MAPK6 (mitogen-activated protein kinase 6) - Rat Genome Database

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Gene: MAPK6 (mitogen-activated protein kinase 6) Homo sapiens
Analyze
Symbol: MAPK6
Name: mitogen-activated protein kinase 6
RGD ID: 733646
HGNC Page HGNC:6879
Description: Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within positive regulation of dendritic spine development. Located in cytosol.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: DKFZp686F03189; ERK-3; ERK3; extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; HsT17250; LOC112268149; MAP kinase 6; MAP kinase isoform p97; MAPK 6; p97-MAPK; p97MAPK; PRKM6; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6; uncharacterized LOC112268149
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: MAPK6P1   MAPK6P2   MAPK6P3   MAPK6P4   MAPK6P5   MAPK6P6  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,971,825 - 52,067,375 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,952,106 - 52,067,375 (+)EnsemblGRCh38hg38GRCh38
GRCh371552,311,416 - 52,359,572 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,098,739 - 50,145,754 (+)NCBINCBI36Build 36hg18NCBI36
Build 341550,098,738 - 50,145,753NCBI
Celera1529,205,905 - 29,252,893 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1529,169,104 - 29,189,428 (+)NCBIHuRef
CHM1_11552,429,454 - 52,476,450 (+)NCBICHM1_1
T2T-CHM13v2.01549,779,463 - 49,875,996 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-nitropyrene  (EXP)
17beta-estradiol  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
2,6-dinitrotoluene  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
aflatoxin B1  (EXP)
all-trans-retinoic acid  (EXP)
alpha-hexachlorocyclohexane  (ISO)
ammonium chloride  (ISO)
aripiprazole  (ISO)
atrazine  (ISO)
benzo[a]pyrene diol epoxide I  (EXP)
bisphenol A  (EXP,ISO)
cadmium atom  (EXP)
carbon nanotube  (ISO)
carboplatin  (ISO)
cisplatin  (ISO)
clozapine  (ISO)
cobalt dichloride  (EXP)
coumarin  (EXP)
cyclosporin A  (EXP)
dehydroepiandrosterone  (ISO)
dicrotophos  (EXP)
diuron  (ISO)
epoxiconazole  (ISO)
flutamide  (ISO)
FR900359  (EXP)
gefitinib  (EXP)
gentamycin  (ISO)
haloperidol  (ISO)
hydrogen peroxide  (EXP)
hypochlorous acid  (ISO)
lead diacetate  (ISO)
leflunomide  (EXP)
limonene  (ISO)
metacetamol  (ISO)
methapyrilene  (ISO)
methoxychlor  (ISO)
methyl methanesulfonate  (EXP)
mifepristone  (EXP)
N-ethyl-N-nitrosourea  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (EXP)
oxybenzone  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phorone  (ISO)
pirinixic acid  (ISO)
propiconazole  (ISO)
prostaglandin F2alpha  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sunitinib  (EXP)
temozolomide  (EXP)
Tetrachlorobisphenol A  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trimellitic anhydride  (ISO)
valproic acid  (EXP)
wortmannin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cytoplasm  (IBA,IEA,ISS)
cytosol  (IDA,TAS)
nucleoplasm  (TAS)
nucleus  (IBA,IEA,ISS)
protein-containing complex  (IEA)
septin cytoskeleton  (IEA)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
4. Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients. Xiong Y, etal., Emerg Microbes Infect. 2020 Dec;9(1):761-770. doi: 10.1080/22221751.2020.1747363.
