Tp53<sup>em1Sage</sup> (tumor protein p53; ZFN induced mutant 1, Sage) - Rat Genome Database

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Gene: Tp53em1Sage (tumor protein p53; ZFN induced mutant 1, Sage) Rattus norvegicus
Symbol: Tp53em1Sage
Name: tumor protein p53; ZFN induced mutant 1, Sage
RGD ID: 12904898
Description: This ZFN allele exhibits a 11 base pair deletion in the rat Tp53 gene.
ASSOCIATED WITH abnormal vacuole morphology; decreased body weight; decreased testis weight; ASSOCIATED WITH Hypogonadism and Testicular Atrophy
Type: allele  of Tp53  
Previously known as: Tp53 tm1sage; Tp53^[em1Sage]; Tp53em1Sage; tumor protein p53; endonuclease induced mutant 1, Sage
Is Marker For: Strains:   SD-Tp53em1Sage  
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position: No map positions available.

Disease Annotations     Click to see Annotation Detail View


References - curated
# Reference Title Reference Citation
1. Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Dai MS, etal., Andrology. 2017 Nov;5(6):1141-1152. doi: 10.1111/andr.12409. Epub 2017 Aug 22.
2. Data curation from Horizon Discovery Data curation from Horizon Discovery (
3. Creation and preliminary characterization of a Tp53 knockout rat. McCoy A, etal., Dis Model Mech. 2013 Jan;6(1):269-78. doi: 10.1242/dmm.009704. Epub 2012 Aug 23.


Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tp53em1Sage-var1 chr10 54307287 54307297 AGATGATATTC - deletion mRatBN7.2
Tp53em1Sage-var1 chr10 56194211 56194221 AGATGATATTC - deletion Rnor_6.0

Related Rat Strains
The following Strains have been annotated to Tp53em1Sage



Nucleotide Sequences

Additional Information

Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-06-20 Tp53em1Sage  tumor protein p53; ZFN induced mutant 1, Sage  Tp53em1Sage  tumor protein p53; endonuclease induced mutant 1, Sage  Name changed 629549 APPROVED