MRE11 (MRE11 homolog, double strand break repair nuclease) - Rat Genome Database

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Gene: MRE11 (MRE11 homolog, double strand break repair nuclease) Homo sapiens
Analyze
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
RGD ID: 1344886
HGNC Page HGNC:7230
Description: Enables 3'-5'-DNA exonuclease activity; identical protein binding activity; and single-stranded DNA endodeoxyribonuclease activity. Contributes to DNA binding activity and DNA helicase activity. Involved in several processes, including DNA metabolic process; R-loop processing; and regulation of DNA metabolic process. Acts upstream of or within DNA damage response. Located in PML body; chromosome; and cytoplasm. Part of BRCA1-C complex and Mre11 complex. Is active in site of double-strand break. Implicated in several diseases, including Lynch syndrome; ataxia-telangiectasia-like disorder-1; endometrial cancer; gastrointestinal system cancer (multiple); and urinary bladder cancer. Biomarker of Alzheimer's disease; breast carcinoma; and malignant astrocytoma.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: AT-like disease; ATLD; DNA recombination and repair protein; double-strand break repair protein MRE11; double-strand break repair protein MRE11A; endo/exonuclease Mre11; HNGS1; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; MRE11 double strand break repair nuclease A; MRE11 homolog 1; MRE11 homolog A; MRE11 homolog A, double strand break repair nuclease; MRE11 homolog, double strand break repair nuclease A; MRE11 meiotic recombination 11 homolog A; MRE11 meiotic recombination 11-like protein A; MRE11A; MRE11B
RGD Orthologs
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: MRE11P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,415,570 - 94,512,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,415,570 - 94,493,885 (-)EnsemblGRCh38hg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
T2T-CHM13v2.01194,422,612 - 94,519,751 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Object Symbol
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Original Reference(s)
MRE11HumanAlzheimer's disease  IEP 2317734protein:decreased expression:cerebral cortex (human)RGD 
MRE11Humanbreast carcinoma  IEP 2300250protein:decreased expression:tumor (human)RGD 
MRE11Humanbreast carcinoma  IAGP 2317721DNA:polymorphisms:intron and exon:multiple (human)RGD 
MRE11Humancolon cancer susceptibilityIAGP 151361212DNA:SNP:3'utr: (rs2155209) (human)RGD 
MRE11HumanColonic Neoplasms  IAGP 2317740DNA:deletions:intron:IVS4_delT (human)RGD 
MRE11Humanendometrial cancer  IAGP 2317737DNA:deletions:intron:IVS4_delT (human)RGD 
MRE11HumanLynch syndrome  IAGP 153297765DNA:mutations:cds: (human)RGD 
MRE11Humanmalignant astrocytoma severityIEP 2317736mRNA:decreased expression:brain tumor (human)RGD 
MRE11HumanNeurocutaneous Syndromes  IAGP 2317722DNA:missense mutation:cds:W210C (human)RGD 
MRE11Humanrectum cancer susceptibilityIAGP 151361212DNA:SNP:3'utr: (rs2155209) (human)RGD 
MRE11Humanstomach carcinoma  IAGP 2317738DNA:deletions:intron:IVS4_delT (human)RGD 
MRE11Humanurinary bladder cancer susceptibilityIAGP 2317733DNA:snp:3' utr:c.2501A>G rs2155209 (human)RGD 
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1 to 20 of 435 rows
Object Symbol
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Original Reference(s)
MRE11Humanataxia telangiectasia  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia syndromeClinVarPMID:23807571 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:26467025 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) and (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:24894818 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:26467025 and PMID:28492532
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:23080121 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens) more ...8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:11371508 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:26467025 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:23080121 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:25741868 more ...
MRE11HumanAtaxia Telangiectasia Like Disorder  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Ataxia-telangiectasia-like disorderClinVarPMID:11196167 more ...
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Original Reference(s)
MRE11HumanAnimal Disease Models  ISOMre11a (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
MRE11HumanAtaxia Telangiectasia Like Disorder  EXP 11554173CTD Direct Evidence: marker/mechanismCTD 
MRE11Humanlung adenocarcinoma  ISOMre11a (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:27602772
MRE11HumanProstatic Neoplasms  ISOMre11a (Mus musculus)11554173CTD Direct Evidence: marker/mechanismCTDPMID:29610475
Object Symbol
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Original Reference(s)
MRE11Humanataxia-telangiectasia-like disorder-1  IAGP 7240710 OMIM 

