PTGFR (prostaglandin F receptor) - Rat Genome Database

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Gene: PTGFR (prostaglandin F receptor) Homo sapiens
Analyze
Symbol: PTGFR
Name: prostaglandin F receptor
RGD ID: 737369
HGNC Page HGNC:9600
Description: Enables prostaglandin F receptor activity. Involved in calcium-mediated signaling using intracellular calcium source; cellular response to prostaglandin D stimulus; and positive regulation of cell population proliferation. Located in cytoplasm; extracellular region; and plasma membrane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: FP; FP prostanoid receptor; MGC120498; MGC46203; PGF receptor; PGF2 alpha receptor; PGF2-alpha receptor; prostaglandin F receptor (FP); prostaglandin F2 alpha receptor; prostaglandin F2-alpha receptor; prostaglandin receptor (2-alpha); prostanoid FP receptor
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,490,974 - 78,540,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,303,884 - 78,540,701 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,956,659 - 79,006,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,729,316 - 78,778,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,668,748 - 78,716,495NCBI
Celera177,196,263 - 77,245,909 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef177,088,559 - 77,137,983 (+)NCBIHuRef
CHM1_1179,073,150 - 79,122,783 (+)NCBICHM1_1
T2T-CHM13v2.0178,329,334 - 78,379,549 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1-dichloroethene  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (ISO)
2-methoxyethanol  (ISO)
2-palmitoylglycerol  (EXP)
3-chloropropane-1,2-diol  (ISO)
3-methylcholanthrene  (ISO)
4-tert-Octylphenol  (ISO)
acetamide  (ISO)
aflatoxin B1  (ISO)
AL 8810  (ISO)
ammonium chloride  (ISO)
antirheumatic drug  (EXP)
arsenous acid  (EXP)
asbestos  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[a]pyrene diol epoxide I  (EXP)
beta-naphthoflavone  (ISO)
bisphenol A  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
calcitriol  (EXP)
carbon nanotube  (ISO)
clothianidin  (EXP)
cyclosporin A  (EXP,ISO)
dexamethasone  (EXP)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP)
dibutyl phthalate  (ISO)
diclofenac  (ISO)
Dicyclohexyl phthalate  (ISO)
dimethylarsinic acid  (ISO)
dioxygen  (ISO)
endosulfan  (ISO)
fluprostenol  (EXP)
furan  (ISO)
GW 4064  (ISO)
iron dichloride  (EXP)
lead diacetate  (ISO)
lipopolysaccharide  (EXP,ISO)
metformin  (ISO)
methylarsonic acid  (ISO)
N-nitrosodiethylamine  (ISO)
Nonylphenol  (ISO)
oxidopamine  (EXP)
ozone  (ISO)
p-tert-Amylphenol  (ISO)
paraquat  (ISO)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
progesterone  (EXP,ISO)
prostaglandin F2alpha  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
thioacetamide  (ISO)
titanium dioxide  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
valproic acid  (EXP)
XL147  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
extracellular region  (IDA)
membrane  (IEA)
plasma membrane  (IBA,IDA,IEA,TAS)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. GOAs Human GO annotations GOA_HUMAN data from the GO Consortium
2. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:7759114   PMID:7988697   PMID:8163486   PMID:8253813   PMID:8300593   PMID:9235889   PMID:9341156   PMID:9918852   PMID:10575000   PMID:11951086   PMID:12477932   PMID:12519077  
PMID:14746914   PMID:14764825   PMID:14984197   PMID:15028279   PMID:15118249   PMID:15489334   PMID:15651980   PMID:15748887   PMID:16061484   PMID:16096282   PMID:16378246   PMID:16710414  
PMID:16754659   PMID:16855208   PMID:16911823   PMID:17467803   PMID:17478553   PMID:17496729   PMID:17582204   PMID:18316157   PMID:18508192   PMID:18577758   PMID:18587449   PMID:18703533  
