MRE11 (MRE11 homolog, double strand break repair nuclease) - Rat Genome Database

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Gene: MRE11 (MRE11 homolog, double strand break repair nuclease) Canis lupus familiaris
Analyze
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
RGD ID: 12411998
Description: ENCODES a protein that exhibits 3'-5' exonuclease activity (ortholog); DNA binding (ortholog); DNA helicase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); cellular response to DNA damage stimulus (ortholog); chromosome organization (ortholog); PARTICIPATES IN altered p53 signaling pathway; ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; ASSOCIATED WITH Alzheimer's disease (ortholog); Animal Disease Models (ortholog); ataxia telangiectasia (ortholog); FOUND IN chromatin (ortholog); chromosome, telomeric region (ortholog); condensed nuclear chromosome (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: double-strand break repair protein MRE11; double-strand break repair protein MRE11A; meiotic recombination 11-like protein; MRE11 homolog A, double strand break repair nuclease; MRE11 meiotic recombination 11 homolog A; MRE11A
RGD Orthologs
Human
Mouse
Rat
Bonobo
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBI
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBI
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBI
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBI
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

Genomics

Comparative Map Data
MRE11
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1216,448,909 - 6,528,185 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl216,449,822 - 6,527,119 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBI
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBI
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBI
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBI
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBI
MRE11
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1194,415,570 - 94,493,885 (-)EnsemblGRCh38hg38GRCh38
GRCh381194,415,570 - 94,512,701 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371194,148,736 - 94,227,010 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361193,790,114 - 93,866,688 (-)NCBINCBI36hg18NCBI36
Build 341193,790,120 - 93,866,688NCBI
Celera1191,438,299 - 91,514,850 (-)NCBI
Cytogenetic Map11q21NCBI
HuRef1190,216,033 - 90,292,535 (-)NCBIHuRef
CHM1_11194,033,481 - 94,110,055 (-)NCBICHM1_1
Mre11a
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39914,695,939 - 14,753,639 (+)NCBIGRCm39mm39
GRCm39 Ensembl914,695,950 - 14,748,419 (+)Ensembl
GRCm38914,784,654 - 14,837,125 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl914,784,654 - 14,837,123 (+)EnsemblGRCm38mm10GRCm38
MGSCv37914,589,151 - 14,638,861 (+)NCBIGRCm37mm9NCBIm37
MGSCv36914,535,100 - 14,584,812 (+)NCBImm8
Celera912,065,444 - 12,115,180 (+)NCBICelera
Cytogenetic Map9A2NCBI
Mre11
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2811,618,876 - 11,680,451 (+)NCBI
Rnor_6.0 Ensembl813,305,152 - 13,352,489 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0813,304,355 - 13,350,329 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0813,244,991 - 13,290,976 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4811,588,409 - 11,632,483 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1811,588,411 - 11,632,483 (+)NCBI
Celera813,102,879 - 13,146,939 (+)NCBICelera
Cytogenetic Map8q12NCBI
MRE11
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11192,908,403 - 92,985,966 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1192,918,549 - 92,985,966 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01189,418,537 - 89,500,705 (-)NCBIMhudiblu_PPA_v0panPan3
Mre11
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494779,363,444 - 79,439,016 (-)NCBI
SpeTri2.0NW_004936674466,495 - 528,072 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MRE11
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl926,572,360 - 26,634,568 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1926,572,352 - 26,634,596 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2930,330,565 - 30,388,455 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MRE11
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1185,615,448 - 85,694,247 (-)NCBI
ChlSab1.1 Ensembl185,610,819 - 85,694,269 (-)Ensembl
Vero_WHO_p1.0NW_02366604340,060,929 - 40,162,758 (+)NCBI
Mre11
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473539,095,559 - 39,153,936 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 3 3
Low 5 5 19 6 6 6 6 6 9 8 7 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_005633351 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005633352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005633354 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005633355 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429749 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429750 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429751 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038429752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038505161 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038505162 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038505163 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038505164 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038568293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_038632437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX04000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY705789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAHUQ010000238 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAQRD010000059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAAUVH010000057 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  REHQ01000021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000006686   ⟹   ENSCAFP00000006191
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl216,449,822 - 6,521,991 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000006688   ⟹   ENSCAFP00000006193
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl216,450,553 - 6,527,119 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000074615   ⟹   ENSCAFP00000059127
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl216,450,553 - 6,527,119 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000078105   ⟹   ENSCAFP00000047923
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl216,450,553 - 6,527,119 (+)Ensembl
RefSeq Acc Id: XM_005633351   ⟹   XP_005633408
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1216,449,753 - 6,528,185 (+)NCBI
Dog10K_Boxer_Tasha216,460,061 - 6,538,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005633352   ⟹   XP_005633409
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1216,449,727 - 6,528,185 (+)NCBI
Dog10K_Boxer_Tasha216,460,061 - 6,538,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005633354   ⟹   XP_005633411
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1216,448,909 - 6,528,185 (+)NCBI
Dog10K_Boxer_Tasha216,459,592 - 6,538,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005633355   ⟹   XP_005633412
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1216,452,495 - 6,528,185 (+)NCBI
Dog10K_Boxer_Tasha216,463,179 - 6,538,889 (+)NCBI
Sequence:
RefSeq Acc Id: XM_038429749   ⟹   XP_038285677
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0216,630,421 - 6,708,953 (+)NCBI
RefSeq Acc Id: XM_038429750   ⟹   XP_038285678
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0216,630,044 - 6,708,953 (+)NCBI
RefSeq Acc Id: XM_038429751   ⟹   XP_038285679
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0216,629,575 - 6,708,953 (+)NCBI
RefSeq Acc Id: XM_038429752   ⟹   XP_038285680
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
ROS_Cfam_1.0216,633,179 - 6,708,953 (+)NCBI
RefSeq Acc Id: XM_038505161   ⟹   XP_038361089
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1216,416,866 - 6,489,663 (+)NCBI
RefSeq Acc Id: XM_038505162   ⟹   XP_038361090
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1216,416,866 - 6,489,663 (+)NCBI
RefSeq Acc Id: XM_038505163   ⟹   XP_038361091
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1216,416,396 - 6,489,663 (+)NCBI
RefSeq Acc Id: XM_038505164   ⟹   XP_038361092
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UMICH_Zoey_3.1216,419,994 - 6,489,663 (+)NCBI
RefSeq Acc Id: XM_038568290   ⟹   XP_038424218
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0216,529,019 - 6,608,693 (+)NCBI
RefSeq Acc Id: XM_038568291   ⟹   XP_038424219
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0216,529,019 - 6,608,693 (+)NCBI
RefSeq Acc Id: XM_038568292   ⟹   XP_038424220
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0216,528,550 - 6,608,693 (+)NCBI
RefSeq Acc Id: XM_038568293   ⟹   XP_038424221
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UU_Cfam_GSD_1.0216,532,137 - 6,608,693 (+)NCBI
RefSeq Acc Id: XM_038632434   ⟹   XP_038488362
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0216,479,939 - 6,558,763 (+)NCBI
RefSeq Acc Id: XM_038632435   ⟹   XP_038488363
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0216,479,939 - 6,558,763 (+)NCBI
RefSeq Acc Id: XM_038632436   ⟹   XP_038488364
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0216,479,470 - 6,558,763 (+)NCBI
RefSeq Acc Id: XM_038632437   ⟹   XP_038488365
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
UNSW_CanFamBas_1.0216,483,071 - 6,558,763 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_005633411   ⟸   XM_005633354
- Peptide Label: isoform X1
- UniProtKB: F1PUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005633408   ⟸   XM_005633351
- Peptide Label: isoform X1
- UniProtKB: F1PUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005633409   ⟸   XM_005633352
- Peptide Label: isoform X1
- UniProtKB: F1PUK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005633412   ⟸   XM_005633355
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000059127   ⟸   ENSCAFT00000074615
RefSeq Acc Id: ENSCAFP00000047923   ⟸   ENSCAFT00000078105
RefSeq Acc Id: ENSCAFP00000006193   ⟸   ENSCAFT00000006688
RefSeq Acc Id: ENSCAFP00000006191   ⟸   ENSCAFT00000006686
RefSeq Acc Id: XP_038361091   ⟸   XM_038505163
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038361089   ⟸   XM_038505161
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038361090   ⟸   XM_038505162
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038361092   ⟸   XM_038505164
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038488364   ⟸   XM_038632436
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488362   ⟸   XM_038632434
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488363   ⟸   XM_038632435
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038488365   ⟸   XM_038632437
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038285679   ⟸   XM_038429751
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038285678   ⟸   XM_038429750
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038285677   ⟸   XM_038429749
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038285680   ⟸   XM_038429752
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038424220   ⟸   XM_038568292
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038424218   ⟸   XM_038568290
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038424219   ⟸   XM_038568291
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038424221   ⟸   XM_038568293
- Peptide Label: isoform X2
Protein Domains
Mre11_DNA_bind


