PATHWAY ONTOLOGY - ANNOTATIONS
The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml ).
Term: phosphatidylinositol 3-kinase-Akt signaling pathway
Accession: PW:0000232
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Definition: The phosphatidylinositol 3-kinase-Akt signaling pathway, involving PI3K class I enzymes, particularly class IA, controls various processes such as cell growth, proliferation and survival. Class IA enzymes couple to receptor tyrosine kinases or their adaptors; class IB couple to G-protein-coupled receptors mainly via Galphai. Members of the Akt family of protein kinases are activated downstream of class I PI3Ks and collectively (Akt1, 2, and 3) phosphorylate more than 70 cytoplasmic and nuclear substrates. Deregulation of the pathway has been linked to various forms of cancer.
Synonyms: related_synonym: PI3K Cascade; PI3K-Akt signaling pathway; PI3K/AKT Signaling; phosphoinositide 3-kinase-Akt signaling pathway
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Akt1
AKT serine/threonine kinase 1
ISO IMP
PID RGD
PMID:17641274 PMID:27188433 PMID:17272396 PMID:12084817
PID:200197, RGD:2290458 , RGD:152995510 , RGD:152177689 , RGD:625444
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
IMP ISO
PID RGD
PMID:12089343 PMID:17641274
PID:200197, RGD:632179 , RGD:2290458
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
ISO
PID RGD
PMID:17641274
PID:200197, RGD:2290458
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Bad
BCL2-associated agonist of cell death
ISO
PID
PID:200197
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Casp9
caspase 9
ISO
PID
PID:200197
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Cdkn1a
cyclin-dependent kinase inhibitor 1A
ISO
PID
PID:200197
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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Cdkn1b
cyclin-dependent kinase inhibitor 1B
ISO
PID
PID:200197
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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Chuk
component of inhibitor of nuclear factor kappa B kinase complex
ISO
PID
PID:200197
NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
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Ckb
creatine kinase B
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 6:130,729,420...130,732,301
Ensembl chr 6:130,729,423...130,732,315
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Esr1
estrogen receptor 1
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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Foxo1
forkhead box O1
ISO
PID
PID:200197
NCBI chr 2:136,312,168...136,390,603
Ensembl chr 2:136,312,168...136,387,790
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Foxo3
forkhead box O3
ISO
PID
PID:200197
NCBI chr20:45,669,708...45,764,606
Ensembl chr20:45,672,995...45,764,561
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Foxo4
forkhead box O4
ISO
PID
PID:200197
NCBI chr X:66,385,241...66,392,115
Ensembl chr X:66,385,558...66,392,115
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Gsk3a
glycogen synthase kinase 3 alpha
ISO
PID
PID:200197
NCBI chr 1:80,815,843...80,825,732
Ensembl chr 1:80,815,850...80,825,802
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Gsk3b
glycogen synthase kinase 3 beta
ISO
PID
PID:200197
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Hif1a
hypoxia inducible factor 1 subunit alpha
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hsp90aa1
heat shock protein 90 alpha family class A member 1
ISO
PID
PID:200197
NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
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Inpp5d
inositol polyphosphate-5-phosphatase D
ISO
RGD
PMID:17371235
RGD:2302068
NCBI chr 9:88,287,680...88,392,748
Ensembl chr 9:88,287,677...88,392,746
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Inppl1
inositol polyphosphate phosphatase-like 1
ISO
RGD
PMID:17371235
RGD:2302068
NCBI chr 1:156,183,043...156,197,500
Ensembl chr 1:156,183,059...156,197,500
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Insr
insulin receptor
IEP
RGD
PMID:29896241 PMID:25352008
RGD:14700925 , RGD:14700927
NCBI chr12:1,193,193...1,330,976
Ensembl chr12:1,197,100...1,330,883
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Kpna1
karyopherin subunit alpha 1
ISO
PID
PID:200197
NCBI chr11:64,715,844...64,774,647