PMID:18818748   PMID:19019335   PMID:19280705   PMID:19289115   PMID:19336370   PMID:19347709   PMID:19527514   PMID:19782748   PMID:19819266   PMID:19913121   PMID:20008143   PMID:20092633  
PMID:20140262   PMID:20237496   PMID:20379614   PMID:20519365   PMID:20536573   PMID:20628086   PMID:20816914   PMID:21873635   PMID:22060278   PMID:22182935   PMID:22919060   PMID:23356224  
PMID:23382691   PMID:24376456   PMID:24457363   PMID:25339146   PMID:25512374   PMID:25704319   PMID:25977569   PMID:26170067   PMID:26186194   PMID:27862086   PMID:28514442   PMID:28584054  
PMID:29773555   PMID:30021884   PMID:33961781   PMID:34174923   PMID:37160891  


Genomics

Comparative Map Data
PTGFR
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38178,490,974 - 78,540,701 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl178,303,884 - 78,540,701 (+)EnsemblGRCh38hg38GRCh38
GRCh37178,956,659 - 79,006,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36178,729,316 - 78,778,974 (+)NCBINCBI36Build 36hg18NCBI36
Build 34178,668,748 - 78,716,495NCBI
Celera177,196,263 - 77,245,909 (+)NCBICelera
Cytogenetic Map1p31.1NCBI
HuRef177,088,559 - 77,137,983 (+)NCBIHuRef
CHM1_1179,073,150 - 79,122,783 (+)NCBICHM1_1
T2T-CHM13v2.0178,329,334 - 78,379,549 (+)NCBIT2T-CHM13v2.0
Ptgfr
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393151,504,247 - 151,543,165 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3151,502,139 - 151,543,267 (-)EnsemblGRCm39 Ensembl
GRCm383151,798,610 - 151,837,528 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3151,796,502 - 151,837,630 (-)EnsemblGRCm38mm10GRCm38
MGSCv373151,461,574 - 151,500,492 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv363151,737,371 - 151,774,818 (-)NCBIMGSCv36mm8
Celera3158,277,266 - 158,316,906 (-)NCBICelera
Cytogenetic Map3H3NCBI
cM Map376.96NCBI
Ptgfr
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82243,390,820 - 243,426,647 (-)NCBIGRCr8
mRatBN7.22240,731,185 - 240,766,674 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2240,733,375 - 240,765,650 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2248,532,501 - 248,564,762 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02246,419,523 - 246,451,794 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02241,298,586 - 241,330,952 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02257,005,813 - 257,039,036 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2257,005,829 - 257,038,105 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02275,684,139 - 275,717,230 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera2232,669,635 - 232,701,826 (-)NCBICelera
RH 3.4 Map21652.91RGD
Cytogenetic Map2q45NCBI
Ptgfr
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542314,768,180 - 14,815,971 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542314,768,208 - 14,816,462 (-)NCBIChiLan1.0ChiLan1.0
PTGFR
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21148,345,010 - 148,397,695 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11147,500,518 - 147,550,952 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0177,714,164 - 77,762,171 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1179,794,831 - 79,841,467 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl179,794,831 - 79,841,467 (+)Ensemblpanpan1.1panPan2
PTGFR
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1668,460,107 - 68,498,793 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl668,460,107 - 68,499,789 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha671,118,473 - 71,157,160 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0669,042,081 - 69,085,711 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl669,042,099 - 69,085,710 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1668,552,458 - 68,591,140 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0668,497,489 - 68,536,279 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0668,982,324 - 69,021,011 (-)NCBIUU_Cfam_GSD_1.0
