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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 3889
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tp53
Name: tumor protein p53
Acc ID: CHEBI:28509
Term: chloroethene
Definition: A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.
Chemical ID: MESH:D014752
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tp53affects response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 polymorphism affects the susceptibility to Vinyl ChloridePMID:24464562
Tp53decreases expressionISOTP53 (Homo sapiens)6480464CTDVinyl Chloride results in decreased expression of TP53 mRNAPMID:22076037
Tp53increases expressionISOTP53 (Homo sapiens)6480464CTDVinyl Chloride results in increased expression of TP53 protein; Vinyl Chloride results in increased expression of TP53 protein mutant formPMID:12670519 PMID:14979067 PMID:16474264
Tp53increases mutagenesisISOTP53 (Homo sapiens)6480464CTDVinyl Chloride results in increased mutagenesis of TP53 genePMID:12010862 PMID:12670519 PMID:16881598 PMID:17384900
Tp53increases response to substanceISOTP53 (Homo sapiens)6480464CTDTP53 gene SNP results in increased susceptibility to Vinyl ChloridePMID:18226366
Tp53multiple interactionsISOTP53 (Homo sapiens)6480464CTDCYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; CYP2E1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]; GSTM1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; GSTT1 gene polymorphism affects the reaction [XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]]; XRCC1 gene polymorphism affects the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride affects the mutagenesis of TP53 gene]; XRCC1 gene polymorphism promotes the reaction [Vinyl Chloride results in increased mutagenesis of TP53 gene]PMID:12010862 PMID:12705718 PMID:14602524 PMID:16097394 PMID:16881598 PMID:17384900
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