  (EXP,ISO)
Aflatoxin G1  (ISO)
AICA ribonucleotide  (ISO)
alantolactone  (ISO)
albendazole  (ISO)
albendazole S-oxide  (ISO)
albuterol  (ISO)
aldehydo-D-glucose  (EXP,ISO)
all-cis-docosa-7,10,13,16-tetraenoic acid  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allethrin  (EXP)
alliin  (ISO)
allose  (ISO)
Aloe emodin  (ISO)
alpha-D-galactose  (EXP,ISO)
alpha-hexachlorocyclohexane  (EXP)
alpha-mangostin  (ISO)
alpha-naphthoflavone  (EXP,ISO)
alpha-phellandrene  (ISO)
alsterpaullone  (ISO)
alternariol  (ISO)
aluminium oxide  (ISO)
alvocidib  (ISO)
ambrisentan  (ISO)
amifostine  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP,ISO)
amodiaquine  (ISO)
amosite asbestos  (EXP,ISO)
amphetamine  (EXP,ISO)
amphibole asbestos  (ISO)
amsacrine  (ISO)
andrographolide  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimony trichloride  (ISO)
antimycin A  (ISO)
aphidicolin  (ISO)
apigenin  (ISO)
apocynin  (EXP)
arachidonic acid  (ISO)
arachidonyl-2'-chloroethylamide  (ISO)
arecoline  (ISO)
arecoline hydrobromide  (EXP)
Arg-Gly-Asp  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (ISO)
Aroclor 1254  (EXP,ISO)
arsane  (EXP,ISO)
arsenic acid  (ISO)
arsenic atom  (EXP,ISO)
arsenic trichloride  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (EXP,ISO)
artesunate  (ISO)
asbestos  (ISO)
aspartame  (ISO)
astaxanthin  (EXP)
astilbin  (ISO)
Atipamezole  (EXP)
atorvastatin calcium  (ISO)
ATP  (ISO)
Atranorin  (ISO)
atrasentan  (EXP)
atrazine  (EXP,ISO)
atropine  (ISO)
Auriculasin  (ISO)
aurofusarin  (ISO)
axitinib  (ISO)
azadirachtin A  (ISO)
azaribine  (ISO)
azathioprine  (ISO)
azetidine  (ISO)
azinphos-ethyl  (ISO)
azinphos-methyl  (ISO)
Azoxymethane  (EXP)
bafilomycin A1  (ISO)
baicalein  (EXP,ISO)
baicalin  (ISO)
barban  (ISO)
bathocuproine disulfonic acid  (ISO)
belinostat  (ISO)
benomyl  (ISO)
Bensulide  (ISO)
benzalkonium chloride  (ISO)
benzene  (EXP,ISO)
benzidine  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (ISO)
Benzo[a]pyrene-7,8-diol  (ISO)
benzo[b]fluoranthene  (ISO)
BENZO[G]CHRYSENE  (EXP)
Benzo[k]fluoranthene  (ISO)
berberine  (ISO)
beryllium dichloride  (ISO)
beryllium sulfate  (ISO)
Besigomsin  (ISO)
beta-carboline  (ISO)
beta-D-fructofuranose 1,6-bisphosphate  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
betalain  (ISO)
betaxolol  (ISO)
betulinic acid  (ISO)
bexarotene  (ISO)
bicalutamide  (ISO)
bifenthrin  (ISO)
biphenyl-2-ol  (ISO)
biphenyl-4-amine  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
Bisoxatin acetate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (EXP)
bisphenol F  (EXP,ISO)
bisphenol F diglycidyl ether  (ISO)
bithionol  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
bortezomib  (ISO)
bosutinib  (ISO)
brassinolide  (ISO)
brequinar  (ISO)
bromochloroacetic acid  (EXP)
Bromofos  (ISO)
Bromophos-ethyl  (ISO)
bromuconazole  (EXP)
bucladesine  (ISO)
budesonide  (ISO)
Bufotalin  (ISO)
buspirone  (EXP)
busulfan  (ISO)
buta-1,3-diene  (ISO)
butanal  (ISO)
butane-2,3-dione  (ISO)
butylated hydroxyanisole  (EXP,ISO)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
C60 fullerene  (EXP,ISO)
cadmium acetate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
Calcimycin  (ISO)
calcitriol  (ISO)
calcium atom  (ISO)
calcium silicate  (ISO)
calcium(0)  (ISO)
calyculin A  (ISO)
camptothecin  (EXP,ISO)
candesartan  (EXP)
cannabidiol  (EXP,ISO)
capsaicin  (ISO)
carbachol  (ISO)
carbamate ester  (ISO)
carbamazepine  (ISO)
carbendazim  (EXP,ISO)
CARBENOXOLONE  (ISO)
carbofuran  (ISO)
carbon nanotube  (ISO)
Carbophenothion  (ISO)
carboplatin  (ISO)
carfilzomib  (ISO)
Carmofur  (ISO)
carmustine  (ISO)
carteolol  (ISO)
carvacrol  (EXP)
carvedilol  (EXP)
casticin  (ISO)
cefalotin  (ISO)
cefotaxime  (ISO)
celastrol  (ISO)
celecoxib  (EXP,ISO)
cepharanthine  (ISO)
ceric oxide  (ISO)
cerium  (ISO)
cetrorelix  (ISO)
CGS-21680  (ISO)
chalcones  (ISO)
chlorambucil  (ISO)
chlorfenvinfos  (ISO)
chloroacetaldehyde  (ISO)
chloroethene  (ISO)
chloroform  (EXP,ISO)
chlorogenic acid  (ISO)
chlorophyllin  (EXP,ISO)
chloropicrin  (ISO)
chloroquine  (ISO)
chlorpromazine  (EXP)
chlorpyrifos  (EXP,ISO)
chlorpyrifos-methyl  (ISO)
cholesterol  (ISO)
choline  (EXP,ISO)
chromium atom  (ISO)
chromium(6+)  (EXP,ISO)
chrysene  (ISO)
chrysin  (EXP,ISO)
chrysin 5,7-dimethyl ether  (EXP)
ciclopirox  (ISO)
cidofovir anhydrous  (ISO)
cilostazol  (EXP,ISO)
Cirsimarin  (ISO)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
cladribine  (ISO)
clodronic acid  (ISO)
clofarabine  (ISO)
clofibric acid  (EXP)
clopidogrel  (ISO)
clotrimazole  (ISO)
clozapine  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (EXP,ISO)
cocaine  (ISO)
coenzyme Q10  (EXP,ISO)
colforsin daropate hydrochloride  (ISO)
colistin  (EXP)
conjugated linoleic acid  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (EXP,ISO)
cordycepin  (EXP,ISO)
coumaphos  (ISO)
coumarin  (ISO)
coumarin 460  (ISO)
Crenigacestat  (ISO)
cridanimod  (ISO)
crocidolite asbestos  (ISO)
crocin-1  (ISO)
crotonaldehyde  (EXP)
Crufomate  (ISO)
cryptolepine  (ISO)
crystal violet  (ISO)
CU-O LINKAGE  (ISO)
cudraflavone B  (ISO)
Cuprizon  (EXP,ISO)
curcumin  (EXP,ISO)
cyanamide  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (EXP,ISO)
cyclosporin A  (EXP,ISO)
cyfluthrin  (ISO)
cyhalothrin  (ISO)
cylindrospermopsin  (EXP)
cypermethrin  (EXP,ISO)
cytarabine  (EXP,ISO)
cytochalasin B  (ISO)
D-fructofuranose 1,6-bisphosphate  (ISO)
D-glucose  (EXP,ISO)
D-mannitol  (ISO)
D-penicillamine  (ISO)
daidzein  (ISO)
dapagliflozin  (EXP)
DAPT  (ISO)
daunorubicin  (EXP,ISO)
DDE  (ISO)
DDT  (EXP,ISO)
deguelin  (ISO)
dehydroepiandrosterone  (ISO)
DENSPM  (ISO)
deoxycholic acid  (EXP)
Deoxycorticosterone acetate  (EXP)
deoxynivalenol  (ISO)
Deoxyschizandrin  (ISO)
dequalinium  (ISO)
desferrioxamine B  (EXP,ISO)
dexamethasone  (EXP,ISO)
dexmedetomidine  (EXP)
dextran sulfate  (ISO)
Di-n-octyl phthalate  (ISO)
Diacetoxyscirpenol  (ISO)
Dialifor  (ISO)
diallyl disulfide  (EXP,ISO)
Diallyl sulfide  (EXP,ISO)
diallyl trisulfide  (ISO)
diarsenic trioxide  (EXP,ISO)
diazinon  (EXP,ISO)
diazoxide  (EXP)
diazoxon  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibenzo[a,e]pyrene  (EXP)
dibenzo[a,l]pyrene  (EXP,ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
Dichlorophen  (ISO)
dichlorvos  (EXP)
dichromic acid  (ISO)
diclofenac  (EXP,ISO)
dicoumarol  (ISO)
dicrotophos  (ISO)
Dictamnine  (ISO)
dicyclanil  (ISO)
Didecyldimethylammonium  (ISO)
dieckol  (ISO)
dieldrin  (EXP,ISO)
dienestrol  (ISO)
diepoxybutane  (ISO)
diethanolamine  (EXP,ISO)
diethyl maleate  (ISO)
diethyl phthalate  (ISO)
diethyl sulfate  (ISO)
diethyldithiocarbamic acid  (ISO)
diethylstilbestrol  (EXP,ISO)
digitoxin  (ISO)
dihydroartemisinin  (ISO)
dihydrocapsaicin  (ISO)
dihydrolipoic acid  (ISO)
Diisodecyl phthalate  (ISO)
diisononyl phthalate  (ISO)
Dimefox  (ISO)
dimethylarsinic acid  (EXP,ISO)
dimetilan  (ISO)
dinophysistoxin 2  (ISO)
dioscin  (EXP,ISO)
diosmin  (EXP)
dioxygen  (EXP,ISO)
diphenoxylate  (ISO)
dipyridamole  (ISO)
diquat  (EXP)
disodium selenite  (ISO)
disulfoton  (ISO)
donepezil hydrochloride  (EXP)
dopamine  (ISO)
dorsomorphin  (ISO)
doxorubicin  (EXP,ISO)
edifenphos  (ISO)
eflornithine  (EXP)
EHT 1864  (ISO)
elemental selenium  (EXP,ISO)
ellagic acid  (EXP,ISO)
ellipticine  (ISO)
emodin  (EXP,ISO)
emtricitabine  (ISO)
endosulfan  (ISO)
endrin  (ISO)
entinostat  (ISO)
enzyme inhibitor  (ISO)
EPN  (ISO)
epoxiconazole  (ISO)
erdosteine  (ISO)
