Ext1 (exostosin glycosyltransferase 1) - Rat Genome Database

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Gene: Ext1 (exostosin glycosyltransferase 1) Mus musculus
Analyze
Symbol: Ext1
Name: exostosin glycosyltransferase 1
RGD ID: 1313967
MGI Page MGI
Description: Enables N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity. Involved in heparan sulfate proteoglycan biosynthetic process. Acts upstream of or within with a positive effect on several processes, including glomerular visceral epithelial cell differentiation; heparin biosynthetic process; and nervous system development. Acts upstream of or within with a negative effect on sulfation. Acts upstream of or within several processes, including animal organ development; cell surface receptor signaling pathway; and leukocyte migration. Is integral component of endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Used to study autism spectrum disorder and hereditary multiple exostoses. Human ortholog(s) of this gene implicated in chondrosarcoma; hereditary multiple exostoses; and trichorhinophalangeal syndrome type II. Orthologous to human EXT1 (exostosin glycosyltransferase 1); PARTICIPATES IN heparan sulfate biosynthetic pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA409028; exostoses (multiple) 1; exostosin-1; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; multiple exostoses protein 1 homolog
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,931,657 - 53,209,579 (-)NCBIGRCm39mm39
GRCm39 Ensembl1552,927,434 - 53,209,555 (-)Ensembl
GRCm381553,068,261 - 53,346,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371552,899,816 - 53,177,738 (-)NCBIGRCm37mm9NCBIm37
MGSCv361552,898,622 - 53,176,027 (-)NCBImm8
Celera1554,621,498 - 54,903,011 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1520.0NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
antigen processing and presentation  (IMP)
axon guidance  (IGI,IMP)
basement membrane organization  (IMP)
blood vessel remodeling  (IMP)
BMP signaling pathway  (IDA,IMP)
bone growth  (IMP)
bone morphogenesis  (IMP)
bone resorption  (IMP)
brain development  (IMP,ISO)
canonical Wnt signaling pathway  (IMP)
cartilage development involved in endochondral bone morphogenesis  (IMP)
cell adhesion  (IMP)
cell adhesion mediated by integrin  (IMP)
cell fate commitment  (IMP)
cell morphogenesis  (IMP)
cell population proliferation  (IMP)
cell surface receptor signaling pathway  (IMP)
cellular component organization  (IMP)
cellular polysaccharide biosynthetic process  (ISO)
cellular response to BMP stimulus  (IMP)
cellular response to fibroblast growth factor stimulus  (IMP)
cellular response to virus  (IMP)
chondrocyte differentiation  (IMP)
chondrocyte hypertrophy  (IMP)
chondrocyte proliferation  (IMP)
chondroitin sulfate metabolic process  (IMP)
collagen fibril organization  (IMP)
cranial skeletal system development  (IMP)
dendrite self-avoidance  (IMP)
dendritic cell migration  (IMP)
developmental growth involved in morphogenesis  (IMP)
embryonic morphogenesis  (IMP)
embryonic skeletal joint development  (IMP)
endochondral bone growth  (IMP)
endochondral bone morphogenesis  (IGI,IMP)
endochondral ossification  (IMP)
endoderm development  (IMP)
epithelial tube branching involved in lung morphogenesis  (IMP)
epithelium development  (IMP)
fear response  (IMP)
fibroblast growth factor receptor signaling pathway  (IDA,IMP)
fluid transport  (IGI)
gastrulation  (IMP)
gene expression  (IMP)
glandular epithelial cell differentiation  (IMP)
glomerular basement membrane development  (IMP)
glomerular visceral epithelial cell differentiation  (IMP)
glycosaminoglycan biosynthetic process  (ISO)
hair cycle process  (IMP)
hair follicle morphogenesis  (IMP)
heart contraction  (IGI)
heart field specification  (IMP)
hematopoietic progenitor cell differentiation  (IMP)
hematopoietic stem cell differentiation  (IMP)
