PTGER2 (prostaglandin E receptor 2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: PTGER2 (prostaglandin E receptor 2) Homo sapiens
Analyze
Symbol: PTGER2
Name: prostaglandin E receptor 2
RGD ID: 1342884
HGNC Page HGNC:9594
Description: Predicted to enable prostaglandin E receptor activity. Predicted to be involved in several processes, including cellular response to prostaglandin E stimulus; negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress; and positive regulation of peptidyl-serine phosphorylation. Predicted to act upstream of or within regulation of cell population proliferation; response to lipopolysaccharide; and response to nematode. Predicted to be located in membrane. Predicted to be active in plasma membrane. Implicated in asthma, nasal polyps, and aspirin intolerance.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: EP2; PGE receptor EP2 subtype; PGE2 receptor EP2 subtype; prostaglandin E receptor 2 (subtype EP2), 53kD; prostaglandin E receptor 2 (subtype EP2), 53kDa; prostaglandin E2 receptor EP2 subtype; prostanoid EP2 receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,314,312 - 52,328,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,314,305 - 52,328,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371452,781,030 - 52,795,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,850,863 - 51,865,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 341451,850,862 - 51,865,070NCBI
Celera1432,648,601 - 32,662,908 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1432,941,341 - 32,955,648 (+)NCBIHuRef
CHM1_11452,720,192 - 52,734,499 (+)NCBICHM1_1
T2T-CHM13v2.01446,521,407 - 46,535,692 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
17beta-estradiol 3-benzoate  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3-bis(4-hydroxyphenyl)propionitrile  (ISO)
2,4,6-trinitrobenzenesulfonic acid  (ISO)
3',5'-cyclic AMP  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (ISO)
acetamide  (ISO)
acetylsalicylic acid  (EXP)
AH23848  (EXP)
all-trans-retinoic acid  (EXP,ISO)
alternariol  (ISO)
ammonium chloride  (ISO)
amphetamine  (ISO)
antirheumatic drug  (EXP)
aristolochic acid A  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
bellidifolin  (EXP)
benzene  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP,ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
cadmium dichloride  (EXP)
calcitriol  (EXP)
carbon nanotube  (ISO)
copper atom  (EXP,ISO)
copper(0)  (EXP,ISO)
Cryptotanshinone  (EXP)
D-penicillamine  (ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
Dibutyl phosphate  (EXP)
dibutyl phthalate  (ISO)
dichloromethane  (EXP)
diosmin  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP)
diuron  (ISO)
ethylbenzene  (EXP)
fonofos  (EXP)
formaldehyde  (ISO)
fulvestrant  (EXP)
hemin  (ISO)
ibuprofen  (ISO)
indometacin  (EXP)
inulin  (ISO)
ketoconazole  (EXP)
levonorgestrel  (EXP)
lipopolysaccharide  (EXP,ISO)
mercury atom  (ISO)
mercury(0)  (ISO)
methylisothiazolinone  (EXP)
mifepristone  (ISO)
misoprostol  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodimethylamine  (ISO)
nickel atom  (EXP)
nickel sulfate  (EXP,ISO)
Nonylphenol  (ISO)
NS-398  (EXP,ISO)
o-xylene  (EXP)
oxaliplatin  (ISO)
paraquat  (ISO)
parathion  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
prostaglandin D2  (EXP)
prostaglandin E2  (EXP,ISO)
prostaglandin F2alpha  (EXP)
resveratrol  (EXP)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
selenic acid  (ISO)
silicon dioxide  (EXP)
sodium arsenite  (EXP,ISO)
sodium hydrogensulfite  (ISO)
sodium sulfite  (ISO)
sulfur dioxide  (ISO)
tamoxifen  (ISO)
temozolomide  (EXP)
terbinafine  (EXP)
terbufos  (EXP)
testosterone  (ISO)
testosterone undecanoate  (EXP)
tetrachloromethane  (ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
toluene  (EXP)
topotecan  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (EXP)
urethane  (ISO)
valproic acid  (EXP)
vinyl carbamate  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
3. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7759114   PMID:8078484   PMID:8163486   PMID:8250933   PMID:8889548   PMID:10462542   PMID:10521663   PMID:11093764   PMID:11418617   PMID:11834444   PMID:11951086   PMID:12036966  
PMID:12051958   PMID:12149218   PMID:12228765   PMID:12466123   PMID:12477932   PMID:12743126   PMID:12788892   PMID:12933667   PMID:14517215   PMID:14562138   PMID:14699136   PMID:15044590  
