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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:28834
Term: deoxycholic acid
Definition: A bile acid that is 5beta-cholan-24-oic acid substituted by hydroxy groups at positions 3 and 12 respectively.
Chemical ID: MESH:D003840
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53increases expressionEXP 6480464CTDDeoxycholic Acid results in increased expression of TP53 mRNAPMID:20137712
Tp53multiple interactionsEXP 6480464CTDTP53 protein affects the reaction [[Deoxycholic Acid results in increased expression of CCND1 protein] which affects the localization of BAX protein]; Ursodeoxycholic Acid inhibits the reaction [Deoxycholic Acid results in increased expression of TP53 mRNA]PMID:17431217 PMID:20137712
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