hematopoietic stem cell homeostasis  (IMP)
hematopoietic stem cell migration to bone marrow  (IMP)
heparan sulfate proteoglycan biosynthetic process  (IDA,IMP,ISO)
heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process  (ISO)
heparin biosynthetic process  (IGI,IMP)
heparin metabolic process  (IMP)
hypersensitivity  (IMP)
leukocyte tethering or rolling  (IMP)
limb joint morphogenesis  (IMP)
lymphocyte adhesion to endothelial cell of high endothelial venule  (IMP)
lymphocyte migration into lymphoid organs  (IMP)
mesenchymal cell differentiation involved in bone development  (IMP)
mesenchyme development  (IMP)
mesoderm development  (IMP)
motor behavior  (IMP)
multicellular organism growth  (IMP)
multicellular organismal water homeostasis  (IGI)
neural crest cell differentiation  (IMP)
neuron projection development  (IMP)
olfactory bulb development  (IMP)
optic nerve development  (IMP)
ossification  (ISO)
ossification involved in bone maturation  (IMP)
perichondral bone morphogenesis  (IMP)
protein catabolic process  (IMP)
protein glycosylation  (IEA)
protein-containing complex assembly  (IMP)
proteoglycan biosynthetic process  (IMP)
regulation of blood pressure  (IGI)
response to growth factor  (IMP)
response to heparin  (IMP)
response to leukemia inhibitory factor  (IMP)
response to light intensity  (IMP)
response to virus  (IMP)
sebaceous gland development  (IMP)
smoothened signaling pathway  (IMP)
smoothened signaling pathway involved in lung development  (IMP)
social behavior  (IMP)
sodium ion homeostasis  (IGI)
stem cell division  (IMP)
stomach development  (IMP)
sulfation  (IDA,IMP)
sweat gland development  (IMP)
synaptic transmission, glutamatergic  (IMP)
tight junction organization  (IMP)
TNFSF11-mediated signaling pathway  (IMP)
vacuole organization  (IMP)
vasodilation  (IGI)
vocalization behavior  (IMP)
wound healing  (IMP)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal aqueous drainage system morphology  (IAGP)
abnormal axon guidance  (IAGP)
abnormal basicranium morphology  (IAGP)
abnormal brain commissure morphology  (IAGP)
abnormal brain development  (IAGP)
abnormal canal of Schlemm morphology  (IAGP)
abnormal cartilage development  (IAGP)
abnormal cartilage morphology  (IAGP)
abnormal cerebral cortex morphology  (IAGP)
abnormal corneal stroma morphology  (IAGP)
abnormal cranial synchondrosis  (IAGP)
abnormal craniofacial morphology  (IAGP)
abnormal developmental patterning  (IAGP)
abnormal ear morphology  (IAGP)
abnormal embryonic tissue morphology  (IAGP)
abnormal epiphyseal plate morphology  (IAGP)
abnormal excitatory postsynaptic currents  (IAGP)
abnormal extraembryonic tissue morphology  (IAGP)
abnormal eye morphology  (IAGP)
abnormal forelimb morphology  (IAGP)
abnormal iridocorneal angle  (IAGP)
abnormal limb morphology  (IAGP)
abnormal long bone epiphyseal plate proliferative zone  (IAGP)
abnormal miniature excitatory postsynaptic currents  (IAGP)
abnormal nest building behavior  (IAGP)
abnormal skeleton morphology  (IAGP)
abnormal social investigation  (IAGP)
abnormal synaptic transmission  (IAGP)
abnormal trabecular meshwork morphology  (IAGP)
absent anterior commissure  (IAGP)
absent cerebellum  (IAGP)
absent corpus callosum  (IAGP)
absent eyelids  (IAGP)
absent hard palate  (IAGP)
absent hippocampal commissure  (IAGP)
absent inferior colliculus  (IAGP)
absent mesoderm  (IAGP)
absent olfactory bulb  (IAGP)
bowed radius  (IAGP)
ciliary body coloboma  (IAGP)
cleft secondary palate  (IAGP)
decreased anxiety-related response  (IAGP)
decreased body height  (IAGP)
decreased cornea thickness  (IAGP)
decreased cranial neural crest cell proliferation  (IAGP)
decreased embryo size  (IAGP)
decreased eye anterior chamber depth  (IAGP)
decreased fear-related response  (IAGP)
decreased thermal nociceptive threshold  (IAGP)
decreased vocalization  (IAGP)
dislocated radius head  (IAGP)