Additional References at PubMed
PMID:2032290   PMID:7969157   PMID:8621539   PMID:8626698   PMID:8875998   PMID:11148204   PMID:11741894   PMID:12239168   PMID:12477932   PMID:12808096   PMID:12915405   PMID:15172640  
PMID:15226418   PMID:15489334   PMID:16344560   PMID:16360641   PMID:16964379   PMID:18235225   PMID:18720373   PMID:19322201   PMID:20936779   PMID:21317288   PMID:21873635   PMID:21900206  
PMID:21988832   PMID:22190034   PMID:22261722   PMID:22505454   PMID:22645313   PMID:23443559   PMID:23602568   PMID:24585635   PMID:25340781   PMID:25416956   PMID:26701725   PMID:26972000  
PMID:28089446   PMID:28167606   PMID:28241849   PMID:28514442   PMID:28611215   PMID:29095526   PMID:29117863   PMID:29426014   PMID:30229830   PMID:30279242   PMID:30585266   PMID:31016619  
PMID:31343991   PMID:32296183   PMID:32314963   PMID:32683582   PMID:32694731   PMID:32707033   PMID:32807901   PMID:33070159   PMID:33114754   PMID:33300070   PMID:33336740   PMID:33495824  
PMID:33579235   PMID:33961781   PMID:34315543   PMID:34703820   PMID:34728620   PMID:34857952   PMID:35228660   PMID:35271311   PMID:35563538   PMID:36250437   PMID:36537216   PMID:36736316  
PMID:37057894   PMID:37215982  


Genomics

Comparative Map Data
MAPK6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381551,971,825 - 52,067,375 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1551,952,106 - 52,067,375 (+)EnsemblGRCh38hg38GRCh38
GRCh371552,311,416 - 52,359,572 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361550,098,739 - 50,145,754 (+)NCBINCBI36Build 36hg18NCBI36
Build 341550,098,738 - 50,145,753NCBI
Celera1529,205,905 - 29,252,893 (+)NCBICelera
Cytogenetic Map15q21.2NCBI
HuRef1529,169,104 - 29,189,428 (+)NCBIHuRef
CHM1_11552,429,454 - 52,476,450 (+)NCBICHM1_1
T2T-CHM13v2.01549,779,463 - 49,875,996 (+)NCBIT2T-CHM13v2.0
Mapk6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39975,294,064 - 75,317,303 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl975,276,344 - 75,317,287 (-)EnsemblGRCm39 Ensembl
GRCm38975,386,782 - 75,410,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl975,369,062 - 75,410,005 (-)EnsemblGRCm38mm10GRCm38
MGSCv37975,234,708 - 75,257,821 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36975,172,810 - 75,195,923 (-)NCBIMGSCv36mm8
Celera972,546,303 - 72,569,234 (-)NCBICelera
Cytogenetic Map9DNCBI
cM Map942.3NCBI
Mapk6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8885,027,141 - 85,050,236 (-)NCBIGRCr8
mRatBN7.2876,146,650 - 76,169,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl876,146,690 - 76,169,720 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx881,654,326 - 81,677,362 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0879,919,074 - 79,942,242 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0877,753,658 - 77,776,692 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0882,328,013 - 82,351,108 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl882,328,020 - 82,351,108 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0881,931,183 - 81,954,196 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4880,212,726 - 80,236,362 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1880,231,926 - 80,243,701 (-)NCBI
Celera875,936,355 - 75,959,409 (-)NCBICelera
Cytogenetic Map8q24NCBI
Mapk6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554092,663,569 - 2,676,544 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554092,664,017 - 2,676,538 (-)NCBIChiLan1.0ChiLan1.0
MAPK6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21641,208,567 - 41,303,169 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11545,389,046 - 45,483,641 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01530,946,218 - 31,007,987 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11549,273,095 - 49,335,754 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1549,273,095 - 49,335,754 (+)Ensemblpanpan1.1panPan2
MAPK6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13017,701,154 - 17,737,334 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3017,701,742 - 17,736,298 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3017,629,919 - 17,666,142 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03017,849,086 - 17,885,310 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3017,849,097 - 17,884,048 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13017,768,544 - 17,804,773 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03017,886,556 - 17,922,799 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03017,992,501 - 18,028,970 (+)NCBIUU_Cfam_GSD_1.0