erlotinib hydrochloride  (ISO)
erythromycin estolate  (EXP)
erythrosin B  (ISO)
esculetin  (ISO)
estragole  (EXP)
etacrynic acid  (ISO)
ethacridine  (ISO)
ethanol  (EXP,ISO)
ethidium  (ISO)
ethion  (ISO)
ethyl 4-nitrophenyl ethylphosphonate  (ISO)
Ethyl acrylate  (ISO)
Ethyl icosapentate  (EXP)
ethylenediaminetetraacetic acid  (ISO)
etomoxir  (EXP)
etoposide  (EXP,ISO)
eugenol  (EXP,ISO)
EUK-134  (ISO)
EUK-8  (ISO)
eurycomanone  (ISO)
Evodiamine  (ISO)
famphur  (ISO)
fenamiphos  (ISO)
fenbendazole  (EXP,ISO)
fenitrothion  (EXP,ISO)
fenofibrate  (EXP,ISO)
fenpropathrin  (EXP)
fenpyroximate  (ISO)
fensulfothion  (ISO)
fenthion  (ISO)
fenticlor  (ISO)
fentin acetate  (ISO)
fenvalerate  (EXP)
ferric ammonium citrate  (EXP,ISO)
ferric oxide  (EXP)
ferrosoferric oxide  (ISO)
ferrostatin-1  (EXP)
finasteride  (EXP)
fingolimod hydrochloride  (ISO)
fipronil  (ISO)
fisetin  (EXP,ISO)
flavanone  (ISO)
flavanones  (ISO)
flavonoids  (ISO)
floxuridine  (ISO)
fluazinam  (ISO)
flubendazole  (ISO)
flucytosine  (ISO)
flumethrin  (ISO)
fluoranthene  (ISO)
fluorometholone  (ISO)
fluoxetine  (ISO)
flurbiprofen  (ISO)
flusalan  (ISO)
flutamide  (EXP)
folic acid  (EXP,ISO)
fonofos  (ISO)
formaldehyde  (EXP,ISO)
formic acid  (ISO)
formononetin  (EXP,ISO)
fosthiazate  (ISO)
fostriecin  (ISO)
fotemustine  (ISO)
fructose  (ISO)
fulvestrant  (ISO)
fumaraldehyde  (ISO)
fumonisin B1  (EXP,ISO)
furan  (EXP)
Fusarenone X  (ISO)
Fusaric acid  (ISO)
galactose  (EXP,ISO)
gallic acid  (ISO)
gamma-hexachlorocyclohexane  (ISO)
gamma-tocopherol  (ISO)
ganciclovir  (ISO)
gefitinib  (EXP,ISO)
geldanamycin  (ISO)
gemcitabine  (ISO)
Geniposide  (ISO)
genistein  (EXP,ISO)
gentamycin  (EXP,ISO)
geraniol  (EXP,ISO)
gingerol  (ISO)
ginkgolide B  (ISO)
ginsenoside Rg1  (ISO)
glafenine  (EXP)
gliclazide  (ISO)
glimepiride  (ISO)
glucaric acid  (ISO)
glucose  (EXP,ISO)
glutaraldehyde  (ISO)
glutathione  (ISO)
glutathione disulfide  (ISO)
Glutathione ethyl ester  (ISO)
glyburide  (EXP,ISO)
glycerol  (ISO)
glycine betaine  (EXP)
glycitein  (ISO)
glycoursodeoxycholic acid  (EXP)
glycyrrhetinate  (EXP)
glycyrrhetinic acid  (EXP)
glycyrrhizinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Goserelin  (ISO)
gossypol  (ISO)
graphene oxide  (ISO)
guggulsterone  (ISO)
GW 4064  (ISO)
GW 6471  (EXP)
Gyrophoric acid  (ISO)
haloperidol  (EXP)
harmalol  (ISO)
heparin  (ISO)
heptachlor  (ISO)
hesperetin  (ISO)
hesperidin  (EXP)
hexachlorophene  (ISO)
hexadecanoic acid  (ISO)
hexanal  (ISO)
homocysteine  (EXP,ISO)
hycanthone  (ISO)
hydralazine  (ISO)
hydrogen peroxide  (EXP,ISO)
hydroquinone  (ISO)
hydroxamic acid  (ISO)
hydroxychloroquine  (ISO)
hydroxyurea  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
Icaritin  (ISO)
ICI D1694  (ISO)
ICI-164384  (ISO)
idarubicin  (ISO)
ifosfamide  (EXP,ISO)
indole-3-methanol  (ISO)
indometacin  (EXP,ISO)
Inotodiol  (ISO)
inuviscolide  (ISO)
Iodofenphos  (ISO)
iohexol  (ISO)
iopamidol  (ISO)
irinotecan  (ISO)
iron atom  (ISO)
iron(0)  (ISO)
iron(III) nitrilotriacetate  (EXP)
isatin  (ISO)
Isazofos  (ISO)
isocarbophos  (ISO)
isocyanates  (ISO)
isofenphos  (ISO)
isoflavones  (EXP)
isoflurane  (EXP)
isoliquiritigenin  (ISO)
isoprenaline  (EXP,ISO)
isoprocarb  (ISO)
isotretinoin  (ISO)
isovitexin  (ISO)
ivermectin  (ISO)
juglone  (ISO)
kaempferol  (EXP,ISO)
kainic acid  (EXP)
ketamine  (ISO)
keto-D-fructose 1,6-bisphosphate  (ISO)
kojic acid  (EXP,ISO)
kresoxim-methyl  (ISO)
L-1,4-dithiothreitol  (ISO)
L-ascorbic acid  (EXP,ISO)
lactacystin  (EXP)
lactucin  (ISO)
lanreotide  (EXP)
lansoprazole  (EXP)
lapachol  (ISO)
lead diacetate  (EXP,ISO)
lead nitrate  (ISO)
lead(0)  (EXP,ISO)
leptomycin B  (EXP,ISO)
leptophos  (ISO)
levamisole  (ISO)
levetiracetam  (EXP)
lidocaine  (EXP,ISO)
limonene  (ISO)
linalool  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
lithium atom  (ISO)
lithium chloride  (EXP,ISO)
lithium hydride  (ISO)
Lobetyolin  (ISO)
losartan  (EXP)
lovastatin  (EXP,ISO)
lupeol  (ISO)
luteolin  (EXP,ISO)
luzindole  (ISO)
LY294002  (EXP,ISO)
lycopene  (ISO)
lysophosphatidylcholine  (ISO)
lysophosphatidylethanolamine  (ISO)
maculosin  (ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
magnesium oxide  (ISO)
malathion  (EXP,ISO)
maleimide  (ISO)
malonaldehyde  (ISO)
mancozeb  (ISO)
maneb  (ISO)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (EXP)
mangiferin  (EXP)
masoprocol  (ISO)
mechlorethamine  (ISO)
medroxyprogesterone acetate  (ISO)
meglumine amidotrizoate  (EXP)
MeIQ  (ISO)
MeIQx  (EXP,ISO)
melatonin  (EXP,ISO)
melphalan  (ISO)
menadione  (ISO)
mercaptopurine  (ISO)
mercury atom  (ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (ISO)
metformin  (EXP,ISO)
methamidophos  (ISO)
methamphetamine  (EXP,ISO)
methapyrilene  (EXP)
methidathion  (ISO)
methoctramine tetrahydrochloride  (EXP)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methoxyacetic acid  (ISO)
methoxychlor  (ISO)
methyl caffeate  (ISO)
methyl isocyanate  (ISO)
methyl methanesulfonate  (ISO)
methylarsonic acid  (ISO)
methylene bis(thiocyanate)  (ISO)
methylene blue  (ISO)
methylisothiazolinone  (ISO)
methylmercury chloride  (ISO)
metiram  (ISO)
mevinphos  (ISO)
microcystin  (EXP)
microcystin RR  (ISO)
microcystin-LR  (EXP,ISO)
midostaurin  (ISO)
mifepristone  (ISO)
minocycline  (EXP)
mitomycin C  (ISO)
Mitotane  (EXP,ISO)
mitoxantrone  (ISO)
MK-2206  (ISO)
molinate  (ISO)
molybdenum atom  (ISO)
mono(2-ethylhexyl) phthalate  (EXP,ISO)
monobenzone  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (EXP,ISO)
monocrotaline  (ISO)
monocrotophos  (EXP)
monomethyl succinate  (ISO)
monosodium L-glutamate  (ISO)
montelukast  (EXP)
morin  (EXP,ISO)
Morindone  (ISO)
morphine  (ISO)
motexafin gadolinium  (ISO)
mozavaptan  (ISO)
mycophenolic acid  (ISO)
myo-inositol hexakisphosphate  (EXP,ISO)
myricetin  (ISO)
myricitrin  (ISO)
myristicin  (ISO)
myrtenal  (EXP)
Myrtucommulone A  (ISO)
N(gamma)-nitro-L-arginine methyl ester  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N,N-dimethylformamide  (ISO)
N-acetoxy-2-acetamidofluorene  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-acetylsphingosine  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (EXP,ISO)
N-butyl-N-(4-hydroxybutyl)nitrosamine  (ISO)
N-ethyl-N-nitrosourea  (EXP,ISO)
N-hydroxy-2-acetamidofluorene  (EXP)
N-hydroxy-4-aminobiphenyl  (ISO)
N-hydroxy-PhIP  (ISO)
N-methyl-4-phenylpyridinium  (EXP,ISO)
N-methyl-N'-nitro-N-nitrosoguanidine  (EXP,ISO)
N-methyl-N-nitrosourea  (EXP,ISO)
N-Nitrosodi-n-butylamine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
N-tosyl-L-phenylalanyl chloromethyl ketone  (ISO)
NAD zwitterion  (ISO)
NAD(+)  (ISO)
NADP zwitterion  (ISO)
NADP(+)  (ISO)
naloxone  (EXP,ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
naringin  (EXP,ISO)
Neferine  (EXP)
neoastilbin  (ISO)
neocuproine  (ISO)
nickel atom  (ISO)
nickel dichloride  (EXP,ISO)
nickel ferrite  (ISO)
nickel subsulfide  (EXP)
nickel sulfate  (EXP,ISO)
niclosamide  (ISO)
nicorandil  (EXP)
nicotinamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP)
nifedipine  (ISO)
nifuroxazide  (ISO)
nilotinib  (ISO)
nimustine  (ISO)
ninhydrin  (ISO)
nitenpyram  (ISO)
nitrates  (ISO)
nitric oxide  (EXP,ISO)
nitrofurazone  (ISO)
nitrogen dioxide  (EXP,ISO)
nitrogen mustard  (ISO)
nitroprusside  (EXP,ISO)
Nitrovin  (ISO)
NMS-873  (ISO)
nocodazole  (ISO)
Nonidet P-40  (ISO)
norethisterone  (ISO)
notoginsenoside R1  (ISO)
NS-398  (EXP,ISO)
Nutlin-3  (ISO)
