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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:131194
Term: 3,3',5,5'-tetraiodothyroacetic acid
Definition: A monocarboxylic acid that is thyroacetic acid carrying four iodo substituents at positions 3, 3', 5 and 5'.
Chemical ID: MESH:C011126
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsEXP 6480464CTDtetraiodothyroacetic acid inhibits the reaction [Thyroxine affects the localization of TP53 protein modified form]PMID:17984113
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDtetraiodothyroacetic acid results in decreased expression of TP53 mRNAPMID:35151786
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTD[heteronemin affects the susceptibility to tetraiodothyroacetic acid] which results in decreased expression of TP53 mRNA; heteronemin promotes the reaction [tetraiodothyroacetic acid results in decreased expression of TP53 mRNA]; tetraiodothyroacetic acid promotes the reaction [heteronemin results in decreased expression of TP53 mRNA]PMID:35151786
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