GENE - TERM ANNOTATION REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: DOID:2626
Term: choroid plexus papilloma
Definition: A usually benign neoplasm that arises from the cuboidal epithelium of the choroid plexus and takes the form of an enlarged CHOROID PLEXUS, which may be associated with oversecretion of CSF. The tumor usually presents in the first decade of life with signs of increased intracranial pressure including HEADACHES; ATAXIA; DIPLOPIA; and alterations of mental status. In children it is most common in the lateral ventricles and in adults it tends to arise in the fourth ventricle. Malignant transformation to choroid plexus carcinomas may rarely occur. (Adams et al., Principles of Neurology, 6th ed, p667; DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, p2072)
Definition Source(s): MESH:D020288
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
 ISORGD:705027240710OMIM  
 ISORGD:705028554872ClinVarClinVar Annotator: match by OMIM:260500

PMID:12085209
 ISORGD:705028554872ClinVarClinVar Annotator: match by term: Choroid plexus papilloma

PMID:10797439, PMID:11139324, PMID:12826609, PMID:15004724, PMID:1565143, PMID:16489069, PMID:1683921, PMID:17606709, PMID:18511570, PMID:19556618, PMID:20128691, PMID:21305319, PMID:21343334, PMID:21552135, PMID:21601526, PMID:23161690, PMID:23891399, PMID:24381225, PMID:24487413, PMID:24641375, PMID:24651012, PMID:25157968, PMID:25741868, PMID:26619011, PMID:26822237, PMID:26845104, PMID:27683180, PMID:28492532, PMID:7887414, PMID:9242456, PMID:9569050
 ISORGD:705028554872ClinVarClinVar Annotator: match by term: Choroid plexus papilloma

PMID:11040944, PMID:11391594, PMID:11793474, PMID:12826609, PMID:15173255, PMID:15580553, PMID:16487937, PMID:17224268, PMID:17289876, PMID:17727479, PMID:19367569, PMID:19714488, PMID:21232794, PMID:21343334, PMID:21512767, PMID:21761402, PMID:22652532, PMID:22710932, PMID:23894400, PMID:24033266, PMID:24728327, PMID:24868540, PMID:25527155, PMID:25637381, PMID:25741868, PMID:26086041, PMID:26467025, PMID:28492532, PMID:30374176, PMID:8198984, PMID:8203469, PMID:9865903
 ISORGD:705028554872ClinVarClinVar Annotator: match by term: Choroid plexus papilloma

PMID:11101847, PMID:12007217, PMID:12826609, PMID:15607980, PMID:15607981, PMID:15977174, PMID:16401470, PMID:16489069, PMID:17606709, PMID:18391940, PMID:18511570, PMID:19127115, PMID:19881536, PMID:20128691, PMID:20516128, PMID:20689556, PMID:21305319, PMID:21343334, PMID:21761402, PMID:22006311, PMID:22233476, PMID:22698404, PMID:23161690, PMID:23263379, PMID:23792586, PMID:24033266, PMID:24573247, PMID:25157968, PMID:25741868, PMID:27153395, PMID:27374712, PMID:27516001, PMID:28492532, PMID:8164043, PMID:8649785, PMID:8825920, PMID:9047394
 ISORGD:705028554872ClinVarClinVar Annotator: match by term: Choroid plexus papilloma

PMID:12826609, PMID:15390294, PMID:15607980, PMID:1565144, PMID:15951970, PMID:16489069, PMID:17540308, PMID:17606709, PMID:17636407, PMID:18511570, PMID:20128691, PMID:20516128, PMID:20693561, PMID:21343334, PMID:21484931, PMID:21552135, PMID:21761402, PMID:22811390, PMID:22899716, PMID:23161690, PMID:24381225, PMID:24487413, PMID:24641375, PMID:24677579, PMID:25157968, PMID:25584008, PMID:25741868, PMID:25787918, PMID:26467025, PMID:26619011, PMID:26681312, PMID:27374712, PMID:28453743, PMID:28492532, PMID:8423216, PMID:9242456, PMID:9569050
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.