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MRE11Human(+)-pilocarpine increases expressionISOMre11 (Rattus norvegicus)6480464Pilocarpine results in increased expression of MRE11A mRNACTDPMID:17971868
MRE11Human(-)-epigallocatechin 3-gallate multiple interactionsEXP 6480464[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of MRE11 mRNACTDPMID:22079256
MRE11Human1,1-dichloroethene increases expressionISOMre11a (Mus musculus)6480464vinylidene chloride results in increased expression of MRE11A mRNACTDPMID:26682919
MRE11Human1,2-dimethylhydrazine increases expressionISOMre11a (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of MRE11A mRNACTDPMID:22206623
MRE11Human2,3,7,8-tetrachlorodibenzodioxine increases expressionISOMre11a (Mus musculus)6480464Tetrachlorodibenzodioxin results in increased expression of MRE11A mRNACTDPMID:19770486
MRE11Human2,3,7,8-tetrachlorodibenzodioxine decreases expressionISOMre11a (Mus musculus)6480464Tetrachlorodibenzodioxin results in decreased expression of MRE11A mRNACTDPMID:15034205
MRE11Human2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOMre11a (Mus musculus)6480464AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of MRE11A mRNA]CTDPMID:15034205
MRE11Human2,3,7,8-tetrachlorodibenzodioxine affects expressionISOMre11a (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of MRE11A mRNACTDPMID:21570461
MRE11Human2,4,6-tribromophenol decreases expressionEXP 64804642 more ...CTDPMID:31675489
MRE11Human2,4-dinitrotoluene affects expressionISOMre11 (Rattus norvegicus)64804642 and 4-dinitrotoluene affects the expression of MRE11A mRNACTDPMID:21346803
MRE11Human2,6-dinitrotoluene affects expressionISOMre11 (Rattus norvegicus)64804642 and 6-dinitrotoluene affects the expression of MRE11A mRNACTDPMID:21346803
MRE11Human3,3',5,5'-tetrabromobisphenol A increases expressionEXP 6480464tetrabromobisphenol A results in increased expression of MRE11 proteinCTDPMID:31675489
MRE11Human3,4-methylenedioxymethamphetamine decreases expressionISOMre11a (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of MRE11A mRNACTDPMID:26251327
MRE11Human4,4'-diaminodiphenylmethane increases expressionISOMre11a (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in increased expression of MRE11A mRNACTDPMID:18648102
MRE11Human4-hydroperoxycyclophosphamide decreases expressionISOMre11 (Rattus norvegicus)6480464perfosfamide results in decreased expression of MRE11A mRNACTDPMID:11754170
MRE11Human5-aza-2'-deoxycytidine affects localizationEXP 6480464Decitabine affects the localization of MRE11 protein modified formCTDPMID:17991895
MRE11Humanaflatoxin B1 increases expressionISOMre11a (Mus musculus)6480464Aflatoxin B1 results in increased expression of MRE11A mRNACTDPMID:19770486
MRE11Humanaflatoxin B1 decreases methylationEXP 6480464Aflatoxin B1 results in decreased methylation of MRE11 geneCTDPMID:27153756
MRE11Humanall-trans-retinoic acid decreases expressionEXP 6480464Tretinoin results in decreased expression of MRE11A mRNACTDPMID:33167477
MRE11Humanammonium chloride affects expressionISOMre11 (Rattus norvegicus)6480464Ammonium Chloride affects the expression of MRE11A mRNACTDPMID:16483693

