GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | | ISO | Trp53 (Mus musculus) | 127285675 | RGD | N-nitrosodiethylamine increases expression of Trp53 mRNA in liver | | Tp53 | decreases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in decreased expression of TP53 mRNA; Diethylnitrosamine results in decreased expression of TP53 protein | PMID:21167192 PMID:21554863 PMID:24954034 PMID:30423403 | Tp53 | increases expression | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased expression of TP53 mRNA; Diethylnitrosamine results in increased expression of TP53 protein | PMID:11751435 PMID:14555611 PMID:18367157 PMID:19254457 PMID:19874807 PMID:20360939 PMID:9163691 | Tp53 | increases phosphorylation | EXP | | 6480464 | CTD | Diethylnitrosamine results in increased phosphorylation of TP53 protein | PMID:11751435 | Tp53 | multiple interactions | EXP | | 6480464 | CTD | [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; [Acetoxyacetylaminofluorene co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of and affects the localization of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in decreased expression of TP53 mRNA; [Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein; [Diethylnitrosamine co-treated with chrysin] results in increased expression of TP53 protein; [Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of TP53 mRNA; [Diethylnitrosamine co-treated with kojic acid co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein; [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA; [Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TP53 protein; AHR protein promotes the reaction [Tetrachlorodibenzodioxin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]]; ATM protein affects the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; caffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; Caffeine inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Caffeine inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]; chrysin inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; cobaltous chloride promotes the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Diethylnitrosamine results in increased expression of and results in increased phosphorylation of TP53 protein; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA]; geraniol inhibits the reaction [[ferric nitrilotriacetate co-treated with Diethylnitrosamine] results in increased expression of TP53 protein]; IFNA2 protein affects the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] affects the expression of TP53 protein]; lanreotide inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 mRNA]; myrtenal inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TP53 mRNA]; myrtenal inhibits the reaction [[Phenobarbital co-treated with Diethylnitrosamine] results in decreased expression of TP53 protein]; neferine inhibits the reaction [Diethylnitrosamine results in decreased expression of TP53 mRNA]; Phenobarbital promotes the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Plant Extracts inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Tetrachlorodibenzodioxin inhibits the reaction [Diethylnitrosamine results in increased expression of and results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein] | PMID:10741303 PMID:11003613 PMID:11751435 PMID:11915028 PMID:14633663 PMID:15459018 PMID:17602206 PMID:18367157 PMID:18544905 PMID:19874807 PMID:20360939 PMID:21167192 PMID:21554863 PMID:21907755 PMID:22436021 PMID:23665045 PMID:30423403 | Tp53 | decreases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in decreased expression of TRP53 mRNA; Diethylnitrosamine results in decreased expression of TRP53 protein | PMID:18506893 PMID:19996281 PMID:34726822 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Diethylnitrosamine results in increased expression of TRP53 protein | PMID:19919837 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Diethylnitrosamine results in increased expression of TP53 protein | PMID:21776270 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [Diethylnitrosamine co-treated with kojic acid co-treated with Ascorbic Acid] results in increased expression of TRP53 mRNA; [Diethylnitrosamine co-treated with S-allylcysteine] results in increased phosphorylation of TRP53 protein; AHR protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; ATM protein inhibits the reaction [Diethylnitrosamine results in increased expression of TRP53 protein]; CLOCK protein promotes the reaction [Diethylnitrosamine results in increased expression of and results in increased phosphorylation of TRP53 protein]; Diethylnitrosamine results in increased expression of and results in increased phosphorylation of TRP53 protein; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; maculosin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]; MG 262 inhibits the reaction [XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 mRNA]; Quercetin inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein]; XRCC6 protein inhibits the reaction [Diethylnitrosamine results in decreased expression of TRP53 protein] | PMID:17917374 PMID:18506893 PMID:19919837 PMID:19996281 PMID:21167249 PMID:31067004 PMID:34726822 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | [CYP2A6 protein results in increased metabolism of Diethylnitrosamine] which affects the localization of TP53 protein | PMID:35882637 | | ||||||||||||||||||||||
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