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Pathways
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ONTOLOGY REPORT - ANNOTATIONS

Term:tumor necrosis factor-mediated signaling pathway
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Accession:GO:0033209 term browser browse the term
Definition:The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.
Synonyms:exact_synonym: tumor necrosis factor-mediated signalling pathway
 narrow_synonym: TNF-alpha-mediated signaling pathway;   tumor necrosis factor alpha-mediated signaling pathway
 related_synonym: adipocytokine signaling pathway


show annotations for term's descendants           Sort by:
tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Actn4 actinin alpha 4 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:28,592,673...28,661,799
Ensembl chr 7:28,592,673...28,661,765 		JBrowse link
G Adam17 a disintegrin and metallopeptidase domain 17 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Aim2 absent in melanoma 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:173,177,105...173,293,606
Ensembl chr 1:173,178,445...173,293,606 		JBrowse link
G Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 involved_in ISO (PMID:23389627) AgBase PMID:23389627 NCBI chr 3:88,500,427...88,556,839
Ensembl chr 3:88,513,273...88,555,359 		JBrowse link
G Birc2 baculoviral IAP repeat-containing 2 involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr 9:7,818,227...7,837,123
Ensembl chr 9:7,818,228...7,837,065 		JBrowse link
G Card14 caspase recruitment domain family, member 14 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:119,197,923...119,236,205
Ensembl chr11:119,198,594...119,236,201 		JBrowse link
G Cd70 CD70 antigen involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr17:57,452,997...57,456,777
Ensembl chr17:57,452,997...57,456,777 		JBrowse link
G Cdip1 cell death inducing Trp53 target 1 acts_upstream_of_or_within ISO MGI GO_REF:0000008 NCBI chr16:4,583,325...4,608,156
Ensembl chr16:4,568,212...4,608,156 		JBrowse link
G Chuk conserved helix-loop-helix ubiquitous kinase involved_in IBA
TAS		 (PMID:30755793) GO_Central
MGI		 PMID:30755793 GO_REF:0000033 NCBI chr19:44,061,773...44,095,940
Ensembl chr19:44,061,774...44,095,919 		JBrowse link
G Commd7 COMM domain containing 7 involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:153,458,850...153,474,712
Ensembl chr 2:153,458,853...153,474,701 		JBrowse link
G Eda2r ectodysplasin A2 receptor involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr  X:96,375,936...96,420,786
Ensembl chr  X:96,377,446...96,420,822 		JBrowse link
G Eed embryonic ectoderm development involved_in ISO (PMID:20080539) MGI PMID:20080539 NCBI chr 7:89,603,862...89,630,184
Ensembl chr 7:89,603,862...89,630,191 		JBrowse link
G Eif5a eukaryotic translation initiation factor 5A involved_in ISO (PMID:17187778) UniProt PMID:17187778 NCBI chr11:69,807,538...69,812,784
Ensembl chr11:69,807,540...69,812,784 		JBrowse link
G Foxo3 forkhead box O3 involved_in ISO (PMID:15084260) UniProt PMID:15084260 NCBI chr10:42,057,841...42,152,691
Ensembl chr10:42,057,837...42,152,751 		JBrowse link
G Ikbkb inhibitor of kappaB kinase beta involved_in IMP
TAS
IBA
ISO		 (MGI:5693235|PMID:15084260)
(PMID:30755793)		 UniProt
MGI
GO_Central		 PMID:15084260 PMID:30755793 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5693235 NCBI chr 8:23,149,228...23,196,605
Ensembl chr 8:23,149,228...23,196,605 		JBrowse link