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Biological Process
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Original Reference(s)
MRE11Humancell population proliferation acts_upstream_of_or_withinIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11Humanchromosome organization involved_inISOMre11a (Mus musculus)9068941 PMID:18854157UniProtPMID:18854157
MRE11Humanchromosome organization acts_upstream_of_or_withinIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11HumanDNA damage response involved_inIDA 150520179 PMID:29670289UniProtPMID:29670289
MRE11HumanDNA damage response involved_inIEAUniProtKB-KW:KW-0227150520179 UniProtGO_REF:0000043
MRE11HumanDNA damage response acts_upstream_of_or_withinIDA 150520179 PMID:17500065MGIPMID:17500065
MRE11HumanDNA double-strand break processing involved_inTAS 150520179 ReactomeReactome:R-HSA-5693608
MRE11HumanDNA double-strand break processing involved_inIMP 150520179 PMID:23080121UniProtPMID:23080121
MRE11HumanDNA double-strand break processing involved_inNAS 150520179 PMID:26512707ComplexPortalPMID:26512707
MRE11HumanDNA recombination involved_inTAS 150520179 PMID:9705271PINCPMID:9705271
MRE11HumanDNA repair involved_inIEAUniProtKB-KW:KW-0234150520179 UniProtGO_REF:0000043
MRE11HumanDNA repair involved_inTAS 150520179 PMID:9705271 and PMID:9931460PINCPMID:9705271 and PMID:9931460
MRE11HumanDNA strand resection involved in replication fork processing involved_inIDA 150520179 PMID:27814491 more ...UniProtPMID:27814491 more ...
MRE11HumanDNA strand resection involved in replication fork processing involved_inIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11HumanDNA strand resection involved in replication fork processing involved_inNAS 150520179 PMID:29709199ComplexPortalPMID:29709199
MRE11Humandouble-strand break repair involved_inTAS 150520179 PMID:10612394PINCPMID:10612394
MRE11Humandouble-strand break repair involved_inIDA 150520179 PMID:14657032 and PMID:26240375UniProtPMID:14657032 and PMID:26240375
MRE11Humandouble-strand break repair acts_upstream_of_or_withinIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11Humandouble-strand break repair involved_inIEAUniRule:UR000925762150520179 UniProtGO_REF:0000104
MRE11Humandouble-strand break repair involved_inIEAInterPro:IPR003701 and InterPro:IPR007281150520179 InterProGO_REF:0000002
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Cellular Component
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Original Reference(s)
MRE11HumanBRCA1-C complex part_ofIPI 150520179 PMID:16391231ComplexPortalPMID:16391231
MRE11Humanchromatin  ISOMre11 (Rattus norvegicus)9068941early meiotic prophaseRGDPMID:10855503 and REF_RGD_ID:2300257
MRE11Humanchromosomal region located_inNAS 150520179 PMID:26512707ComplexPortalPMID:26512707
MRE11Humanchromosome located_inIEAUniProtKB-SubCell:SL-0468150520179 UniProtGO_REF:0000044
MRE11Humanchromosome located_inIEAUniProtKB-KW:KW-0158150520179 UniProtGO_REF:0000043
MRE11Humanchromosome, telomeric region located_inISSUniProtKB:Q61216150520179 BHF-UCLGO_REF:0000024
MRE11Humanchromosome, telomeric region located_inIEAUniProtKB-SubCell:SL-0276150520179 UniProtGO_REF:0000044
MRE11Humanchromosome, telomeric region located_inHDA 150520179 PMID:19135898BHF-UCLPMID:19135898
MRE11Humanchromosome, telomeric region located_inIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11Humanchromosome, telomeric region located_inIEAUniProtKB-KW:KW-0779150520179 UniProtGO_REF:0000043
MRE11Humanchromosome, telomeric region located_inIDA 150520179 PMID:10811102 more ...BHF-UCLPMID:10811102 more ...
MRE11Humancondensed nuclear chromosome  ISOMre11 (Rattus norvegicus)9068941sex vesicles/chromatin of XY bivalentRGDPMID:10855503 and REF_RGD_ID:2300257
MRE11Humancytoplasm located_inIDA 150520179 PMID:25468996BHF-UCLPMID:25468996
MRE11Humancytosol located_inTAS 150520179 ReactomeReactome:R-HSA-3204303
MRE11HumanMre11 complex part_ofIPI 150520179 PMID:31147924ComplexPortalPMID:31147924
MRE11HumanMre11 complex part_ofIBAFB:FBgn0020270 more ...150520179 GO_CentralGO_REF:0000033
MRE11HumanMre11 complex part_ofIEAUniProtKB:Q61216 and ensembl:ENSMUSP00000034405150520179 EnsemblGO_REF:0000107
MRE11HumanMre11 complex part_ofIDA 150520179 PMID:10888888 more ...UniProtPMID:10888888 more ...
MRE11HumanMre11 complex part_ofIEAUniRule:UR000925762150520179 UniProtGO_REF:0000104
MRE11HumanMre11 complex part_ofTAS 150520179 PMID:27918544BHF-UCLPMID:27918544
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Molecular Function
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MRE11Human3'-5' exonuclease activity enablesTAS 150520179 PMID:9651580PINCPMID:9651580
MRE11Human3'-5' exonuclease activity enablesIDA 150520179 PMID:15741314 more ...CACAOPMID:15741314 more ...
MRE11Human3'-5'-DNA exonuclease activity enablesIDA 150520179 PMID:26240375 more ...UniProtPMID:26240375 more ...
MRE11Human3'-5'-DNA exonuclease activity enablesIEAInterPro:IPR003701150520179 InterProGO_REF:0000002
MRE11Humancadherin binding enablesHDA 150520179 PMID:25468996BHF-UCLPMID:25468996
MRE11HumanDNA binding contributes_toIDA 150520179 PMID:15790808BHF-UCLPMID:15790808
MRE11HumanDNA endonuclease activity enablesIDA 150520179 PMID:22078559 more ...UniProtPMID:22078559 more ...
MRE11HumanDNA endonuclease activity enablesIMP 150520179 PMID:23080121UniProtPMID:23080121
MRE11HumanDNA endonuclease activity enablesTAS 150520179 PMID:9651580ReactomePMID:9651580 and Reactome:R-HSA-5693608
MRE11HumanDNA endonuclease activity enablesIEAInterPro:IPR003701150520179 InterProGO_REF:0000002
MRE11HumanDNA helicase activity contributes_toIMP 150520179 PMID:15790808BHF-UCLPMID:15790808
MRE11Humandouble-stranded DNA binding enablesTAS 150520179 PMID:10802669PINCPMID:10802669
MRE11Humanendonuclease activity enablesIEAUniProtKB-KW:KW-0255150520179 UniProtGO_REF:0000043
MRE11Humanendonuclease activity enablesIEAInterPro:IPR007281150520179 InterProGO_REF:0000002
MRE11Humanexonuclease activity enablesIEAUniProtKB-KW:KW-0269150520179 UniProtGO_REF:0000043
MRE11Humanhydrolase activity enablesIEAInterPro:IPR004843150520179 InterProGO_REF:0000002
MRE11Humanhydrolase activity enablesIEAUniProtKB-KW:KW-0378150520179 UniProtGO_REF:0000043
MRE11Humanidentical protein binding enablesIPIUniProtKB:P49959150520179 PMID:22078559IntActPMID:22078559
MRE11Humanmanganese ion binding enablesIEAUniRule:UR000925762150520179 UniProtGO_REF:0000104
MRE11Humanmanganese ion binding enablesIEAInterPro:IPR007281150520179 InterProGO_REF:0000002
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RGD Manual Annotations


  

Imported Annotations - KEGG (archival)