Mapk6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864096,001,083 - 96,031,523 (+)NCBIHiC_Itri_2
SpeTri2.0NW_00493647113,849,169 - 13,879,595 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAPK6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1119,725,029 - 119,771,312 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11119,725,026 - 119,770,988 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21132,815,469 - 132,850,071 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAPK6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12631,320,025 - 31,365,599 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2631,321,281 - 31,339,672 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666048109,846,674 - 109,908,016 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mapk6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247318,413,430 - 8,434,897 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247318,413,430 - 8,438,779 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in MAPK6
22 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 15q21.1-21.3(chr15:46042302-54195828)x1 copy number loss See cases [RCV000051619] Chr15:46042302..54195828 [GRCh38]
Chr15:46334500..54488025 [GRCh37]
Chr15:44121792..52275317 [NCBI36]
Chr15:15q21.1-21.3		 pathogenic
GRCh38/hg38 15q21.1-21.3(chr15:48695331-53923002)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051620]|See cases [RCV000051620] Chr15:48695331..53923002 [GRCh38]
Chr15:48987528..54215199 [GRCh37]
Chr15:46774820..52002491 [NCBI36]
Chr15:15q21.1-21.3		 pathogenic
GRCh38/hg38 15q21.2-22.2(chr15:50864913-59646577)x1 copy number loss See cases [RCV000051621] Chr15:50864913..59646577 [GRCh38]
Chr15:51157110..59938776 [GRCh37]
Chr15:48944402..57726068 [NCBI36]
Chr15:15q21.2-22.2		 pathogenic
GRCh38/hg38 15q21.2(chr15:52005056-52098273)x1 copy number loss See cases [RCV000051968] Chr15:52005056..52098273 [GRCh38]
Chr15:52297253..52390470 [GRCh37]
Chr15:50084545..50177762 [NCBI36]
Chr15:15q21.2		 uncertain significance
NM_002748.3(MAPK6):c.423G>A (p.Lys141=) single nucleotide variant Malignant melanoma [RCV000070819] Chr15:52046883 [GRCh38]
Chr15:52339080 [GRCh37]
Chr15:50126372 [NCBI36]
Chr15:15q21.2		 not provided
GRCh38/hg38 15q21.1-21.2(chr15:47460844-52494222)x1 copy number loss See cases [RCV000135639] Chr15:47460844..52494222 [GRCh38]
Chr15:47753041..52786419 [GRCh37]
Chr15:45540333..50573711 [NCBI36]
Chr15:15q21.1-21.2		 pathogenic
GRCh38/hg38 15q21.2-21.3(chr15:51276690-57088386)x1 copy number loss See cases [RCV000136661] Chr15:51276690..57088386 [GRCh38]
Chr15:51568887..57380584 [GRCh37]
Chr15:49356179..55167876 [NCBI36]
Chr15:15q21.2-21.3		 pathogenic
GRCh37/hg19 15q21.1-21.3(chr15:48744917-53851050)x1 copy number loss not provided [RCV001270659] Chr15:48744917..53851050 [GRCh37]
Chr15:15q21.1-21.3		 pathogenic
NM_002748.4(MAPK6):c.1765T>C (p.Tyr589His) single nucleotide variant Inborn genetic diseases [RCV003268919] Chr15:52064599 [GRCh38]
Chr15:52356796 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q15.1-26.3(chr15:41745084-102354798)x4 copy number gain See cases [RCV000447123] Chr15:41745084..102354798 [GRCh37]
Chr15:15q15.1-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:20733395-102511616)x4 copy number gain See cases [RCV000447765] Chr15:20733395..102511616 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q15.1-21.2(chr15:41689327-52446981)x1 copy number loss See cases [RCV000448968] Chr15:41689327..52446981 [GRCh37]
Chr15:15q15.1-21.2		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112)x3 copy number gain See cases [RCV000510717] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
GRCh37/hg19 15q11.2-26.3(chr15:22770422-102429112) copy number gain See cases [RCV000512019] Chr15:22770422..102429112 [GRCh37]
Chr15:15q11.2-26.3		 pathogenic
NM_002748.4(MAPK6):c.1214A>G (p.Asp405Gly) single nucleotide variant Inborn genetic diseases [RCV003241630] Chr15:52064048 [GRCh38]
Chr15:52356245 [GRCh37]
Chr15:15q21.2		 uncertain significance
Single allele duplication not provided [RCV000677926] Chr15:31115047..102354857 [GRCh37]
Chr15:15q13.2-26.3		 pathogenic
GRCh37/hg19 15q21.2-21.3(chr15:50727285-57603305)x3 copy number gain not provided [RCV000683691] Chr15:50727285..57603305 [GRCh37]
