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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:78492
Term: diallyl trisulfide
Definition: An organic trisulfide that is trisulfane in which both of the hydrogens are replaced by allyl groups. A component of the essential oil of garlic and a major component of the traditional Chinese medicine allitridium, it exhibits antifungal, antitumour and antioxidant activity
Chemical ID: MESH:C042577
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects localizationISOTP53 (Homo sapiens)6480464CTDdiallyl trisulfide affects the localization of TP53 proteinPMID:24415872
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of TP53 mRNA; diallyl trisulfide results in increased expression of TP53 proteinPMID:19823037 PMID:23754639 PMID:24415872 PMID:28571773
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDdiallyl trisulfide results in increased expression of and affects the localization of TP53 proteinPMID:19823037
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