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MRE11Humanhomologous recombination pathway of double-strand break repair   IEA 6907045 KEGGhsa:03440
MRE11Humannon-homologous end joining pathway of double-strand break repair   IEA 6907045 KEGGhsa:03450
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Original Reference(s)
MRE11HumanNeoplasm of the rectum susceptibilityIAGP 151361212DNA:SNP:3'utr: (rs2155209) (human)RGD 
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MRE11HumanAbnormal fallopian tube morphology  IAGP 8699517 HPOORPHA:145
MRE11HumanAbnormality of ocular smooth pursuit  IAGP 8699517 HPOORPHA:251347
MRE11HumanAbsent Achilles reflex  IAGP 8699517 HPOORPHA:251347
MRE11HumanAbsent Achilles reflex  IAGP 8699517 HPOMIM:604391
MRE11HumanAtaxia  IAGP 8699517 HPOORPHA:251347
MRE11HumanAtaxia  IAGP 8699517 HPOMIM:604391
MRE11HumanAutosomal recessive inheritance  IAGP 8699517 HPOMIM:604391
MRE11HumanBreast carcinoma  IAGP 8699517 HPOORPHA:145
MRE11HumanCerebellar atrophy  IAGP 8699517 HPOORPHA:251347
MRE11HumanCerebellar atrophy  IAGP 8699517 HPOMIM:604391
MRE11HumanCerebellar vermis hypoplasia  IAGP 8699517 HPOORPHA:251347
MRE11HumanChildhood onset  IAGP 8699517 HPOMIM:604391
MRE11HumanChorea  IAGP 8699517 HPOMIM:604391
MRE11HumanChorea  IAGP 8699517 HPOORPHA:251347
MRE11HumanChoreoathetosis  IAGP 8699517 HPOMIM:604391
MRE11HumanDelayed speech and language development  IAGP 8699517 HPOORPHA:251347
MRE11HumanDelayed speech and language development  IAGP 8699517 HPOMIM:604391
MRE11HumanDilated fourth ventricle  IAGP 8699517 HPOORPHA:251347
MRE11HumanDistal amyotrophy  IAGP 8699517 HPOMIM:604391
MRE11HumanDrooling  IAGP 8699517 HPOORPHA:251347
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Original Reference(s)
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVarPMID:28492532
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
MRE11HumanBladder neoplasm  IAGP (Homo sapiens)8554872ClinVar Annotator: match by term: Bladder cancerClinVar 
1 to 20 of 43 rows

1 to 20 of 21 rows
#
Reference Title
Reference Citation
1. Altered expression of DNA double-strand break detection and repair proteins in breast carcinomas. Angele S, etal., Histopathology. 2003 Oct;43(4):347-53.
2. Aberrations of the MRE11-RAD50-NBS1 DNA damage sensor complex in human breast cancer: MRE11 as a candidate familial cancer-predisposing gene. Bartkova J, etal., Mol Oncol. 2008 Dec;2(4):296-316. Epub 2008 Oct 7.
3. ATM protein kinase: the linchpin of cellular defenses to stress. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
4. Analysis of variants in DNA damage signalling genes in bladder cancer. Choudhury A, etal., BMC Med Genet. 2008 Jul 18;9:69.
5. Identification and functional consequences of a novel MRE11 mutation affecting 10 Saudi Arabian patients with the ataxia telangiectasia-like disorder. Fernet M, etal., Hum Mol Genet. 2005 Jan 15;14(2):307-18. Epub 2004 Dec 1.
6. Human MRE11 is inactivated in mismatch repair-deficient cancers. Giannini G, etal., EMBO Rep. 2002 Mar;3(3):248-54. Epub 2002 Feb 15.
7. Mutations of an intronic repeat induce impaired MRE11 expression in primary human cancer with microsatellite instability. Giannini G, etal., Oncogene. 2004 Apr 8;23(15):2640-7.
8. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
9. Regulation of homologous recombination in eukaryotes. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
10. Deficiency of the Mre11 DNA repair complex in Alzheimer's disease brains. Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
11. Expression analyses of 27 DNA repair genes in astrocytoma by TaqMan low-density array. Jiang Z, etal., Neurosci Lett. 2006 Dec 1;409(2):112-7. Epub 2006 Oct 10.
12. Frameshift mutational target gene analysis identifies similarities and differences in constitutional mismatch repair-deficiency and Lynch syndrome. Maletzki C, etal., Mol Carcinog. 2017 Jul;56(7):1753-1764. doi: 10.1002/mc.22632. Epub 2017 Mar 30.
13. p53 mutations in cancer. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
14. Double-strand break repair and colorectal cancer: gene variants within 3' UTRs and microRNAs binding as modulators of cancer risk and clinical outcome. Naccarati A, etal., Oncotarget. 2016 Apr 26;7(17):23156-69. doi: 10.18632/oncotarget.6804.
15. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
16. MRE11 expression is impaired in gastric cancer with microsatellite instability. Ottini L, etal., Carcinogenesis. 2004 Dec;25(12):2337-43. Epub 2004 Aug 19.
17. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
18. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
19. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
20. RGD HPO Phenotype Annotation Pipeline RGD automated import pipeline for human HPO-to-gene-to-disease annotations
1 to 20 of 21 rows
1 to 10 of 43 rows
PMID:8530104   PMID:8756642   PMID:9590181   PMID:9651580   PMID:9705271   PMID:9931460   PMID:10426999   PMID:10508516   PMID:10608806   PMID:10612394   PMID:10783165   PMID:10811102  
PMID:10888888   PMID:11060040   PMID:11062235   PMID:11196167   PMID:11238951   PMID:11353843   PMID:11371344   PMID:11371508   PMID:11504724   PMID:11877377   PMID:12124628   PMID:12419185  
PMID:12447395   PMID:12477932   PMID:12607003   PMID:12607005   PMID:12660252   PMID:12679336   PMID:12750284   PMID:12861053   PMID:14519663   PMID:14657032   PMID:14684699   PMID:14690447  
PMID:14702039   PMID:15026416   PMID:15047855   PMID:15100233   PMID:15149599   PMID:15180989   PMID:15195510   PMID:15201865   PMID:15234984   PMID:15269180   PMID:15302935   PMID:15383534  
PMID:15456891   PMID:15489334   PMID:15653682   PMID:15723659   PMID:15734743   PMID:15741314   PMID:15758953   PMID:15790808   PMID:15806145   PMID:15864295   PMID:15916964   PMID:15917200  
PMID:15937485   PMID:15970667   PMID:16051665   PMID:16163361   PMID:16196087   PMID:16254336   PMID:16327781   PMID:16344560   PMID:16374507   PMID:16377563   PMID:16391231   PMID:16417627  
PMID:16431910   PMID:16540636   PMID:16788144   PMID:16889989   PMID:16905549   PMID:16948520   PMID:16982765   PMID:17081983   PMID:17169801   PMID:17202845   PMID:17349953   PMID:17349954  
PMID:17417627   PMID:17428914   PMID:17429352   PMID:17477953   PMID:17500065   PMID:17500595   PMID:17526493   PMID:17534377   PMID:17591703   PMID:17612497   PMID:17693401   PMID:17694070  
PMID:17700070   PMID:17715134   PMID:17898048   PMID:17932350   PMID:18025084   PMID:18029348   PMID:18040525   PMID:18171670   PMID:18177684   PMID:18212065   PMID:18234271   PMID:18256278  
PMID:18285453   PMID:18373977   PMID:18458108   PMID:18469862   PMID:18553220   PMID:18583988   PMID:18596698   PMID:18632984   PMID:18652530   PMID:18710941   PMID:18716619   PMID:18763866  
1 to 10 of 43 rows



