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Gene: PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1) Homo sapiens
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Symbol: PIN1
Name: peptidylprolyl cis/trans isomerase, NIMA-interacting 1
Description: Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DOD; FLJ40239; FLJ77628; MGC10717; peptidyl-prolyl cis-trans isomerase NIMA-interacting 1; peptidyl-prolyl cis-trans isomerase Pin1; peptidyl-prolyl cis/trans isomerase, NIMA-interacting; PPIase Pin1; prolyl isomerase; protein (peptidyl-prolyl cis/trans isomerase) NIMA-interacting 1; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting 1; rotamase Pin1; UBL5
Orthologs:
Related Pseudogenes: PIN1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38199,835,207 - 9,849,689 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37199,945,883 - 9,960,365 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36199,806,999 - 9,821,358 (+)NCBINCBI36hg18NCBI36
Build 34199,806,998 - 9,821,358NCBI
Celera199,841,421 - 9,855,782 (+)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,526,513 - 9,540,997 (+)NCBIHuRef
CHM1_1199,945,595 - 9,960,077 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on PIN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1321121
Created: 2005-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.