disorganized embryonic tissue  (IAGP)
embryonic lethality  (IAGP)
embryonic lethality between implantation and somite formation, complete penetrance  (IAGP)
embryonic lethality during organogenesis, complete penetrance  (IAGP)
exostosis  (IAGP)
failure of primitive streak formation  (IAGP)
failure to gastrulate  (IAGP)
hyperactivity  (IAGP)
increased diameter of radius  (IAGP)
increased diameter of ulna  (IAGP)
increased osteochondroma incidence  (IAGP)
increased stereotypic behavior  (IAGP)
iris coloboma  (IAGP)
neonatal lethality, complete penetrance  (IAGP)
no abnormal phenotype detected  (IEA)
ocular hypertension  (IAGP)
premature death  (IEA)
prenatal lethality, complete penetrance  (IAGP)
prenatal lethality, incomplete penetrance  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
reduced AMPA-mediated synaptic currents  (IAGP)
scoliosis  (IAGP)
thin cerebral cortex  (IAGP)
References

Additional References at PubMed
PMID:1856833   PMID:7726168   PMID:8889548   PMID:9186511   PMID:9254013   PMID:9620772   PMID:9703997   PMID:10349636   PMID:10639137   PMID:10864928   PMID:10878610   PMID:10922068  
PMID:10926768   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11431694   PMID:11849148   PMID:12477932   PMID:12520002   PMID:12644256   PMID:12676797   PMID:14605369   PMID:14610273  
PMID:14681479   PMID:15161920   PMID:15177029   PMID:15489334   PMID:15777636   PMID:16141072   PMID:16141073   PMID:17130131   PMID:17442818   PMID:17761672   PMID:18064305   PMID:18337501  
PMID:18479348   PMID:18480751   PMID:18667431   PMID:19287388   PMID:19509472   PMID:19782070   PMID:19850926   PMID:19965677   PMID:20022960   PMID:20080592   PMID:20133829   PMID:20377530  
PMID:20404326   PMID:20463653   PMID:20534475   PMID:20974861   PMID:21093315   PMID:21148566   PMID:21185280   PMID:21267068   PMID:21310272   PMID:21586278   PMID:21743013   PMID:21873635  
PMID:21880786   PMID:22345168   PMID:22411800   PMID:22556407   PMID:22848466   PMID:23054193   PMID:23192691   PMID:23458899   PMID:23733868   PMID:23744737   PMID:23958822   PMID:24835176  
PMID:25053416   PMID:25202142   PMID:25284049   PMID:25468659   PMID:25568062   PMID:25644707   PMID:25741008   PMID:25976459   PMID:26024086   PMID:26273529   PMID:26295701   PMID:26491162  
PMID:27030596   PMID:28445472   PMID:28768899   PMID:28859094   PMID:29415886   PMID:29545125   PMID:29605295   PMID:29700203   PMID:30550785   PMID:30617207   PMID:30977233   PMID:31365577  
PMID:32201365   PMID:32325033   PMID:32810562   PMID:32882513   PMID:33278339  


Genomics

Comparative Map Data
Ext1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391552,931,657 - 53,209,579 (-)NCBIGRCm39mm39
GRCm39 Ensembl1552,927,434 - 53,209,555 (-)Ensembl
GRCm381553,068,261 - 53,346,183 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)EnsemblGRCm38mm10GRCm38
MGSCv371552,899,816 - 53,177,738 (-)NCBIGRCm37mm9NCBIm37
MGSCv361552,898,622 - 53,176,027 (-)NCBImm8
Celera1554,621,498 - 54,903,011 (-)NCBICelera
Cytogenetic Map15CNCBI
cM Map1520.0NCBI
EXT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8117,794,490 - 118,111,826 (-)EnsemblGRCh38hg38GRCh38
GRCh388117,794,490 - 118,111,826 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378118,806,729 - 119,124,065 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368118,880,783 - 119,193,239 (-)NCBINCBI36hg18NCBI36
Build 348118,880,786 - 119,193,239NCBI
Celera8115,000,160 - 115,312,582 (-)NCBI
Cytogenetic Map8q24.11NCBI
HuRef8114,138,448 - 114,450,830 (-)NCBIHuRef
CHM1_18118,852,044 - 119,165,143 (-)NCBICHM1_1
Ext1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2784,375,769 - 84,654,625 (-)NCBI
Rnor_6.0 Ensembl792,605,728 - 92,882,068 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.0792,605,008 - 92,881,392 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0793,245,551 - 93,521,935 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4789,392,837 - 89,671,523 (-)NCBIRGSC3.4rn4RGSC3.4