MRE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381194,415,570 - 94,512,412 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1194,415,570 - 94,493,885 (-)EnsemblGRCh38hg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBINCBI36Build 36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBICelera
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
T2T-CHM13v2.01194,422,612 - 94,519,751 (-)NCBIT2T-CHM13v2.0
Mre11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,971 - 14,748,421 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)EnsemblGRCm39 Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBIMGSCv36mm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
cM Map94.33NCBI
Mre11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8819,900,211 - 19,961,906 (+)NCBIGRCr8
mRatBN7.2811,618,876 - 11,680,451 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl811,632,354 - 11,678,279 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx815,618,017 - 15,661,868 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0813,915,762 - 13,959,614 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0811,891,307 - 11,935,517 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Celera813,102,879 - 13,146,939 (+)NCBICelera
Cytogenetic Map8q12NCBI
MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2995,258,930 - 95,341,115 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11196,350,676 - 96,432,591 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01189,418,537 - 89,500,705 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11192,908,403 - 92,985,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,918,549 - 92,985,966 (-)Ensemblpanpan1.1panPan2
MRE11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl216,630,485 - 6,708,909 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBIUU_Cfam_GSD_1.0
Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,363,444 - 79,439,016 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936674466,456 - 530,317 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936674466,495 - 528,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,572,361 - 26,634,567 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,572,352 - 26,634,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,330,565 - 30,388,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRE11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,615,448 - 85,694,247 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl185,610,819 - 85,694,269 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604340,060,929 - 40,162,758 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mre11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473539,092,781 - 39,153,920 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in MRE11
2166 total Variants

1 to 10 of 2285 rows
Name
Type
Condition(s)
Position(s)
Clinical significance
NM_005591.4(MRE11):c.820C>T (p.Leu274Phe) single nucleotide variant Hereditary cancer-predisposing syndrome [RCV000561002] Chr11:94471599 [GRCh38]
Chr11:94204765 [GRCh37]
Chr11:11q21		 uncertain significance
NM_005591.4(MRE11):c.1379A>G (p.Glu460Gly) single nucleotide variant Ataxia-telangiectasia-like disorder [RCV003757185]|Hereditary cancer-predisposing syndrome [RCV000563508] Chr11:94459529 [GRCh38]
Chr11:94192695 [GRCh37]
Chr11:11q21		 uncertain significance
NM_005591.4(MRE11):c.139G>T (p.Ala47Ser) single nucleotide variant Hereditary cancer-predisposing syndrome [RCV000561468] Chr11:94490847 [GRCh38]
Chr11:94224013 [GRCh37]
Chr11:11q21		 uncertain significance
NM_005591.4(MRE11):c.2080G>C (p.Asp694His) single nucleotide variant Hereditary cancer-predisposing syndrome [RCV000563649] Chr11:94420172 [GRCh38]
Chr11:94153338 [GRCh37]
Chr11:11q21		 uncertain significance
NM_005591.4(MRE11):c.291G>A (p.Gln97=) single nucleotide variant Ataxia-telangiectasia-like disorder [RCV000525869]|Hereditary cancer-predisposing syndrome [RCV000569581] Chr11:94485947 [GRCh38]
Chr11:94219113 [GRCh37]
Chr11:11q21		 likely benign
NM_005591.4(MRE11):c.942A>G (p.Leu314=) single nucleotide variant Ataxia-telangiectasia-like disorder [RCV002232139]|Hereditary cancer-predisposing syndrome [RCV000561774] Chr11:94470546 [GRCh38]
Chr11:94203712 [GRCh37]
Chr11:11q21		 likely benign
NM_005591.4(MRE11):c.573A>C (p.Arg191=) single nucleotide variant Ataxia-telangiectasia-like disorder [RCV003591753]|Hereditary cancer-predisposing syndrome [RCV000563994]|not specified [RCV003987609] Chr11:94476375 [GRCh38]
Chr11:94209541 [GRCh37]
Chr11:11q21		 likely benign
NM_005591.4(MRE11):c.923T>C (p.Phe308Ser) single nucleotide variant Hereditary cancer-predisposing syndrome [RCV000566860] Chr11:94470565 [GRCh38]
Chr11:94203731 [GRCh37]
Chr11:11q21		 uncertain significance
NC_000011.9:g.(?_94209449)_(94212048_?)dup duplication Ataxia-telangiectasia-like disorder 1 [RCV000528294]|Ataxia-telangiectasia-like disorder [RCV001379841] Chr11:94476283..94478882 [GRCh38]
Chr11:94209449..94212048 [GRCh37]
Chr11:11q21		 likely pathogenic
NM_005591.4(MRE11):c.1479C>T (p.Leu493=) single nucleotide variant Ataxia-telangiectasia-like disorder [RCV002527985]|Hereditary cancer-predisposing syndrome [RCV000566306] Chr11:94459429 [GRCh38]
Chr11:94192595 [GRCh37]
Chr11:11q21		 likely benign
1 to 10 of 2285 rows

