GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | multiple interactions | EXP | | 6480464 | CTD | [7-nitroindazole results in decreased chemical synthesis of Nitric Oxide] inhibits the reaction [Paraquat results in increased phosphorylation of TP53 protein]; [NOS2 protein results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; [S-Nitrosoglutathione results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein | PMID:20478973 PMID:8982730 PMID:9743513 | Tp53 | affects response to substance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein affects the susceptibility to Nitric Oxide | PMID:16024610 | Tp53 | decreases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Nitric Oxide results in decreased expression of TRP53 protein | PMID:14634119 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in increased expression of TP53 protein | PMID:15979383 | Tp53 | increases glutathionylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in increased glutathionylation of TP53 protein | PMID:17555331 | Tp53 | increases phosphorylation | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Nitric Oxide results in increased phosphorylation of TP53 protein | PMID:15177039 PMID:16024610 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [S-Nitroso-N-Acetylpenicillamine results in increased abundance of Nitric Oxide] which results in increased expression of TRP53 mRNA | PMID:7673702 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; [Nitric Oxide Donors results in increased abundance of Nitric Oxide] which results in increased expression of TP53 protein; Caffeine inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein] | PMID:10608825 PMID:16024610 | | ||||||||||||||||||||||
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