Ptgfr
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505889,724,967 - 89,764,078 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365715,235,687 - 5,274,432 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365715,235,678 - 5,274,417 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTGFR
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl6134,727,343 - 134,777,072 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.16134,727,334 - 134,777,067 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.26124,884,700 - 124,933,160 (-)NCBISscrofa10.2Sscrofa10.2susScr3
Pig Cytomap6q31-q32NCBI
PTGFR
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12054,660,329 - 54,706,212 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2054,659,197 - 54,704,452 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603362,818,688 - 62,866,086 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptgfr
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474218,723,458 - 18,768,083 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462474218,723,558 - 19,031,578 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in PTGFR
17 total Variants

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p31.1-13.3(chr1:72661709-107456880)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051825]|See cases [RCV000051825] Chr1:72661709..107456880 [GRCh38]
Chr1:73127392..107999502 [GRCh37]
Chr1:72899980..107801025 [NCBI36]
Chr1:1p31.1-13.3
pathogenic
NM_000959.3(PTGFR):c.817G>A (p.Gly273Arg) single nucleotide variant Malignant melanoma [RCV000064909] Chr1:78536424 [GRCh38]
Chr1:79002109 [GRCh37]
Chr1:78774697 [NCBI36]
Chr1:1p31.1
not provided
NM_000959.3(PTGFR):c.1022C>T (p.Ser341Phe) single nucleotide variant Malignant melanoma [RCV000064910] Chr1:78536629 [GRCh38]
Chr1:79002314 [GRCh37]
Chr1:78774902 [NCBI36]
Chr1:1p31.1
not provided
NM_000959.3(PTGFR):c.86C>T (p.Ser29Phe) single nucleotide variant Malignant melanoma [RCV000060249] Chr1:78492829 [GRCh38]
Chr1:78958514 [GRCh37]
Chr1:78731102 [NCBI36]
Chr1:1p31.1
not provided
NM_000959.3(PTGFR):c.1064A>C (p.Lys355Thr) single nucleotide variant Lung cancer [RCV000090993] Chr1:78536671 [GRCh38]
Chr1:79002356 [GRCh37]
Chr1:1p31.1
uncertain significance
NM_000959.3(PTGFR):c.-562T>C single nucleotide variant latanoprost response - Efficacy [RCV000211367] Chr1:78490747 [GRCh38]
Chr1:78956432 [GRCh37]
Chr1:1p31.1
drug response
GRCh38/hg38 1p32.1-22.3(chr1:58819605-86098611)x1 copy number loss See cases [RCV000136913] Chr1:58819605..86098611 [GRCh38]
Chr1:59285277..86564294 [GRCh37]
Chr1:59057865..86336882 [NCBI36]
Chr1:1p32.1-22.3
pathogenic
GRCh38/hg38 1p31.1-22.2(chr1:76419302-88628464)x1 copy number loss See cases [RCV000138957] Chr1:76419302..88628464 [GRCh38]
Chr1:76884987..89094147 [GRCh37]
Chr1:76657575..88866735 [NCBI36]
Chr1:1p31.1-22.2
pathogenic
GRCh38/hg38 1p31.1(chr1:77777821-79122486)x1 copy number loss See cases [RCV000140751] Chr1:77777821..79122486 [GRCh38]
Chr1:78243506..79588171 [GRCh37]
Chr1:78016094..79360759 [NCBI36]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p36.12-12(chr1:20608823-120546301)x3 copy number loss not provided [RCV000762767] Chr1:20608823..120546301 [GRCh37]
Chr1:1p36.12-12
likely benign
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684)x3 copy number gain See cases [RCV000510383] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p31.1-22.1(chr1:72044544-92505091)x1 copy number loss See cases [RCV000510161] Chr1:72044544..92505091 [GRCh37]
Chr1:1p31.1-22.1
pathogenic
