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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:prostaglandin F2alpha
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Accession:CHEBI:15553 term browser browse the term
Definition:A prostaglandins Falpha that is prosta-5,13-dien-1-oic acid substituted by hydroxy groups at positions 9, 11 and 15. It is a naturally occurring prostaglandin used to induce labor.
Synonyms:exact_synonym: (5Z,13E,15S)-9alpha,11alpha,15-trihydroxyprosta-5,13-dien-1-oic acid
 related_synonym: (5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate;   7-[3,5-Dihydroxy-2-(3-hydroxy-1-octenyl)cyclopentyl]-5-heptenoic acid;   9,11,15-Trihydroxy-(5Z,9a,11a,13E,15S)-prosta-5,13-dien-1-oic acid;   9a,11a-PGF2;   Amoglandin;   Cyclosin;   Dinoprost;   Enzaprost;   Enzaprost F;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-19,21-23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,18-,19+/m0/s1;   InChIKey=PXGPLTODNUVGFL-YNNPMVKQSA-N;   PGF2a;   PGF2alpha;   Panacelan;   Prostaglandin F2a;   Prostin F 2 alpha;   Protamodin;   SMILES=CCCCC[C@H](O)\\C=C\\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   U 14583;   dinoprosta;   dinoprostum;   l-PGF2-alpha;   l-Prostaglandin F2-alpha
 alt_id: CHEBI:10913;   CHEBI:26327;   CHEBI:8516
 xref: Beilstein:2225571;   CAS:551-11-1;   Drug_Central:912;   HMDB:HMDB0001139;   KEGG:C00639;   KEGG:D00081;   LIPID_MAPS_instance:LMFA03010002
 xref_mesh: MESH:D015237
 xref: MetaCyc:5Z13E-15S-9-ALPHA11-ALPHA15-TRIHY;   PMID:11438482;   PMID:23807981;   Reaxys:2225571;   VSDB:1803;   Wikipedia:Dinoprost
 cyclic_relationship: is_conjugate_acid_of CHEBI:57404


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prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G AKR1C2 aldo-keto reductase family 1 member C2 increases metabolic processing EXP AKR1C2 protein results in increased metabolism of Dinoprost CTD PMID:8573067 NCBI chr10:4,987,775...5,018,000
Ensembl chr10:4,987,775...5,018,031 		JBrowse link
G AKR1C3 aldo-keto reductase family 1 member C3 multiple interactions EXP [AKR1C3 protein results in increased reduction of Prostaglandin D2] which results in increased chemical synthesis of Dinoprost; [Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost]] which results in increased abundance of 15-deoxy-delta(12,14)-prostaglandin J2; Medroxyprogesterone Acetate inhibits the reaction [[AKR1C3 protein results in increased metabolism of Prostaglandin D2] which results in increased abundance of Dinoprost] CTD PMID:19997560 PMID:20036328 NCBI chr10:5,048,781...5,107,686
Ensembl chr10:5,035,354...5,107,686 		JBrowse link
G ANXA4 annexin A4 increases expression ISO Dinoprost results in increased expression of ANXA4 mRNA CTD PMID:11517196 NCBI chr 2:69,643,808...69,827,112
Ensembl chr 2:69,644,425...69,827,112 		JBrowse link
G ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 increases expression ISO Dinoprost results in increased expression of ATP1A1 mRNA CTD PMID:11517196 NCBI chr 1:116,373,244...116,404,774
Ensembl chr 1:116,372,668...116,410,261 		JBrowse link
G ATP2B4 ATPase plasma membrane Ca2+ transporting 4 increases response to substance EXP ATP2B4 protein results in increased susceptibility to Dinoprost CTD PMID:12933703 NCBI chr 1:203,626,832...203,744,081
Ensembl chr 1:203,626,832...203,744,081 		JBrowse link
G CAT catalase multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein] CTD PMID:20826536 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCND2 cyclin D2 decreases expression ISO Dinoprost results in decreased expression of CCND2 mRNA CTD PMID:11517196 NCBI chr12:4,273,762...4,305,353
Ensembl chr12:4,269,771...4,305,353 		JBrowse link
G CES1 carboxylesterase 1 increases hydrolysis EXP CES1 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr16:55,802,851...55,833,096
Ensembl chr16:55,802,851...55,833,337 		JBrowse link
G CES2 carboxylesterase 2 increases hydrolysis EXP CES2 protein results in increased hydrolysis of Dinoprost CTD PMID:21049984 NCBI chr16:66,934,471...66,945,096
Ensembl chr16:66,934,444...66,945,096 		JBrowse link
G CGB3 chorionic gonadotropin subunit beta 3 multiple interactions
