Mre11a (MRE11A homolog A, double strand break repair nuclease) - Rat Genome Database

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Gene: Mre11a (MRE11A homolog A, double strand break repair nuclease) Mus musculus
Analyze
Symbol: Mre11a
Name: MRE11A homolog A, double strand break repair nuclease
RGD ID: 735478
MGI Page MGI
Description: Is predicted to contribute to DNA binding activity and DNA helicase activity. Involved in several processes, including double-strand break repair; homologous chromosome pairing at meiosis; and mitotic DNA damage checkpoint. Localizes to PML body. Colocalizes with chromosome, telomeric region. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: double-strand break repair protein MRE11; double-strand break repair protein MRE11A; meiotic recombination 11 homolog 1; meiotic recombination 11 homolog A; mmMRE11A; Mre11; MRE11 homolog 1; MRE11 homolog A; Mre11b
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,939 - 14,753,639 (+)NCBIGRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBImm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-pilocarpine  (ISO)
(-)-epigallocatechin 3-gallate  (ISO)
1,1-dichloroethene  (EXP)
1,2-dimethylhydrazine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,4-dinitrotoluene  (ISO)
2,6-dinitrotoluene  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroperoxycyclophosphamide  (ISO)
5-aza-2'-deoxycytidine  (ISO)
aflatoxin B1  (EXP,ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
aristolochic acid  (ISO)
benzo[a]pyrene  (EXP,ISO)
bisphenol A  (ISO)
camptothecin  (ISO)
capecitabine  (ISO)
carbon nanotube  (EXP)
chlordecone  (EXP)
chlorpyrifos  (EXP)
choline  (EXP)
chromium(6+)  (ISO)
cisplatin  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
coumestrol  (ISO)
cyclosporin A  (ISO)
cylindrospermopsin  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
doxifluridine  (ISO)
doxorubicin  (ISO)
Enterolactone  (ISO)
fenvalerate  (ISO)
ferroheme b  (EXP)
folic acid  (EXP)
heme b  (EXP)
hydrogen peroxide  (ISO)
imiquimod  (EXP)
isocyanates  (EXP)
L-methionine  (EXP)
lipopolysaccharide  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
myristicin  (ISO)
N,N-dimethylformamide  (ISO)
N-nitrosodiethylamine  (EXP)
Nonidet P-40  (ISO)
oxaliplatin  (ISO)
paracetamol  (EXP,ISO)
pentamidine  (ISO)
pirinixic acid  (EXP)
potassium chromate  (ISO)
quercetin  (EXP,ISO)
resveratrol  (EXP,ISO)
rotenone  (ISO)
sunitinib  (ISO)
thioacetamide  (ISO)
topotecan  (ISO)
trimellitic anhydride  (EXP)
valproic acid  (EXP,ISO)
veliparib  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
1. Angele S, etal., Histopathology. 2003 Oct;43(4):347-53.
2. Bartkova J, etal., Mol Oncol. 2008 Dec;2(4):296-316. Epub 2008 Oct 7.
3. Bhatti S, etal., Cell Mol Life Sci. 2011 Sep;68(18):2977-3006. doi: 10.1007/s00018-011-0683-9. Epub 2011 May 2.
4. Choudhury A, etal., BMC Med Genet. 2008 Jul 18;9:69.
5. Fernet M, etal., Hum Mol Genet. 2005 Jan 15;14(2):307-18. Epub 2004 Dec 1.
6. Giannini G, etal., EMBO Rep. 2002 Mar;3(3):248-54. Epub 2002 Feb 15.
7. Giannini G, etal., Oncogene. 2004 Apr 8;23(15):2640-7.
8. Heyer WD, etal., Annu Rev Genet. 2010;44:113-39. doi: 10.1146/annurev-genet-051710-150955.
9. Jacobsen E, etal., Brain Res Mol Brain Res. 2004 Sep 10;128(1):1-7.
10. Jiang Z, etal., Neurosci Lett. 2006 Dec 1;409(2):112-7. Epub 2006 Oct 10.
11. MGD and Homologene mouse data transfer
12. MGD data from the GO Consortium
13. MGD IEA
14. Muller PA and Vousden KH, Nat Cell Biol. 2013 Jan;15(1):2-8. doi: 10.1038/ncb2641.
15. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
16. OMIM Disease Annotation Pipeline
17. Ottini L, etal., Carcinogenesis. 2004 Dec;25(12):2337-43. Epub 2004 Aug 19.
18. Pipeline to import KEGG annotations from KEGG into RGD
19. RGD automated import pipeline
20. RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. RGD automated import pipeline for gene-chemical interactions
22. Xu Y Nat Rev Immunol. 2006 Apr;6(4):261-70.
Additional References at PubMed
PMID:8889548   PMID:9224597   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11544199   PMID:12208847   PMID:12477932   PMID:12684226   PMID:12687013  
PMID:14610273   PMID:14690604   PMID:14691545   PMID:15364958   PMID:15489334   PMID:15734743   PMID:15782199   PMID:16141072   PMID:16141073   PMID:16357220   PMID:17291760   PMID:17429352  
PMID:17500065   PMID:17967808   PMID:18381424   PMID:18411308   PMID:18614044   PMID:18799693   PMID:18854157   PMID:19015239   PMID:19075003   PMID:19124014   PMID:19171781   PMID:19221393  
PMID:19633651   PMID:19633669   PMID:19633670   PMID:19667071   PMID:19667076   PMID:19876815   PMID:19910469   PMID:20086180   PMID:21267068   PMID:21677273   PMID:21826105   PMID:21852425  
PMID:21873635   PMID:21884979   PMID:22560297   PMID:23388631   PMID:23444137   PMID:23912341   PMID:24120666   PMID:24457600   PMID:24793032   PMID:25768017   PMID:26232174   PMID:26280532  
PMID:26365490   PMID:26745237   PMID:27708105   PMID:27746211   PMID:27814490   PMID:28076792   PMID:28115467   PMID:28362262   PMID:28819025   PMID:29973640   PMID:31123184   PMID:31285322  
PMID:32098917   PMID:32325033  