Celera781,215,848 - 81,493,311 (-)NCBICelera
Cytogenetic Map7q31NCBI
Ext1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541723,798,393 - 24,067,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541723,798,044 - 24,067,759 (-)NCBIChiLan1.0ChiLan1.0
EXT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.18117,011,571 - 117,325,464 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl8117,011,919 - 117,324,851 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v08114,489,325 - 114,803,763 (-)NCBIMhudiblu_PPA_v0panPan3
EXT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11317,172,497 - 17,457,084 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1317,172,705 - 17,456,469 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1317,173,248 - 17,457,626 (-)NCBI
ROS_Cfam_1.01317,470,129 - 17,750,747 (-)NCBI
UMICH_Zoey_3.11317,205,173 - 17,489,568 (-)NCBI
UNSW_CanFamBas_1.01317,305,318 - 17,589,066 (-)NCBI
UU_Cfam_GSD_1.01317,549,676 - 17,834,137 (-)NCBI
Ext1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530320,877,114 - 21,140,365 (+)NCBI
SpeTri2.0NW_00493647028,303,213 - 28,566,470 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EXT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl420,645,809 - 20,935,564 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1420,645,002 - 20,935,769 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2421,837,627 - 22,128,132 (+)NCBISscrofa10.2Sscrofa10.2susScr3
EXT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.18112,435,733 - 112,751,301 (-)NCBI
Vero_WHO_p1.0NW_02366603927,547,084 - 27,862,637 (+)NCBI
Ext1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476316,126,582 - 16,393,476 (-)NCBI

Position Markers
D15Mit232  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,112,510 - 53,112,623UniSTSGRCm38
MGSCv371552,944,065 - 52,944,178UniSTSGRCm37
Celera1554,665,651 - 54,665,764UniSTS
Cytogenetic Map15CUniSTS
cM Map1529.7UniSTS
Whitehead Genetic1524.0UniSTS
Whitehead_YAC15 UniSTS
D15Mit25  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,259,225 - 53,259,358UniSTSGRCm38
MGSCv371553,090,780 - 53,090,913UniSTSGRCm37
Celera1554,812,073 - 54,812,206UniSTS
Cytogenetic Map15CUniSTS
cM Map1522.2UniSTS
Whitehead Genetic1521.9UniSTS
Whitehead/MRC_RH15477.99UniSTS
Whitehead_YAC15 UniSTS
RH124390  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,341,891 - 53,342,192UniSTSGRCm38
MGSCv371553,173,446 - 53,173,747UniSTSGRCm37
Celera1554,898,669 - 54,898,970UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
RH124561  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,308,691 - 53,308,970UniSTSGRCm38
MGSCv371553,140,246 - 53,140,525UniSTSGRCm37
Celera1554,860,296 - 54,860,575UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
RH124810  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,068,586 - 53,068,674UniSTSGRCm38
MGSCv371552,900,141 - 52,900,229UniSTSGRCm37
Celera1554,621,823 - 54,621,911UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
RH138727  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,068,391 - 53,068,571UniSTSGRCm38
MGSCv371552,899,946 - 52,900,126UniSTSGRCm37
Celera1554,621,628 - 54,621,808UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
REN13326  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,345,948 - 53,346,175UniSTSGRCm38
MGSCv371553,177,503 - 53,177,730UniSTSGRCm37
Celera1554,902,776 - 54,903,003UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
REN13329  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,345,297 - 53,345,551UniSTSGRCm38
MGSCv371553,176,852 - 53,177,106UniSTSGRCm37
Celera1554,902,125 - 54,902,379UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
REN13332  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,344,585 - 53,344,846UniSTSGRCm38
MGSCv371553,176,140 - 53,176,401UniSTSGRCm37
