RGD Reference Report - p53 mutations in cancer. - Rat Genome Database

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p53 mutations in cancer.

Authors: Muller, Patricia A J  Vousden, Karen H 
Citation: Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
RGD ID: 8663431
Pubmed: PMID:23263379   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb2641   (Journal Full-text)

In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
MRE11Humanaltered p53 signaling pathway   TAS  RGD 
Mre11Rataltered p53 signaling pathway   ISOMRE11 (Homo sapiens) RGD 
Mre11aMousealtered p53 signaling pathway   ISOMRE11 (Homo sapiens) RGD 
NFYAHumanaltered p53 signaling pathway   TAS  RGD 
NFYBHumanaltered p53 signaling pathway   TAS  RGD 
NFYCHumanaltered p53 signaling pathway   TAS  RGD 
NfyaRataltered p53 signaling pathway   ISONFYA (Homo sapiens) RGD 
NfyaMousealtered p53 signaling pathway   ISONFYA (Homo sapiens) RGD 
NfybRataltered p53 signaling pathway   ISONFYB (Homo sapiens) RGD 
NfybMousealtered p53 signaling pathway   ISONFYB (Homo sapiens) RGD 
NfycRataltered p53 signaling pathway   ISONFYC (Homo sapiens) RGD 
NfycMousealtered p53 signaling pathway   ISONFYC (Homo sapiens) RGD 
SREBF2Humanaltered p53 signaling pathway   TAS  RGD 
Srebf2Mousealtered p53 signaling pathway   ISOSREBF2 (Homo sapiens) RGD 
Srebf2Rataltered p53 signaling pathway   ISOSREBF2 (Homo sapiens) RGD 
TP53Humanaltered p53 signaling pathway   TAS  RGD 
TP63Humanaltered p53 signaling pathway   TAS  RGD 
TP73Humanaltered p53 signaling pathway   TAS  RGD 
Tp53Rataltered p53 signaling pathway   ISOTP53 (Homo sapiens) RGD 
Tp63Rataltered p53 signaling pathway   ISOTP63 (Homo sapiens) RGD 
Tp73Rataltered p53 signaling pathway   ISOTP73 (Homo sapiens) RGD 
Trp53Mousealtered p53 signaling pathway   ISOTP53 (Homo sapiens) RGD 
Trp63Mousealtered p53 signaling pathway   ISOTP63 (Homo sapiens) RGD 
Trp73Mousealtered p53 signaling pathway   ISOTP73 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Mre11  (MRE11 homolog, double strand break repair nuclease)
Nfya  (nuclear transcription factor Y subunit alpha)
Nfyb  (nuclear transcription factor Y subunit beta)
Nfyc  (nuclear transcription factor Y subunit gamma)
Srebf2  (sterol regulatory element binding transcription factor 2)
Tp53  (tumor protein p53)
Tp63  (tumor protein p63)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Mre11a  (MRE11A homolog A, double strand break repair nuclease)
Nfya  (nuclear transcription factor-Y alpha)
Nfyb  (nuclear transcription factor-Y beta)
Nfyc  (nuclear transcription factor-Y gamma)
Srebf2  (sterol regulatory element binding factor 2)
Trp53  (transformation related protein 53)
Trp63  (transformation related protein 63)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
MRE11  (MRE11 homolog, double strand break repair nuclease)
NFYA  (nuclear transcription factor Y subunit alpha)
NFYB  (nuclear transcription factor Y subunit beta)
NFYC  (nuclear transcription factor Y subunit gamma)
SREBF2  (sterol regulatory element binding transcription factor 2)
TP53  (tumor protein p53)
TP63  (tumor protein p63)
TP73  (tumor protein p73)


Additional Information