G Ikbkg inhibitor of kappaB kinase gamma involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr  X:73,436,883...73,498,013
Ensembl chr  X:73,436,896...73,497,460 		JBrowse link
G Ilk integrin linked kinase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:105,385,797...105,392,132
Ensembl chr 7:105,385,799...105,392,132 		JBrowse link
G Jak2 Janus kinase 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:29,229,006...29,290,495
Ensembl chr19:29,229,228...29,290,480 		JBrowse link
G Krt18 keratin 18 acts_upstream_of_or_within IGI (PMID:10747083) MGI PMID:10747083 NCBI chr15:101,936,651...101,940,461
Ensembl chr15:101,936,615...101,940,462 		JBrowse link
G Krt8 keratin 8 acts_upstream_of_or_within IMP
IGI		 (PMID:10747083) MGI PMID:10747083 NCBI chr15:101,905,146...101,912,777
Ensembl chr15:101,905,133...101,912,917 		JBrowse link
G Lims1 LIM and senescent cell antigen-like domains 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr10:58,159,164...58,260,513
Ensembl chr10:58,159,288...58,260,513 		JBrowse link
G Mir34a microRNA 34a involved_in ISO (PMID:26949937) ARUK-UCL PMID:26949937 NCBI chr 4:150,152,911...150,153,012
Ensembl chr 4:150,152,911...150,153,012 		JBrowse link
G Nfkbia nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:55,536,194...55,539,432
Ensembl chr12:55,536,195...55,539,432 		JBrowse link
G Nsmaf neutral sphingomyelinase (N-SMase) activation associated factor involved_in ISO
IMP		 (PMID:8808629)
(PMID:14985352)		 MGI PMID:8808629 PMID:14985352 NCBI chr 4:6,396,207...6,454,840
Ensembl chr 4:6,396,207...6,454,271 		JBrowse link
G Plvap plasmalemma vesicle associated protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:71,950,397...71,964,446
Ensembl chr 8:71,950,409...71,964,396 		JBrowse link
G Ptk2b PTK2 protein tyrosine kinase 2 beta involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr14:66,390,706...66,518,549
Ensembl chr14:66,390,706...66,518,501 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Rack1 receptor for activated C kinase 1 involved_in ISO (PMID:12391233) MGI PMID:12391233 NCBI chr11:48,691,187...48,697,068
Ensembl chr11:48,691,159...48,697,261 		JBrowse link
G Rbck1 RanBP-type and C3HC4-type zinc finger containing 1 involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr 2:152,158,254...152,174,592
Ensembl chr 2:152,158,254...152,174,573 		JBrowse link
G Rela v-rel reticuloendotheliosis viral oncogene homolog A (avian) involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr19:5,686,993...5,698,162
Ensembl chr19:5,687,511...5,698,158 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Rnf31 ring finger protein 31 involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr14:55,829,199...55,841,131
Ensembl chr14:55,829,165...55,841,150 		JBrowse link
G Rraga Ras-related GTP binding A involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 4:86,493,910...86,495,522
Ensembl chr 4:86,493,905...86,495,522 		JBrowse link
G Sharpin SHANK-associated RH domain interacting protein involved_in TAS (PMID:30755793) MGI PMID:30755793 NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311 		JBrowse link
G St18 suppression of tumorigenicity 18 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:6,557,455...6,931,164
Ensembl chr 1:6,557,455...6,931,164 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 1:52,158,588...52,201,024
Ensembl chr 1:52,158,599...52,201,024 		JBrowse link
G Tifa TRAF-interacting protein with forkhead-associated domain involved_in IPI (PMID:11798190) MGI PMID:11798190 NCBI chr 3:127,582,524...127,592,043