O-(chloroacetylcarbamoyl)fumagillol  (ISO)
O-methyleugenol  (EXP)
Obacunone  (ISO)
ochratoxin A  (EXP,ISO)
Octicizer  (ISO)
octreotide  (ISO)
okadaic acid  (ISO)
olanzapine  (ISO)
olaparib  (ISO)
oleandrigenin  (ISO)
oleanolic acid  (ISO)
oleic acid  (ISO)
oleuropein  (EXP)
olomoucine  (ISO)
olsalazine  (ISO)
omacetaxine mepesuccinate  (ISO)
omethoate  (ISO)
orlistat  (EXP)
oroxylin A  (ISO)
ortho-Aminoazotoluene  (ISO)
ouabain  (ISO)
oxaliplatin  (ISO)
oxamyl  (ISO)
oxfendazole  (EXP)
oxidopamine  (EXP)
oxirane  (ISO)
oxybenzone  (EXP)
oxycarboxin  (ISO)
ozone  (EXP,ISO)
p-menthan-3-ol  (ISO)
p-tert-Amylphenol  (EXP,ISO)
paclitaxel  (ISO)
paeoniflorin  (ISO)
palbociclib  (ISO)
panobinostat  (ISO)
para-Cresidine  (ISO)
para-Nitrosodiphenylamine  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
Paraoxon-methyl  (ISO)
paraquat  (EXP,ISO)
parathion  (ISO)
parathion-methyl  (ISO)
parthenolide  (ISO)
patulin  (ISO)
pazopanib  (ISO)
PCB138  (ISO)
PD 0325901  (ISO)
PD 168393  (ISO)
pectolinarigenin  (ISO)
pemetrexed  (ISO)
pentachlorophenol  (EXP,ISO)
pentamidine  (ISO)
pentanal  (ISO)
pentetic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
pergolide  (ISO)
perifosine  (ISO)
permethrin  (EXP)
phenethyl caffeate  (EXP,ISO)
phenethyl isothiocyanate  (ISO)
phenindione  (ISO)
phenobarbital  (EXP,ISO)
phenol  (ISO)
phenylmercury acetate  (ISO)
phenytoin  (ISO)
PhIP  (ISO)
phloretin  (EXP,ISO)
phorate  (EXP,ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosalone  (EXP)
phosmet  (ISO)
phosphamidon  (ISO)
phosphatidylcholine  (ISO)
phoxim  (ISO)
phthalaldehyde  (ISO)
picoxystrobin  (ISO)
pifithrin-alpha hydrobromide  (EXP,ISO)
pinostrobin  (ISO)
pinosylvin  (ISO)
piperine  (ISO)
pirarubicin  (ISO)
pirimicarb  (ISO)
Pirimiphos-ethyl  (ISO)
pirinixic acid  (EXP)
piroxicam  (ISO)
PK-11195  (ISO)
platycodin D  (ISO)
plumbagin  (EXP)
poly(I:C)  (ISO)
poly(vinylpyrrolidone)  (ISO)
polymyxin B2  (ISO)
ponatinib  (ISO)
potassium bromate  (EXP,ISO)
potassium chloride  (EXP)
potassium chromate  (ISO)
potassium dichromate  (EXP,ISO)
potassium iodide  (EXP)
pravastatin  (EXP,ISO)
proanthocyanidin  (ISO)
procyanidin  (ISO)
procyanidin B1  (ISO)
progesterone  (EXP,ISO)
Promecarb  (ISO)
promethazine  (EXP)
propachlor  (ISO)
propanal  (ISO)
propetamphos  (ISO)
propofol  (EXP,ISO)
propylparaben  (ISO)
prothiofos  (ISO)
Ptaquiloside  (ISO)
pterostilbene  (ISO)
purine-6-thiol  (ISO)
pyrazophos  (ISO)
pyrene  (ISO)
Pyridostigmine bromide  (EXP)
pyrogallol  (ISO)
pyrroles  (ISO)
pyrrolidine dithiocarbamate  (EXP,ISO)
pyruvic acid  (EXP)
quartz  (EXP,ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
quinacrine  (ISO)
quinalphos  (ISO)
quinidine  (EXP)
quinoline  (ISO)
quizartinib  (ISO)
raloxifene  (ISO)
razoxane  (ISO)
Reactive blue 2  (ISO)
reactive oxygen species  (ISO)
resveratrol  (EXP,ISO)
RGFP966  (ISO)
ribavirin  (ISO)
riboflavin  (ISO)
riddelliine  (EXP,ISO)
ritonavir  (ISO)
rivastigmine  (ISO)
romidepsin  (ISO)
Roridin A  (ISO)
rotenone  (EXP,ISO)
royal jelly  (ISO)
rubitecan  (ISO)
ruthenium atom  (EXP,ISO)
rutin  (EXP,ISO)
ruxolitinib  (ISO)
RV 538  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-(2-Chloroethyl)glutathione  (ISO)
S-allylcysteine  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (EXP,ISO)
S-nitroso-L-cysteine  (ISO)
S-nitroso-N-acetyl-D-penicillamine  (ISO)
S-nitrosoglutathione  (EXP,ISO)
Salinomycin  (ISO)
salvianolic acid B  (EXP,ISO)
sappanchalcone  (ISO)
sapropterin  (ISO)
SB 203580  (EXP,ISO)
selenium atom  (EXP,ISO)
selenomethionine  (ISO)
selinexor  (ISO)
senecionine  (ISO)
serpentine asbestos  (EXP,ISO)
sevoflurane  (ISO)
Shikonin  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
silmitasertib  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
silver(1+) nitrate  (ISO)
simvastatin  (EXP,ISO)
sinapic acid  (EXP)
sirolimus  (EXP,ISO)
sirtinol  (ISO)
skatole  (ISO)
sodium arsenite  (EXP,ISO)
sodium azide  (ISO)
sodium benzoate  (EXP,ISO)
sodium chloride  (EXP,ISO)
sodium cholate  (ISO)
sodium chromate  (ISO)
sodium dichromate  (EXP,ISO)
sodium disulfite  (ISO)
sodium fluoride  (EXP,ISO)
sodium hydrogencarbonate  (ISO)
Sodium salicylate  (EXP)
Soman  (ISO)
sorafenib  (ISO)
spermidine  (EXP)
starch  (ISO)
staurosporine  (EXP,ISO)
sterigmatocystin  (EXP)
stilbenoid  (ISO)
streptozocin  (EXP,ISO)
styrene oxide  (ISO)
succimer  (EXP)
sucrose  (EXP,ISO)
sulforaphane  (ISO)
sulfotep  (ISO)
sulfur dioxide  (EXP,ISO)
sulindac  (ISO)
sulindac sulfide  (ISO)
sulprofos  (ISO)
sunitinib  (EXP,ISO)
suramin  (ISO)
swainsonine  (ISO)
syringic acid  (ISO)
syringin  (ISO)
T-2 toxin  (EXP,ISO)
tacrine  (EXP)
tacrolimus hydrate  (EXP,ISO)
tamoxifen  (EXP,ISO)
tanespimycin  (ISO)
Tanshinone I  (ISO)
tartrazine  (EXP)
taurine  (EXP)
tauroursodeoxycholic acid  (EXP,ISO)
Tegafur  (ISO)
temozolomide  (ISO)
tenofovir disoproxil fumarate  (ISO)
terbufos  (ISO)
terbutylazine  (ISO)
Terfenadine  (ISO)
teriflunomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetrachlorvinphos  (ISO)
tetracycline  (EXP)
tetraphene  (ISO)
tetrathiomolybdate(2-)  (EXP,ISO)
tetrazolium violet  (ISO)
thalidomide  (ISO)
thapsigargin  (ISO)
theaflavin  (EXP,ISO)
theophylline  (EXP,ISO)
thiabendazole  (EXP)
thimerosal  (ISO)
thioacetamide  (EXP)
Thiobencarb  (ISO)
Thioinosine  (ISO)
thioridazine  (ISO)
thiostrepton  (ISO)
thiourea  (ISO)
thiram  (ISO)
thymoquinone  (EXP,ISO)
thyroxine  (EXP)
tioguanine  (ISO)
tipifarnib  (EXP)
tirapazamine  (ISO)
tiratricol  (ISO)
Tiron  (EXP)
titanium dioxide  (EXP,ISO)
tocopherol  (ISO)
tolbutamide  (EXP)
toluene  (EXP,ISO)
Tomentosin  (ISO)
toosendanin  (ISO)
topotecan  (ISO)
trans-caffeic acid  (ISO)
trans-piceid  (EXP)
trans-pinosylvin  (ISO)
triamterene  (ISO)
triazophos  (ISO)
tribufos  (ISO)
tributylstannane  (ISO)
trichlorfon  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP,ISO)
triclosan  (ISO)
triethyl phosphate  (ISO)
trifluridine  (ISO)
trimethyl phosphate  (ISO)
trimethylenediamine  (ISO)
trimethyltin  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP,ISO)
triptonide  (ISO)
tris(2,3-dibromopropyl) phosphate  (EXP)
tris(2-chloroethyl) phosphate  (ISO)
Tris(2-ethylhexyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tropan-3alpha-yl 3-hydroxy-2-phenylpropanoate  (ISO)
tropisetron  (EXP)
Tryptanthrine  (ISO)
Tungsten carbide  (ISO)
tunicamycin  (EXP,ISO)
tyrphostin AG 1478  (ISO)
uracil  (ISO)
urethane  (ISO)
uridine  (ISO)
Urolithin A  (ISO)
ursodeoxycholic acid  (EXP,ISO)
usnic acid  (ISO)
valproic acid  (EXP,ISO)
valsartan  (EXP)
vanadium atom  (EXP,ISO)
vanadium dioxide  (ISO)
vanadium(0)  (EXP,ISO)
vancomycin  (EXP)
vanillin  (ISO)
venlafaxine hydrochloride  (EXP)
venom  (ISO)
versicolorin A  (ISO)
vincaleukoblastine  (ISO)
vinclozolin  (EXP,ISO)
vincristine  (ISO)
vitamin D  (EXP,ISO)
vitamin E  (EXP,ISO)
vorinostat  (ISO)
warfarin  (ISO)
WIN 55212-2  (ISO)
withaferin A  (ISO)
Withanone  (ISO)
wogonin  (ISO)
wortmannin  (EXP,ISO)
Xanthatin  (ISO)
xanthohumol  (ISO)
XMU-MP-1  (ISO)
Y-27632  (ISO)
zearalenone  (ISO)
zebularine  (ISO)
zerumbone  (ISO)
zidovudine  (ISO)
zinc acetate  (ISO)
zinc atom  (EXP,ISO)
zinc dichloride  (ISO)
zinc molecular entity  (ISO)
zinc oxide  (ISO)
zinc protoporphyrin  (EXP,ISO)
zinc pyrithione  (ISO)
zinc sulfate  (ISO)
zinc(0)  (EXP,ISO)
zingerone  (EXP)
zoledronic acid  (ISO)
zoxamide  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
apoptotic process  (IEA)
apoptotic signaling pathway  (IEA,IMP)
autophagy  (IEA,ISO)