GRCh37/hg19 1p31.1(chr1:78633282-79140880)x1 copy number loss See cases [RCV000511847] Chr1:78633282..79140880 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.3-22.3(chr1:64321264-88153669)x1 copy number loss See cases [RCV000511392] Chr1:64321264..88153669 [GRCh37]
Chr1:1p31.3-22.3
pathogenic|uncertain significance
GRCh37/hg19 1p31.1(chr1:74848936-80324850)x3 copy number gain See cases [RCV000510973] Chr1:74848936..80324850 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:849467-249224684) copy number gain See cases [RCV000510926] Chr1:849467..249224684 [GRCh37]
Chr1:1p36.33-q44
pathogenic
NM_000959.4(PTGFR):c.299G>A (p.Arg100His) single nucleotide variant Inborn genetic diseases [RCV003245805] Chr1:78493042 [GRCh38]
Chr1:78958727 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.3-31.1(chr1:61351024-79583933)x1 copy number loss See cases [RCV000512152] Chr1:61351024..79583933 [GRCh37]
Chr1:1p31.3-31.1
pathogenic
GRCh37/hg19 1p31.1(chr1:78889336-79190906)x1 copy number loss not provided [RCV000684593] Chr1:78889336..79190906 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p36.33-q44(chr1:47851-249228449)x3 copy number gain not provided [RCV000736295] Chr1:47851..249228449 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p36.33-q44(chr1:82154-249218992)x3 copy number gain not provided [RCV000736305] Chr1:82154..249218992 [GRCh37]
Chr1:1p36.33-q44
pathogenic
GRCh37/hg19 1p31.1(chr1:78887208-79188388)x1 copy number loss not provided [RCV000736546] Chr1:78887208..79188388 [GRCh37]
Chr1:1p31.1
benign
NM_000959.4(PTGFR):c.653T>C (p.Leu218Ser) single nucleotide variant not provided [RCV000883584] Chr1:78493396 [GRCh38]
Chr1:78959081 [GRCh37]
Chr1:1p31.1
benign
Single allele deletion not provided [RCV000844927] Chr1:66085524..88429789 [GRCh37]
Chr1:1p31.3-22.2
not provided
GRCh37/hg19 1p36.22-21.1(chr1:103343285-103455144)x3 copy number gain Global developmental delay [RCV000787285] Chr1:103343285..103455144 [GRCh37]
Chr1:1p36.22-21.1
uncertain significance
GRCh37/hg19 1p31.1(chr1:78186240-81611776)x3 copy number gain not provided [RCV000846841] Chr1:78186240..81611776 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.1(chr1:78849920-79027405)x3 copy number gain not provided [RCV000848174] Chr1:78849920..79027405 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.1(chr1:78186240-81611776)x3 copy number gain not provided [RCV000847217] Chr1:78186240..81611776 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.1(chr1:78257937-79159519)x3 copy number gain not provided [RCV001005117] Chr1:78257937..79159519 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.3-22.3(chr1:67851233-86101340)x1 copy number loss not provided [RCV000846441] Chr1:67851233..86101340 [GRCh37]
Chr1:1p31.3-22.3
pathogenic
NM_000959.4(PTGFR):c.23A>T (p.Gln8Leu) single nucleotide variant not provided [RCV000894100] Chr1:78492766 [GRCh38]
Chr1:78958451 [GRCh37]
Chr1:1p31.1
benign
GRCh37/hg19 1p31.3-22.1(chr1:68180293-92731957) copy number loss not specified [RCV002053392] Chr1:68180293..92731957 [GRCh37]
Chr1:1p31.3-22.1
pathogenic
NM_000959.4(PTGFR):c.449A>T (p.Lys150Ile) single nucleotide variant Myoepithelial tumor [RCV002463963] Chr1:78493192 [GRCh38]
Chr1:78958877 [GRCh37]
Chr1:1p31.1
uncertain significance
NM_000959.4(PTGFR):c.611T>A (p.Leu204His) single nucleotide variant Inborn genetic diseases [RCV002882347] Chr1:78493354 [GRCh38]
Chr1:78959039 [GRCh37]
Chr1:1p31.1
uncertain significance
NM_000959.4(PTGFR):c.29T>C (p.Val10Ala) single nucleotide variant Inborn genetic diseases [RCV002970185] Chr1:78492772 [GRCh38]
Chr1:78958457 [GRCh37]
Chr1:1p31.1
uncertain significance
NM_000959.4(PTGFR):c.442A>G (p.Thr148Ala) single nucleotide variant Inborn genetic diseases [RCV003004142] Chr1:78493185 [GRCh38]
Chr1:78958870 [GRCh37]
Chr1:1p31.1
uncertain significance