Ensembl chr 3:127,583,454...127,625,813 		JBrowse link
G Tmsb4x thymosin, beta 4, X chromosome acts_upstream_of_or_within_positive_effect ISO (PMID:21343177) CAFA PMID:21343177 NCBI chr  X:165,990,089...165,996,475
Ensembl chr  X:165,990,089...165,992,311 		JBrowse link
G Tnf tumor necrosis factor involved_in
acts_upstream_of_or_within		 ISO
IDA
TAS
IBA		 (PMID:10411298), (PMID:14985352)
(PMID:30755793)
(PMID:3898078)		 MGI
GO_Central		 PMID:3898078 PMID:10411298 PMID:14985352 PMID:30755793 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr17:35,418,343...35,420,983
Ensembl chr17:35,418,357...35,420,983 		JBrowse link
G Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a, NFKB activator involved_in IMP
IBA
ISO		 (MGI:4413614|PMID:19940926) BHF-UCL
GO_Central
MGI		 PMID:19940926 GO_REF:0000033 GO_REF:0000119 MGI:4413614 MGI:4834177 NCBI chr 1:105,708,443...105,777,172
Ensembl chr 1:105,708,443...105,775,709 		JBrowse link
G Tnfrsf13c tumor necrosis factor receptor superfamily, member 13c involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr15:82,105,943...82,108,581
Ensembl chr15:82,105,944...82,108,570 		JBrowse link
G Tnfrsf17 tumor necrosis factor receptor superfamily, member 17 involved_in IEA UniProt GO_REF:0000002 MGI:2152098 NCBI chr16:11,131,131...11,137,938
Ensembl chr16:11,131,676...11,137,938 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a involved_in
acts_upstream_of_or_within		 ISO
TAS
IGI
IMP		 (PMID:30755793)
(PMID:14985352)
(MGI:2152007|PMID:11588035)		 RGD
MGI
GOC		 PMID:11588035 PMID:14985352 PMID:20967881 PMID:30755793 GO_REF:0000096 GO_REF:0000119 MGI:2152007 MGI:4417868 MGI:4834177 RGD:5130945 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
G Tnfrsf4 tumor necrosis factor receptor superfamily, member 4 acts_upstream_of_or_within IPI (MGI:2683815|PMID:14635034) GOC PMID:14635034 MGI:2683815 NCBI chr 4:156,098,049...156,101,070
Ensembl chr 4:156,098,300...156,101,069 		JBrowse link
G Tnfsf11 tumor necrosis factor (ligand) superfamily, member 11 involved_in
acts_upstream_of_or_within		 IGI
IDA
ISO		 (MGI:4413614|PMID:19940926)
(PMID:17442941), (PMID:18269914), (PMID:22437732)		 BHF-UCL
MGI		 PMID:17442941 PMID:18269914 PMID:19940926 PMID:22437732 GO_REF:0000119 MGI:4413614 MGI:4834177 NCBI chr14:78,514,886...78,545,483
Ensembl chr14:78,514,885...78,545,483 		JBrowse link
G Tnfsf13b tumor necrosis factor (ligand) superfamily, member 13b involved_in IGI (PMID:18624351) MGI PMID:18624351 NCBI chr 8:10,056,637...10,086,000
Ensembl chr 8:10,056,467...10,089,072 		JBrowse link
G Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 involved_in IMP
IBA		 (MGI:5306317|PMID:14521928) UniProt
GO_Central		 PMID:14521928 GO_REF:0000033 MGI:5306317 NCBI chr 1:161,322,221...161,333,903
Ensembl chr 1:161,322,224...161,332,859 		JBrowse link
G Tradd TNFRSF1A-associated via death domain involved_in ISO
TAS		 (PMID:30755793) MGI PMID:30755793 GO_REF:0000119 MGI:4834177 NCBI chr 8:105,985,207...105,991,226
Ensembl chr 8:105,984,918...105,991,241 		JBrowse link
G Traf1 TNF receptor-associated factor 1 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:34,831,762...34,851,784
Ensembl chr 2:34,831,762...34,851,784 		JBrowse link
G Traf2 TNF receptor-associated factor 2 involved_in ISO
TAS
IBA
IDA		 (PMID:30755793)
(PMID:8710854)		 RGD
MGI