bone marrow development  (IEA,ISO)
cellular response to actinomycin D  (IEA,ISO)
cellular response to gamma radiation  (IEA,ISO)
cellular response to glucose starvation  (ISO)
cellular response to heat  (IEP)
cellular response to hypoxia  (IEA,IEP,ISO)
cellular response to ionizing radiation  (IEA,ISO)
cellular response to polyamine macromolecule  (IEP)
cellular response to reactive oxygen species  (IMP)
cellular response to triglyceride  (IEP)
cellular response to UV  (IEA,ISO)
cellular response to xenobiotic stimulus  (IEA,ISO)
cellular senescence  (IEA,ISO,ISS)
circadian behavior  (IEA,ISO,ISS)
circadian rhythm  (IEA,ISO)
determination of adult lifespan  (IEA,ISO)
DNA damage response  (ISO,ISS)
DNA damage response, signal transduction by p53 class mediator  (IEA,ISO)
entrainment of circadian clock by photoperiod  (IEA,ISO,ISS)
ER overload response  (ISO)
hematopoietic progenitor cell differentiation  (IEA,ISO)
hematopoietic stem cell differentiation  (IEA,ISO)
intracellular protein localization  (IEA,ISO)
intrinsic apoptotic signaling pathway by p53 class mediator  (IEA,ISO)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator  (IBA,IEA,ISO)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  (IEA,ISO)
mitotic G1 DNA damage checkpoint signaling  (IEA,ISO)
mRNA transcription  (IEA,ISO)
negative regulation of apoptotic process  (IEA,IMP,ISO)
negative regulation of cell growth  (IEA,ISO,ISS)
negative regulation of cell population proliferation  (IEA,IMP,ISO)
negative regulation of DNA biosynthetic process  (IMP)
negative regulation of DNA metabolic process  (IEA)
negative regulation of DNA-templated transcription  (IDA,IEA,ISO)
negative regulation of fibroblast proliferation  (IEA,ISO)
negative regulation of G1 to G0 transition  (IEA,ISO)
negative regulation of pentose-phosphate shunt  (IEA,ISO)
negative regulation of progesterone secretion  (ISO)
negative regulation of smooth muscle cell proliferation  (IMP)
negative regulation of telomere maintenance via telomerase  (IEA,ISO)
negative regulation of transcription by RNA polymerase II  (IEA,ISO)
nucleotide-excision repair  (IEA,ISO,ISS)
oligodendrocyte apoptotic process  (IEA,ISO,ISS)
oxidative stress-induced premature senescence  (IEA,ISO)
positive regulation of apoptotic process  (IEA,IMP,ISO,ISS)
positive regulation of cell cycle  (IMP)
positive regulation of cellular senescence  (IEA,ISO)
positive regulation of DNA-templated transcription  (IEA,ISO)
positive regulation of execution phase of apoptosis  (IEA,ISO)
positive regulation of gene expression  (IEA,IGI,ISO)
positive regulation of intrinsic apoptotic signaling pathway  (IEA,IMP,ISO,ISS)
positive regulation of leukocyte migration  (IMP)
positive regulation of miRNA transcription  (IEA,ISO)
positive regulation of outer hair cell apoptotic process  (ISO)
positive regulation of programmed necrotic cell death  (IEA,ISO)
positive regulation of reactive oxygen species metabolic process  (IEA,ISO)
positive regulation of release of cytochrome c from mitochondria  (IEA,ISO)
positive regulation of RNA polymerase II transcription preinitiation complex assembly  (IEA,ISO)
positive regulation of thymocyte apoptotic process  (IEA,ISO)
positive regulation of transcription by RNA polymerase II  (IBA,IDA,IEA,ISO)
programmed cell death  (IEA)
protein tetramerization  (IEA)
protein-containing complex assembly  (IEA,ISO)
Ras protein signal transduction  (IEA,ISO)
regulation of apoptotic process  (IBA,ISO)
regulation of cell cycle  (IEA,IMP,ISO)
regulation of cell cycle G2/M phase transition  (ISO)
regulation of DNA-templated transcription  (IEA,ISO)
regulation of intracellular pH  (IMP)
regulation of intrinsic apoptotic signaling pathway  (IEA)
regulation of peptide hormone secretion  (ISO)
regulation of prostaglandin secretion  (ISO)
regulation of transcription by RNA polymerase II  (IEA,ISO)
replicative senescence  (IEA,ISO)
response to amino acid  (IEP)
response to antibiotic  (IEA,ISO)
response to benzene  (IEP)
response to caffeine  (IEP)
response to cytokine  (IEP)
response to ethanol  (IEP)
response to gamma radiation  (IEA,ISO)
response to hyperoxia  (IEP)
response to metal ion  (IEP)
response to oxidative stress  (IEA,IEP)
response to retinoic acid  (IEP)
response to UV  (IEA,IEP)
response to UV-B  (IEP)
response to vitamin B3  (IEP)
response to X-ray  (IEA,IEP,IMP)
response to xenobiotic stimulus  (IEA,IEP)
rhythmic process  (IEA)
signal transduction by p53 class mediator  (IEA,ISO)
spermatogenesis  (IMP)
transcription initiation-coupled chromatin remodeling  (IEA,ISO)
tumor necrosis factor-mediated signaling pathway  (IEA,ISO)
type II interferon-mediated signaling pathway  (IEA,ISO)
viral process  (IEA,ISO)

Cellular Component
centrosome  (IEA,ISO,ISS)
chromatin  (IBA,IDA,IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
cytosol  (IEA,ISO)
endoplasmic reticulum  (IEA)
mitochondrial matrix  (IEA)
mitochondrion  (IEA,ISO,ISS)
nuclear body  (IEA,ISO)
nuclear matrix  (IEA,ISO)
nucleolus  (IEA,ISO,ISS)
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IDA,IEA,ISO,ISS)
PML body  (IDA,IEA,ISO)
protein-containing complex  (IEA,ISO)
RNA polymerase II transcription regulator complex  (IDA)
transcription regulator complex  (IDA,IEA,ISO)
transcription repressor complex  (IEA,ISO)

Molecular Function
14-3-3 protein binding  (ISO)
ATP-dependent DNA/DNA annealing activity  (IEA,ISO,ISS)
chromatin binding  (IEA,ISO)
cis-regulatory region sequence-specific DNA binding  (IEA,ISO)
copper ion binding  (IEA,ISO,ISS)
core promoter sequence-specific DNA binding  (IEA,ISO)
disordered domain specific binding  (IEA,ISO)
DNA binding  (IEA,ISO,ISS)
DNA-binding transcription activator activity, RNA polymerase II-specific  (IEA,ISO)
DNA-binding transcription factor activity  (IEA,ISO)
DNA-binding transcription factor activity, RNA polymerase II-specific  (IBA,IEA,ISO,ISS)
DNA-binding transcription repressor activity, RNA polymerase II-specific  (IEA,ISO)
enzyme binding  (IEA,ISO)
general transcription initiation factor binding  (IEA,ISO)
histone deacetylase binding  (IEA,ISO)
identical protein binding  (IEA,ISO)
MDM2/MDM4 family protein binding  (IEA,IPI,ISO)
metal ion binding  (IEA)
molecular condensate scaffold activity  (IEA,ISO,ISS)
molecular function activator activity  (IEA,ISO)
mRNA 3'-UTR binding  (IEA,ISO)
p53 binding  (IEA,ISO)
promoter-specific chromatin binding  (IBA,IEA,ISO,ISS)
protease binding  (IEA,ISO)
protein binding  (IPI,ISO)
protein heterodimerization activity  (IEA,ISO)
protein phosphatase 2A binding  (IEA,ISO)
protein-folding chaperone binding  (IEA,ISO)
receptor tyrosine kinase binding  (IEA,ISO)
RNA polymerase II cis-regulatory region sequence-specific DNA binding  (IBA,IEA,ISO,ISS)
RNA polymerase II-specific DNA-binding transcription factor binding  (IEA,IPI,ISO)
sequence-specific DNA binding  (IDA)
TFIID-class transcription factor complex binding  (IEA,ISO)
transcription cis-regulatory region binding  (IEA,ISO)
transcription coactivator binding  (IEA,ISO)
transcription coregulator binding  (IPI)
transmembrane transporter binding  (IPI)
ubiquitin protein ligase binding  (IEA,IPI,ISO)

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. P21-dependent protective effects of a carbon monoxide-releasing molecule-3 in pulmonary hypertension. Abid S, etal., Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):304-12. doi: 10.1161/ATVBAHA.113.302302. Epub 2013 Dec 12.
