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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:30146
Term: lithium hydride
Definition: An alkali metal hydride where the metal is specified as lithium.
Chemical ID: MESH:D008094
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53multiple interactionsISOTrp53 (Mus musculus)6480464CTDTP53 affects the reaction [Lithium results in increased expression of CDKN1A protein]PMID:11337498
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDLithium inhibits the reaction [GSK3B protein binds to TP53 protein]; Lithium inhibits the reaction [sodium arsenite results in increased expression of and affects the localization of TP53 protein]PMID:15475000 PMID:17849503
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