Ensembl chr11:64,717,563...64,774,623
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Map3k5
mitogen-activated protein kinase kinase kinase 5
ISO
PID
PID:200197
NCBI chr 1:14,685,776...14,904,935
Ensembl chr 1:14,685,492...14,904,800
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Mapkap1
MAPK associated protein 1
ISO
PID
PID:200197
NCBI chr 3:17,715,813...17,918,387
Ensembl chr 3:17,715,834...17,918,384
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Mlst8
MTOR associated protein, LST8 homolog
ISO
PID
PID:200197
NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
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Mtor
mechanistic target of rapamycin kinase
ISO
PID
PID:200197
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Pdpk1
3-phosphoinositide dependent protein kinase-1
ISO
PID RGD
PMID:17641274
PID:200197, RGD:2290458
NCBI chr10:13,105,435...13,182,664
Ensembl chr10:13,105,498...13,174,623
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Pgr
progesterone receptor
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 8:6,072,673...6,131,552
Ensembl chr 8:6,072,673...6,131,344
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Phlpp1
PH domain and leucine rich repeat protein phosphatase 1
ISO
RGD
PMID:24794538
RGD:11535053
NCBI chr13:22,308,532...22,530,978
Ensembl chr13:22,308,548...22,530,977
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Phlpp2
PH domain and leucine rich repeat protein phosphatase 2
ISO
RGD
PMID:24794538
RGD:11535053
NCBI chr19:37,835,125...37,901,804
Ensembl chr19:37,835,125...37,905,513
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
RGD
PMID:17641274 PMID:27188433
RGD:2290458 , RGD:152995510
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pik3cb
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
ISO
RGD
PMID:17641274
RGD:2290458
NCBI chr 8:99,594,600...99,699,772
Ensembl chr 8:99,594,644...99,699,663
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Pik3cd
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
ISO
RGD
PMID:17641274 PMID:26311905 PMID:29893841
RGD:2290458 , RGD:40890274 , RGD:40890270
NCBI chr 5:160,094,952...160,142,962
Ensembl chr 5:160,094,952...160,120,930
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Pik3cg
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
ISO IMP
RGD
PMID:29666415 PMID:29323718 PMID:21665152
RGD:38599151 , RGD:38599216 , RGD:38599159
NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043
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Pik3r1
phosphoinositide-3-kinase regulatory subunit 1
ISO
RGD
PMID:17641274
RGD:2290458
NCBI chr 2:32,878,942...32,963,668
Ensembl chr 2:32,882,032...32,963,631
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Pik3r2
phosphoinositide-3-kinase regulatory subunit 2
ISO
RGD
PMID:17641274
RGD:2290458
NCBI chr16:18,665,517...18,674,067
Ensembl chr16:18,665,457...18,674,065
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Pik3r3
phosphoinositide-3-kinase regulatory subunit 3
ISO
RGD
PMID:17641274
RGD:2290458
NCBI chr 5:129,700,925...129,772,591
Ensembl chr 5:129,701,229...129,772,583
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Ppp2ca
protein phosphatase 2 catalytic subunit alpha
ISO
RGD
PMID:23454242
RGD:11535052
NCBI chr10:36,358,110...36,377,864
Ensembl chr10:36,358,101...36,377,862
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Ppp2cb
protein phosphatase 2 catalytic subunit beta
ISO
RGD
PMID:23454242
RGD:11535052
NCBI chr16:58,558,119...58,579,325
Ensembl chr16:58,558,122...58,579,576
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Ppp2r1a
protein phosphatase 2 scaffold subunit A alpha
ISO
RGD
PMID:23454242
RGD:11535052
NCBI chr 1:60,540,223...60,559,467
Ensembl chr 1:60,540,194...60,560,129
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Ppp2r1b
protein phosphatase 2 scaffold subunit A beta
ISO
RGD
PMID:23454242
RGD:11535052
NCBI chr 8:51,195,860...51,228,442
Ensembl chr 8:51,186,717...51,228,485
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Ppp2r2a
protein phosphatase 2, regulatory subunit B, alpha
ISO
RGD
PMID:23454242
RGD:11535052
NCBI chr15:41,204,659...41,263,924
Ensembl chr15:41,204,200...41,263,924
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Prkaca
protein kinase cAMP-activated catalytic subunit alpha
ISO
PID
PID:200197
NCBI chr19:24,155,081...24,178,430