2. Polymorphisms of DNA damage response genes in radiation-related and sporadic papillary thyroid carcinoma. Akulevich NM, etal., Endocr Relat Cancer. 2009 Jun;16(2):491-503. doi: 10.1677/ERC-08-0336. Epub 2009 Mar 13.
3. Bcl-xL expression and regulation in the progression, recurrence, and cisplatin resistance of oral cancer. Alam M and Mishra R, Life Sci. 2021 Sep 1;280:119705. doi: 10.1016/j.lfs.2021.119705. Epub 2021 Jun 8.
4. Expression of p53 protein in human middle ear cholesteatomas: pathogenetic implications. Albino AP, etal., Am J Otol. 1998 Jan;19(1):30-6.
5. The role of TP53 and MDM2 polymorphisms in TP53 mutagenesis and risk of non-melanoma skin cancer. Almquist LM, etal., Carcinogenesis. 2011 Mar;32(3):327-30. doi: 10.1093/carcin/bgq256. Epub 2010 Dec 1.
6. TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari Population Asadi M, etal., Asian Pac J Cancer Prev. 2017 Dec 29;18(12):3423-3427. doi: 10.22034/APJCP.2017.18.12.3423.
7. p53 expression and apoptosis in the lens after ultraviolet radiation exposure. Ayala M, etal., Invest Ophthalmol Vis Sci. 2007 Sep;48(9):4187-91.
8. Prognosis of adenocarcinoma of the uterine cervix: p53 expression correlates with higher incidence of mortality. Baalbergen A, etal., Int J Cancer. 2007 Jul 1;121(1):106-10.
9. Prognostic value of TP53 gene mutations in myelodysplastic syndromes and acute myeloid leukemia treated with azacitidine. Bally C, etal., Leuk Res. 2014 Jul;38(7):751-5. doi: 10.1016/j.leukres.2014.03.012. Epub 2014 Mar 23.
10. The molecular biology of endometrial cancers and the implications for pathogenesis, classification, and targeted therapies. Bansal N, etal., Cancer Control. 2009 Jan;16(1):8-13.
11. The mutational landscape of prostate cancer. Barbieri CE, etal., Eur Urol. 2013 Oct;64(4):567-76. doi: 10.1016/j.eururo.2013.05.029. Epub 2013 May 18.
12. The genetic association database. Becker KG, etal., Nat Genet. 2004 May;36(5):431-2.
13. Targeted-simultaneous expression of Gas1 and p53 using a bicistronic adenoviral vector in gliomas. Benitez JA, etal., Cancer Gene Ther. 2007 Oct;14(10):836-46. Epub 2007 Jun 29.
14. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Bhanoori M, etal., Oncogene 2003 Jan 9;22(1):117-30.
15. The 5' region of the p53 gene: evolutionary conservation and evidence for a negative regulatory element. Bienz-Tadmor B, etal., EMBO J 1985 Dec 1;4(12):3209-13.
16. Caveolin-1/PTRF upregulation constitutes a mechanism for mediating p53-induced cellular senescence: implications for evidence-based therapy of delayed wound healing in diabetes. Bitar MS, etal., Am J Physiol Endocrinol Metab. 2013 Oct 15;305(8):E951-63. doi: 10.1152/ajpendo.00189.2013. Epub 2013 Aug 13.
17. Expression of p53 in arsenic-related and sporadic basal cell carcinoma. Boonchai W, etal., Arch Dermatol. 2000 Feb;136(2):195-8.
18. Tp53 status as guide for the management of ethmoid sinus intestinal-type adenocarcinoma. Bossi P, etal., Oral Oncol. 2013 May;49(5):413-9. doi: 10.1016/j.oraloncology.2012.12.011. Epub 2013 Jan 29.
19. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. Budhram-Mahadeo V, etal., J Biol Chem. 1999 May 21;274(21):15237-44. doi: 10.1074/jbc.274.21.15237.
20. Genetic polymorphisms associated with cigarette smoking and the risk of Graves' disease. Bufalo NE, etal., Clin Endocrinol (Oxf). 2008 Jun;68(6):982-7. Epub 2007 Nov 2.
21. Stabilization and activation of p53 by the coactivator protein TAFII31. Buschmann T, etal., J Biol Chem. 2001 Apr 27;276(17):13852-7. Epub 2001 Feb 1.
22. TP53 suppression promotes erythropoiesis in del(5q) MDS, suggesting a targeted therapeutic strategy in lenalidomide-resistant patients. Caceres G, etal., Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16127-32. doi: 10.1073/pnas.1311055110. Epub 2013 Sep 16.
23. Long noncoding RNA H19 mediates melatonin inhibition of premature senescence of c-kit(+) cardiac progenitor cells by promoting miR-675. Cai B, etal., J Pineal Res. 2016 Aug;61(1):82-95. doi: 10.1111/jpi.12331. Epub 2016 Apr 29.
24. Nupr1/Chop signal axis is involved in mitochondrion-related endothelial cell apoptosis induced by methamphetamine. Cai D, etal., Cell Death Dis. 2016 Mar 31;7:e2161. doi: 10.1038/cddis.2016.67.
25. Effects of chronic treatment with valproate and oxcarbazepine on ovarian folliculogenesis in rats. Cansu A, etal., Epilepsia. 2008 Mar 10;.
26. p53 Suppression partially rescues the mutant phenotype in mouse models of DiGeorge syndrome. Caprio C and Baldini A, Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13385-90. doi: 10.1073/pnas.1401923111. Epub 2014 Sep 2.
27. Analysis of p53 and NF-kappaB signaling in modulating the cardiomyocyte fate during hypertrophy. Chatterjee A, etal., J Cell Physiol. 2011 Oct;226(10):2543-54. doi: 10.1002/jcp.22599.
28. p53 nuclear expression correlates with hemizygous TP53 deletion and predicts an adverse outcome for patients with relapsed/refractory multiple myeloma treated with lenalidomide. Chen MH, etal., Am J Clin Pathol. 2012 Feb;137(2):208-12. doi: 10.1309/AJCPHC85DGAXZDBE.
29. High p53 protein expression in therapy-related myeloid neoplasms is associated with adverse karyotype and poor outcome. Cleven AH, etal., Mod Pathol. 2015 Apr;28(4):552-63. doi: 10.1038/modpathol.2014.153. Epub 2014 Nov 21.
30. Importance of TP53 codon 72 and intron 3 duplication 16bp polymorphisms in prediction of susceptibility on breast cancer. Costa S, etal., BMC Cancer. 2008 Jan 29;8:32.
31. Differential gene expression in mouse mammary adenocarcinomas in the presence and absence of wild type p53. Cui XS and Donehower LA, Oncogene. 2000 Dec 7;19(52):5988-96.
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173. Age-dependent upregulation of p53 and cytochrome c release and susceptibility to apoptosis in skeletal muscle fiber of aged rats: role of carnitine and lipoic acid. Tamilselvan J, etal., Free Radic Biol Med. 2007 Dec 15;43(12):1656-69. Epub 2007 Sep 14.
174. Mutant ubiquitin found in Alzheimer's disease causes neuritic beading of mitochondria in association with neuronal degeneration. Tan Z, etal., Cell Death Differ. 2007 Oct;14(10):1721-32. Epub 2007 Jun 15.
175. Clinical significance of p21(WAF1/CIP1) and p53 expression in serous cystadenocarcinoma of the ovary. Terauchi F, etal., Oncol Rep. 2005 Aug;14(2):363-8.
176. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells. Tsai RY and McKay RD, Genes Dev 2002 Dec 1;16(23):2991-3003.
177. Functional inactivation but not structural mutation of p53 causes liver cancer. Ueda H, etal., Nat Genet 1995 Jan;9(1):41-7.
178. Diabetes alters expression of p53 and c-myc in different stages of oral oncogenesis. Vairaktaris E, etal., Anticancer Res. 2007 May-Jun;27(3B):1465-73.
179. Homozygous and heterozygous p53 knockout rats develop metastasizing sarcomas with high frequency. van Boxtel R, etal., Am J Pathol. 2011 Oct;179(4):1616-22. doi: 10.1016/j.ajpath.2011.06.036. Epub 2011 Aug 18.
180. Immunohistochemical detection of p53 and p63 in oral squamous cell carcinoma, oral leukoplakia, and oral submucous fibrosis. Varun BR, etal., J Investig Clin Dent. 2013 Jun 18. doi: 10.1111/jicd.12038.
181. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, etal., Sci Rep. 2019 May 14;9(1):7390. doi: 10.1038/s41598-019-43222-6.
