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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:13,14-dihydro-15-keto-PGF2alpha
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Accession:CHEBI:63976 term browser browse the term
Definition:A prostaglandin Falpha obtained by formal oxidation of the 15-hydroxy group and hydrogenation of the 13,14-double bond of prostaglandin F2alpha.
Synonyms:exact_synonym: (5Z,9alpha,11alpha)-9,11-dihydroxy-15-oxoprost-5-en-1-oic acid
 related_synonym: 13,14-Dihydro-15-ketoprostaglandin F2alpha;   13,14-dihydro-15-keto-Prostaglandin F2a;   15-Keto-13,14-dihydroprostaglandin F2-alpha;   15-Keto-13,14-dihydroprostaglandin F2alpha;   9S,11S-dihydroxy-15-oxo-5Z-prostenoic acid;   Formula=C20H34O5;   InChI=1S/C20H34O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,16-19,22-23H,2-3,5-6,8-14H2,1H3,(H,24,25)/b7-4-/t16-,17-,18+,19-/m1/s1;   InChIKey=VKTIONYPMSCHQI-XAGFEHLVSA-N;   PGFM;   SMILES=CCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\\C=C/CCCC(O)=O;   dhk-PGF2alpha
 xref: CAS:27376-76-7;   HMDB:HMDB0004685;   LIPID_MAPS_instance:LMFA03010027
 xref_mesh: MESH:C008228
 xref: PMID:20961606;   PMID:21228218;   PMID:21615801;   PMID:21653895;   PMID:21741578;   PMID:21924479;   PMID:21940119;   PMID:22192399;   Patent:US5397797;   Reaxys:6227023
 cyclic_relationship: is_conjugate_acid_of CHEBI:133374


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13,14-dihydro-15-keto-PGF2alpha term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G PTGR1 prostaglandin reductase 1 increases abundance
multiple interactions		 EXP PTGR1 protein results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha
[PTGR1 protein results in increased metabolism of 15-ketoprostaglandin F2alpha] which results in increased abundance of 15-keto-13,14-dihydroprostaglandin F2alpha		 CTD PMID:25619643 NCBI chr 9:111,549,722...111,599,647
Ensembl chr 9:111,549,722...111,599,893 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      biological role 25929
        biochemical role 25162
          metabolite 25092
            13,14-dihydro-15-keto-PGF2alpha 1
              13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    p-block element atom 25834
                      carbon group element atom 25434
                        carbon atom 25403
                          organic molecular entity 25392
                            heteroorganic entity 24766
                              organochalcogen compound 24378
                                organooxygen compound 24054
                                  carbon oxoacid 22749
                                    carboxylic acid 22729
                                      monocarboxylic acid 21724
                                        fatty acid 18997
                                          fatty acid derivative 9189
                                            icosanoid 475
                                              prostanoid 409
                                                prostaglandin 403
                                                  prostaglandins F 102
                                                    prostaglandins Falpha 101
                                                      prostaglandin F2alpha 87
                                                        13,14-dihydro-15-keto-PGF2alpha 1
                                                          13,14-dihydro-15-keto PGF2alpha isopropyl ester 0
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