Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:78887
Term: tirapazamine
Definition: A member of the class of benzotriazines that is 1,2,4-benzotriazine carrying an amino substituent at position 3 and two oxido substituents at positions 1 and 4.
Chemical ID: MESH:C049947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionISORGD:705026480464CTDtirapazamine results in increased expression of TP53

PMID:15814660
Tp53increases response to substanceISORGD:114406480464CTDTRP53 protein mutant form results in increased susceptibility to tirapazamine

PMID:16012721
Tp53increases response to substanceISORGD:705026480464CTDTP53 results in increased susceptibility to tirapazamine

PMID:15814660
Go Back to source page   Continue to Ontology report

NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.