GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects localization | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Reactive Oxygen Species affects the localization of TRP53 protein | PMID:26884717 | Tp53 | affects localization | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Reactive Oxygen Species affects the localization of TP53 protein | PMID:26884717 | Tp53 | increases abundance | ISO | TP53 (Homo sapiens) | 6480464 | CTD | TP53 protein results in increased abundance of Reactive Oxygen Species | PMID:15059885 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Reactive Oxygen Species results in increased expression of TP53 protein | PMID:10951577 PMID:27634759 | Tp53 | increases phosphorylation | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Reactive Oxygen Species results in increased phosphorylation of TRP53 protein | PMID:16412576 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [pifithrin results in decreased activity of TRP53 protein] inhibits the reaction [zearalenol affects the abundance of Reactive Oxygen Species]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased activity of TRP53 protein]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased expression of TRP53 mRNA]; Acetylcysteine inhibits the reaction [[Excitatory Amino Acid Agents results in increased abundance of Reactive Oxygen Species] which results in increased expression of TRP53 protein]; Cyclosporine inhibits the reaction [Reactive Oxygen Species affects the localization of TRP53 protein] | PMID:20955365 PMID:23376438 PMID:26884717 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in decreased expression of BCL2 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in decreased expression of BCL2L11 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BCL2A1 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BCL2L1 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of BID protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of DDR1 mRNA; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of ICAM1 mRNA; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MCL1 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of MDM2 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of NR4A2 mRNA; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of PTGS2 mRNA; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SCO2 protein; [[[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein] which results in increased expression of SOCS1 mRNA; [[CD40LG protein co-treated with IL4 protein] results in increased abundance of Reactive Oxygen Species] which results in increased expression of and results in increased phosphorylation of and results in increased stability of TP53 protein; [chromium hexavalent ion results in increased abundance of Reactive Oxygen Species] which results in increased activity of TP53 protein; [Sulindac results in increased abundance of Reactive Oxygen Species] which results in increased activity of TP53 protein; Acetylcysteine inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; Acetylcysteine inhibits the reaction [TP53 protein results in increased abundance of Reactive Oxygen Species]; Cyclosporine inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; pifithrin inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; sanglifehrin A inhibits the reaction [Reactive Oxygen Species affects the localization of TP53 protein]; TP53 protein inhibits the reaction [USP39 protein inhibits the reaction [Cisplatin results in increased abundance of Reactive Oxygen Species]]; TP53 protein promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in increased abundance of Reactive Oxygen Species]; TP53 protein promotes the reaction [Copper results in increased abundance of Reactive Oxygen Species]; TP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of GPX1 protein]; TP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of SCO2 mRNA]; TP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of SOD2 protein]; TP53 protein promotes the reaction [Reactive Oxygen Species results in increased expression of TIGAR mRNA]; TP53 protein promotes the reaction [Zinc results in increased abundance of Reactive Oxygen Species] | PMID:15059885 PMID:15880691 PMID:17136320 PMID:21042727 PMID:22886373 PMID:26884717 PMID:27634759 PMID:34822033 | | ||||||||||||||||||||||
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