PMID:15347673   PMID:15489334   PMID:15539459   PMID:15970595   PMID:16267225   PMID:16461132   PMID:16607275   PMID:16879213   PMID:17028262   PMID:17078003   PMID:17290397   PMID:17384145  
PMID:17496729   PMID:17525067   PMID:17533365   PMID:17555711   PMID:17611676   PMID:17728378   PMID:17877755   PMID:18005048   PMID:18086382   PMID:18254372   PMID:18296611   PMID:18319253  
PMID:18537828   PMID:18666211   PMID:18790761   PMID:18792407   PMID:18818748   PMID:18829529   PMID:18989535   PMID:19019335   PMID:19050969   PMID:19169646   PMID:19273625   PMID:19336370  
PMID:19407222   PMID:19527514   PMID:19542367   PMID:19582788   PMID:19782748   PMID:19789190   PMID:19808686   PMID:19913121   PMID:20018632   PMID:20086108   PMID:20140262   PMID:20200425  
PMID:20237496   PMID:20304053   PMID:20347274   PMID:20357748   PMID:20382140   PMID:20452482   PMID:20484658   PMID:20516073   PMID:20551148   PMID:20587336   PMID:20628086   PMID:20673868  
PMID:20705717   PMID:20889571   PMID:21052031   PMID:21081469   PMID:21111772   PMID:21209948   PMID:21419570   PMID:21873635   PMID:22099390   PMID:22244821   PMID:22276108   PMID:22329897  
PMID:22551900   PMID:22580611   PMID:22706114   PMID:22929011   PMID:23048027   PMID:23069790   PMID:23242524   PMID:23337716   PMID:23786281   PMID:23861370   PMID:23898208   PMID:24146253  
PMID:24471568   PMID:24561081   PMID:24586238   PMID:24626807   PMID:24728410   PMID:24812667   PMID:24827772   PMID:24883443   PMID:24980222   PMID:25059824   PMID:25329458   PMID:25634217  
PMID:25681680   PMID:25828575   PMID:26051534   PMID:26538827   PMID:26560040   PMID:27012192   PMID:27230257   PMID:27321910   PMID:27377703   PMID:27616330   PMID:27636113   PMID:28336329  
PMID:28630103   PMID:28963072   PMID:29401596   PMID:29491476   PMID:30012671   PMID:30053598   PMID:30103548   PMID:30835912   PMID:30890164   PMID:30917001   PMID:31217077   PMID:31980713  
PMID:32313117   PMID:32438662   PMID:32595209   PMID:32851536   PMID:33011635   PMID:33545665   PMID:33786738   PMID:34529833   PMID:34742290   PMID:34822808   PMID:34886911   PMID:34914140  
PMID:35543087   PMID:37232020   PMID:37796697   PMID:38639976   PMID:38753641  


Genomics

Comparative Map Data
PTGER2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381452,314,312 - 52,328,598 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1452,314,305 - 52,328,598 (+)EnsemblGRCh38hg38GRCh38
GRCh371452,781,030 - 52,795,316 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361451,850,863 - 51,865,074 (+)NCBINCBI36Build 36hg18NCBI36
Build 341451,850,862 - 51,865,070NCBI
Celera1432,648,601 - 32,662,908 (+)NCBICelera
Cytogenetic Map14q22.1NCBI
HuRef1432,941,341 - 32,955,648 (+)NCBIHuRef
CHM1_11452,720,192 - 52,734,499 (+)NCBICHM1_1
T2T-CHM13v2.01446,521,407 - 46,535,692 (+)NCBIT2T-CHM13v2.0
Ptger2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391445,225,568 - 45,241,277 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1445,225,652 - 45,241,277 (+)EnsemblGRCm39 Ensembl
GRCm381444,988,111 - 45,003,820 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1444,988,195 - 45,003,820 (+)EnsemblGRCm38mm10GRCm38
MGSCv371445,607,786 - 45,623,495 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361443,910,468 - 43,925,027 (+)NCBIMGSCv36mm8
Celera1441,179,301 - 41,195,008 (+)NCBICelera
Cytogenetic Map14C1NCBI
cM Map1422.68NCBI
Ptger2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81520,694,765 - 20,708,475 (+)NCBIGRCr8
mRatBN7.21518,215,013 - 18,228,714 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1518,217,285 - 18,228,714 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1521,008,805 - 21,020,249 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01521,965,749 - 21,977,190 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01520,222,303 - 20,233,747 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01519,336,029 - 19,349,759 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1519,338,175 - 19,350,210 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01523,301,463 - 23,315,207 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41520,205,443 - 20,216,872 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11520,878,084 - 20,889,615 (+)NCBI
Celera1518,649,190 - 18,660,619 (+)NCBICelera
Cytogenetic Map15p14NCBI
Ptger2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540910,757,888 - 10,774,688 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540910,760,801 - 10,775,197 (-)NCBIChiLan1.0ChiLan1.0