Chr15:15q21.2-21.3		 pathogenic
GRCh37/hg19 15q21.2(chr15:52247897-52335721)x1 copy number loss not provided [RCV000683693] Chr15:52247897..52335721 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q15.3-21.3(chr15:43759773-53252240)x1 copy number loss not provided [RCV000683686] Chr15:43759773..53252240 [GRCh37]
Chr15:15q15.3-21.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20016811-102493540)x3 copy number gain not provided [RCV000751155] Chr15:20016811..102493540 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q11.1-26.3(chr15:20071673-102461162)x3 copy number gain not provided [RCV000751156] Chr15:20071673..102461162 [GRCh37]
Chr15:15q11.1-26.3		 pathogenic
GRCh37/hg19 15q21.2-21.3(chr15:50083229-53439931)x1 copy number loss not provided [RCV000848123] Chr15:50083229..53439931 [GRCh37]
Chr15:15q21.2-21.3		 uncertain significance
GRCh37/hg19 15q21.2(chr15:52326567-52425740)x3 copy number gain not provided [RCV000847052] Chr15:52326567..52425740 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q21.2(chr15:52326471-52425740)x3 copy number gain not provided [RCV000847154] Chr15:52326471..52425740 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q21.2(chr15:51735136-52620104)x1 copy number loss not provided [RCV000849163] Chr15:51735136..52620104 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:49031132-56740397)x3 copy number gain not provided [RCV000849275] Chr15:49031132..56740397 [GRCh37]
Chr15:15q21.1-21.3		 pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48000433-60747551)x3 copy number gain not provided [RCV000845891] Chr15:48000433..60747551 [GRCh37]
Chr15:15q21.1-22.2		 pathogenic
NC_000015.9:g.(?_50999997)_(54025330_?)del deletion Spastic paraplegia [RCV003105621]|not provided [RCV003105622] Chr15:50999997..54025330 [GRCh37]
Chr15:15q21.2-21.3		 pathogenic|no classifications from unflagged records
NC_000015.9:g.(?_50731271)_(54025330_?)dup duplication not provided [RCV003105626] Chr15:50731271..54025330 [GRCh37]
Chr15:15q21.2-21.3		 uncertain significance
GRCh37/hg19 15q21.2(chr15:52198882-52573715)x4 copy number gain not provided [RCV001259214] Chr15:52198882..52573715 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q21.2-21.3(chr15:51792729-55134365)x1 copy number loss not provided [RCV001259215] Chr15:51792729..55134365 [GRCh37]
Chr15:15q21.2-21.3		 likely pathogenic
NC_000015.9:g.(?_32964879)_(91358519_?)dup duplication Bloom syndrome [RCV001343104]|Familial colorectal cancer [RCV001325176] Chr15:32964879..91358519 [GRCh37]
Chr15:15q13.3-26.1		 uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:47635238-56509908) copy number loss not specified [RCV002052472] Chr15:47635238..56509908 [GRCh37]
Chr15:15q21.1-21.3		 pathogenic
GRCh37/hg19 15q21.1-22.2(chr15:48589845-63543438)x3 copy number gain not provided [RCV002472512] Chr15:48589845..63543438 [GRCh37]
Chr15:15q21.1-22.2		 pathogenic
NM_002748.4(MAPK6):c.1247A>C (p.Asp416Ala) single nucleotide variant Inborn genetic diseases [RCV003302534] Chr15:52064081 [GRCh38]
Chr15:52356278 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1544C>G (p.Ala515Gly) single nucleotide variant Inborn genetic diseases [RCV002836806] Chr15:52064378 [GRCh38]
Chr15:52356575 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1964G>A (p.Arg655Lys) single nucleotide variant Inborn genetic diseases [RCV002946683] Chr15:52064798 [GRCh38]
Chr15:52356995 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.653C>G (p.Ala218Gly) single nucleotide variant Inborn genetic diseases [RCV002689991] Chr15:52050090 [GRCh38]
Chr15:52342287 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1343C>A (p.Thr448Lys) single nucleotide variant Inborn genetic diseases [RCV002707828] Chr15:52064177 [GRCh38]
Chr15:52356374 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.767G>A (p.Arg256His) single nucleotide variant Inborn genetic diseases [RCV002822733] Chr15:52058699 [GRCh38]
Chr15:52350896 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.475T>C (p.Phe159Leu) single nucleotide variant Inborn genetic diseases [RCV002799859] Chr15:52046935 [GRCh38]
Chr15:52339132 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1217G>A (p.Arg406Gln) single nucleotide variant Inborn genetic diseases [RCV002986177] Chr15:52064051 [GRCh38]
Chr15:52356248 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1253A>G (p.Asn418Ser) single nucleotide variant Inborn genetic diseases [RCV002921785] Chr15:52064087 [GRCh38]