GO_Central		 PMID:8710854 PMID:10713108 PMID:20967881 PMID:30755793 GO_REF:0000033 GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 RGD:2298798 RGD:5130945 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Traf3 TNF receptor-associated factor 3 involved_in IMP
IBA
ISO		 (MGI:3722053|PMID:17015635) UniProt
GO_Central
MGI		 PMID:17015635 GO_REF:0000033 GO_REF:0000119 MGI:3722053 MGI:4834177 NCBI chr12:111,132,799...111,233,589
Ensembl chr12:111,132,804...111,233,587 		JBrowse link
G Traf3ip2 TRAF3 interacting protein 2 involved_in IGI (PMID:18624351) MGI PMID:18624351 NCBI chr10:39,488,930...39,531,303
Ensembl chr10:39,488,930...39,531,303 		JBrowse link
G Traf5 TNF receptor-associated factor 5 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 1:191,729,164...191,776,899
Ensembl chr 1:191,729,166...191,776,868 		JBrowse link
G Traf6 TNF receptor-associated factor 6 involved_in IBA GO_Central GO_REF:0000033 NCBI chr 2:101,508,765...101,532,013
Ensembl chr 2:101,508,774...101,532,014 		JBrowse link
G Trp53 transformation related protein 53 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:69,471,174...69,482,699
Ensembl chr11:69,471,185...69,482,699 		JBrowse link
G Txndc17 thioredoxin domain containing 17 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:72,098,380...72,101,313
Ensembl chr11:72,098,373...72,100,841 		JBrowse link
G Umod uromodulin acts_upstream_of_or_within IMP (PMID:28990932) MGI PMID:28990932 NCBI chr 7:119,061,931...119,078,485
Ensembl chr 7:119,061,934...119,078,505 		JBrowse link
negative regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr16:22,965,286...22,976,718
Ensembl chr16:22,965,286...22,976,778 		JBrowse link
G Apoa1 apolipoprotein A-I involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:46,139,928...46,141,767
Ensembl chr 9:46,139,878...46,141,764 		JBrowse link
G Birc7 baculoviral IAP repeat-containing 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:180,570,402...180,575,803
Ensembl chr 2:180,570,816...180,575,803 		JBrowse link
G Ccdc3 coiled-coil domain containing 3 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 2:5,142,587...5,235,682
Ensembl chr 2:5,142,587...5,235,689 		JBrowse link
G Cldn18 claudin 18 acts_upstream_of_or_within IMP (PMID:22437732) MGI PMID:22437732 NCBI chr 9:99,572,849...99,599,320
Ensembl chr 9:99,571,514...99,599,320 		JBrowse link
G Dicer1 dicer 1, ribonuclease type III acts_upstream_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:104,654,001...104,718,331
Ensembl chr12:104,654,001...104,718,211 		JBrowse link
G F2rl1 F2R like trypsin receptor 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:95,648,226...95,661,748
Ensembl chr13:95,648,240...95,661,735 		JBrowse link
G Gas6 growth arrest specific 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:13,515,374...13,544,535
Ensembl chr 8:13,515,374...13,544,490 		JBrowse link
G Gps2 G protein pathway suppressor 2 involved_in IMP (MGI:6148454|PMID:22424771) UniProt PMID:22424771 MGI:6148454 NCBI chr11:69,804,805...69,807,882
Ensembl chr11:69,804,714...69,807,417 		JBrowse link
G H2bc21 H2B clustered histone 21 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:96,128,435...96,131,057
Ensembl chr 3:96,128,435...96,131,054 		JBrowse link
G Mir125b-1 microRNA 125b-1 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 9:41,493,222...41,493,298
Ensembl chr 9:41,493,222...41,493,298 		JBrowse link
G Mir125b-2 microRNA 125b-2 acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr16:77,443,161...77,443,231
Ensembl chr16:77,443,161...77,443,231 		JBrowse link