182. MDM2 rs2279744 and TP53 rs1042522 polymorphisms associated with etoposide- and cisplatin-induced grade III/IV neutropenia in Chinese extensive-stage small-cell lung cancer patients. Wang X, etal., Oncol Res Treat. 2014;37(4):176-80. doi: 10.1159/000360785. Epub 2014 Mar 20.
183. Induction of p53 by GKLF is essential for inhibition of proliferation of vascular smooth muscle cells. Wassmann S, etal., J Mol Cell Cardiol. 2007 Sep;43(3):301-7. Epub 2007 Jun 16.
184. Differentially expressed pro- and anti-apoptogenic genes in response to benzene exposure: Immunohistochemical localization of p53, Bag, Bad, Bax, Bcl-2, and Bcl-w in lung epithelia. Weaver CV and Liu SP, Exp Toxicol Pathol. 2008 Mar;59(5):265-72. Epub 2008 Feb 21.
185. Expression of TP53, BCL-2, and VEGFA Genes in Esophagus Carcinoma and its Biological Significance. Wei W, etal., Med Sci Monit. 2015 Oct 6;21:3016-22. doi: 10.12659/MSM.894640.
186. p53 polymorphisms: cancer implications. Whibley C, etal., Nat Rev Cancer. 2009 Feb;9(2):95-107.
187. The physical association of multiple molecular chaperone proteins with mutant p53 is altered by geldanamycin, an hsp90-binding agent. Whitesell L, etal., Mol Cell Biol. 1998 Mar;18(3):1517-24.
188. Activation of the p53-p21(Cip1) pathway is required for CDK2 activation and S-phase entry in primary rat hepatocytes. Wierod L, etal., Oncogene. 2007 Nov 19;.
189. The p53 codon 72 PRO/PRO genotype may be associated with initial central visual field defects in caucasians with primary open angle glaucoma. Wiggs JL, etal., PLoS One. 2012;7(9):e45613. doi: 10.1371/journal.pone.0045613. Epub 2012 Sep 26.
190. The tumor suppressor gene Trp53 protects the mouse lens against posterior subcapsular cataracts and the BMP receptor Acvr1 acts as a tumor suppressor in the lens. Wiley LA, etal., Dis Model Mech. 2011 Jul;4(4):484-95. doi: 10.1242/dmm.006593. Epub 2011 Apr 18.
191. Intense p53 staining is a valuable prognostic indicator for poor prognosis in medulloblastoma/central nervous system primitive neuroectodermal tumors. Woodburn RT, etal., J Neurooncol. 2001 Mar;52(1):57-62.
192. [Expression and significance of P53 and P21 in nasal NK/T-cell lymphoma]. Xu G, etal., Sichuan Da Xue Xue Bao Yi Xue Ban. 2010 Jan;41(1):132-6.
193. Mutations in Tp53 gene sequences from lung tumors in rats that inhaled plutonium dioxide. Yamada Y and Oghiso Y, Radiat Res. 1999 Dec;152(6 Suppl):S107-9.
194. CELF1/p53 axis: a sustained antiproliferative signal leading to villus atrophy under total parenteral nutrition. Yan JK, etal., FASEB J. 2019 Mar;33(3):3378-3391. doi: 10.1096/fj.201801695R. Epub 2018 Dec 4.
195. Post-traumatic administration of the p53 inactivator pifithrin-α oxygen analogue reduces hippocampal neuronal loss and improves cognitive deficits after experimental traumatic brain injury. Yang LY, etal., Neurobiol Dis. 2016 Dec;96:216-226. doi: 10.1016/j.nbd.2016.08.012. Epub 2016 Aug 20.
196. Silencing of long non-coding RNA H19 downregulates CTCF to protect against atherosclerosis by upregulating PKD1 expression in ApoE knockout mice. Yang Y, etal., Aging (Albany NY). 2019 Nov 22;11(22):10016-10030. doi: 10.18632/aging.102388. Epub 2019 Nov 22.
197. TP53 inactivation and expression of methylation-associated proteins in gastric adenocarcinoma with enteroblastic differentiation. Yatagai N, etal., Virchows Arch. 2019 Mar;474(3):315-324. doi: 10.1007/s00428-018-2508-9. Epub 2018 Dec 15.
198. A novel animal model to investigate fractionated radiotherapy-induced alimentary mucositis: the role of apoptosis, p53, nuclear factor-kappaB, COX-1, and COX-2. Yeoh AS, etal., Mol Cancer Ther. 2007 Aug;6(8):2319-27.
199. Neonatal bronchopulmonary dysplasia increases neuronal apoptosis in the hippocampus through the HIF-1alpha and p53 pathways. Yin R, etal., Respir Physiol Neurobiol. 2016 Jan;220:81-7. doi: 10.1016/j.resp.2015.09.011. Epub 2015 Sep 30.
200. Correlation of p53 and MIB-1 expression with both the systemic recurrence and survival in cases of phyllodes tumors of the breast. Yonemori K, etal., Pathol Res Pract. 2006;202(10):705-12. Epub 2006 Aug 2.
201. TP53 haplotype-based analysis and incidence of post-angioplasty restenosis. Zee RY, etal., Hum Genet. 2004 Mar;114(4):386-90. Epub 2004 Jan 22.
202. Panax ginseng ginsenoside-Rg2 protects memory impairment via anti-apoptosis in a rat model with vascular dementia. Zhang G, etal., J Ethnopharmacol. 2008 Feb 12;115(3):441-8. Epub 2007 Oct 25.
203. Hyperbaric Oxygen Attenuates Apoptosis and Decreases Inflammation in an Ischemic Wound Model. Zhang Q, etal., J Invest Dermatol. 2008 Mar 13;.
204. p53 Transgenic mice are highly susceptible to 4-nitroquinoline-1-oxide-induced oral cancer. Zhang Z, etal., Mol Cancer Res. 2006 Jun;4(6):401-10.
205. Retinoic acid downregulates microRNAs to induce abnormal development of spinal cord in spina bifida rat model. Zhao JJ, etal., Childs Nerv Syst. 2008 Apr;24(4):485-92. Epub 2007 Oct 26.
206. Predicting pelvic lymph node metastases in penile cancer patients: a comparison of computed tomography, Cloquet's node, and disease burden of inguinal lymph nodes. Zhu Y, etal., Onkologie. 2008 Feb;31(1-2):37-41. Epub 2008 Jan 22.
207. Polyamine depletion induces nucleophosmin modulating stability and transcriptional activity of p53 in intestinal epithelial cells. Zou T, etal., Am J Physiol Cell Physiol. 2005 Sep;289(3):C686-96. Epub 2005 May 4.
208. Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1. Öner MG, etal., Gastroenterology. 2018 Dec;155(6):1868-1882. doi: 10.1053/j.gastro.2018.08.011. Epub 2018 Aug 10.
Additional References at PubMed
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Genomics

Comparative Map Data
Tp53
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81054,798,871 - 54,810,300 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1054,798,851 - 54,810,299 (+)EnsemblGRCr8
mRatBN7.21054,300,070 - 54,311,525 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1054,300,048 - 54,311,524 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1058,962,496 - 58,973,951 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01058,451,039 - 58,462,496 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01053,958,739 - 53,970,151 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01056,186,299 - 56,198,449 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1056,187,020 - 56,198,449 (+)Ensemblrn6Rnor6.0
Rnor_5.01055,932,658 - 55,944,087 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41056,399,721 - 56,411,150 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1053,454,375 - 53,465,803 (+)NCBICelera
RGSC_v3.11056,413,290 - 56,424,751 (+)NCBI
Cytogenetic Map10q24NCBI
TP53
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38177,668,421 - 7,687,490 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl177,661,779 - 7,687,546 (-)Ensemblhg38GRCh38
GRCh37177,571,739 - 7,590,808 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,512,445 - 7,531,642 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34177,512,463 - 7,531,642NCBI
Celera177,598,099 - 7,617,224 (-)NCBICelera
Cytogenetic Map17p13.1NCBI
HuRef177,465,169 - 7,484,283 (-)NCBIHuRef
CHM1_1177,580,866 - 7,600,003 (-)NCBICHM1_1
T2T-CHM13v2.0177,572,544 - 7,591,594 (-)NCBIT2T-CHM13v2.0
Trp53
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,471,174 - 69,482,699 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1169,471,185 - 69,482,699 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381169,580,348 - 69,591,873 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,580,359 - 69,591,873 (+)Ensemblmm10GRCm38
MGSCv371169,393,861 - 69,405,375 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361169,396,176 - 69,408,066 (+)NCBIMGSCv36mm8
Celera1176,543,319 - 76,554,788 (+)NCBICelera
Cytogenetic Map11B3NCBI
cM Map1142.83NCBI
Tp53
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,252,130 - 9,255,928 (+)Ensembl
ChiLan1.0NW_0049554679,241,391 - 9,256,716 (+)NCBIChiLan1.0ChiLan1.0
TP53
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21915,262,550 - 15,280,917 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11717,217,636 - 17,246,939 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,699,449 - 7,717,812 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1177,687,132 - 7,706,120 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,684,922 - 7,706,120 (-)EnsemblpanPan2panpan1.1
TP53
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1532,561,406 - 32,565,149 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl532,560,598 - 32,574,109 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha532,699,559 - 32,713,071 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0532,665,395 - 32,678,721 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl532,665,394 - 32,678,755 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1532,633,092 - 32,646,601 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0532,589,339 - 32,602,824 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0532,768,467 - 32,781,775 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tp53
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560247,445,372 - 47,461,208 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936595919,428 - 925,425 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936595919,807 - 935,367 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TP53
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,939,644 - 52,953,818 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11252,939,643 - 52,953,786 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21255,220,545 - 55,234,668 (+)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap12q12-q14NCBI
TP53
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1167,047,686 - 7,065,567 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl167,045,146 - 7,066,223 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605914,343,255 - 14,361,299 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tp53
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478610,263,518 - 10,271,218 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478610,266,316 - 10,282,664 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Tp53