increases chemical synthesis		 EXP [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; Indomethacin inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost] CTD PMID:18555068 NCBI chr19:49,022,869...49,024,333
Ensembl chr19:49,022,869...49,024,333 		JBrowse link
G COL10A1 collagen type X alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL10A1 mRNA; Dinoprost results in increased expression of COL10A1 protein CTD PMID:27050768 NCBI chr 6:116,118,909...116,217,144
Ensembl chr 6:116,118,909...116,158,747 		JBrowse link
G COL2A1 collagen type II alpha 1 chain increases expression ISO Dinoprost results in increased expression of COL2A1 mRNA; Dinoprost results in increased expression of COL2A1 protein CTD PMID:27050768 NCBI chr12:47,972,967...48,006,212
Ensembl chr12:47,972,967...48,004,554 		JBrowse link
G CYP19A1 cytochrome P450 family 19 subfamily A member 1 decreases expression
multiple interactions		 ISO Dinoprost results in decreased expression of CYP19A1 mRNA
Dinoprost results in decreased expression of CYP19A1 mRNA; Dinoprost results in decreased expression of CYP19A1 protein
Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]		 CTD PMID:11517196 PMID:15271885 NCBI chr15:51,208,057...51,338,596
Ensembl chr15:51,208,057...51,338,601 		JBrowse link
G DLL4 delta like canonical Notch ligand 4 decreases expression ISO Dinoprost results in decreased expression of DLL4 mRNA CTD PMID:21209419 NCBI chr15:40,929,340...40,939,073
Ensembl chr15:40,929,340...40,939,073 		JBrowse link
G EREG epiregulin multiple interactions
increases expression		 ISO [AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG; [trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG
Dinoprost results in increased expression of EREG		 CTD PMID:22583689 NCBI chr 4:74,365,145...74,388,749
Ensembl chr 4:74,365,145...74,388,749 		JBrowse link
G ESR1 estrogen receptor 1 increases expression ISO Dinoprost results in increased expression of ESR1 mRNA CTD PMID:21654155 NCBI chr 6:151,656,672...152,129,619
Ensembl chr 6:151,656,691...152,129,619 		JBrowse link
G FABP4 fatty acid binding protein 4 multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of FABP4 protein CTD PMID:21236357 NCBI chr 8:81,478,419...81,483,233
Ensembl chr 8:81,478,419...81,483,236 		JBrowse link
G FGF2 fibroblast growth factor 2 multiple interactions
affects localization		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Cycloheximide inhibits the reaction [Dinoprost affects the localization of FGF2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGF2 protein] CTD PMID:15654655 PMID:16365892 NCBI chr 4:122,826,682...122,898,236
Ensembl chr 4:122,826,682...122,898,236 		JBrowse link
G FGFR2 fibroblast growth factor receptor 2 multiple interactions
affects localization
decreases expression		 ISO 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]; Dinoprost affects the localization of [FGF2 protein binds to FGFR2 protein]; Dinoprost promotes the reaction [FGF2 protein binds to FGFR2 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of FGFR2 protein]
Dinoprost results in decreased expression of FGFR2 mRNA		 CTD PMID:15654655 PMID:16365892 NCBI chr10:121,478,330...121,598,458
Ensembl chr10:121,478,332...121,598,458 		JBrowse link
G FOSL2 FOS like 2, AP-1 transcription factor subunit increases expression ISO Dinoprost results in increased expression of FOSL2 mRNA CTD PMID:11517196 NCBI chr 2:28,392,858...28,417,317
Ensembl chr 2:28,392,448...28,417,317 		JBrowse link
G GATA4 GATA binding protein 4 multiple interactions
increases activity		 ISO Dinoprost promotes the reaction [GATA4 protein binds to CYP19A1 promoter]
Dinoprost results in increased activity of GATA4 protein		 CTD PMID:15271885 NCBI chr 8:11,676,935...11,760,002
Ensembl chr 8:11,676,959...11,760,002 		JBrowse link
G GPX1 glutathione peroxidase 1 increases response to substance ISO GPX1 gene mutant form results in increased susceptibility to Dinoprost CTD PMID:24296279 NCBI chr 3:49,357,176...49,358,353
Ensembl chr 3:49,357,174...49,358,605 		JBrowse link
G HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 decreases expression ISO Dinoprost results in decreased expression of HMGCS2 mRNA CTD PMID:11517196 NCBI chr 1:119,747,996...119,768,932