G Mir130a microRNA 130a acts_upstream_of ISO (PMID:26435691) ARUK-UCL PMID:26435691 NCBI chr 2:84,571,459...84,571,522
Ensembl chr 2:84,571,459...84,571,522 		JBrowse link
G Mir152 microRNA 152 involved_in ISO (PMID:24813629) BHF-UCL PMID:24813629 NCBI chr11:96,741,219...96,741,291
Ensembl chr11:96,741,219...96,741,291 		JBrowse link
G Mir27b microRNA 27b acts_upstream_of_or_within ISO (PMID:31124343) ARUK-UCL PMID:31124343 NCBI chr13:63,448,526...63,448,598
Ensembl chr13:63,448,526...63,448,598 		JBrowse link
G Naip1 NLR family, apoptosis inhibitory protein 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,544,272...100,589,372
Ensembl chr13:100,544,272...100,589,377 		JBrowse link
G Naip2 NLR family, apoptosis inhibitory protein 2 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,280,571...100,338,630
Ensembl chr13:100,280,571...100,338,600 		JBrowse link
G Naip5 NLR family, apoptosis inhibitory protein 5 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,348,243...100,387,437
Ensembl chr13:100,348,247...100,382,831 		JBrowse link
G Naip6 NLR family, apoptosis inhibitory protein 6 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:100,417,629...100,453,124
Ensembl chr13:100,417,629...100,454,182 		JBrowse link
G Naip7 NLR family, apoptosis inhibitory protein 7 involved_in ISO MGI GO_REF:0000119 MGI:4834177
G Nol3 nucleolar protein 3 (apoptosis repressor with CARD domain) involved_in IMP (MGI:5617337|PMID:24440909) UniProt PMID:24440909 MGI:5617337 NCBI chr 8:106,002,777...106,008,571
Ensembl chr 8:106,002,772...106,008,571 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 involved_in IMP (MGI:5707586|PMID:18972444) UniProt PMID:18972444 MGI:5707586 NCBI chr10:89,290,096...89,369,484
Ensembl chr10:89,290,096...89,369,447 		JBrowse link
G Peli3 pellino 3 acts_upstream_of_or_within IMP
ISO		 (PMID:23950925) MGI PMID:23950925 GO_REF:0000008 NCBI chr19:4,979,745...4,993,155
Ensembl chr19:4,979,745...4,993,155 		JBrowse link
G Pias4 protein inhibitor of activated STAT 4 acts_upstream_of_or_within IMP (PMID:20054338) MGI PMID:20054338 NCBI chr10:80,989,795...81,003,554
Ensembl chr10:80,989,100...81,003,757 		JBrowse link
G Ppp2cb protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform acts_upstream_of ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 8:34,089,672...34,109,831
Ensembl chr 8:34,089,653...34,109,469 		JBrowse link
G Ptpn2 protein tyrosine phosphatase, non-receptor type 2 involved_in IMP (MGI:3530208|PMID:15696169) UniProt PMID:15696169 MGI:3530208 NCBI chr18:67,798,571...67,857,697
Ensembl chr18:67,798,581...67,857,665 		JBrowse link
G Rffl ring finger and FYVE like domain containing protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr11:82,694,645...82,762,065
Ensembl chr11:82,693,275...82,762,036 		JBrowse link
G Tank TRAF family member-associated Nf-kappa B activator involved_in IDA (PMID:8710854) MGI PMID:8710854 NCBI chr 2:61,408,901...61,484,515
Ensembl chr 2:61,408,929...61,484,515 		JBrowse link
G Tjp2 tight junction protein 2 acts_upstream_of_or_within IMP (PMID:22437732) MGI PMID:22437732 NCBI chr19:24,071,860...24,202,492
Ensembl chr19:24,071,869...24,202,394 		JBrowse link
G Tnfrsf11b tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) acts_upstream_of_or_within IDA (PMID:29415886) MGI PMID:29415886 NCBI chr15:54,114,014...54,141,700
Ensembl chr15:54,114,015...54,141,880 		JBrowse link
G Traip TRAF-interacting protein involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:107,828,158...107,849,469
