GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects expression | EXP | | 6480464 | CTD | bisphenol A affects the expression of TP53 mRNA | PMID:25181051 | Tp53 | decreases expression | EXP | | 6480464 | CTD | bisphenol A analog results in decreased expression of TP53 mRNA; bisphenol A analog results in decreased expression of TP53 protein; bisphenol A results in decreased expression of TP53 mRNA | PMID:26982218 PMID:33296240 PMID:35427877 | Tp53 | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of TP53 mRNA; bisphenol A results in increased expression of TP53 protein; bisphenol A results in increased expression of TRP53 mRNA | PMID:23146694 PMID:25344109 PMID:25454643 PMID:27208089 PMID:27296223 PMID:27539358 PMID:32172062 PMID:32428650 PMID:32810514 PMID:34505250 | Tp53 | increases methylation | EXP | | 6480464 | CTD | bisphenol A results in increased methylation of TP53 gene | PMID:28505145 | Tp53 | multiple interactions | EXP | | 6480464 | CTD | [bisphenol A co-treated with naringin] results in decreased expression of TP53 protein; [bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein; [NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein; bisphenol A inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of TP53 protein]; Grape Seed Proanthocyanidins inhibits the reaction [bisphenol A results in increased expression of TP53 mRNA]; Melatonin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; naringin inhibits the reaction [[bisphenol A co-treated with NG-Nitroarginine Methyl Ester] results in increased expression of TP53 protein]; naringin inhibits the reaction [[NG-Nitroarginine Methyl Ester co-treated with bisphenol A] results in increased expression of TP53 protein]; naringin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; NG-Nitroarginine Methyl Ester promotes the reaction [bisphenol A results in increased expression of TP53 protein] | PMID:25454643 PMID:32172062 PMID:32428650 PMID:32810514 PMID:34505250 | Tp53 | affects expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | bisphenol A affects the expression of TRP53 protein | PMID:33509759 | Tp53 | decreases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased expression of TP53 mRNA; bisphenol A results in decreased expression of TP53 protein | PMID:23222814 PMID:27998958 PMID:28238728 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | bisphenol A results in increased expression of TRP53 protein | PMID:38021376 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | bisphenol A analog results in increased expression of TP53 mRNA; bisphenol A results in increased expression of TP53 mRNA; bisphenol A results in increased expression of TP53 protein; bisphenol A results in increased expression of TRP53 protein | PMID:21277958 PMID:24831732 PMID:29128613 PMID:29275510 PMID:31681507 PMID:32387340 PMID:36572933 | Tp53 | increases phosphorylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | bisphenol A results in increased phosphorylation of TP53 protein | PMID:29275510 PMID:29383186 PMID:32466334 PMID:36232920 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of and results in increased phosphorylation of TP53 protein; [bisphenol A co-treated with Diethylhexyl Phthalate co-treated with Dibutyl Phthalate co-treated with butylbenzyl phthalate co-treated with diethyl phthalate co-treated with di-n-octyl phthalate co-treated with diisodecyl phthalate co-treated with diisononyl phthalate] results in increased expression of TP53 mRNA | PMID:35739755 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]; bicalutamide inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]; bisphenol A inhibits the reaction [Progesterone results in increased expression of TP53 mRNA]; Curcumin inhibits the reaction [bisphenol A results in decreased expression of TP53 protein]; Curcumin inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; Fulvestrant inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]; Gefitinib inhibits the reaction [bisphenol A results in increased phosphorylation of TP53 protein]; ICI 164384 inhibits the reaction [bisphenol A results in increased expression of TP53 protein]; MIR149 mRNA inhibits the reaction [bisphenol A results in decreased expression of TP53 mRNA]; Tamoxifen inhibits the reaction [bisphenol A results in increased expression of TP53 protein] | PMID:23222814 PMID:24831732 PMID:28238728 PMID:29383186 PMID:31681507 PMID:37009741 | | ||||||||||||||||||||||
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