GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Tp53 | affects expression | EXP | | 6480464 | CTD | Nicotine affects the expression of TP53 mRNA | PMID:10837795 | Tp53 | affects response to substance | EXP | | 6480464 | CTD | TP53 protein affects the susceptibility to Nicotine | PMID:15983034 | Tp53 | increases expression | EXP | | 6480464 | CTD | Nicotine results in increased expression of TP53 mRNA | PMID:20339300 PMID:20426880 | Tp53 | decreases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Nicotine results in decreased expression of TRP53 protein | PMID:18835254 | Tp53 | decreases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Nicotine results in decreased expression of TP53 mRNA; Nicotine results in decreased expression of TP53 protein | PMID:16011614 PMID:18247414 PMID:18805435 PMID:19139119 PMID:30272249 | Tp53 | increases expression | ISO | Trp53 (Mus musculus) | 6480464 | CTD | Nicotine results in increased expression of TRP53 mRNA; Nicotine results in increased expression of TRP53 protein | PMID:30896085 PMID:31507073 | Tp53 | increases expression | ISO | TP53 (Homo sapiens) | 6480464 | CTD | Nicotine results in increased expression of TP53 protein | PMID:20727180 | Tp53 | multiple interactions | ISO | Trp53 (Mus musculus) | 6480464 | CTD | [Nicotine co-treated with Polylactic Acid-Polyglycolic Acid Copolymer] inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; Nicotine inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TRP53 protein]; royal jelly inhibits the reaction [Nicotine results in increased expression of TRP53 mRNA] | PMID:23933227 PMID:30896085 | Tp53 | multiple interactions | ISO | TP53 (Homo sapiens) | 6480464 | CTD | 4-(5-(4-chlorophenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; [[Nicotine results in decreased expression of RPS27A protein] which results in increased phosphorylation of MDM2 protein] which results in increased ubiquitination of TP53 protein; Nicotine inhibits the reaction [aflatoxin G1 results in increased expression of TP53 protein modified form]; Nicotine inhibits the reaction [Cisplatin results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Gemcitabine results in increased expression of TP53 protein]; Nicotine inhibits the reaction [Paclitaxel results in increased expression of TP53 protein]; Rosiglitazone inhibits the reaction [Nicotine results in decreased expression of TP53 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK1 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK3 protein]; TP53 protein affects the reaction [Nicotine results in increased phosphorylation of MAPK8 protein] | PMID:16601104 PMID:18805435 PMID:19139119 PMID:20727180 PMID:23907605 PMID:30272249 | | ||||||||||||||||||||||
| Go Back to source page | Continue to Ontology report |