Ensembl chr 9:107,827,335...107,849,469 		JBrowse link
G Xiap X-linked inhibitor of apoptosis involved_in ISO (PMID:11865055) UniProt PMID:11865055 NCBI chr  X:41,148,483...41,198,541
Ensembl chr  X:41,148,556...41,198,533 		JBrowse link
positive regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adam17 a disintegrin and metallopeptidase domain 17 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr12:21,373,510...21,423,633
Ensembl chr12:21,373,510...21,423,633 		JBrowse link
G Casp1 caspase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 9:5,298,517...5,307,281
Ensembl chr 9:5,298,508...5,307,290 		JBrowse link
G Casp4 caspase 4, apoptosis-related cysteine peptidase involved_in ISO (PMID:16920334) UniProt PMID:16920334 NCBI chr 9:5,308,816...5,336,791
Ensembl chr 9:5,308,828...5,336,783 		JBrowse link
G Cpne1 copine I involved_in ISO
IBA		 MGI
GO_Central		 GO_REF:0000033 GO_REF:0000119 MGI:4834177 NCBI chr 2:155,913,765...155,953,847
Ensembl chr 2:155,913,762...155,953,885 		JBrowse link
G Hspa1a heat shock protein 1A involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr17:35,188,335...35,191,132
Ensembl chr17:35,188,166...35,191,132 		JBrowse link
G Hspa1b heat shock protein 1B involved_in ISO (PMID:24790089) UniProt PMID:24790089 NCBI chr17:35,175,405...35,178,214
Ensembl chr17:35,175,412...35,178,214 		JBrowse link
G Laptm5 lysosomal-associated protein transmembrane 5 involved_in IMP (MGI:6391873|PMID:22733818) ARUK-UCL PMID:22733818 MGI:6391873 NCBI chr 4:130,640,627...130,663,459
Ensembl chr 4:130,640,436...130,663,452 		JBrowse link
G Mmp8 matrix metallopeptidase 8 involved_in IMP (MGI:6201889|PMID:25049354) ARUK-UCL PMID:25049354 MGI:6201889 NCBI chr 9:7,558,430...7,568,487
Ensembl chr 9:7,558,457...7,568,486 		JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr17:11,059,227...12,282,257
Ensembl chr17:11,059,271...12,282,248 		JBrowse link
G Ripk1 receptor (TNFRSF)-interacting serine-threonine kinase 1 involved_in IDA (MGI:6271183|PMID:30439713) ARUK-UCL PMID:30439713 MGI:6271183 NCBI chr13:34,181,072...34,219,153
Ensembl chr13:34,186,346...34,221,130 		JBrowse link
G Traf2 TNF receptor-associated factor 2 involved_in IDA (MGI:5616328|PMID:11374864) AgBase PMID:11374864 MGI:5616328 NCBI chr 2:25,407,994...25,436,952
Ensembl chr 2:25,407,994...25,436,952 		JBrowse link
G Trim32 tripartite motif-containing 32 acts_upstream_of_or_within IMP (PMID:20054338) MGI PMID:20054338 NCBI chr 4:65,523,223...65,534,477
Ensembl chr 4:65,523,223...65,534,475 		JBrowse link
G Ube2k ubiquitin-conjugating enzyme E2K involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 5:65,694,588...65,756,332
Ensembl chr 5:65,694,576...65,756,331 		JBrowse link
regulation of tumor necrosis factor-mediated signaling pathway term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyld CYLD lysine 63 deubiquitinase involved_in IDA
ISO		 (MGI:5912943|PMID:28701375) UniProt
MGI		 PMID:28701375 GO_REF:0000119 MGI:4834177 MGI:5912943 NCBI chr 8:89,423,506...89,478,574
Ensembl chr 8:89,423,675...89,478,573 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 acts_upstream_of_or_within IMP (PMID:29415886) MGI PMID:29415886 NCBI chr15:52,931,657...53,209,579
Ensembl chr15:52,927,434...53,209,555 		JBrowse link
G Hipk1 homeodomain interacting protein kinase 1 involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 3:103,647,131...103,699,210
Ensembl chr 3:103,647,131...103,698,879 		JBrowse link