Chr15:52356284 [GRCh37]
Chr15:15q21.2		 likely benign
NM_002748.4(MAPK6):c.1609C>G (p.Leu537Val) single nucleotide variant Inborn genetic diseases [RCV003283313] Chr15:52064443 [GRCh38]
Chr15:52356640 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1079G>C (p.Cys360Ser) single nucleotide variant Inborn genetic diseases [RCV003215461] Chr15:52063913 [GRCh38]
Chr15:52356110 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1031T>C (p.Met344Thr) single nucleotide variant Inborn genetic diseases [RCV003357678] Chr15:52061464 [GRCh38]
Chr15:52353661 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.1970A>G (p.His657Arg) single nucleotide variant Inborn genetic diseases [RCV003374212] Chr15:52064804 [GRCh38]
Chr15:52357001 [GRCh37]
Chr15:15q21.2		 uncertain significance
NM_002748.4(MAPK6):c.673A>T (p.Met225Leu) single nucleotide variant Inborn genetic diseases [RCV003368831] Chr15:52050110 [GRCh38]
Chr15:52342307 [GRCh37]
Chr15:15q21.2		 uncertain significance
GRCh37/hg19 15q21.1-21.3(chr15:49390592-56800964)x1 copy number loss not provided [RCV003483230] Chr15:49390592..56800964 [GRCh37]
Chr15:15q21.1-21.3		 pathogenic
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1036
Count of miRNA genes:575
Interacting mature miRNAs:625
Transcripts:ENST00000261845, ENST00000558063, ENST00000558100, ENST00000558841, ENST00000558891, ENST00000560254, ENST00000560774, ENST00000560802
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G43355  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371552,357,418 - 52,357,673UniSTSGRCh37
GRCh378110,483,567 - 110,483,826UniSTSGRCh37
Build 368110,552,743 - 110,553,002RGDNCBI36
Celera1529,251,854 - 29,252,109UniSTS
Celera8106,671,250 - 106,671,509RGD
Cytogenetic Map8q23.1UniSTS
Cytogenetic Map15q21UniSTS
Cytogenetic Map8q23UniSTS
HuRef1529,188,389 - 29,188,644UniSTS
HuRef8105,805,607 - 105,805,866UniSTS
MAPK6_180.2  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37847,883,624 - 47,884,472UniSTSGRCh37
GRCh371552,356,821 - 52,357,665UniSTSGRCh37
Build 36848,002,789 - 48,003,637RGDNCBI36
Celera843,867,794 - 43,868,642RGD
Celera1529,251,257 - 29,252,101UniSTS
HuRef1529,187,792 - 29,188,636UniSTS
HuRef843,353,542 - 43,354,390UniSTS
G19713  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q21UniSTS
FB21D1  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q21UniSTS
RH66852  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q21UniSTS
RH39451  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map15q21UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High
Medium 1126 908 1300 515 975 360 3472 885 2347 285 1248 1436 168 815 2133 4
Low 1306 2036 424 109 936 104 884 1305 1363 132 201 173 3 389 655 2
Below cutoff 1 40 1 38 1 3 15 2 6 1 3 1 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_002748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005254537 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_005254538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_011521782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432847 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432848 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432849 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047432855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378432 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378433 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378434 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378435 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378436 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378437 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378438 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378439 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378441 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054378442 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB451301 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC023906 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090970 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC090971 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF420474 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK313633 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC035492 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068263 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR749401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA109756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  KC877556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L77964 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X80692 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000261845   ⟹   ENSP00000261845