Genomics

Comparative Map Data
Mre11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,939 - 14,753,639 (+)NCBIGRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBImm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
MRE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1194,415,570 - 94,493,885 (-)EnsemblGRCh38hg38GRCh38
GRCh381194,415,570 - 94,512,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBINCBI36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBI
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
Mre11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2811,618,876 - 11,680,451 (+)NCBI
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Celera813,102,879 - 13,146,939 (+)NCBICelera
Cytogenetic Map8q12NCBI
MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11192,908,403 - 92,985,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,918,549 - 92,985,966 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01189,418,537 - 89,500,705 (-)NCBIMhudiblu_PPA_v0panPan3
MRE11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBI
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBI
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBI
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBI
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBI
Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,363,444 - 79,439,016 (-)NCBI
SpeTri2.0NW_004936674466,495 - 528,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,572,360 - 26,634,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,572,352 - 26,634,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,330,565 - 30,388,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRE11
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,615,448 - 85,694,247 (-)NCBI
ChlSab1.1 Ensembl185,610,819 - 85,694,269 (-)Ensembl
Vero_WHO_p1.0NW_02366604340,060,929 - 40,162,758 (+)NCBI
Mre11
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBI

Position Markers
UniSTS:236059  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38914,833,631 - 14,833,790UniSTSGRCm38
MGSCv37914,638,075 - 14,638,234UniSTSGRCm37
Celera912,114,394 - 12,114,553UniSTS
Cytogenetic Map9A2UniSTS
U60318  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38914,833,793 - 14,833,884UniSTSGRCm38
MGSCv37914,638,237 - 14,638,328UniSTSGRCm37
Celera912,114,556 - 12,114,647UniSTS
Cytogenetic Map9A2UniSTS
Whitehead/MRC_RH9196.93UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4142326Tgq19_mtriglyceride QTL 19 (mouse)Not determined121060750Mouse
1300899Chol6_mcholesterol 6 (mouse)Not determined9129902908Mouse
13434920Dcollq1_mdifferential colonization level QTL 1 (mouse)9130430544Mouse
35673312Ari7_mantibody response to influenza 7, day 45, IgG3 (mouse)9780000022300000Mouse
1300849Sles4_msystemic lupus erythmatosus suppressor 4 (mouse)Not determined9910756137395074Mouse
13504833Bglu19_mblood glucose level 19 (mouse)9999947243999472Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91245867446458818Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91347987947479879Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1495
Count of miRNA genes:666
Interacting mature miRNAs:827
Transcripts:ENSMUST00000034405, ENSMUST00000115632, ENSMUST00000136568, ENSMUST00000147305, ENSMUST00000147676
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001310728 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_018736 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510048 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510049 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510051 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510053 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006510054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_030244083 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036154644 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004935334 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_379107 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC136743 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI842697 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK041248 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK141214 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146234 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK146370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161013 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168180 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK168208 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190567 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC065144 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF747058 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466522 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN534976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN718973 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CT030247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U58987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U60318 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000034405   ⟹   ENSMUSP00000034405
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,784,654 - 14,834,646 (+)Ensembl
RefSeq Acc Id: ENSMUST00000115632   ⟹   ENSMUSP00000111295
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,784,676 - 14,837,123 (+)Ensembl
RefSeq Acc Id: ENSMUST00000136568
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,797,166 - 14,803,853 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147305   ⟹   ENSMUSP00000116321
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,784,702 - 14,799,620 (+)Ensembl
RefSeq Acc Id: ENSMUST00000147676   ⟹   ENSMUSP00000119999
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,797,153 - 14,811,939 (+)Ensembl
RefSeq Acc Id: ENSMUST00000215820   ⟹   ENSMUSP00000149184
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl914,785,008 - 14,790,590 (+)Ensembl
RefSeq Acc Id: NM_001310728   ⟹   NP_001297657
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,950 - 14,748,421 (+)NCBI