Ensembl chr 1:119,748,002...119,768,905 		JBrowse link
G HSD11B2 hydroxysteroid 11-beta dehydrogenase 2 decreases activity
decreases expression		 EXP
ISO		 Dinoprost results in decreased activity of HSD11B2 protein
Dinoprost results in decreased expression of HSD11B2 mRNA		 CTD PMID:10377029 PMID:11517196 NCBI chr16:67,429,801...67,437,553
Ensembl chr16:67,430,652...67,437,553 		JBrowse link
G ID1 inhibitor of DNA binding 1 decreases expression ISO Dinoprost results in decreased expression of ID1 mRNA CTD PMID:11517196 NCBI chr20:31,605,289...31,606,510
Ensembl chr20:31,605,283...31,606,515 		JBrowse link
G ID2 inhibitor of DNA binding 2 decreases expression ISO Dinoprost results in decreased expression of ID2 mRNA CTD PMID:11517196 NCBI chr 2:8,682,056...8,684,461
Ensembl chr 2:8,678,845...8,684,461 		JBrowse link
G ID3 inhibitor of DNA binding 3 decreases expression ISO Dinoprost results in decreased expression of ID3 mRNA CTD PMID:11517196 NCBI chr 1:23,557,926...23,559,501
Ensembl chr 1:23,557,926...23,559,501 		JBrowse link
G IL10 interleukin 10 multiple interactions
increases abundance		 EXP IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]
IL10 protein results in increased abundance of Dinoprost		 CTD PMID:12548226 NCBI chr 1:206,767,602...206,772,494
Ensembl chr 1:206,767,602...206,774,541 		JBrowse link
G IL1A interleukin 1 alpha increases abundance EXP IL1A protein results in increased abundance of Dinoprost CTD PMID:21513769 NCBI chr 2:112,773,925...112,784,493
Ensembl chr 2:112,773,925...112,784,493 		JBrowse link
G IL1B interleukin 1 beta increases abundance
multiple interactions		 EXP IL1B protein results in increased abundance of Dinoprost
Dexamethasone inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; IL10 protein inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; licochalcone A inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [IL1B protein results in increased abundance of Dinoprost]		 CTD PMID:12548226 PMID:16354411 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G IL2RA interleukin 2 receptor subunit alpha increases expression ISO Dinoprost results in increased expression of IL2RA mRNA CTD PMID:11517196 NCBI chr10:6,010,689...6,062,367
Ensembl chr10:6,010,689...6,062,370 		JBrowse link
G IL4 interleukin 4 increases secretion
multiple interactions		 EXP IL4 protein results in increased secretion of Dinoprost
[Poly I-C co-treated with IL4 protein] results in increased secretion of Dinoprost		 CTD PMID:23688403 NCBI chr 5:132,673,989...132,682,678
Ensembl chr 5:132,673,986...132,682,678 		JBrowse link
G KPNB1 karyopherin subunit beta 1 increases expression ISO Dinoprost results in increased expression of KPNB1 protein CTD PMID:16365892 NCBI chr17:47,649,919...47,685,505
Ensembl chr17:47,649,476...47,685,505 		JBrowse link
G LHCGR luteinizing hormone/choriogonadotropin receptor decreases expression ISO Dinoprost results in decreased expression of LHCGR mRNA CTD PMID:11517196 NCBI chr 2:48,686,774...48,755,724
Ensembl chr 2:48,686,774...48,755,730 		JBrowse link
G LYPLA2 lysophospholipase 2 increases hydrolysis EXP LYPLA2 protein results in increased hydrolysis of Dinoprost analog CTD PMID:25301951 NCBI chr 1:23,791,145...23,795,539
Ensembl chr 1:23,791,110...23,795,539 		JBrowse link
G MAP2K1 mitogen-activated protein kinase kinase 1 increases phosphorylation
multiple interactions		 ISO Dinoprost results in increased phosphorylation of MAP2K1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K1 protein]		 CTD PMID:24333336 NCBI chr15:66,386,912...66,491,544
Ensembl chr15:66,386,837...66,491,656 		JBrowse link
G MAP2K2 mitogen-activated protein kinase kinase 2 increases phosphorylation
multiple interactions		 ISO Dinoprost results in increased phosphorylation of MAP2K2 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAP2K2 protein]		 CTD PMID:24333336 NCBI chr19:4,090,321...4,124,122
Ensembl chr19:4,090,321...4,124,122 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 affects localization
multiple interactions