PTGER2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21553,441,812 - 53,459,334 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11452,661,559 - 52,676,942 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01432,910,755 - 32,926,138 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11451,195,381 - 51,209,686 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1451,195,381 - 51,209,686 (+)Ensemblpanpan1.1panPan2
PTGER2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1828,523,318 - 28,536,936 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl828,522,681 - 28,536,922 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha828,274,789 - 28,288,408 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0828,698,142 - 28,712,635 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl828,699,025 - 28,712,635 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1828,369,315 - 28,383,055 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0828,428,898 - 28,442,522 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0828,777,540 - 28,791,160 (+)NCBIUU_Cfam_GSD_1.0
Ptger2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864076,666,763 - 76,679,725 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366972,440,901 - 2,453,975 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366972,440,943 - 2,453,897 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGER2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1181,994,560 - 182,009,953 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11181,993,961 - 182,009,959 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21202,268,089 - 202,282,621 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTGER2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12429,395,799 - 29,410,723 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2429,396,464 - 29,409,575 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366605317,664,018 - 17,678,316 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptger2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473116,726,975 - 16,741,557 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473116,729,846 - 16,741,529 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGER2
13 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
NC_000014.9:g.52300623G>A single nucleotide variant Asthma, aspirin-induced, susceptibility to [RCV000014288] Chr14:52300623 [GRCh38]
Chr14:52767341 [GRCh37]
Chr14:14q22.1
risk factor
GRCh38/hg38 14q22.1-22.3(chr14:50591011-56286919)x1 copy number loss See cases [RCV000051519] Chr14:50591011..56286919 [GRCh38]
Chr14:51057729..56753637 [GRCh37]
Chr14:50127479..55823390 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh38/hg38 14q22.1-22.3(chr14:51544846-55320598)x1 copy number loss See cases [RCV000135883] Chr14:51544846..55320598 [GRCh38]
Chr14:52011564..55787316 [GRCh37]
Chr14:51081314..54857069 [NCBI36]
Chr14:14q22.1-22.3
pathogenic
GRCh38/hg38 14q21.1-22.3(chr14:39196172-56714461)x3 copy number gain See cases [RCV000140717] Chr14:39196172..56714461 [GRCh38]
Chr14:39665376..57181179 [GRCh37]
Chr14:38735127..56250932 [NCBI36]
Chr14:14q21.1-22.3
likely pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-22.2(chr14:23164384-54733411)x3 copy number gain See cases [RCV000447658] Chr14:23164384..54733411 [GRCh37]
Chr14:14q11.2-22.2
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19794561-107234280)x3 copy number gain See cases [RCV000446256] Chr14:19794561..107234280 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:20511673-107285437) copy number gain See cases [RCV000512041] Chr14:20511673..107285437 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.1-32.33(chr14:19000422-107289053)x3 copy number gain not provided [RCV000738412] Chr14:19000422..107289053 [GRCh37]
Chr14:14q11.1-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19280733-107287663)x3 copy number gain not provided [RCV000738413] Chr14:19280733..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q11.2-32.33(chr14:19327823-107287663)x3 copy number gain not provided [RCV000738414] Chr14:19327823..107287663 [GRCh37]
Chr14:14q11.2-32.33
pathogenic
GRCh37/hg19 14q22.1(chr14:52733030-52803703)x1 copy number loss not provided [RCV000751014] Chr14:52733030..52803703 [GRCh37]
Chr14:14q22.1
benign