GRCh37/hg19 1p31.1(chr1:78421460-79541287)x3 copy number gain not provided [RCV003484020] Chr1:78421460..79541287 [GRCh37]
Chr1:1p31.1
uncertain significance
NM_000959.4(PTGFR):c.1012A>G (p.Ile338Val) single nucleotide variant not provided [RCV003406570] Chr1:78536619 [GRCh38]
Chr1:79002304 [GRCh37]
Chr1:1p31.1
likely benign
GRCh37/hg19 1p31.1-22.3(chr1:73616197-87012961)x1 copy number loss not provided [RCV003885448] Chr1:73616197..87012961 [GRCh37]
Chr1:1p31.1-22.3
likely pathogenic
NM_000959.4(PTGFR):c.504G>T (p.Leu168Phe) single nucleotide variant Inborn genetic diseases [RCV003379775] Chr1:78493247 [GRCh38]
Chr1:78958932 [GRCh37]
Chr1:1p31.1
uncertain significance
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:3509
Count of miRNA genes:793
Interacting mature miRNAs:930
Transcripts:ENST00000370756, ENST00000370757, ENST00000370758, ENST00000497923
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

Markers in Region
D1S2876  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37178,984,153 - 78,984,369UniSTSGRCh37
Build 36178,756,741 - 78,756,957RGDNCBI36
Celera177,223,689 - 77,223,895RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,115,829 - 77,116,035UniSTS
Marshfield Genetic Map1105.45UniSTS
Marshfield Genetic Map1105.45RGD
Genethon Genetic Map1109.6UniSTS
deCODE Assembly Map1103.43UniSTS
Stanford-G3 RH Map13897.0UniSTS
GeneMap99-GB4 RH Map1212.13UniSTS
Whitehead-YAC Contig Map1 UniSTS
NCBI RH Map1518.0UniSTS
GeneMap99-G3 RH Map13853.0UniSTS
SHGC-150722  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37178,984,202 - 78,984,400UniSTSGRCh37
Build 36178,756,790 - 78,756,988RGDNCBI36
Celera177,223,738 - 77,223,926RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,115,878 - 77,116,066UniSTS
TNG Radiation Hybrid Map144298.0UniSTS
G16225  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37178,995,299 - 78,995,530UniSTSGRCh37
Build 36178,767,887 - 78,768,118RGDNCBI36
Celera177,234,822 - 77,235,053RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,126,952 - 77,127,183UniSTS
SHGC-153836  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37178,958,374 - 78,958,677UniSTSGRCh37
Build 36178,730,962 - 78,731,265RGDNCBI36
Celera177,197,909 - 77,198,212RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,090,205 - 77,090,508UniSTS
TNG Radiation Hybrid Map144312.0UniSTS
PMC170950P7  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37178,958,489 - 78,958,589UniSTSGRCh37
Build 36178,731,077 - 78,731,177RGDNCBI36
Celera177,198,024 - 77,198,124RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,090,320 - 77,090,420UniSTS
G15961  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37179,002,896 - 79,003,144UniSTSGRCh37
Build 36178,775,484 - 78,775,732RGDNCBI36
Celera177,242,419 - 77,242,667RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,134,489 - 77,134,737UniSTS
SHGC-12571  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37179,003,132 - 79,003,463UniSTSGRCh37
Build 36178,775,720 - 78,776,051RGDNCBI36
Celera177,242,655 - 77,242,986RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,134,725 - 77,135,056UniSTS
Whitehead-YAC Contig Map1 UniSTS
GeneMap99-G3 RH Map13853.0UniSTS
SHGC-75045  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh37179,003,137 - 79,003,260UniSTSGRCh37
Build 36178,775,725 - 78,775,848RGDNCBI36
Celera177,242,660 - 77,242,783RGD
Cytogenetic Map1p31.1UniSTS
HuRef177,134,730 - 77,134,853UniSTS
TNG Radiation Hybrid Map144293.0UniSTS
GeneMap99-GB4 RH Map1210.2UniSTS
NCBI RH Map1518.0UniSTS
SHGC-75020  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1p31.1UniSTS
HuRef177,135,609 - 77,135,732UniSTS
TNG Radiation Hybrid Map144268.0UniSTS
GeneMap99-GB4 RH Map1193.67UniSTS
GeneMap99-GB4 RH Map1191.96UniSTS
Whitehead-RH Map1220.9UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 277 421 43 55 18 21 1753 251 665 30 212 46 36 512 1172 1