increases phosphorylation		 ISO Dinoprost affects the localization of MAPK1 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK1 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK1 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK1 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK1 protein]		 CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 affects localization
increases phosphorylation
multiple interactions		 ISO Dinoprost affects the localization of MAPK3 protein
Dinoprost results in increased phosphorylation of MAPK3 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]; AG 1879 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein; Egtazic Acid inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK3 protein]; N-(8-aminooctyl)-5-iodonaphthalene-1-sulfonamide inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; Tetradecanoylphorbol Acetate inhibits the reaction [Dinoprost affects the localization of MAPK3 protein]; Trifluoperazine inhibits the reaction [Dinoprost results in increased activity of MAPK3 protein]; W 7 inhibits the reaction [Dinoprost results in increased activity of and results in increased phosphorylation of MAPK3 protein]		 CTD PMID:11914123 PMID:15654655 PMID:24333336 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK6 mitogen-activated protein kinase 6 increases expression ISO Dinoprost results in increased expression of MAPK6 mRNA CTD PMID:11517196 NCBI chr15:51,971,825...52,067,375
Ensembl chr15:51,952,106...52,067,375 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 increases phosphorylation
multiple interactions		 ISO Dinoprost results in increased phosphorylation of MAPK8 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK8 protein]		 CTD PMID:24333336 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 increases phosphorylation
multiple interactions		 ISO Dinoprost results in increased phosphorylation of MAPK9 protein
resveratrol inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]; SRT1720 inhibits the reaction [Dinoprost results in increased phosphorylation of MAPK9 protein]		 CTD PMID:24333336 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions EXP Dinoprost results in increased expression of and results in increased activity of MMP2 protein CTD PMID:11719597 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 multiple interactions EXP Dinoprost results in increased expression of and results in increased activity of MMP9 protein CTD PMID:11719597 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G NOTCH1 notch receptor 1 decreases cleavage
decreases expression		 ISO Dinoprost results in decreased cleavage of NOTCH1 protein
Dinoprost results in decreased expression of NOTCH1 mRNA		 CTD PMID:21209419 NCBI chr 9:136,494,433...136,546,048
Ensembl chr 9:136,494,433...136,546,048 		JBrowse link
G NOTCH4 notch receptor 4 decreases expression
decreases cleavage		 ISO Dinoprost results in decreased expression of NOTCH4 mRNA
Dinoprost results in decreased cleavage of NOTCH4 protein		 CTD PMID:21209419 NCBI chr 6:32,194,843...32,224,067
Ensembl chr 6:32,194,843...32,224,067 		JBrowse link
G PDIA4 protein disulfide isomerase family A member 4 decreases expression ISO Dinoprost results in decreased expression of PDIA4 mRNA CTD PMID:11517196 NCBI chr 7:149,003,051...149,028,505
Ensembl chr 7:149,003,062...149,028,662 		JBrowse link
G PLCD1 phospholipase C delta 1 increases expression ISO Dinoprost results in increased expression of PLCD1 mRNA CTD PMID:11517196 NCBI chr 3:38,007,496...38,029,642
Ensembl chr 3:38,007,496...38,029,642 		JBrowse link
G POR cytochrome p450 oxidoreductase increases expression ISO Dinoprost results in increased expression of POR mRNA CTD PMID:11517196 NCBI chr 7:75,915,155...75,986,855
Ensembl chr 7:75,899,200...75,986,855 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG mRNA; [Niacin results in decreased abundance of Dinoprost] which results in increased expression of PPARG protein CTD PMID:21236357 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PRL prolactin multiple interactions ISO [Dinoprost results in decreased abundance of Progesterone] which results in increased expression of PRL protein CTD PMID:21654155 NCBI chr 6:22,287,246...22,302,835
Ensembl chr 6:22,287,244...22,302,826 		JBrowse link
G PRLR prolactin receptor increases expression ISO Dinoprost results in increased expression of PRLR mRNA CTD PMID:21654155 NCBI chr 5:35,048,756...35,230,487