GRCh37/hg19 14q22.1(chr14:52727933-52809716)x1 copy number loss not provided [RCV001006634] Chr14:52727933..52809716 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.854A>G (p.Tyr285Cys) single nucleotide variant not provided [RCV000892480] Chr14:52327231 [GRCh38]
Chr14:52793949 [GRCh37]
Chr14:14q22.1
likely benign
NM_000956.4(PTGER2):c.247T>G (p.Cys83Gly) single nucleotide variant not provided [RCV000882465] Chr14:52314795 [GRCh38]
Chr14:52781513 [GRCh37]
Chr14:14q22.1
benign|likely benign
GRCh37/hg19 14q22.1(chr14:52566666-52846237)x1 copy number loss not provided [RCV001259665] Chr14:52566666..52846237 [GRCh37]
Chr14:14q22.1
uncertain significance
GRCh37/hg19 14q13.3-32.33(chr14:37671058-106985955)x2 copy number gain See cases [RCV002286356] Chr14:37671058..106985955 [GRCh37]
Chr14:14q13.3-32.33
pathogenic
NM_000956.4(PTGER2):c.540G>C (p.Gln180His) single nucleotide variant not specified [RCV004087438] Chr14:52315088 [GRCh38]
Chr14:52781806 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.377T>C (p.Met126Thr) single nucleotide variant not specified [RCV004129166] Chr14:52314925 [GRCh38]
Chr14:52781643 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.232G>C (p.Asp78His) single nucleotide variant not specified [RCV004110742] Chr14:52314780 [GRCh38]
Chr14:52781498 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.311C>T (p.Pro104Leu) single nucleotide variant not specified [RCV004088304] Chr14:52314859 [GRCh38]
Chr14:52781577 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.5G>A (p.Gly2Asp) single nucleotide variant not specified [RCV004120227] Chr14:52314553 [GRCh38]
Chr14:52781271 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.260C>T (p.Pro87Leu) single nucleotide variant not specified [RCV004150284] Chr14:52314808 [GRCh38]
Chr14:52781526 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.82A>G (p.Ser28Gly) single nucleotide variant not specified [RCV004180867] Chr14:52314630 [GRCh38]
Chr14:52781348 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.728G>T (p.Gly243Val) single nucleotide variant not specified [RCV004267379] Chr14:52315276 [GRCh38]
Chr14:52781994 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.724C>T (p.Arg242Trp) single nucleotide variant not specified [RCV004252821] Chr14:52315272 [GRCh38]
Chr14:52781990 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.347T>G (p.Met116Arg) single nucleotide variant not specified [RCV004361707] Chr14:52314895 [GRCh38]
Chr14:52781613 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.647T>G (p.Phe216Cys) single nucleotide variant not specified [RCV004343784] Chr14:52315195 [GRCh38]
Chr14:52781913 [GRCh37]
Chr14:14q22.1
uncertain significance
GRCh37/hg19 14q11.2-23.1(chr14:20511673-61826023)x3 copy number gain not provided [RCV003485022] Chr14:20511673..61826023 [GRCh37]
Chr14:14q11.2-23.1
pathogenic
NM_000956.4(PTGER2):c.125C>T (p.Ala42Val) single nucleotide variant not specified [RCV004515604] Chr14:52314673 [GRCh38]
Chr14:52781391 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.856A>G (p.Met286Val) single nucleotide variant not specified [RCV004515609] Chr14:52327233 [GRCh38]
Chr14:52793951 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.205G>A (p.Val69Met) single nucleotide variant not specified [RCV004515605] Chr14:52314753 [GRCh38]
Chr14:52781471 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.439C>T (p.Arg147Cys) single nucleotide variant not specified [RCV004515606] Chr14:52314987 [GRCh38]
Chr14:52781705 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.482A>T (p.Tyr161Phe) single nucleotide variant not specified [RCV004515607] Chr14:52315030 [GRCh38]
Chr14:52781748 [GRCh37]
Chr14:14q22.1
uncertain significance
NM_000956.4(PTGER2):c.747G>T (p.Arg249Ser) single nucleotide variant not specified [RCV004515608] Chr14:52315295 [GRCh38]
Chr14:52782013 [GRCh37]
Chr14:14q22.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:545
Count of miRNA genes:330
Interacting mature miRNAs:349
Transcripts:ENST00000245457, ENST00000557436
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
G59837  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,794,293 - 52,794,483UniSTSGRCh37
Build 361451,864,043 - 51,864,233RGDNCBI36
Celera1432,661,877 - 32,662,067RGD
Cytogenetic Map14q22UniSTS
HuRef1432,954,617 - 32,954,807UniSTS
PTGER2_2277  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,794,654 - 52,795,415UniSTSGRCh37
Build 361451,864,404 - 51,865,165RGDNCBI36
Celera1432,662,238 - 32,662,999RGD
HuRef1432,954,978 - 32,955,739UniSTS