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1949,190,388 - 49,201,759 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tp53
59 total Variants
miRNA Target Status (No longer updated)

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Mir30arno-miR-30a-5pMirtarbaseexternal_infoWestern blot//Luciferase reporter assayFunctional MTI20062521

Predicted Target Of
Summary Value
Count of predictions:340
Count of miRNA genes:177
Interacting mature miRNAs:198
Transcripts:ENSRNOT00000046490
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61441Btemp1Thermal response to stress QTL 14body temperature trait (VT:0005535)core body temperature (CMO:0001036)103589345164140567Rat
1549846Scl47Serum cholesterol level QTL 473.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)105107189796071897Rat
152025229Scl83Serum cholesterol level QTL 834.33blood cholesterol amount (VT:0000180)103621155669161158Rat
1578779Tcas10Tongue tumor susceptibility QTL 103.12tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)103179628176796281Rat
152025227Bw195Body weight QTL 1955.73body mass (VT:0001259)104748901769161158Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101577675460776754Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102702353598502431Rat
2293669Bmd33Bone mineral density QTL 334.50.0001femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)102744378772443787Rat
152025224Bw193Body weight QTL 1936.47body mass (VT:0001259)105216243375582749Rat
631552Vetf2Vascular elastic tissue fragility QTL 24.50.0002aorta elastic tissue integrity trait (VT:0010556)artery internal elastic lamina non-tumorous lesion count (CMO:0001913)103550938391417879Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)10125055464349221Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293679Bmd30Bone mineral density QTL 303.50.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
1298078Stresp5Stress response QTL 52.990.00025blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)1042546145107713808Rat
1578762Toxo1Toxoplasma gondii resistance QTL 1brain integrity trait (VT:0010579)percentage of study population displaying Toxoplasma gondii brain cysts at a point in time (CMO:0002028)105269900459876693Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)101993920764939207Rat
61332Eau3Experimental allergic uveoretinitis QTL 30.004uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)101803578263035782Rat
70164Bw21Body weight QTL 214.360.00005body mass (VT:0001259)body weight (CMO:0000012)105429633699451733Rat
61463Bp12Blood pressure QTL 126.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104183127886831278Rat
1579919Bp281Blood pressure QTL 2810.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105046480295464802Rat
8694173Bw149Body weight QTL 1494.380.001body mass (VT:0001259)body weight gain (CMO:0000420)104493935989939359Rat
2300218Hpcl2Hepatic cholesterol level QTL 2liver cholesterol amount (VT:0010498)liver cholesterol level (CMO:0001597)104552916496099749Rat
70171Cari1Carrageenan-induced inflammation QTL 14.90.0005hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)1054296227107713808Rat
1598852Anxrr19Anxiety related response QTL 195.07body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)101866841963668419Rat
1581497Esta1Estrogen-induced thymic atrophy QTL 1thymus mass (VT:0004954)thymus wet weight (CMO:0000855)102183375861843633Rat
10450493Bp382Blood pressure QTL 3820.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105086028895860288Rat
724527Bp148Blood pressure QTL 1480.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)102895035373950353Rat
1358897Stresp6Stress response QTL 64.170.022blood norepinephrine amount (VT:0005663)plasma norepinephrine level (CMO:0001010)103589326364653589Rat
1331762Rf40Renal function QTL 403.873kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)102980091064653589Rat
2300171Bmd58Bone mineral density QTL 584.90.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)102744378772443787Rat
61354Pia10Pristane induced arthritis QTL 100.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2301967Cm73Cardiac mass QTL 734.55heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)101499153586964295Rat
70188BpQTLcluster1Blood pressure QTL cluster 14.864arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)14282327487823274Rat
9589030Epfw9Epididymal fat weight QTL 919.240.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)104493935989939359Rat
2316949Gluco60Glucose level QTL 603.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1014991535107556066Rat
2293652Bmd22Bone mineral density QTL 224.90.0001femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)102744378772443787Rat
70198BpQTLcluster9Blood pressure QTL cluster 92.94arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)104282327487823274Rat
2306787Ean3Experimental allergic neuritis QTL 33.1nervous system integrity trait (VT:0010566)body weight loss (CMO:0001399)105429622767476781Rat
724556Pur2Proteinuria QTL 25.5urine protein amount (VT:0005160)urine protein level (CMO:0000591)102293137391127454Rat
8662860Vetf10Vascular elastic tissue fragility QTL 10artery integrity trait (VT:0010639)number of ruptures of the internal elastic lamina of the abdominal aorta and iliac arteries (CMO:0002562)10666092373950353Rat
2306792Ean4Experimental allergic neuritis QTL 44nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)104949549294495492Rat
61387Bp1Blood pressure QTL 15.1arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1052269185107713808Rat
1354585Eae18aExperimental allergic encephalomyelitis QTL 18a7.50.0004nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)105429622758944345Rat
70223Bp57Blood pressure QTL 575arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)101465354159653541Rat
1354587Kidm21Kidney mass QTL 213.3kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)101553301273695498Rat
634329Pia15Pristane induced arthritis QTL 153.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)102466212373695339Rat
70224Eae3Experimental allergic encephalomyelitis QTL 34.1nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)102702353561843633Rat
2298480Eau7Experimental allergic uveoretinitis QTL 70.0049uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)103550938380509383Rat
1331791Cm31Cardiac mass QTL 313.84606heart mass (VT:0007028)heart wet weight (CMO:0000069)102980091091417879Rat
2298495Eae23Experimental allergic encephalomyelitis QTL 2316.93nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis duration (CMO:0001424)101617552561175525Rat
2313087Bmd80Bone mineral density QTL 803.20.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)102011061465110614Rat
631530Tls3T-lymphoma susceptibility QTL 300.0001thymus integrity trait (VT:0010555)percentage of study population developing T-cell lymphomas during a period of time (CMO:0001911)102758722696099902Rat
2289985Bp305Blood pressure QTL 305arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102907697874076978Rat
631532Cm50Cardiac mass QTL 506.6heart mass (VT:0007028)calculated heart weight (CMO:0000073)101803578263035782Rat
8552805Bw145Body weight QTL 1452.2body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)104360879388608793Rat
631267Cia20Collagen induced arthritis QTL 203.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023948641107713808Rat
2293705Bmd25Bone mineral density QTL 257.10.0001femur mineral mass (VT:0010011)compact volumetric bone mineral density (CMO:0001730)102744378772443787Rat
631269Cia22Collagen induced arthritis QTL 228.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
1576308Schws1Schwannoma susceptibility QTL 10.0041nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1040535708107713808Rat
631268Cia21Collagen induced arthritis QTL 213.1joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1014991535107713808Rat
7207811Bmd90Bone mineral density QTL 905.2femur size trait (VT:1000369)femoral neck cross-sectional area (CMO:0001697)104994371094943710Rat
1576311Pia26Pristane induced arthritis QTL 26joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)103112911376129113Rat
631270Cia23Collagen induced arthritis QTL 233.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1040535708107713808Rat
7411614Foco18Food consumption QTL 180.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)104493935989939359Rat
631547Bp87Blood pressure QTL 874.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)104786912992869129Rat
61427Cia16Collagen induced arthritis QTL 163.2joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)10686461896620484Rat
12880050Am10Aortic mass QTL 100.016aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)103950348784503487Rat
2292436Bp310Blood pressure QTL 310arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)105060467795604677Rat
6893342Cm78Cardiac mass QTL 780.10.88heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)103550938388177745Rat
2313055Bw96Body weight QTL 963.60.0001body mass (VT:0001259)body weight (CMO:0000012)102011061465110614Rat
631542Bp82Blood pressure QTL 826.8arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)102702353599451848Rat

Markers in Region
RH128204  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,311,066 - 54,311,282 (+)MAPPERmRatBN7.2
Rnor_6.01056,197,991 - 56,198,206NCBIRnor6.0
Rnor_5.01055,943,629 - 55,943,844UniSTSRnor5.0
RGSC_v3.41056,410,692 - 56,410,907UniSTSRGSC3.4
Celera1053,465,345 - 53,465,560UniSTS
Cytogenetic Map10q24UniSTS
X00876  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,311,363 - 54,311,441 (+)MAPPERmRatBN7.2
mRatBN7.21880,956,863 - 80,956,942 (+)MAPPERmRatBN7.2
Rnor_6.01884,790,380 - 84,790,458NCBIRnor6.0
Rnor_6.01056,198,288 - 56,198,365NCBIRnor6.0
Rnor_5.01883,848,025 - 83,848,103UniSTSRnor5.0
Rnor_5.01055,943,926 - 55,944,003UniSTSRnor5.0
RGSC_v3.41056,410,989 - 56,411,066UniSTSRGSC3.4
RGSC_v3.41884,480,395 - 84,480,473UniSTSRGSC3.4
Celera1879,535,283 - 79,535,361UniSTS
Celera1053,465,642 - 53,465,719UniSTS
Cytogenetic Map10q24UniSTS
GDB:190076  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,807,589 - 54,807,975 (+)Marker Load Pipeline
mRatBN7.21054,308,814 - 54,309,200 (+)MAPPERmRatBN7.2
Rnor_6.0249,382,697 - 49,382,771NCBIRnor6.0
Rnor_6.01056,195,739 - 56,196,124NCBIRnor6.0