Confirmed Target Of
miRNA GeneMature miRNAMethod NameResult TypeData TypeSupport TypePMID
MIR210hsa-miR-210-3pMirtarbaseexternal_infoWestern blotNon-Functional MTI19141645

Predicted Target Of
Summary Value
Count of predictions:981
Count of miRNA genes:576
Interacting mature miRNAs:622
Transcripts:ENST00000323929, ENST00000323977, ENST00000393241, ENST00000407439, ENST00000535120, ENST00000536144, ENST00000536754, ENST00000538923, ENST00000540013, ENST00000541157
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
597348962GWAS1445036_Hpreeclampsia QTL GWAS1445036 (human)0.000003preeclampsia119445496394454964Human
407049742GWAS698718_Htriacylglycerol 52:2 measurement QTL GWAS698718 (human)0.000006blood triglyceride amount (VT:0002644)119443780994437810Human
407047773GWAS696749_Htriacylglycerol 50:3 measurement QTL GWAS696749 (human)0.000007blood triglyceride amount (VT:0002644)119450760194507602Human
597294102GWAS1390176_Hcardiac troponin T measurement QTL GWAS1390176 (human)0.000006cardiac troponin T measurementblood troponin T level (CMO:0001284)119448449094484491Human

D11S3482  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,215,798 - 94,216,095UniSTSGRCh37
Build 361193,855,446 - 93,855,743RGDNCBI36
Celera1191,503,605 - 91,503,902RGD
Cytogenetic Map11q21UniSTS
HuRef1190,281,289 - 90,281,586UniSTS
WI-17886  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,151,594 - 94,151,695UniSTSGRCh37
Build 361193,791,242 - 93,791,343RGDNCBI36
Celera1191,439,427 - 91,439,528RGD
Cytogenetic Map11q21UniSTS
HuRef1190,217,161 - 90,217,262UniSTS
GeneMap99-GB4 RH Map11317.45UniSTS
Whitehead-RH Map11414.4UniSTS
NCBI RH Map11794.1UniSTS
G67220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,226,847 - 94,227,066UniSTSGRCh37
Build 361193,866,495 - 93,866,714RGDNCBI36
Celera1191,514,657 - 91,514,876RGD
Cytogenetic Map11q21UniSTS
HuRef1190,292,342 - 90,292,561UniSTS
G67219  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,200,881 - 94,201,133UniSTSGRCh37
Build 361193,840,529 - 93,840,781RGDNCBI36
Celera1191,488,687 - 91,488,939RGD
Cytogenetic Map11q21UniSTS
HuRef1190,266,370 - 90,266,622UniSTS
G67297  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,197,212 - 94,197,451UniSTSGRCh37
Build 361193,836,860 - 93,837,099RGDNCBI36
Celera1191,485,018 - 91,485,257RGD
Cytogenetic Map11q21UniSTS
HuRef1190,262,701 - 90,262,940UniSTS
G67300  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,192,386 - 94,192,785UniSTSGRCh37
Build 361193,832,034 - 93,832,433RGDNCBI36
Celera1191,480,192 - 91,480,591RGD
Cytogenetic Map11q21UniSTS
HuRef1190,257,875 - 90,258,274UniSTS
G67301  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,168,903 - 94,169,115UniSTSGRCh37
Build 361193,808,551 - 93,808,763RGDNCBI36
Celera1191,456,710 - 91,456,922RGD
Cytogenetic Map11q21UniSTS
HuRef1190,234,444 - 90,234,656UniSTS
G67298  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,225,897 - 94,226,153UniSTSGRCh37
Build 361193,865,545 - 93,865,801RGDNCBI36
Celera1191,513,707 - 91,513,963RGD
Cytogenetic Map11q21UniSTS
HuRef1190,291,392 - 90,291,648UniSTS
G67296  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,152,977 - 94,153,436UniSTSGRCh37
Build 361193,792,625 - 93,793,084RGDNCBI36
Celera1191,440,810 - 91,441,269RGD
Cytogenetic Map11q21UniSTS
HuRef1190,218,544 - 90,219,003UniSTS
G67299  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,223,954 - 94,224,202UniSTSGRCh37
Build 361193,863,602 - 93,863,850RGDNCBI36
Celera1191,511,763 - 91,512,011RGD
Cytogenetic Map11q21UniSTS
HuRef1190,289,447 - 90,289,695UniSTS
PMC138375P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,212,882 - 94,213,003UniSTSGRCh37
Build 361193,852,530 - 93,852,651RGDNCBI36
Celera1191,500,689 - 91,500,810RGD
Cytogenetic Map11q21UniSTS
HuRef1190,278,372 - 90,278,494UniSTS
MRE11  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,153,098 - 94,153,204UniSTSGRCh37
Build 361193,792,746 - 93,792,852RGDNCBI36
Celera1191,440,931 - 91,441,037RGD
Cytogenetic Map11q21UniSTS
HuRef1190,218,665 - 90,218,771UniSTS
GeneMap99-GB4 RH Map11317.48UniSTS
NCBI RH Map11793.3UniSTS
D11S1058  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371194,164,768 - 94,165,027UniSTSGRCh37
Build 361193,804,416 - 93,804,675RGDNCBI36
Celera1191,452,575 - 91,452,834RGD
Cytogenetic Map11q21UniSTS
HuRef1190,230,309 - 90,230,568UniSTS




adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
pharyngeal arch
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2439 2788 2253 4974 1726 2351 6 624 1951 465 2270 7306 6472 53 3734 1 852 1744 1617 175 1