G Nkiras1 NFKB inhibitor interacting Ras-like protein 1 acts_upstream_of_or_within IGI (PMID:25220458) MGI PMID:25220458 NCBI chr14:4,185,693...4,198,560
Ensembl chr14:4,185,693...4,198,560 		JBrowse link
G Nkiras2 NFKB inhibitor interacting Ras-like protein 2 acts_upstream_of_or_within IGI (PMID:25220458) MGI PMID:25220458 NCBI chr11:100,510,007...100,518,436
Ensembl chr11:100,510,070...100,518,433 		JBrowse link
G Otulin OTU deubiquitinase with linear linkage specificity involved_in IMP
IBA
ISO		 (MGI:5804663|PMID:27523608), (MGI:6192867|PMID:29950720) UniProt
GO_Central
MGI		 PMID:27523608 PMID:29950720 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5804663 MGI:6192867 NCBI chr15:27,606,005...27,630,793
Ensembl chr15:27,542,721...27,630,779 		JBrowse link
G Pias3 protein inhibitor of activated STAT 3 acts_upstream_of_or_within IDA (PMID:17442941) MGI PMID:17442941 NCBI chr 3:96,603,679...96,613,386
Ensembl chr 3:96,603,700...96,613,386 		JBrowse link
G Pycard PYD and CARD domain containing involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr 7:127,590,545...127,593,039
Ensembl chr 7:127,588,880...127,593,039 		JBrowse link
G Sharpin SHANK-associated RH domain interacting protein involved_in IMP
ISO		 (MGI:4947438|PMID:21455180), (MGI:4947439|PMID:21455173) UniProt
MGI		 PMID:21455173 PMID:21455180 GO_REF:0000119 MGI:4834177 MGI:4947438 MGI:4947439 NCBI chr15:76,231,240...76,235,310
Ensembl chr15:76,231,240...76,235,311 		JBrowse link
G Spata2 spermatogenesis associated 2 involved_in IMP
IBA
ISO		 (MGI:5912943|PMID:28701375) UniProt
GO_Central
MGI		 PMID:28701375 GO_REF:0000033 GO_REF:0000119 MGI:4834177 MGI:5912943 NCBI chr 2:167,323,053...167,334,804
Ensembl chr 2:167,323,053...167,334,807 		JBrowse link
G Sphk1 sphingosine kinase 1 involved_in ISO MGI GO_REF:0000096 GO_REF:0000119 MGI:4417868 MGI:4834177 NCBI chr11:116,421,662...116,427,502
Ensembl chr11:116,421,751...116,427,501 		JBrowse link
G Syk spleen tyrosine kinase involved_in ISO MGI GO_REF:0000119 MGI:4834177 NCBI chr13:52,736,670...52,802,828
Ensembl chr13:52,737,209...52,802,828 		JBrowse link
G Tnfrsf1a tumor necrosis factor receptor superfamily, member 1a acts_upstream_of_or_within IGI (PMID:25220458) MGI PMID:25220458 NCBI chr 6:125,326,686...125,339,446
Ensembl chr 6:125,326,325...125,339,447 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  biological_process 28577
    cellular process 17497
      signal transduction 6663
        cell surface receptor signaling pathway 2924
          cytokine-mediated signaling pathway 513
            tumor necrosis factor-mediated signaling pathway 109
              negative regulation of tumor necrosis factor-mediated signaling pathway 32
              positive regulation of tumor necrosis factor-mediated signaling pathway 13
              regulation of tumor necrosis factor-mediated signaling pathway + 58
Path 2
Term Annotations click to browse term
  biological_process 28577
    response to stimulus 10767
      response to chemical 5330
        response to peptide 1380
          response to cytokine 1356
            cellular response to cytokine stimulus 1207
              cytokine-mediated signaling pathway 513
                tumor necrosis factor-mediated signaling pathway 109
                  negative regulation of tumor necrosis factor-mediated signaling pathway 32
                  positive regulation of tumor necrosis factor-mediated signaling pathway 13
                  regulation of tumor necrosis factor-mediated signaling pathway + 58
paths to the root