Rnor_5.01055,941,377 - 55,941,762UniSTSRnor5.0
Rnor_5.0267,753,862 - 67,753,936UniSTSRnor5.0
RGSC_v3.41056,408,440 - 56,408,825UniSTSRGSC3.4
Celera1053,463,093 - 53,463,478UniSTS
Cytogenetic Map10q24UniSTS
PMC316663P6  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21054,308,611 - 54,308,724 (+)MAPPERmRatBN7.2
Rnor_6.01056,195,536 - 56,195,648NCBIRnor6.0
Rnor_5.01055,941,174 - 55,941,286UniSTSRnor5.0
RGSC_v3.41056,408,237 - 56,408,349UniSTSRGSC3.4
Celera1053,462,890 - 53,463,002UniSTS
Cytogenetic Map10q24UniSTS
PMC316856P2  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,807,224 - 54,807,389 (+)Marker Load Pipeline
mRatBN7.21054,308,448 - 54,308,614 (+)MAPPERmRatBN7.2
Rnor_6.01056,195,373 - 56,195,538NCBIRnor6.0
Rnor_5.01055,941,011 - 55,941,176UniSTSRnor5.0
RGSC_v3.41056,408,074 - 56,408,239UniSTSRGSC3.4
Celera1053,462,727 - 53,462,892UniSTS
Cytogenetic Map10q24UniSTS


Related Rat Strains
The following Strains have been annotated to Tp53
F344-Tp53m1Kyo     STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc    


Genetic Models
This gene Tp53 is modified in the following models/strains:
SD-Tp53em3Mcwi     SD-Tp53em1Sage     STOCK-Tp53tm1(EGFP-Pac)Qly/Rrrc     F344-Tp53m1Kyo    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429993 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429994 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429996 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030989 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008767773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017597018 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268429 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063268430 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136563 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF190270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF209191 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002222 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010014 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY009504 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC081788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC098663 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CV126174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ232659 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000010 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  M26863 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U90328 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X13058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z93723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000046490   ⟹   ENSRNOP00000047840
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,798,884 - 54,810,299 (+)Ensembl
mRatBN7.2 Ensembl1054,300,052 - 54,311,521 (+)Ensembl
Rnor_6.0 Ensembl1056,187,020 - 56,198,448 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000080584   ⟹   ENSRNOP00000068796
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,798,979 - 54,809,882 (+)Ensembl
mRatBN7.2 Ensembl1054,306,942 - 54,309,573 (+)Ensembl
Rnor_6.0 Ensembl1056,193,856 - 56,198,031 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083458   ⟹   ENSRNOP00000075724
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,300,052 - 54,310,666 (+)Ensembl
Rnor_6.0 Ensembl1056,193,866 - 56,198,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000085115   ⟹   ENSRNOP00000074031
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,798,853 - 54,810,299 (+)Ensembl
mRatBN7.2 Ensembl1054,300,753 - 54,311,523 (+)Ensembl
Rnor_6.0 Ensembl1056,187,679 - 56,198,449 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091216   ⟹   ENSRNOP00000075683
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,306,942 - 54,311,524 (+)Ensembl
Rnor_6.0 Ensembl1056,193,866 - 56,198,000 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102405   ⟹   ENSRNOP00000080907
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1054,798,851 - 54,810,299 (+)Ensembl
mRatBN7.2 Ensembl1054,300,048 - 54,311,519 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104927   ⟹   ENSRNOP00000092831
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,305,746 - 54,311,524 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114382   ⟹   ENSRNOP00000089020
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1054,305,746 - 54,310,954 (+)Ensembl
RefSeq Acc Id: NM_030989   ⟹   NP_112251
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,798,871 - 54,810,300 (+)NCBI
mRatBN7.21054,300,096 - 54,311,525 (+)NCBI
Rnor_6.01056,187,020 - 56,198,449 (+)NCBI
Rnor_5.01055,932,658 - 55,944,087 (+)NCBI
RGSC_v3.41056,399,721 - 56,411,150 (+)RGD
Celera1053,454,375 - 53,465,803 (+)RGD
Sequence:
RefSeq Acc Id: XM_008767773   ⟹   XP_008765995
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,798,933 - 54,810,300 (+)NCBI
mRatBN7.21054,300,070 - 54,311,023 (+)NCBI
Rnor_6.01056,186,299 - 56,197,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017597018   ⟹   XP_017452507
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,799,817 - 54,810,300 (+)NCBI
mRatBN7.21054,301,043 - 54,311,025 (+)NCBI
Rnor_6.01056,187,961 - 56,197,912 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063268429   ⟹   XP_063124499
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,805,369 - 54,810,300 (+)NCBI
RefSeq Acc Id: XM_063268430   ⟹   XP_063124500
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81054,799,817 - 54,810,300 (+)NCBI
RefSeq Acc Id: NP_112251   ⟸   NM_030989
- UniProtKB: Q4KMA9 (UniProtKB/Swiss-Prot),   O09168 (UniProtKB/Swiss-Prot),   Q66HM0 (UniProtKB/Swiss-Prot),   P10361 (UniProtKB/Swiss-Prot),   A6HFR6 (UniProtKB/TrEMBL),   A0A8L2R913 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008765995   ⟸   XM_008767773
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_017452507   ⟸   XM_017597018
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSRNOP00000068796   ⟸   ENSRNOT00000080584
Ensembl Acc Id: ENSRNOP00000074031   ⟸   ENSRNOT00000085115
Ensembl Acc Id: ENSRNOP00000075683   ⟸   ENSRNOT00000091216
Ensembl Acc Id: ENSRNOP00000075724   ⟸   ENSRNOT00000083458
Ensembl Acc Id: ENSRNOP00000047840   ⟸   ENSRNOT00000046490
Ensembl Acc Id: ENSRNOP00000080907   ⟸   ENSRNOT00000102405
Ensembl Acc Id: ENSRNOP00000092831   ⟸   ENSRNOT00000104927
Ensembl Acc Id: ENSRNOP00000089020   ⟸   ENSRNOT00000114382
RefSeq Acc Id: XP_063124500   ⟸   XM_063268430
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063124499   ⟸   XM_063268429
- Peptide Label: isoform X1
Protein Domains
p53 DNA-binding   p53 tetramerisation   p53 transactivation

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P10361-F1-model_v2 AlphaFold P10361 1-391 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13697316
Promoter ID:EPDNEW_R7839
Type:initiation region
Name:Tp53_1
Description:tumor protein p53
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01056,187,031 - 56,187,091EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:3889 AgrOrtholog
BioCyc Gene G2FUF-24540 BioCyc
Ensembl Genes ENSRNOG00000010756 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000046490 ENTREZGENE
  ENSRNOT00000046490.4 UniProtKB/Swiss-Prot
  ENSRNOT00000085115 ENTREZGENE
  ENSRNOT00000102405 ENTREZGENE
Gene3D-CATH 2.60.40.720 UniProtKB/Swiss-Prot
  4.10.170.10 UniProtKB/Swiss-Prot
  6.10.50.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193583 IMAGE-MGC_LOAD
  IMAGE:7384467 IMAGE-MGC_LOAD
InterPro p53-like_TF_DNA-bd UniProtKB/Swiss-Prot
  p53/RUNT-type_TF_DNA-bd_sf UniProtKB/Swiss-Prot
  p53_DNA-bd UniProtKB/Swiss-Prot
  p53_tetramer_sf UniProtKB/Swiss-Prot
  p53_tetrameristn UniProtKB/Swiss-Prot
  p53_transactivation_domain UniProtKB/Swiss-Prot
  p53_tumour_suppressor UniProtKB/Swiss-Prot
KEGG Report rno:24842 UniProtKB/Swiss-Prot
MGC_CLONE MGC:112612 IMAGE-MGC_LOAD
  MGC:93394 IMAGE-MGC_LOAD
NCBI Gene 24842 ENTREZGENE
PANTHER CELLULAR TUMOR ANTIGEN P53 UniProtKB/Swiss-Prot
  PTHR11447 UniProtKB/Swiss-Prot
Pfam P53 UniProtKB/Swiss-Prot
  P53_TAD UniProtKB/Swiss-Prot
  P53_tetramer UniProtKB/Swiss-Prot
PharmGKB TP53 RGD
PhenoGen Tp53 PhenoGen
PRINTS P53SUPPRESSR UniProtKB/Swiss-Prot
PROSITE P53 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010756 RatGTEx
Superfamily-SCOP SSF47719 UniProtKB/Swiss-Prot
  SSF49417 UniProtKB/Swiss-Prot
UniProt A0A0G2JTP9_RAT UniProtKB/TrEMBL
  A0A8I5ZQW3_RAT UniProtKB/TrEMBL
  A0A8I6AAP4 ENTREZGENE
  A0A8L2R913 ENTREZGENE, UniProtKB/TrEMBL
  A6HFR6 ENTREZGENE, UniProtKB/TrEMBL
  A6HFR8_RAT UniProtKB/TrEMBL
  O09168 ENTREZGENE
  P10361 ENTREZGENE, UniProtKB/Swiss-Prot
  Q4KMA9 ENTREZGENE
  Q66HM0 ENTREZGENE
  Q9EQL0_RAT UniProtKB/TrEMBL
UniProt Secondary O09168 UniProtKB/Swiss-Prot
  Q4KMA9 UniProtKB/Swiss-Prot
  Q66HM0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-10-23 Tp53  tumor protein p53  Trp53  transformation related protein 53  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-15 Trp53  transformation related protein 53  Tp53  tumor protein p53   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2003-04-09 Tp53  tumor protein p53     tumor protein p53 (Li-Fraumeni syndrome)  Name updated 629478 APPROVED
2002-06-10 Tp53  tumor protein p53 (Li-Fraumeni syndrome)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression nuclear accumulation increased in estrogen- and progesterone-treated animals and in pregnant-involuted mammary glands 69666
gene_expression nuclear accumulation increased in estrogen- and progesterone-treated animals and in pregnant-involuted mammary glands 625510
gene_function transcription factor 70312
gene_mutations_overexpression mutations found in the DNA binding domain of the gene 625510
gene_process directly phosphorylates casein kinase I and II, double-stranded RNA-dependent protein kinase, c-Jun N-terminal kinase, and p38 MAP kinase 625510
gene_process maintains genome integrety 70312
gene_process maintains genome integrety 70313
gene_process plays a critical role in cell cycle arrest, DNA repair and apoptosis 70313
gene_protein 390 amino acid protein 70312
gene_regulation mRNA stability regulated by polyamines and Mdm2 in intestinal mucosal cells 70312
gene_regulation regulated by DNA damage or stress such as hypoxia or nucleotide deprivation 625510