RGD Reference Report - p53 mutations in cancer. - Rat Genome Database

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p53 mutations in cancer.

Authors: Muller, Patricia A J  Vousden, Karen H 
Citation: Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
RGD ID: 8663431
Pubmed: PMID:23263379   (View Abstract at PubMed)
DOI: DOI:10.1038/ncb2641   (Journal Full-text)

In the past fifteen years, it has become apparent that tumour-associated p53 mutations can provoke activities that are different to those resulting from simply loss of wild-type tumour-suppressing p53 function. Many of these mutant p53 proteins acquire oncogenic properties that enable them to promote invasion, metastasis, proliferation and cell survival. Here we highlight some of the emerging molecular mechanisms through which mutant p53 proteins can exert these oncogenic functions.

Objects Annotated

Genes (Rattus norvegicus)
Mre11  (MRE11 homolog, double strand break repair nuclease)
Nfya  (nuclear transcription factor Y subunit alpha)
Nfyb  (nuclear transcription factor Y subunit beta)
Nfyc  (nuclear transcription factor Y subunit gamma)
Srebf2  (sterol regulatory element binding transcription factor 2)
Tp53  (tumor protein p53)
Tp63  (tumor protein p63)
Tp73  (tumor protein p73)

Genes (Mus musculus)
Mre11a  (MRE11A homolog A, double strand break repair nuclease)
Nfya  (nuclear transcription factor-Y alpha)
Nfyb  (nuclear transcription factor-Y beta)
Nfyc  (nuclear transcription factor-Y gamma)
Srebf2  (sterol regulatory element binding factor 2)
Trp53  (transformation related protein 53)
Trp63  (transformation related protein 63)
Trp73  (transformation related protein 73)

Genes (Homo sapiens)
MRE11  (MRE11 homolog, double strand break repair nuclease)
NFYA  (nuclear transcription factor Y subunit alpha)
NFYB  (nuclear transcription factor Y subunit beta)
NFYC  (nuclear transcription factor Y subunit gamma)
SREBF2  (sterol regulatory element binding transcription factor 2)
TP53  (tumor protein p53)
TP63  (tumor protein p63)
TP73  (tumor protein p73)


Additional Information