p53 mutations in cancer.

Authors: Muller, Patricia A J  Vousden, Karen H 
Citation: Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
Pubmed: (View Article at PubMed) PMID:23263379
DOI: Full-text: DOI:10.1038/ncb2641

In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.

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RGD ID: 8663431
Created: 2014-07-02
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Last Modified: 2017-01-03
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.