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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:73458
Term: NS-398
Definition: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2.
Chemical ID: MESH:C080955
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased phosphorylation of TP53 protein]PMID:17984113
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased expression of TP53 mRNAPMID:29242151
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [Ceramides results in increased phosphorylation of TP53 protein]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [resveratrol results in increased activity of TP53 protein]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased expression of TP53 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [resveratrol results in increased phosphorylation of TP53 protein]PMID:16928824 PMID:18446786 PMID:23495037 PMID:29242151
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