Ensembl chr19:24,155,090...24,178,430
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Prkdc
protein kinase, DNA-activated, catalytic subunit
ISO
PID
PID:200197
NCBI chr11:85,040,790...85,258,357
Ensembl chr11:85,040,792...85,257,952
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Pten
phosphatase and tensin homolog
ISO
RGD
PMID:17641274 PMID:27188433
RGD:2290458 , RGD:152995510
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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Raf1
Raf-1 proto-oncogene, serine/threonine kinase
ISO
PID
PID:200197
NCBI chr 4:148,679,534...148,740,265
Ensembl chr 4:148,679,530...148,740,317
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Rictor
RPTOR independent companion of MTOR, complex 2
ISO
PID
PID:200197
NCBI chr 2:55,811,877...55,903,893
Ensembl chr 2:55,811,322...55,901,426
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Sfn
stratifin
ISO
PID
PID:200197
NCBI chr 5:145,826,722...145,827,994
Ensembl chr 5:145,826,201...145,831,314
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Slc2a4
solute carrier family 2 member 4
ISO
PID
PID:200197
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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Sp1
Sp1 transcription factor
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 7:133,541,302...133,571,961
Ensembl chr 7:133,541,491...133,571,961
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Src
SRC proto-oncogene, non-receptor tyrosine kinase
ISO
PID
PID:200197
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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Tbc1d4
TBC1 domain family, member 4
ISO
PID
PID:200197
NCBI chr15:78,256,030...78,434,168
Ensembl chr15:78,257,121...78,434,265
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Vegfa
vascular endothelial growth factor A
IMP
RGD
PMID:17272396
RGD:152177689
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Ywhab
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ISO
PID
PID:200197
NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
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Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ISO
PID
PID:200197
NCBI chr10:60,584,665...60,622,352
Ensembl chr10:60,584,652...60,671,589
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Ywhag
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma
ISO
PID
PID:200197
NCBI chr12:20,744,500...20,772,828
Ensembl chr12:20,744,535...20,772,827
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Ywhah
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta
ISO
PID
PID:200197
NCBI chr14:77,696,332...77,705,715
Ensembl chr14:77,696,333...77,705,741
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Ywhaq
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
ISO
PID
PID:200197
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
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Ywhaz
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ISO
PID
PID:200197
NCBI chr 7:67,941,353...67,963,651
Ensembl chr 7:67,940,017...67,963,668
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Akt1
AKT serine/threonine kinase 1
ISO
RGD
PMID:18955974 PMID:21277552
RGD:2313763 , RGD:5133243
NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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Akt2
AKT serine/threonine kinase 2
ISO
RGD
PMID:18955974 PMID:15166380 PMID:19506583
RGD:2313763 , RGD:2313408 , RGD:5490965
NCBI chr 1:82,877,228...82,933,828
Ensembl chr 1:82,883,547...82,933,817
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Akt3
AKT serine/threonine kinase 3
ISO
RGD
PMID:18955974
RGD:2313763
NCBI chr13:88,943,708...89,225,831
Ensembl chr13:88,946,091...89,225,708
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Pik3ca
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
ISO
RGD
PMID:18955974 PMID:19078924 PMID:20951313 PMID:21277552
RGD:2313763 , RGD:4143515 , RGD:5133242 , RGD:5133243
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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Pten
phosphatase and tensin homolog
ISO
RGD
PMID:18955974 PMID:19506583 PMID:20951313 PMID:19078924 PMID:18008377
RGD:2313763 , RGD:5490965 , RGD:5133242 , RGD:4143515 , RGD:2326139
NCBI chr 1:230,630,443...230,697,070
Ensembl chr 1:230,630,338...230,696,838
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