Low 1846 1412 1119 403 412 276 2196 1444 808 273 918 1201 128 674 1449 1
Below cutoff 196 1075 500 140 878 141 346 481 2174 79 213 252 4 18 167

Sequence

Nucleotide Sequences
RefSeq Transcripts NG_052997 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_000959 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001039585 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017001873 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426085 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_047426101 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337809 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_054337810 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001737338 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_946715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB041713 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AB201108 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF004021 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH007033 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK292845 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312816 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL136324 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY337000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY485530 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC112965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BG771316 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ897935 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CA429969 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CD013876 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471059 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CP068277 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS008570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS008574 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CS008582 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  H02113 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  L24470 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENST00000370756   ⟹   ENSP00000359792
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl178,491,072 - 78,539,749 (+)Ensembl
RefSeq Acc Id: ENST00000370757   ⟹   ENSP00000359793
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl178,490,974 - 78,540,701 (+)Ensembl
RefSeq Acc Id: ENST00000370758   ⟹   ENSP00000359794
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl178,303,884 - 78,539,749 (+)Ensembl
RefSeq Acc Id: ENST00000497923   ⟹   ENSP00000432599
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl178,491,072 - 78,537,010 (+)Ensembl
RefSeq Acc Id: NM_000959   ⟹   NP_000950
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,974 - 78,540,701 (+)NCBI
GRCh37178,956,728 - 79,006,386 (+)ENTREZGENE
Build 36178,729,316 - 78,778,974 (+)NCBI Archive
HuRef177,088,559 - 77,137,983 (+)ENTREZGENE
CHM1_1179,073,150 - 79,122,783 (+)NCBI
T2T-CHM13v2.0178,329,818 - 78,379,549 (+)NCBI
Sequence:
RefSeq Acc Id: NM_001039585   ⟹   NP_001034674
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,974 - 78,540,701 (+)NCBI
GRCh37178,956,728 - 79,006,386 (+)ENTREZGENE
Build 36178,729,316 - 78,778,974 (+)NCBI Archive
HuRef177,088,559 - 77,137,983 (+)ENTREZGENE
CHM1_1179,073,150 - 79,122,783 (+)NCBI
T2T-CHM13v2.0178,329,818 - 78,379,549 (+)NCBI
Sequence:
RefSeq Acc Id: XM_017001873   ⟹   XP_016857362
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,974 - 78,504,514 (+)NCBI
Sequence:
RefSeq Acc Id: XM_047426085   ⟹   XP_047282041
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,974 - 78,540,701 (+)NCBI
RefSeq Acc Id: XM_047426101   ⟹   XP_047282057