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000004162 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000006191 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000006193 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000047923 UniProtKB/TrEMBL
  ENSCAFP00000059127 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000006686 UniProtKB/TrEMBL
  ENSCAFT00000006688 UniProtKB/TrEMBL
  ENSCAFT00000074615 UniProtKB/TrEMBL
  ENSCAFT00000078105 UniProtKB/TrEMBL
Gene3D-CATH 3.30.110.110 UniProtKB/TrEMBL
  3.60.21.10 UniProtKB/TrEMBL
InterPro Calcineurin-like_PHP_ApaH UniProtKB/TrEMBL
  Metallo-depent_PP-like UniProtKB/TrEMBL
  Mre11 UniProtKB/TrEMBL
  Mre11_DNA-bd UniProtKB/TrEMBL
  Mre11_DNA-bd_sf UniProtKB/TrEMBL
  Mre11_N UniProtKB/TrEMBL
KEGG Report cfa:494006 UniProtKB/TrEMBL
NCBI Gene MRE11 ENTREZGENE
Pfam Metallophos UniProtKB/TrEMBL
  Mre11_DNA_bind UniProtKB/TrEMBL
PIRSF DSB_repair_MRE11 UniProtKB/TrEMBL
SMART Mre11_DNA_bind UniProtKB/TrEMBL
TIGRFAMs mre11 UniProtKB/TrEMBL
UniProt A0A5F4C2Y4_CANLF UniProtKB/TrEMBL
  A0A5F4CXQ9_CANLF UniProtKB/TrEMBL
  E2RTK8_CANLF UniProtKB/TrEMBL
  F1PUK4 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43361 ENTREZGENE