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Strain Registration

Strain: SD-Tp53em1Sage

Symbol: SD-Tp53em1Sage
Strain: SD-Tp53em1
Substrain: Sage
RGD ID: 12904897
Citation ID: RRID:RGD_12904897
Ontology ID: RS:0004442
Alleles: Tp53em1Sage
Also Known As: TGRA3990; SD- Tp53 tm1sage; p53 Knockout Rat; Tp53delta11/+; SD-Tp53em1Sage; SD-Tp53^[em1Sage]
Type: mutant
Available Source: Horizon Discovery
Origination: Horizon Discovery
Description: This ZFN model carries the monoallelic 11 base pair deletion in Tp53 gene. Animals exhibit broad tumor spectrum with high degree of tumor malignancy.
Genetic Status: Heterozygous
Last Known Status: Extinct (as of 2024-04-16)
Research Usage carcinogenicity
Position
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81054,798,871 - 54,810,300RGD_MAPPER_PIPELINE
mRatBN7.21054,307,287 - 54,307,297RGD_MAPPER_PIPELINEmRatBN7.2
Rnor_6.01056,194,211 - 56,194,221RGD_MAPPER_PIPELINERnor6.0
Rnor_5.01055,932,658 - 55,944,087RGD_MAPPER_PIPELINERnor5.0
RGSC_v3.41056,399,721 - 56,411,150RGD_MAPPER_PIPELINERGSC3.4





Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Spontaneous testicular atrophy occurs despite normal spermatogonial proliferation in a Tp53 knockout rat. Dai MS, etal., Andrology. 2017 Nov;5(6):1141-1152. doi: 10.1111/andr.12409. Epub 2017 Aug 22.
2. Data curation from Horizon Discovery Data curation from Horizon Discovery (https://www.horizondiscovery.com/)
3. Creation and preliminary characterization of a Tp53 knockout rat. McCoy A, etal., Dis Model Mech. 2013 Jan;6(1):269-78. doi: 10.1242/dmm.009704. Epub 2012 Aug 23.

Region

Allelic Variants
Name Chromosome Start Pos End Pos Reference Nucleotide Variant Nucleotide Variant Type Assembly
Tp53em1Sage-var1 chr10 54307287 54307297 AGATGATATTC - deletion mRatBN7.2
Tp53em1Sage-var1 chr10 56194211 56194221 AGATGATATTC - deletion Rnor_6.0

Additional Information


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-24 SD-Tp53em1Sage    SD-Tp53>em1Sage    Symbol updated 68687 APPROVED
2017-05-24 SD-Tp53em1Sage    SD-Tp53>em1Sage    Symbol updated 68687 APPROVED