SHGC-12634  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh371452,794,475 - 52,794,809UniSTSGRCh37
Build 361451,864,225 - 51,864,559RGDNCBI36
Celera1432,662,059 - 32,662,393RGD
Cytogenetic Map14q22UniSTS
HuRef1432,954,799 - 32,955,133UniSTS
Stanford-G3 RH Map141586.0UniSTS
GeneMap99-G3 RH Map141634.0UniSTS


Expression

RNA-SEQ Expression

adipose tissue
alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
entire extraembryonic component
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1204 2395 2775 2220 4752 1711 2284 3 613 1764 454 2225 7055 6278 27 3559 839 1716 1560 171 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_013082 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000956 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AH007997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL365475 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY275471 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093927 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC093929 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BE739744 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BF029797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BM986745 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ014559 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CF132756 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471078 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CN484094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068264 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR977661 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ398948 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U19487 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X83868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENST00000245457   ⟹   ENSP00000245457
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1452,314,312 - 52,328,598 (+)Ensembl
Ensembl Acc Id: ENST00000557436   ⟹   ENSP00000450933
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1452,314,305 - 52,327,509 (+)Ensembl
RefSeq Acc Id: NM_000956   ⟹   NP_000947
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,314,312 - 52,328,598 (+)NCBI
GRCh371452,781,016 - 52,795,324 (+)ENTREZGENE
Build 361451,850,863 - 51,865,074 (+)NCBI Archive
HuRef1432,941,341 - 32,955,648 (+)ENTREZGENE
CHM1_11452,720,192 - 52,734,499 (+)NCBI
T2T-CHM13v2.01446,521,407 - 46,535,692 (+)NCBI
Sequence:
RefSeq Acc Id: NP_000947   ⟸   NM_000956
- UniProtKB: D3DSC0 (UniProtKB/Swiss-Prot),   Q52LG8 (UniProtKB/Swiss-Prot),   P43116 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSP00000450933   ⟸   ENST00000557436
Ensembl Acc Id: ENSP00000245457   ⟸   ENST00000245457

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43116-F1-model_v2 AlphaFold P43116 1-358 view protein structure

Promoters
RGD ID:6791822
Promoter ID:HG_KWN:19381
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:CD4+TCell,   CD4+TCell_12Hour,   Lymphoblastoid
Transcripts:OTTHUMT00000276890
Position:
Human AssemblyChrPosition (strand)Source
Build 361451,850,591 - 51,851,492 (+)MPROMDB
RGD ID:7227611
Promoter ID:EPDNEW_H19552
Type:initiation region
Name:PTGER2_1
Description:prostaglandin E receptor 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh381452,314,312 - 52,314,372EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9594 AgrOrtholog
COSMIC PTGER2 COSMIC
Ensembl Genes ENSG00000125384 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000245457 ENTREZGENE
  ENST00000245457.6 UniProtKB/Swiss-Prot
  ENST00000557436.1 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000125384 GTEx
HGNC ID HGNC:9594 ENTREZGENE
Human Proteome Map PTGER2 Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostglndn_EP2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5732 UniProtKB/Swiss-Prot
NCBI Gene 5732 ENTREZGENE
OMIM 176804 OMIM
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot
PharmGKB PA287 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PROSTANOIDR UniProtKB/Swiss-Prot
  PRSTNOIDEP2R UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D3DSC0 ENTREZGENE
  G3V2Y6_HUMAN UniProtKB/TrEMBL
  P43116 ENTREZGENE, UniProtKB/Swiss-Prot
  Q52LG8 ENTREZGENE
UniProt Secondary D3DSC0 UniProtKB/Swiss-Prot
  Q52LG8 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-17 PTGER2  prostaglandin E receptor 2    prostaglandin E receptor 2 (subtype EP2), 53kDa  Symbol and/or name change 5135510 APPROVED