1 to 30 of 42 rows
RefSeq Transcripts NG_007261 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001330347 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_005591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005274008 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006718842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011542837 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017017772 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426967 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426968 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368841 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368843 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368844 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054368845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007062482 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007062483 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_007062484 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_947828 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AF022778 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF073362 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH010534 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK095388 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK308318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000765 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AP000943 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY584241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC005241 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 30 of 42 rows

Ensembl Acc Id: ENST00000323929   ⟹   ENSP00000325863
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,415,570 - 94,493,844 (-)Ensembl
Ensembl Acc Id: ENST00000323977   ⟹   ENSP00000326094
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,419,876 - 94,493,874 (-)Ensembl
Ensembl Acc Id: ENST00000393241   ⟹   ENSP00000376933
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,419,878 - 94,493,848 (-)Ensembl
Ensembl Acc Id: ENST00000407439   ⟹   ENSP00000385614
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,419,866 - 94,493,843 (-)Ensembl
Ensembl Acc Id: ENST00000535120
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,445,739 - 94,447,300 (-)Ensembl
Ensembl Acc Id: ENST00000536144
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,483,770 - 94,493,813 (-)Ensembl
Ensembl Acc Id: ENST00000536754   ⟹   ENSP00000439511
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,479,695 - 94,493,885 (-)Ensembl
Ensembl Acc Id: ENST00000538923   ⟹   ENSP00000442809
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,479,743 - 94,493,812 (-)Ensembl
Ensembl Acc Id: ENST00000540013   ⟹   ENSP00000440986
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,475,216 - 94,493,834 (-)Ensembl
Ensembl Acc Id: ENST00000541157
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1194,478,761 - 94,493,849 (-)Ensembl
RefSeq Acc Id: NM_001330347   ⟹   NP_001317276
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005590   ⟹   NP_005581
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
GRCh371194,150,466 - 94,227,040 (-)ENTREZGENE
GRCh371194,150,466 - 94,227,040 (-)NCBI
Build 361193,790,114 - 93,866,688 (-)NCBI Archive
HuRef1190,216,033 - 90,292,535 (-)ENTREZGENE
CHM1_11194,033,481 - 94,110,055 (-)NCBI
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
Sequence:
RefSeq Acc Id: NM_005591   ⟹   NP_005582
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
GRCh371194,150,466 - 94,227,040 (-)ENTREZGENE
GRCh371194,150,466 - 94,227,040 (-)NCBI
Build 361193,790,114 - 93,866,688 (-)NCBI Archive
HuRef1190,216,033 - 90,292,535 (-)ENTREZGENE
CHM1_11194,033,481 - 94,110,055 (-)NCBI
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005274008   ⟹   XP_005274065
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,486,015 (-)NCBI
GRCh371194,150,466 - 94,227,040 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006718842   ⟹   XP_006718905
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_011542837   ⟹   XP_011541139
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,512,412 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017017772   ⟹   XP_016873261
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
Sequence:
RefSeq Acc Id: XM_047426967   ⟹   XP_047282923
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
RefSeq Acc Id: XM_047426968   ⟹   XP_047282924
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,478,796 (-)NCBI
RefSeq Acc Id: XM_054368840   ⟹   XP_054224815
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
RefSeq Acc Id: XM_054368841   ⟹   XP_054224816
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,519,751 (-)NCBI
RefSeq Acc Id: XM_054368842   ⟹   XP_054224817
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
RefSeq Acc Id: XM_054368843   ⟹   XP_054224818
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,500,884 (-)NCBI
RefSeq Acc Id: XM_054368844   ⟹   XP_054224819
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,493,052 (-)NCBI
RefSeq Acc Id: XM_054368845   ⟹   XP_054224820
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01194,422,612 - 94,485,833 (-)NCBI
RefSeq Acc Id: XR_007062482
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
RefSeq Acc Id: XR_007062483
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
RefSeq Acc Id: XR_007062484
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
RefSeq Acc Id: XR_947828
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,415,570 - 94,493,844 (-)NCBI
Sequence:
1 to 30 of 40 rows
Protein RefSeqs NP_001317276 (Get FASTA)   NCBI Sequence Viewer  
  NP_005581 (Get FASTA)   NCBI Sequence Viewer  
  NP_005582 (Get FASTA)   NCBI Sequence Viewer  
  XP_005274065 (Get FASTA)   NCBI Sequence Viewer  
  XP_006718905 (Get FASTA)   NCBI Sequence Viewer  
  XP_011541139 (Get FASTA)   NCBI Sequence Viewer  
  XP_016873261 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282923 (Get FASTA)   NCBI Sequence Viewer  
  XP_047282924 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224815 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224816 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224817 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224818 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224819 (Get FASTA)   NCBI Sequence Viewer  
  XP_054224820 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC36249 (Get FASTA)   NCBI Sequence Viewer  
  AAC78721 (Get FASTA)   NCBI Sequence Viewer  
  AAD10197 (Get FASTA)   NCBI Sequence Viewer  
  AAH05241 (Get FASTA)   NCBI Sequence Viewer  
  AAH17823 (Get FASTA)   NCBI Sequence Viewer  
  AAH63458 (Get FASTA)   NCBI Sequence Viewer  
  AAK18790 (Get FASTA)   NCBI Sequence Viewer  
  AAP35376 (Get FASTA)   NCBI Sequence Viewer  
  AAS79320 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33657 (Get FASTA)   NCBI Sequence Viewer  
  ALQ33658 (Get FASTA)   NCBI Sequence Viewer  
  BAG53039 (Get FASTA)   NCBI Sequence Viewer  
  CCQ43331 (Get FASTA)   NCBI Sequence Viewer  
  EAW66930 (Get FASTA)   NCBI Sequence Viewer  
  EAW66931 (Get FASTA)   NCBI Sequence Viewer  
1 to 30 of 40 rows
1 to 5 of 22 rows
1 to 5 of 22 rows
RefSeq Acc Id: NP_005582   ⟸   NM_005591
- Peptide Label: isoform 1
- UniProtKB: B3KTC7 (UniProtKB/Swiss-Prot),   O43475 (UniProtKB/Swiss-Prot),   P49959 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_005581   ⟸   NM_005590
- Peptide Label: isoform 2
- UniProtKB: P49959 (UniProtKB/Swiss-Prot),   Q05D78 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005274065   ⟸   XM_005274008
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006718905   ⟸   XM_006718842
- Peptide Label: isoform X2
- UniProtKB: F8W7U8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011541139   ⟸   XM_011542837
- Peptide Label: isoform X1
- UniProtKB: B3KTC7 (UniProtKB/Swiss-Prot),   O43475 (UniProtKB/Swiss-Prot),   P49959 (UniProtKB/Swiss-Prot)
- Sequence:
Calcineurin-like phosphoesterase   Mre11 DNA-binding

