RGD Reference Report - Mutant p53: one name, many proteins. - Rat Genome Database

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Mutant p53: one name, many proteins.

Authors: Freed-Pastor, WA  Prives, C 
Citation: Freed-Pastor WA and Prives C, Genes Dev. 2012 Jun 15;26(12):1268-86. doi: 10.1101/gad.190678.112.
RGD ID: 8663430
Pubmed: PMID:22713868   (View Abstract at PubMed)
PMCID: PMC3387655   (View Article at PubMed Central)
DOI: DOI:10.1101/gad.190678.112   (Journal Full-text)

There is now strong evidence that mutation not only abrogates p53 tumor-suppressive functions, but in some instances can also endow mutant proteins with novel activities. Such neomorphic p53 proteins are capable of dramatically altering tumor cell behavior, primarily through their interactions with other cellular proteins and regulation of cancer cell transcriptional programs. Different missense mutations in p53 may confer unique activities and thereby offer insight into the mutagenic events that drive tumor progression. Here we review mechanisms by which mutant p53 exerts its cellular effects, with a particular focus on the burgeoning mutant p53 transcriptome, and discuss the biological and clinical consequences of mutant p53 gain of function.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
ETS1Humanaltered p53 signaling pathway   TAS  RGD 
Ets1Rataltered p53 signaling pathway   ISOETS1 (Homo sapiens) RGD 
Ets1Mousealtered p53 signaling pathway   ISOETS1 (Homo sapiens) RGD 
NFYAHumanaltered p53 signaling pathway   TAS  RGD 
NFYBHumanaltered p53 signaling pathway   TAS  RGD 
NFYCHumanaltered p53 signaling pathway   TAS  RGD 
NfyaRataltered p53 signaling pathway   ISONFYA (Homo sapiens) RGD 
NfyaMousealtered p53 signaling pathway   ISONFYA (Homo sapiens) RGD 
NfybRataltered p53 signaling pathway   ISONFYB (Homo sapiens) RGD 
NfybMousealtered p53 signaling pathway   ISONFYB (Homo sapiens) RGD 
NfycRataltered p53 signaling pathway   ISONFYC (Homo sapiens) RGD 
NfycMousealtered p53 signaling pathway   ISONFYC (Homo sapiens) RGD 
PIN1Humanaltered p53 signaling pathway   TAS  RGD 
Pin1Rataltered p53 signaling pathway   ISOPIN1 (Homo sapiens) RGD 
Pin1Mousealtered p53 signaling pathway   ISOPIN1 (Homo sapiens) RGD 
SREBF2Humanaltered p53 signaling pathway   TAS  RGD 
Srebf2Mousealtered p53 signaling pathway   ISOSREBF2 (Homo sapiens) RGD 
Srebf2Rataltered p53 signaling pathway   ISOSREBF2 (Homo sapiens) RGD 
TP53Humanaltered p53 signaling pathway   TAS  RGD 
TP63Humanaltered p53 signaling pathway   TAS  RGD 
TP73Humanaltered p53 signaling pathway   TAS  RGD 
Tp53Rataltered p53 signaling pathway   ISOTP53 (Homo sapiens) RGD 
Tp63Rataltered p53 signaling pathway   ISOTP63 (Homo sapiens) RGD 
Tp73Rataltered p53 signaling pathway   ISOTP73 (Homo sapiens) RGD 
Trp53Mousealtered p53 signaling pathway   ISOTP53 (Homo sapiens) RGD 
Trp63Mousealtered p53 signaling pathway   ISOTP63 (Homo sapiens) RGD 
Trp73Mousealtered p53 signaling pathway   ISOTP73 (Homo sapiens) RGD 
VDRHumanaltered p53 signaling pathway   TAS  RGD 
VdrRataltered p53 signaling pathway   ISOVDR (Homo sapiens) RGD 
VdrMousealtered p53 signaling pathway   ISOVDR (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ets1  (ETS proto-oncogene 1, transcription factor)
Nfya  (nuclear transcription factor Y subunit alpha)
Nfyb  (nuclear transcription factor Y subunit beta)
Nfyc  (nuclear transcription factor Y subunit gamma)
Pin1  (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)
Srebf2  (sterol regulatory element binding transcription factor 2)
Tp53  (tumor protein p53)
Tp63  (tumor protein p63)
Tp73  (tumor protein p73)
Vdr  (vitamin D receptor)

Genes (Mus musculus)
Ets1  (E26 avian leukemia oncogene 1, 5' domain)
Nfya  (nuclear transcription factor-Y alpha)
Nfyb  (nuclear transcription factor-Y beta)
Nfyc  (nuclear transcription factor-Y gamma)
Pin1  (peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1)
Srebf2  (sterol regulatory element binding factor 2)
Trp53  (transformation related protein 53)
Trp63  (transformation related protein 63)
Trp73  (transformation related protein 73)
Vdr  (vitamin D (1,25-dihydroxyvitamin D3) receptor)

Genes (Homo sapiens)
ETS1  (ETS proto-oncogene 1, transcription factor)
NFYA  (nuclear transcription factor Y subunit alpha)
NFYB  (nuclear transcription factor Y subunit beta)
NFYC  (nuclear transcription factor Y subunit gamma)
PIN1  (peptidylprolyl cis/trans isomerase, NIMA-interacting 1)
SREBF2  (sterol regulatory element binding transcription factor 2)
TP53  (tumor protein p53)
TP63  (tumor protein p63)
TP73  (tumor protein p73)
VDR  (vitamin D receptor)


Additional Information