Ensembl chr 5:35,048,756...35,230,487 		JBrowse link
G PTGDR prostaglandin D2 receptor multiple interactions EXP Dinoprost binds to and results in increased activity of PTGDR protein; Dinoprost inhibits the reaction [Prostaglandin D2 binds to PTGDR protein] CTD PMID:9579725 PMID:27636113 NCBI chr14:52,267,698...52,280,914
Ensembl chr14:52,267,698...52,276,724 		JBrowse link
G PTGER2 prostaglandin E receptor 2 multiple interactions EXP Dinoprost binds to and results in increased activity of PTGER2 protein CTD PMID:27636113 NCBI chr14:52,314,312...52,328,598
Ensembl chr14:52,314,305...52,328,598 		JBrowse link
G PTGFR prostaglandin F receptor increases expression
multiple interactions		 ISO Dinoprost results in increased expression of PTGFR mRNA
[AL 8810 results in decreased activity of PTGFR protein] inhibits the reaction [[trans-10,cis-12-conjugated linoleic acid results in increased abundance of Dinoprost] which results in increased expression of EREG]		 CTD PMID:11517196 PMID:22583689 NCBI chr 1:78,490,974...78,540,701
Ensembl chr 1:78,303,884...78,540,701 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions
increases abundance
increases expression		 ISO
EXP		 [Celecoxib results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [meloxicam results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [trans-10,cis-12-conjugated linoleic acid results in increased chemical synthesis of Dinoprost]; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [Niacin results in decreased expression of PTGS2 mRNA] which results in decreased abundance of Dinoprost; [PTGS2 gene mutant form results in increased susceptibility to Kainic Acid] which results in increased abundance of Dinoprost; [trans-10,cis-12-conjugated linoleic acid promotes the reaction [PTGS2 protein results in increased chemical synthesis of Dinoprost]] which results in increased expression of EREG
PTGS2 protein results in increased abundance of Dinoprost
Dinoprost results in increased expression of PTGS2 mRNA
[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost; [Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] inhibits the reaction [CGB3 protein results in increased chemical synthesis of Dinoprost]; Resveratrol inhibits the reaction [[Linoleic Acids, Conjugated results in increased expression of PTGS2 protein] which results in increased chemical synthesis of Dinoprost]; Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]; SIRT1 protein promotes the reaction [Resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]]
[Dinoprost results in increased expression of PTGS2 mRNA] which results in increased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased abundance of Dinoprost; [N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide results in decreased activity of PTGS2 protein] which results in decreased secretion of Dinoprost; CAT protein inhibits the reaction [Dinoprost results in increased expression of PTGS2 mRNA]; N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PTGS2 protein results in increased abundance of Dinoprost]		 CTD PMID:18555068 PMID:18776171 PMID:18834901 PMID:20826536 PMID:20844277 More... NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTK2B protein tyrosine kinase 2 beta increases expression ISO Dinoprost results in increased expression of PTK2B mRNA CTD PMID:11517196 NCBI chr 8:27,310,506...27,459,391
Ensembl chr 8:27,311,482...27,459,391 		JBrowse link
G RAF1 Raf-1 proto-oncogene, serine/threonine kinase increases expression
multiple interactions		 ISO Dinoprost results in increased expression of RAF1 protein modified form
resveratrol inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of RAF1 protein modified form]		 CTD PMID:24333336 NCBI chr 3:12,583,601...12,664,117
Ensembl chr 3:12,582,101...12,664,201 		JBrowse link
G RBL2 RB transcriptional corepressor like 2 decreases expression ISO Dinoprost results in decreased expression of RBL2 mRNA CTD PMID:11517196 NCBI chr16:53,434,471...53,491,648
Ensembl chr16:53,433,977...53,491,648 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit multiple interactions ISO CAT protein inhibits the reaction [Dinoprost results in increased localization of RELA protein]; Dinoprost results in increased localization of and results in increased activity of RELA protein CTD PMID:20826536 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RUNX2 RUNX family transcription factor 2 increases expression ISO Dinoprost results in increased expression of RUNX2 mRNA; Dinoprost results in increased expression of RUNX2 protein CTD PMID:27050768 NCBI chr 6:45,328,330...45,551,082
Ensembl chr 6:45,328,157...45,664,349 		JBrowse link
G SCN1B sodium voltage-gated channel beta subunit 1 increases expression ISO Dinoprost results in increased expression of SCN1B mRNA CTD PMID:11517196 NCBI chr19:35,030,470...35,040,449
Ensembl chr19:35,030,470...35,040,449 		JBrowse link
G SHC1 SHC adaptor protein 1 increases phosphorylation ISO Dinoprost results in increased phosphorylation of SHC1 protein alternative form CTD PMID:19168439 NCBI chr 1:154,962,298...154,974,376
Ensembl chr 1:154,962,298...154,974,395 		JBrowse link
G SIRT1 sirtuin 1 multiple interactions EXP SIRT1 protein promotes the reaction [resveratrol inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 mRNA] which results in increased chemical synthesis of Dinoprost]] CTD PMID:20844277 NCBI chr10:67,884,656...67,918,390
Ensembl chr10:67,884,656...67,918,390 		JBrowse link
G SLC22A7 solute carrier family 22 member 7 increases uptake EXP SLC22A7 protein results in increased uptake of Dinoprost CTD PMID:15901346 NCBI chr 6:43,295,714...43,305,538
Ensembl chr 6:43,295,694...43,305,538 		JBrowse link
G SLC22A8 solute carrier family 22 member 8 increases transport ISO SLC22A8 protein results in increased transport of Dinoprost CTD PMID:15100168 NCBI chr11:62,992,824...63,015,841
Ensembl chr11:62,989,154...63,015,841 		JBrowse link
G SOCS1 suppressor of cytokine signaling 1 increases expression ISO Dinoprost results in increased expression of SOCS1 mRNA CTD PMID:21654155 NCBI chr16:11,254,417...11,256,204
Ensembl chr16:11,254,417...11,256,204 		JBrowse link
G SOCS3 suppressor of cytokine signaling 3 increases expression ISO Dinoprost results in increased expression of SOCS3 mRNA CTD PMID:21654155 NCBI chr17:78,356,778...78,360,925
Ensembl chr17:78,356,778...78,360,077 		JBrowse link
G SOX9 SRY-box transcription factor 9 increases expression ISO Dinoprost results in increased expression of SOX9 mRNA; Dinoprost results in increased expression of SOX9 protein CTD PMID:27050768 NCBI chr17:72,121,020...72,126,416
Ensembl chr17:72,121,020...72,126,416 		JBrowse link
G STAT5A signal transducer and activator of transcription 5A increases expression ISO Dinoprost results in increased expression of STAT5A mRNA CTD PMID:21654155 NCBI chr17:42,287,439...42,311,943
Ensembl chr17:42,287,547...42,311,943 		JBrowse link
G SYN2 synapsin II decreases expression ISO Dinoprost results in decreased expression of SYN2 mRNA CTD PMID:11517196 NCBI chr 3:12,004,388...12,192,032
Ensembl chr 3:12,004,388...12,192,032 		JBrowse link
G TGFB1 transforming growth factor beta 1 increases expression ISO Dinoprost results in increased expression of TGFB1 mRNA CTD PMID:11517196 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G THRSP thyroid hormone responsive decreases expression ISO Dinoprost results in decreased expression of THRSP mRNA CTD PMID:10357836 NCBI chr11:78,063,861...78,068,351
Ensembl chr11:78,063,861...78,068,351 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 decreases expression EXP Dinoprost results in decreased expression of TIMP1 protein CTD PMID:11719597 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TIMP3 TIMP metallopeptidase inhibitor 3 decreases expression ISO Dinoprost results in decreased expression of TIMP3 mRNA CTD PMID:11517196 NCBI chr22:32,801,705...32,863,041
Ensembl chr22:32,801,705...32,863,041 		JBrowse link
G TNF tumor necrosis factor increases abundance EXP TNF protein results in increased abundance of Dinoprost CTD PMID:1993070 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TNFRSF11B TNF receptor superfamily member 11b multiple interactions
