PTGDR (prostaglandin D2 receptor) - Rat Genome Database
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Gene: PTGDR (prostaglandin D2 receptor) Homo sapiens
Analyze
Symbol: PTGDR
Name: prostaglandin D2 receptor
RGD ID: 1349248
HGNC Page HGNC
Description: Predicted to have prostaglandin D receptor activity. Predicted to be involved in inflammatory response and positive regulation of cytosolic calcium ion concentration. Localizes to plasma membrane. Implicated in asthma and cerebral infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AS1; ASRT1; DP; DP1; MGC49004; PGD receptor; PGD2 receptor; prostaglandin D2 receptor (DP); PTGDR1
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1452,267,698 - 52,276,724 (+)EnsemblGRCh38hg38GRCh38
GRCh381452,267,256 - 52,276,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371452,734,310 - 52,743,808 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,804,181 - 51,813,192 (+)NCBINCBI36hg18NCBI36
Build 341451,804,180 - 51,813,191NCBI
Celera1432,602,359 - 32,611,369 (+)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1432,895,105 - 32,904,115 (+)NCBIHuRef
CHM1_11452,673,595 - 52,682,607 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
asthma  (EXP,IAGP)
COVID-19  (HEP)

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Additional References at PubMed
PMID:1422574   PMID:7642548   PMID:8833158   PMID:10827082   PMID:11139429   PMID:11742277   PMID:12002745   PMID:12036966   PMID:12119603   PMID:12230502   PMID:12477932   PMID:12494276  
PMID:12672054   PMID:12895603   PMID:15004188   PMID:15028279   PMID:15489334   PMID:15496624   PMID:15749909   PMID:16629782   PMID:17157653   PMID:17307163   PMID:17496729   PMID:17538632  
PMID:17541272   PMID:17845306   PMID:17878378   PMID:17965752   PMID:18005048   PMID:18797183   PMID:18802357   PMID:18811623   PMID:18957281   PMID:19064572   PMID:19220773   PMID:19237393  
PMID:19247692   PMID:19264973   PMID:19423540   PMID:19710676   PMID:19748656   PMID:19913121   PMID:20237496   PMID:20308056   PMID:20379614   PMID:20406964   PMID:20438785   PMID:20628086  
PMID:20959461   PMID:20973774   PMID:21199159   PMID:21307858   PMID:21426314   PMID:21624751   PMID:21832046   PMID:21832049   PMID:21873635   PMID:21883277   PMID:21930295   PMID:22182808  
PMID:23082233   PMID:23181793   PMID:23192614   PMID:23307871   PMID:23762421   PMID:23770605   PMID:24045676   PMID:24493589   PMID:24836286   PMID:24922638   PMID:25142778   PMID:25681680  
PMID:26792210   PMID:27336732   PMID:27636113   PMID:28630327   PMID:29088248   PMID:29607536   PMID:31575663   PMID:31917615  


Genomics

Comparative Map Data
PTGDR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1452,267,698 - 52,276,724 (+)EnsemblGRCh38hg38GRCh38
GRCh381452,267,256 - 52,276,724 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371452,734,310 - 52,743,808 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,804,181 - 51,813,192 (+)NCBINCBI36hg18NCBI36
Build 341451,804,180 - 51,813,191NCBI
Celera1432,602,359 - 32,611,369 (+)NCBI
Cytogenetic Map14q22.1NCBI
HuRef1432,895,105 - 32,904,115 (+)NCBIHuRef
CHM1_11452,673,595 - 52,682,607 (+)NCBICHM1_1
Ptgdr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,088,692 - 45,096,832 (-)NCBIGRCm39mm39
GRCm381444,851,235 - 44,859,375 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1444,851,235 - 44,859,375 (-)EnsemblGRCm38mm10GRCm38
MGSCv371445,470,910 - 45,479,050 (-)NCBIGRCm37mm9NCBIm37
MGSCv361443,773,112 - 43,781,252 (-)NCBImm8
Celera1441,045,205 - 41,053,310 (-)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.59NCBI
Ptgdr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01519,195,606 - 19,196,508 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01523,162,010 - 23,162,912 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41519,345,555 - 19,352,929 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11519,345,554 - 19,352,929 (+)NCBI
Celera1517,315,866 - 17,323,221 (+)NCBICelera
Cytogenetic Map15p14NCBI
Ptgdr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,801,328 - 10,810,066 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,801,370 - 10,810,161 (-)NCBIChiLan1.0ChiLan1.0
PTGDR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11451,149,155 - 51,158,158 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,149,155 - 51,158,161 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01432,863,852 - 32,873,492 (+)NCBIMhudiblu_PPA_v0panPan3
PTGDR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl828,480,478 - 28,488,855 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1828,480,446 - 28,491,331 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ptgdr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049366972,481,340 - 2,488,868 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGDR
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,347,796 - 29,359,783 (+)NCBI
ChlSab1.1 Ensembl2429,350,749 - 29,359,754 (+)Ensembl
Ptgdr
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473116,776,050 - 16,785,178 (-)NCBI