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,219 - 52,067,375 (+)Ensembl
RefSeq Acc Id: ENST00000558063
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,004,180 - 52,046,109 (+)Ensembl
RefSeq Acc Id: ENST00000558100
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,238 - 52,046,124 (+)Ensembl
RefSeq Acc Id: ENST00000558841
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,922 - 52,046,374 (+)Ensembl
RefSeq Acc Id: ENST00000558891
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,021,464 - 52,046,311 (+)Ensembl
RefSeq Acc Id: ENST00000560254
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,004,208 - 52,046,208 (+)Ensembl
RefSeq Acc Id: ENST00000560774
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,024,581 - 52,046,053 (+)Ensembl
RefSeq Acc Id: ENST00000560802
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1551,952,106 - 52,046,065 (+)Ensembl
RefSeq Acc Id: ENST00000680066   ⟹   ENSP00000505862
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,229 - 52,067,359 (+)Ensembl
RefSeq Acc Id: ENST00000680652   ⟹   ENSP00000506184
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,251 - 52,067,359 (+)Ensembl
RefSeq Acc Id: ENST00000680777   ⟹   ENSP00000505601
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,232 - 52,067,359 (+)Ensembl
RefSeq Acc Id: ENST00000681888   ⟹   ENSP00000506036
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1552,019,209 - 52,067,359 (+)Ensembl
RefSeq Acc Id: ENST00000691380   ⟹   ENSP00000509662
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1551,971,822 - 52,067,359 (+)Ensembl
RefSeq Acc Id: NM_002748   ⟹   NP_002739
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,219 - 52,067,375 (+)NCBI
GRCh371552,296,377 - 52,358,462 (+)NCBI
Build 361550,098,739 - 50,145,754 (+)NCBI Archive
HuRef1529,169,104 - 29,189,428 (+)ENTREZGENE
CHM1_11552,429,454 - 52,476,450 (+)NCBI
T2T-CHM13v2.01549,827,935 - 49,875,996 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005254537   ⟹   XP_005254594
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,219 - 52,067,375 (+)NCBI
GRCh371552,296,377 - 52,358,462 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005254538   ⟹   XP_005254595
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,219 - 52,067,375 (+)NCBI
GRCh371552,296,377 - 52,358,462 (+)NCBI
Sequence:
RefSeq Acc Id: XM_011521782   ⟹   XP_011520084
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,219 - 52,067,375 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047432847   ⟹   XP_047288803
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,941 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432848   ⟹   XP_047288804
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,043,778 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432849   ⟹   XP_047288805
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,941 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432850   ⟹   XP_047288806
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,941 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432851   ⟹   XP_047288807
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,941 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432852   ⟹   XP_047288808
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381551,971,825 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432853   ⟹   XP_047288809
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381551,971,836 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432854   ⟹   XP_047288810
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,043,778 - 52,067,375 (+)NCBI
RefSeq Acc Id: XM_047432855   ⟹   XP_047288811
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,219 - 52,050,142 (+)NCBI
RefSeq Acc Id: XM_054378432   ⟹   XP_054234407
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,827,932 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378433   ⟹   XP_054234408
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,827,935 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378434   ⟹   XP_054234409