GRCm38914,784,654 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: NM_018736   ⟹   NP_061206
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,950 - 14,748,421 (+)NCBI
GRCm38914,784,654 - 14,837,125 (+)NCBI
MGSCv37914,589,151 - 14,638,861 (+)RGD
Celera912,065,444 - 12,115,180 (+)RGD
cM Map9 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006510048   ⟹   XP_006510111
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,953 - 14,753,639 (+)NCBI
GRCm38914,784,669 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006510049   ⟹   XP_006510112
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,967 - 14,748,421 (+)NCBI
GRCm38914,784,719 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006510051   ⟹   XP_006510114
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,696,015 - 14,748,421 (+)NCBI
GRCm38914,784,719 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006510053   ⟹   XP_006510116
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,696,015 - 14,748,421 (+)NCBI
GRCm38914,790,642 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006510054   ⟹   XP_006510117
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,715,061 - 14,753,639 (+)NCBI
GRCm38914,803,765 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_030244083   ⟹   XP_030099943
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,939 - 14,745,970 (+)NCBI
GRCm38914,784,671 - 14,837,125 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036154643   ⟹   XP_036010536
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,966 - 14,748,421 (+)NCBI
RefSeq Acc Id: XM_036154644   ⟹   XP_036010537
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,966 - 14,748,421 (+)NCBI
RefSeq Acc Id: XR_004935334
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,964 - 14,745,937 (+)NCBI
RefSeq Acc Id: XR_379107
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39914,695,965 - 14,748,421 (+)NCBI
GRCm38914,784,669 - 14,837,125 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_061206   ⟸   NM_018736
- Peptide Label: isoform 1
- UniProtKB: Q61216 (UniProtKB/Swiss-Prot),   Q3TU24 (UniProtKB/TrEMBL),   Q3URU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510111   ⟸   XM_006510048
- Peptide Label: isoform X1
- UniProtKB: Q61216 (UniProtKB/Swiss-Prot),   Q3URU4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006510112   ⟸   XM_006510049
- Peptide Label: isoform X2
- UniProtKB: Q61216 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006510114   ⟸   XM_006510051
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_006510116   ⟸   XM_006510053
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_006510117   ⟸   XM_006510054
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: NP_001297657   ⟸   NM_001310728
- Peptide Label: isoform 2
- UniProtKB: Q61216 (UniProtKB/Swiss-Prot),   Q3TU24 (UniProtKB/TrEMBL),   Q8BRV3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030099943   ⟸   XM_030244083
- Peptide Label: isoform X4
RefSeq Acc Id: ENSMUSP00000116321   ⟸   ENSMUST00000147305
RefSeq Acc Id: ENSMUSP00000119999   ⟸   ENSMUST00000147676
RefSeq Acc Id: ENSMUSP00000034405   ⟸   ENSMUST00000034405
RefSeq Acc Id: ENSMUSP00000111295   ⟸   ENSMUST00000115632
RefSeq Acc Id: ENSMUSP00000149184   ⟸   ENSMUST00000215820
RefSeq Acc Id: XP_036010536   ⟸   XM_036154643
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036010537   ⟸   XM_036154644
- Peptide Label: isoform X5
Protein Domains
Metallophos   Mre11_DNA_bind

Promoters
RGD ID:6844161
Promoter ID:MM_KWN:56402
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000078494,   OTTMUST00000078495,   OTTMUST00000078496,   UC009OEZ.1,   UC009OFB.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36914,588,536 - 14,589,397 (-)MPROMDB
RGD ID:8668878
Promoter ID:EPDNEW_M12443
Type:initiation region
Name:Mre11a_1
Description:Mus musculus MRE11A homolog A, double strand break repair nuclease, transcript variant 2, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38914,784,675 - 14,784,735EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1100512 AgrOrtholog
Ensembl Genes ENSMUSG00000031928 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000034405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000111295 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000116321 UniProtKB/TrEMBL
  ENSMUSP00000119999 UniProtKB/TrEMBL
  ENSMUSP00000149184 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000034405 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000115632 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000147305 UniProtKB/TrEMBL
  ENSMUST00000147676 UniProtKB/TrEMBL
  ENSMUST00000215820 UniProtKB/TrEMBL
Gene3D-CATH 3.30.110.110 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.60.21.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mre11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mre11_DNA-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mre11_DNA-bd_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mre11_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:17535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1100512 ENTREZGENE
NCBI Gene 17535 ENTREZGENE
Pfam Metallophos UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mre11_DNA_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Mre11a PhenoGen
PIRSF DSB_repair_MRE11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART Mre11_DNA_bind UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGRFAMs mre11 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SQT7_MOUSE UniProtKB/TrEMBL
  B2KF76_MOUSE UniProtKB/TrEMBL
  F6RX99_MOUSE UniProtKB/TrEMBL
  MRE11_MOUSE UniProtKB/Swiss-Prot
  Q3TU24 ENTREZGENE, UniProtKB/TrEMBL
  Q3UJN6_MOUSE UniProtKB/TrEMBL
  Q3URU4 ENTREZGENE, UniProtKB/TrEMBL
  Q61216 ENTREZGENE
  Q8BRV3 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q62430 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-29 Mre11a  MRE11A homolog A, double strand break repair nuclease    meiotic recombination 11 homolog A (S. cerevisiae)  Symbol and/or name change 5135510 APPROVED