Name Modeler Protein Id AA Range Protein Structure
AF-P49959-F1-model_v2 AlphaFold P49959 1-708 view protein structure

RGD ID:6789139
Promoter ID:HG_KWN:13976
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:NM_005590,   NM_005591,   NM_017704,   UC001PEX.2,   UC009YWJ.1
Position:
Human AssemblyChrPosition (strand)Source
Build 361193,866,584 - 93,867,084 (-)MPROMDB
RGD ID:7221841
Promoter ID:EPDNEW_H16666
Type:initiation region
Name:MRE11A_1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381194,493,834 - 94,493,894EPDNEW


1 to 40 of 41 rows
Database
Acc Id
Source(s)
COSMIC MRE11 COSMIC
Ensembl Genes ENSG00000020922 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000323929 ENTREZGENE
  ENST00000323929.8 UniProtKB/Swiss-Prot
  ENST00000323977 ENTREZGENE
  ENST00000323977.7 UniProtKB/Swiss-Prot
  ENST00000393241 ENTREZGENE
  ENST00000407439.7 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.110.110 UniProtKB/Swiss-Prot
  3.60.21.10 UniProtKB/Swiss-Prot
GTEx ENSG00000020922 GTEx
HGNC ID HGNC:7230 ENTREZGENE
Human Proteome Map MRE11 Human Proteome Map
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot
  Metallo-depent_PP-like UniProtKB/Swiss-Prot
  Mre11 UniProtKB/Swiss-Prot
  Mre11_DNA-bd UniProtKB/Swiss-Prot
  Mre11_DNA-bd_sf UniProtKB/Swiss-Prot
  Mre11_N UniProtKB/Swiss-Prot
KEGG Report hsa:4361 UniProtKB/Swiss-Prot
NCBI Gene 4361 ENTREZGENE
OMIM 600814 OMIM
PANTHER DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/Swiss-Prot
  DOUBLE-STRAND BREAK REPAIR PROTEIN MRE11 UniProtKB/Swiss-Prot
Pfam Metallophos UniProtKB/Swiss-Prot
  Mre11_DNA_bind UniProtKB/Swiss-Prot
PharmGKB PA30934 PharmGKB
PIRSF DSB_repair_MRE11 UniProtKB/Swiss-Prot
SMART Mre11_DNA_bind UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56300 UniProtKB/Swiss-Prot
UniProt B3KTC7 ENTREZGENE
  F5GXT0_HUMAN UniProtKB/TrEMBL
  F5H256_HUMAN UniProtKB/TrEMBL
  F5H742_HUMAN UniProtKB/TrEMBL
  F8W7U8 ENTREZGENE, UniProtKB/TrEMBL
  MRE11_HUMAN UniProtKB/Swiss-Prot
  O43475 ENTREZGENE
  P49959 ENTREZGENE
  Q05D78 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary B3KTC7 UniProtKB/Swiss-Prot
1 to 40 of 41 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-10-04 MRE11  MRE11 homolog, double strand break repair nuclease  MRE11A  MRE11 homolog A, double strand break repair nuclease  Symbol and/or name change 5135510 APPROVED
2015-07-28 MRE11A  MRE11 homolog A, double strand break repair nuclease  MRE11A  MRE11 homolog, double strand break repair nuclease A  Symbol and/or name change 5135510 APPROVED
2015-07-07 MRE11A  MRE11 homolog, double strand break repair nuclease A  MRE11A  MRE11 meiotic recombination 11 homolog A (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED