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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:13,14-dihydro-15-keto-PGF2alpha
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Accession:CHEBI:63976 term browser browse the term
Definition:A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha.
Synonyms:exact_synonym: (5Z,9alpha,11alpha)-9,11-dihydroxy-15-oxoprost-5-en-1-oic acid
 related_synonym: 13,14-Dihydro-15-ketoprostaglandin F2alpha;   13,14-dihydro-15-keto-Prostaglandin F2a;   15-Keto-13,14-dihydroprostaglandin F2-alpha;   15-Keto-13,14-dihydroprostaglandin F2alpha;   9S,11S-dihydroxy-15-oxo-5Z-prostenoic acid;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19-/m1/s1;   InChIKey=VKTIONYPMSCHQI-XAGFEHLVSA-N;   PGFM;   SMILES=CCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   dhk-PGF2alpha
 xref: CAS:27376-76-7;   HMDB:HMDB0004685;   LIPID_MAPS_instance:LMFA03010027
 xref_mesh: MESH:C008228
 xref: PMID:20961606;   PMID:21228218;   PMID:21615801;   PMID:21653895;   PMID:21741578;   PMID:21924479;   PMID:21940119;   PMID:22192399;   Patent:US5397797;   Reaxys:6227023
 cyclic_relationship: is_conjugate_acid_of CHEBI:133374


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13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgr1 prostaglandin reductase 1 increases abundance
multiple interactions
ISO PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
CTD PMID:25619643 NCBI chr 5:73,784,000...73,802,624
Ensembl chr 5:73,784,009...73,802,666
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Term paths to the root
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Term Annotations click to browse term
  CHEBI ontology 19812
    role 19761
      biological role 19761
        biochemical role 19381
          metabolite 19356
            13,14-dihydro-15-keto-PGF2alpha 1
              13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19812
    subatomic particle 19811
      composite particle 19811
        hadron 19811
          baryon 19811
            nucleon 19811
              atomic nucleus 19811
                atom 19811
                  main group element atom 19708
                    p-block element atom 19708
                      carbon group element atom 19630
                        carbon atom 19620
                          organic molecular entity 19620
                            organic group 18728
                              organic divalent group 18719
                                organodiyl group 18719
                                  carbonyl group 18667
                                    carbonyl compound 18667
                                      carboxylic acid 18364
                                        monocarboxylic acid 17632
                                          fatty acid 16012
                                            fatty acid derivative 1047
                                              icosanoid 460
                                                prostanoid 399
                                                  prostaglandin 394
                                                    prostaglandins F 101
                                                      prostaglandins Falpha 100
                                                        prostaglandin F2alpha 86
                                                          13,14-dihydro-15-keto-PGF2alpha 1
                                                            13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
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