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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:41423
Term: celecoxib
Definition: A member of the class of pyrazoles that is 1H-pyrazole which is substituted at positions 1, 3 and 5 by 4-sulfamoylphenyl, trifluoromethyl and p-tolyl groups, respectively. A cyclooxygenase-2 inhibitor, it is used in the treatment of arthritis.
Chemical ID: MESH:C105934
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTDCelecoxib inhibits the reaction [Gentamicins results in increased expression of TP53 protein]PMID:31628940
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDCelecoxib results in increased expression of TP53 mRNA; Celecoxib results in increased expression of TP53 proteinPMID:18202791 PMID:19706164
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 results in increased susceptibility to CelecoxibPMID:19706164
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTD[Celecoxib co-treated with docetaxel] results in increased expression of TRP53 protein; Celecoxib promotes the reaction [Doxorubicin results in increased expression of TRP53 protein]PMID:15458769 PMID:16052515
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[FEC protocol co-treated with Celecoxib] results in decreased expression of TP53 protein; Celecoxib results in increased activity of and results in increased localization of TP53 protein; Celecoxib results in increased expression of and results in increased phosphorylation of TP53 protein; pifithrin inhibits the reaction [Celecoxib results in increased expression of TP53 protein]; pifithrin inhibits the reaction [TP53 results in increased susceptibility to Celecoxib]; TP53 affects the reaction [Celecoxib results in increased expression of CDKN1A mRNA]; TP53 protein promotes the reaction [Celecoxib results in increased expression of BBC3 protein]PMID:16507397 PMID:18760266 PMID:19706164
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