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,827,928 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378435   ⟹   XP_054234410
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,828,507 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378436   ⟹   XP_054234411
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,828,438 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378437   ⟹   XP_054234412
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,828,400 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378438   ⟹   XP_054234413
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,828,772 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378439   ⟹   XP_054234414
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,779,463 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378440   ⟹   XP_054234415
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,779,474 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378441   ⟹   XP_054234416
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,852,476 - 49,875,996 (+)NCBI
RefSeq Acc Id: XM_054378442   ⟹   XP_054234417
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.01549,852,476 - 49,875,996 (+)NCBI
Protein Sequences
Protein RefSeqs NP_002739 (Get FASTA)   NCBI Sequence Viewer  
  XP_005254594 (Get FASTA)   NCBI Sequence Viewer  
  XP_005254595 (Get FASTA)   NCBI Sequence Viewer  
  XP_011520084 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288803 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288804 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288805 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288806 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288807 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288808 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288809 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288810 (Get FASTA)   NCBI Sequence Viewer  
  XP_047288811 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234407 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234408 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234409 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234410 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234411 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234412 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234413 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234414 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234415 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234416 (Get FASTA)   NCBI Sequence Viewer  
  XP_054234417 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA98769 (Get FASTA)   NCBI Sequence Viewer  
  AAH35492 (Get FASTA)   NCBI Sequence Viewer  
  AAL17605 (Get FASTA)   NCBI Sequence Viewer  
  BAG36392 (Get FASTA)   NCBI Sequence Viewer  
  BAG70115 (Get FASTA)   NCBI Sequence Viewer  
  CAA56709 (Get FASTA)   NCBI Sequence Viewer  
  CAH18246 (Get FASTA)   NCBI Sequence Viewer  
  EAW77434 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSP00000261845
  ENSP00000261845.5
  ENSP00000505601.1
  ENSP00000505862.1
  ENSP00000506036
  ENSP00000506036.1
  ENSP00000506184.1
  ENSP00000509662
  ENSP00000509662.1
GenBank Protein Q16659 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_002739   ⟸   NM_002748
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005254595   ⟸   XM_005254538
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_005254594   ⟸   XM_005254537
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_011520084   ⟸   XM_011521782
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000261845   ⟸   ENST00000261845
RefSeq Acc Id: ENSP00000506184   ⟸   ENST00000680652
RefSeq Acc Id: ENSP00000505601   ⟸   ENST00000680777
RefSeq Acc Id: ENSP00000506036   ⟸   ENST00000681888
RefSeq Acc Id: ENSP00000505862   ⟸   ENST00000680066
RefSeq Acc Id: ENSP00000509662   ⟸   ENST00000691380
RefSeq Acc Id: XP_047288808   ⟸   XM_047432852
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288809   ⟸   XM_047432853
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288811   ⟸   XM_047432855
- Peptide Label: isoform X2
RefSeq Acc Id: XP_047288807   ⟸   XM_047432851
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288803   ⟸   XM_047432847
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288806   ⟸   XM_047432850
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288805   ⟸   XM_047432849
