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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:74077
Term: S-allylcysteine
Definition: An S-hydrocarbyl-L-cysteine that is L-cysteine in which the hydrogen attached to the sulphur is replaced by a prop-2-enyl group. It commonly occurs in garlic and has been found to exhibit antineoplastic activity.
Chemical ID: MESH:C065299
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases phosphorylationISOTP53 (Homo sapiens)6480464CTDS-allylcysteine results in increased phosphorylation of TP53 proteinPMID:31067004
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD[Diethylnitrosamine co-treated with S-allylcysteine] results in increased phosphorylation of TRP53 proteinPMID:31067004
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDSB 203580 inhibits the reaction [S-allylcysteine results in increased phosphorylation of TP53 protein]PMID:31067004
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