increases expression		 ISO 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein; pyrazolanthrone inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; resveratrol inhibits the reaction [Dinoprost results in increased expression of TNFRSF11B mRNA]; SB 203580 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein]; SRT1720 inhibits the reaction [Dinoprost results in increased expression of and results in increased secretion of TNFRSF11B protein] CTD PMID:24333336 NCBI chr 8:118,923,557...118,951,885
Ensembl chr 8:118,923,557...118,951,885 		JBrowse link
G UGT1A1 UDP glucuronosyltransferase family 1 member A1 increases chemical synthesis ISO UGT1A1 protein mutant form results in increased chemical synthesis of Dinoprost CTD PMID:3864191 NCBI chr 2:233,760,270...233,773,300
Ensembl chr 2:233,760,270...233,773,300 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Dinoprost results in decreased expression of VEGFA mRNA CTD PMID:11517196 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
G YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon increases expression ISO Dinoprost results in increased expression of YWHAE mRNA CTD PMID:11517196 NCBI chr17:1,344,275...1,400,222
Ensembl chr17:1,344,275...1,400,222 		JBrowse link
G YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma increases expression ISO Dinoprost results in increased expression of YWHAG mRNA CTD PMID:11517196 NCBI chr 7:76,326,799...76,358,991
Ensembl chr 7:76,326,799...76,358,991 		JBrowse link
G YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta increases expression ISO Dinoprost results in increased expression of YWHAZ mRNA CTD PMID:11517196 NCBI chr 8:100,916,523...100,953,382
Ensembl chr 8:100,916,523...100,953,388 		JBrowse link
13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases abundance
multiple interactions		 EXP PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha		 CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
15-oxoprostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases metabolic processing
multiple interactions		 EXP PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha		 CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
8-epi-prostaglandin F2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G APOE apolipoprotein E multiple interactions ISO [APOE gene mutant form affects the susceptibility to Folic Acid] which results in decreased abundance of 8-epi-prostaglandin F2alpha CTD PMID:17118406 NCBI chr19:44,905,796...44,909,393
Ensembl chr19:44,905,791...44,909,393 		JBrowse link
G APP amyloid beta precursor protein multiple interactions
increases abundance		 EXP [Lead co-treated with APP protein modified form] results in increased abundance of 8-epi-prostaglandin F2alpha
APP protein modified form results in increased abundance of 8-epi-prostaglandin F2alpha		 CTD PMID:22610977 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G IL1B interleukin 1 beta multiple interactions
increases abundance
increases chemical synthesis		 EXP
ISO		 1-((4-methylsulfonyl)phenyl)-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Ascorbic Acid promotes the reaction [Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]]; Aspirin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Dehydroascorbic Acid inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Indomethacin inhibits the reaction [IL1B results in increased chemical synthesis of 8-epi-prostaglandin F2alpha]; Resveratrol inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]
pyrrolidine dithiocarbamic acid inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]; Rotenone inhibits the reaction [IL1B protein results in increased abundance of 8-epi-prostaglandin F2alpha]		 CTD PMID:11530235 PMID:16529823 PMID:19751497 NCBI chr 2:112,829,751...112,836,779
Ensembl chr 2:112,829,751...112,836,816 		JBrowse link
G PAFAH2 platelet activating factor acetylhydrolase 2 affects metabolic processing
multiple interactions		 ISO PAFAH2 protein affects the metabolism of 8-epi-prostaglandin F2alpha
PAFAH2 protein affects the reaction [Carbon Tetrachloride results in increased abundance of 8-epi-prostaglandin F2alpha]		 CTD PMID:18024956 NCBI chr 1:25,959,767...25,998,063