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288810   ⟸   XM_047432854
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047288804   ⟸   XM_047432848
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234414   ⟸   XM_054378439
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234415   ⟸   XM_054378440
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234409   ⟸   XM_054378434
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234407   ⟸   XM_054378432
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234408   ⟸   XM_054378433
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234412   ⟸   XM_054378437
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234411   ⟸   XM_054378436
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234410   ⟸   XM_054378435
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234413   ⟸   XM_054378438
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234417   ⟸   XM_054378442
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054234416   ⟸   XM_054378441
- Peptide Label: isoform X1
- UniProtKB: Q68DH4 (UniProtKB/Swiss-Prot),   Q16659 (UniProtKB/Swiss-Prot),   B5BU65 (UniProtKB/Swiss-Prot),   B2R945 (UniProtKB/Swiss-Prot),   Q8IYN8 (UniProtKB/Swiss-Prot)
Protein Domains
Protein kinase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q16659-F1-model_v2 AlphaFold Q16659 1-721 view protein structure

Promoters
RGD ID:6792234
Promoter ID:HG_KWN:21415
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   K562,   Lymphoblastoid,   NB4
Transcripts:ENST00000403865,   OTTHUMT00000254841
Position:
Human AssemblyChrPosition (strand)Source
Build 361550,098,336 - 50,098,836 (+)MPROMDB
RGD ID:6810788
Promoter ID:HG_ACW:26243
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_2Hour,   HeLa_S3,   Jurkat,   Lymphoblastoid
Transcripts:MAPK6.DAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361550,099,219 - 50,099,719 (+)MPROMDB
RGD ID:6810789
Promoter ID:HG_ACW:26244
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:K562
Transcripts:MAPK6.EAPR07
Position:
Human AssemblyChrPosition (strand)Source
Build 361550,100,521 - 50,101,021 (+)MPROMDB
RGD ID:7229519
Promoter ID:EPDNEW_H20505
Type:initiation region
Name:MAPK6_1
Description:mitogen-activated protein kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20503  EPDNEW_H20506  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,229 - 52,019,289EPDNEW
RGD ID:7229521
Promoter ID:EPDNEW_H20506
Type:initiation region
Name:MAPK6_3
Description:mitogen-activated protein kinase 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H20503  EPDNEW_H20505  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381552,019,943 - 52,020,003EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:6879 AgrOrtholog
COSMIC MAPK6 COSMIC
Ensembl Genes ENSG00000069956 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENST00000261845 ENTREZGENE
  ENST00000261845.7 UniProtKB/Swiss-Prot
  ENST00000680066.1 UniProtKB/Swiss-Prot
  ENST00000680652.1 UniProtKB/Swiss-Prot
  ENST00000680777.1 UniProtKB/Swiss-Prot
  ENST00000681888 ENTREZGENE
  ENST00000681888.1 UniProtKB/Swiss-Prot
  ENST00000691380 ENTREZGENE
  ENST00000691380.1 UniProtKB/Swiss-Prot
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/Swiss-Prot
GTEx ENSG00000069956 GTEx
HGNC ID HGNC:6879 ENTREZGENE
Human Proteome Map MAPK6 Human Proteome Map
InterPro Kinase-like_dom_sf UniProtKB/Swiss-Prot
  MAPK_ERK3/4 UniProtKB/Swiss-Prot
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Protein_kinase_ATP_BS UniProtKB/Swiss-Prot
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
KEGG Report hsa:5597 UniProtKB/Swiss-Prot
NCBI Gene 5597 ENTREZGENE
OMIM 602904 OMIM
PANTHER MITOGEN-ACTIVATED PROTEIN KINASE UniProtKB/Swiss-Prot
  MITOGEN-ACTIVATED PROTEIN KINASE 6 UniProtKB/Swiss-Prot
Pfam Pkinase UniProtKB/Swiss-Prot
PharmGKB PA30624 PharmGKB
PRINTS ERK3ERK4MAPK UniProtKB/Swiss-Prot
PROSITE PROTEIN_KINASE_ATP UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56112 UniProtKB/Swiss-Prot
UniProt B2R945 ENTREZGENE
  B5BU65 ENTREZGENE
  MK06_HUMAN UniProtKB/Swiss-Prot, ENTREZGENE
  Q68DH4 ENTREZGENE
  Q8IYN8 ENTREZGENE
UniProt Secondary B2R945 UniProtKB/Swiss-Prot
  B5BU65 UniProtKB/Swiss-Prot
  Q68DH4 UniProtKB/Swiss-Prot
  Q8IYN8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-04-14 MAPK6  mitogen-activated protein kinase 6  LOC112268149  uncharacterized LOC112268149  Data merged from RGD:38612389 737654 PROVISIONAL