Position Markers
D14S588  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371470,220,286 - 70,220,405UniSTSGRCh37
Build 361469,290,039 - 69,290,158RGDNCBI36
Celera1450,284,394 - 50,284,517RGD
Cytogenetic Map14q22.1UniSTS
HuRef1450,388,838 - 50,388,957UniSTS
Marshfield Genetic Map1475.61UniSTS
Marshfield Genetic Map1475.61RGD
TNG Radiation Hybrid Map1424454.0UniSTS
deCODE Assembly Map1468.16UniSTS
Whitehead-RH Map14250.7UniSTS
Whitehead-YAC Contig Map14 UniSTS
D14S603  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371470,523,953 - 70,524,075UniSTSGRCh37
Build 361469,593,706 - 69,593,828RGDNCBI36
Celera1450,588,068 - 50,588,193RGD
Cytogenetic Map14q24.1UniSTS
Cytogenetic Map14q22.1UniSTS
HuRef1450,692,055 - 50,692,181UniSTS
Marshfield Genetic Map1476.28RGD
Marshfield Genetic Map1476.28UniSTS
deCODE Assembly Map1468.46UniSTS
Whitehead-YAC Contig Map14 UniSTS
RH92017  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,740,279 - 52,740,464UniSTSGRCh37
Build 361451,810,029 - 51,810,214RGDNCBI36
Celera1432,608,206 - 32,608,391RGD
Cytogenetic Map14q22.1UniSTS
HuRef1432,900,952 - 32,901,137UniSTS
GeneMap99-GB4 RH Map14122.63UniSTS
PMC58788P1  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,735,043 - 52,735,155UniSTSGRCh37
Build 361451,804,793 - 51,804,905RGDNCBI36
Celera1432,602,971 - 32,603,083RGD
HuRef1432,895,717 - 32,895,829UniSTS
PTGDR_8575  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,742,635 - 52,743,557UniSTSGRCh37
Build 361451,812,385 - 51,813,307RGDNCBI36
Celera1432,610,562 - 32,611,484RGD
HuRef1432,903,308 - 32,904,230UniSTS
RH71220  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,741,475 - 52,741,648UniSTSGRCh37
Build 361451,811,225 - 51,811,398RGDNCBI36
Celera1432,609,402 - 32,609,575RGD
Cytogenetic Map14q22.1UniSTS
HuRef1432,902,148 - 32,902,321UniSTS
GeneMap99-GB4 RH Map14122.74UniSTS
NCBI RH Map14513.8UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:737
Count of miRNA genes:563
Interacting mature miRNAs:619
Transcripts:ENST00000306051, ENST00000553372
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 154 103 29 166 72 58 23 29 26 51
Low 1606 2292 1122 338 1070 215 2809 1115 1119 176 757 1266 123 1153 1767 1 2
Below cutoff 571 589 528 260 175 220 1367 1023 2383 178 554 97 43 1 25 958

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000306051   ⟹   ENSP00000303424
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,267,698 - 52,276,724 (+)Ensembl
RefSeq Acc Id: ENST00000553372   ⟹   ENSP00000452408
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1452,267,812 - 52,275,006 (+)Ensembl
RefSeq Acc Id: NM_000953   ⟹   NP_000944
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,267,698 - 52,276,724 (+)NCBI
GRCh371452,734,310 - 52,743,808 (+)NCBI
Build 361451,804,181 - 51,813,192 (+)NCBI Archive
HuRef1432,895,105 - 32,904,115 (+)ENTREZGENE
CHM1_11452,673,595 - 52,682,607 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001281469   ⟹   NP_001268398
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,267,698 - 52,276,724 (+)NCBI
GRCh371452,734,310 - 52,743,808 (+)NCBI
HuRef1432,895,105 - 32,904,115 (+)NCBI
CHM1_11452,673,595 - 52,682,607 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005267891   ⟹   XP_005267948
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,267,256 - 52,276,724 (+)NCBI
GRCh371452,734,310 - 52,743,808 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_000944   ⟸   NM_000953
- Peptide Label: isoform 1
- UniProtKB: Q13258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001268398   ⟸   NM_001281469
- Peptide Label: isoform 2
- UniProtKB: Q13258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005267948   ⟸   XM_005267891
- Peptide Label: isoform X1
- UniProtKB: Q13258 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000303424   ⟸   ENST00000306051
RefSeq Acc Id: ENSP00000452408   ⟸   ENST00000553372

Promoters
RGD ID:6791821
Promoter ID:HG_KWN:19380
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell_12Hour
Transcripts:NM_000953
Position:
Human AssemblyChrPosition (strand)Source
Build 361451,804,006 - 51,804,506 (+)MPROMDB
RGD ID:7227613
Promoter ID:EPDNEW_H19551
Type:initiation region
Name:PTGDR_1
Description:prostaglandin D2 receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.; Paired-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,267,698 - 52,267,758EPDNEW

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
PTGDR, HAPLOTYPE TCT variation Asthma-related traits, susceptibility to, 1 [RCV000005736] Chr14:14q22.1 risk factor
PTGDR, HAPLOTYPE CCC variation Asthma-related traits, susceptibility to, 1 [RCV000005737] Chr14:14q22.1 risk factor
GRCh38/hg38 14q22.1-22.3(chr14:50591011-56286919)x1 copy number loss See cases [RCV000051519] Chr14:50591011..56286919 [GRCh38]
Chr14:51057729..56753637 [GRCh37]
Chr14:50127479..55823390 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
NM_000953.2(PTGDR):c.568G>A (p.Glu190Lys) single nucleotide variant Malignant melanoma [RCV000062760] Chr14:52268382 [GRCh38]
Chr14:52735100 [GRCh37]
Chr14:51804850 [NCBI36]
Chr14:14q22.1
not provided
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q22.1-22.3(chr14:51544846-55320598)x1 copy number loss See cases [RCV000135883] Chr14:51544846..55320598 [GRCh38]
Chr14:52011564..55787316 [GRCh37]
Chr14:51081314..54857069 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q21.1-22.3(chr14:39196172-56714461)x3 copy number gain See cases [RCV000140717] Chr14:39196172..56714461 [GRCh38]
Chr14:39665376..57181179 [GRCh37]
Chr14:38735127..56250932 [NCBI36]
Chr14:14q21.1-22.3
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.1(chr14:52733030-52803703)x1 copy number loss not provided [RCV000751014] Chr14:52733030..52803703 [GRCh37]
Chr14:14q22.1
benign
NM_000953.3(PTGDR):c.19C>T (p.Arg7Cys) single nucleotide variant not provided [RCV000973516] Chr14:52267833 [GRCh38]
Chr14:52734551 [GRCh37]
Chr14:14q22.1
benign
GRCh37/hg19 14q22.1(chr14:52630033-52741520)x1 copy number loss not provided [RCV001006633] Chr14:52630033..52741520 [GRCh37]
Chr14:14q22.1
uncertain significance
GRCh37/hg19 14q22.1(chr14:52727933-52809716)x1 copy number loss not provided [RCV001006634] Chr14:52727933..52809716 [GRCh37]
Chr14:14q22.1
uncertain significance
GRCh37/hg19 14q22.1(chr14:52566666-52846237)x1 copy number loss not provided [RCV001259665] Chr14:52566666..52846237 [GRCh37]
Chr14:14q22.1
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9591 AgrOrtholog
COSMIC PTGDR COSMIC
Ensembl Genes ENSG00000168229 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSP00000303424 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000452408 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000306051 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000553372 ENTREZGENE, UniProtKB/Swiss-Prot
GTEx ENSG00000168229 GTEx
HGNC ID HGNC:9591 ENTREZGENE
Human Proteome Map PTGDR Human Proteome Map
InterPro GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Pglndn_D_rcpt UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot
KEGG Report hsa:5729 UniProtKB/Swiss-Prot
NCBI Gene 5729 ENTREZGENE
OMIM 604687 OMIM
  607277 OMIM
PANTHER PTHR11866 UniProtKB/Swiss-Prot
  PTHR11866:SF14 UniProtKB/Swiss-Prot
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA285 PharmGKB, RGD
PRINTS PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDDPR UniProtKB/Swiss-Prot
PROSITE G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
UniProt PD2R_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary G3V5L3 UniProtKB/Swiss-Prot
  Q13250 UniProtKB/Swiss-Prot
  Q13251 UniProtKB/Swiss-Prot
  Q1ZZ52 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-07-05 PTGDR  prostaglandin D2 receptor    prostaglandin D2 receptor (DP)  Symbol and/or name change 5135510 APPROVED