Ensembl chr 1:25,959,767...25,998,117 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP [L 745337 results in decreased activity of PTGS2 protein] which results in decreased chemical synthesis of 8-epi-prostaglandin F2alpha; [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha; [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] which results in increased chemical synthesis of 8-epi-prostaglandin F2alpha CTD PMID:8621535 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G TBXA2R thromboxane A2 receptor multiple interactions
affects response to substance		 EXP
ISO		 8-epi-prostaglandin F2alpha binds to and results in increased activity of TBXA2R protein
TBXA2R protein affects the susceptibility to 8-epi-prostaglandin F2alpha		 CTD PMID:18158556 PMID:22565502 NCBI chr19:3,594,507...3,606,875
Ensembl chr19:3,594,507...3,606,875 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26040
    role 25956
      chemical role 24245
        donor 23232
          Bronsted acid 23019
            oxoacid 22986
              carbon oxoacid 22761
                carboxylic acid 22741
                  monocarboxylic acid 21745
                    prostaglandin F2alpha 87
                      11-epi-prostaglandin F2alpha + 0
                      13,14-dihydro-15-keto-PGF2alpha + 1
                      13,14-dihydroprostaglandin F2alpha 0
                      15-oxoprostaglandin F2alpha + 1
                      2,3-dinor-8-epi-prostaglandin F2alpha 0
                      8-epi-prostaglandin F2alpha + 6
                      carboprost 0
                      prostaglandin F2alpha 1-ethanolamide 0
                      prostaglandin F2alpha 1-glyceryl ester 0
                      prostaglandin F2alpha 2-glyceryl ester 0
                      prostaglandin F2alpha dimethylamine 0
                      tafluprost 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26040
    subatomic particle 26015
      composite particle 26015
        hadron 26015
          baryon 26015
            nucleon 26015
              atomic nucleus 26015
                atom 26015
                  main group element atom 25840
                    p-block element atom 25840
                      carbon group element atom 25437
                        carbon atom 25395
                          organic molecular entity 25395
                            heteroorganic entity 24770
                              organochalcogen compound 24383
                                organooxygen compound 24060
                                  carbon oxoacid 22761
                                    carboxylic acid 22741
                                      monocarboxylic acid 21745
                                        fatty acid 19090
                                          fatty acid derivative 9229
                                            icosanoid 477
                                              prostanoid 411
                                                prostaglandin 404
                                                  prostaglandins F 102
                                                    prostaglandins Falpha 101
                                                      prostaglandin F2alpha 87
                                                        11-epi-prostaglandin F2alpha + 0
                                                        13,14-dihydro-15-keto-PGF2alpha + 1
                                                        13,14-dihydroprostaglandin F2alpha 0
                                                        15-oxoprostaglandin F2alpha + 1
                                                        2,3-dinor-8-epi-prostaglandin F2alpha 0
                                                        8-epi-prostaglandin F2alpha + 6
                                                        carboprost 0
                                                        prostaglandin F2alpha 1-ethanolamide 0
                                                        prostaglandin F2alpha 1-glyceryl ester 0
                                                        prostaglandin F2alpha 2-glyceryl ester 0
                                                        prostaglandin F2alpha dimethylamine 0
                                                        tafluprost 0
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