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,974 - 78,497,948 (+)NCBI
RefSeq Acc Id: XM_054337809   ⟹   XP_054193784
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0178,329,334 - 78,379,549 (+)NCBI
RefSeq Acc Id: XM_054337810   ⟹   XP_054193785
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
T2T-CHM13v2.0178,329,818 - 78,343,358 (+)NCBI
RefSeq Acc Id: NP_001034674   ⟸   NM_001039585
- Peptide Label: isoform b precursor
- UniProtKB: F2Z2Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_000950   ⟸   NM_000959
- Peptide Label: isoform a precursor
- UniProtKB: Q6RYQ6 (UniProtKB/Swiss-Prot),   Q2KHP3 (UniProtKB/Swiss-Prot),   A8K9Y0 (UniProtKB/Swiss-Prot),   Q9P1X4 (UniProtKB/Swiss-Prot),   P43088 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_016857362   ⟸   XM_017001873
- Peptide Label: isoform X2
- UniProtKB: F2Z2Z6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSP00000359792   ⟸   ENST00000370756
RefSeq Acc Id: ENSP00000359793   ⟸   ENST00000370757
RefSeq Acc Id: ENSP00000359794   ⟸   ENST00000370758
RefSeq Acc Id: ENSP00000432599   ⟸   ENST00000497923
RefSeq Acc Id: XP_047282041   ⟸   XM_047426085
- Peptide Label: isoform X1
- UniProtKB: Q6RYQ6 (UniProtKB/Swiss-Prot),   Q2KHP3 (UniProtKB/Swiss-Prot),   P43088 (UniProtKB/Swiss-Prot),   A8K9Y0 (UniProtKB/Swiss-Prot),   Q9P1X4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_047282057   ⟸   XM_047426101
- Peptide Label: isoform X3
RefSeq Acc Id: XP_054193784   ⟸   XM_054337809
- Peptide Label: isoform X1
- UniProtKB: Q6RYQ6 (UniProtKB/Swiss-Prot),   Q2KHP3 (UniProtKB/Swiss-Prot),   P43088 (UniProtKB/Swiss-Prot),   A8K9Y0 (UniProtKB/Swiss-Prot),   Q9P1X4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: XP_054193785   ⟸   XM_054337810
- Peptide Label: isoform X2
Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P43088-F1-model_v2 AlphaFold P43088 1-359 view protein structure

Promoters
RGD ID:6855980
Promoter ID:EPDNEW_H1155
Type:initiation region
Name:PTGFR_1
Description:prostaglandin F receptor
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_H1154  
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh38178,490,987 - 78,491,047EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:9600 AgrOrtholog
COSMIC PTGFR COSMIC
Ensembl Genes ENSG00000122420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript ENST00000370756 ENTREZGENE
  ENST00000370756.3 UniProtKB/Swiss-Prot
  ENST00000370757 ENTREZGENE
  ENST00000370757.8 UniProtKB/Swiss-Prot
  ENST00000370758.5 UniProtKB/Swiss-Prot
  ENST00000497923.5 UniProtKB/TrEMBL
Gene3D-CATH Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000122420 GTEx
HGNC ID HGNC:9600 ENTREZGENE
Human Proteome Map PTGFR Human Proteome Map
InterPro GPCR_Rhodpsn UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PglndnF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prostanoid_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:5737 UniProtKB/Swiss-Prot
NCBI Gene 5737 ENTREZGENE
OMIM 600563 OMIM
PANTHER PTHR11866 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11866:SF4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA290 PharmGKB
PRINTS GPCRRHODOPSN UniProtKB/Swiss-Prot
  PROSTANOIDR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PRSTNOIDFPR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A8K9Y0 ENTREZGENE
  F2Z2Z6 ENTREZGENE, UniProtKB/TrEMBL
  P43088 ENTREZGENE, UniProtKB/Swiss-Prot
  Q2KHP3 ENTREZGENE
  Q4LEK1_HUMAN UniProtKB/TrEMBL
  Q6RYQ6 ENTREZGENE
  Q71UN9_HUMAN UniProtKB/TrEMBL
  Q9P1X4 ENTREZGENE
UniProt Secondary A8K9Y0 UniProtKB/Swiss-Prot
  Q2KHP3 UniProtKB/Swiss-Prot
  Q6RYQ6 UniProtKB/Swiss-Prot
  Q9P1X4 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-02 PTGFR  prostaglandin F receptor  PTGFR  prostaglandin F receptor (FP)  Symbol and/or name change 5135510 APPROVED