Celera1554,901,413 - 54,901,674UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
REN13331  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,344,848 - 53,345,094UniSTSGRCm38
MGSCv371553,176,403 - 53,176,649UniSTSGRCm37
Celera1554,901,676 - 54,901,922UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
ECD12225  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,344,819 - 53,345,368UniSTSGRCm38
MGSCv371553,176,374 - 53,176,923UniSTSGRCm37
Celera1554,901,647 - 54,902,196UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
ECD12830  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,345,407 - 53,345,935UniSTSGRCm38
MGSCv371553,176,962 - 53,177,490UniSTSGRCm37
Celera1554,902,235 - 54,902,763UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS
RH125649  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,308,785 - 53,309,034UniSTSGRCm38
MGSCv371553,140,340 - 53,140,589UniSTSGRCm37
Celera1554,860,390 - 54,860,639UniSTS
Cytogenetic Map15CUniSTS
cM Map1530.0UniSTS
Whitehead/MRC_RH15477.89UniSTS
Ext1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381553,068,547 - 53,068,688UniSTSGRCm38
MGSCv371552,900,102 - 52,900,243UniSTSGRCm37
Celera1554,621,784 - 54,621,925UniSTS
Cytogenetic Map15CUniSTS
cM Map1526.55UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
10401902Sicd2_mseizure-induced cell death 2 (mouse)Not determined15344490771325689Mouse
4141952W3q7_mweight 3 weeks QTL 7 (mouse)Not determined346021278717086Mouse
4142448Tailq6_mtail length QTL 6 (mouse)Not determined346021278717086Mouse
4142252Tailaq4_mtail length adjusted QTL 4 (mouse)Not determined346021278717086Mouse
1357559Scfq2_msubcutaneous fat pad weight QTL 2 (mouse)Not determined15346021278717086Mouse
1357659Epfpq4_mepididymal fat percentage QTL 4 (mouse)Not determined15346021278717086Mouse
26884387Skwq8_mskull length QTL 8, 10 week (mouse)15610000068400000Mouse
26884412Bzwq10_mbi-zygomatic width QTL 10, 10 week (mouse)15610000071600000Mouse
26884417Bzwq4_mbi-zygomatic width QTL 4, 5 week (mouse)15610000072600000Mouse
27226786Feml11_mfemur length 11, 5 week (mouse)15610000076000000Mouse
27095932Ulnl11_mulna length 11, 16 week (mouse)15610000076500000Mouse
27226717Tibw4_mtibia width 4, proximal, 10 week (mouse)15610000078800000Mouse
27226734Tibmd5_mtibia midshaft diameter 5, 10 week (mouse)15610000086800000Mouse
26884442Sklq6_mskull length QTL 6, 5 week (mouse)156100000100900000Mouse
27226721Tibw8_mtibia width 8, proximal, 16 week (mouse)15690000076000000Mouse
27226773Tibl16_mtibia length 16, 10 week (mouse)15690000076000000Mouse
27226777Tibl8_mtibia length 8, 5 week (mouse)15690000084700000Mouse
27095940Ulnl8_mulna length 8, 10 week (mouse)15720000055400000Mouse
27226759Feml17_mfemur length 17, 10 week (mouse)15760000055400000Mouse
27226755Feml22_mfemur length 22, 16 week (mouse)15760000059400000Mouse
4141192Ssrq2_mstress response QTL 2 (mouse)Not determined927293656323454Mouse
1301433Rapop5_mradiation-induced apoptosis 5 (mouse)Not determined15927293679590561Mouse
1357526Hyplip2_mhyperlipidemia 2 (mouse)Not determined1512402117102988123Mouse
14928313Manh78_mmandible shape 78 (mouse)152148439755484397Mouse
12859289Criq3_mCitrobacter rodentium infection QTL 3 (mouse)152273036956730369Mouse
4142160Femwf10_mfemur work to failure 10 (mouse)Not determined2302961857029764Mouse
1301557Bbaa22_mB.burgdorferi-associated arthritis 22 (mouse)Not determined152459917658599409Mouse
1300967Bdt6_mbone density traits 6 (mouse)Not determined152543241059432532Mouse
4141409Radsvq1_mradiation sensitivity QTL 1 (mouse)Not determined2562158259621582Mouse
1301345Bgeq14_mbody growth early QTL 14 (mouse)Not determined152644838460448484Mouse
1300772Bglq16_mbody growth late QTL 16 (mouse)Not determined152644838460448484Mouse
1357514Mbis3_mMycobacterium bovis-induced systemic lupus erythematosus 3 (mouse)Not determined162644838460448484Mouse
1301406Egrd2_mearly growth rate (mouse)Not determined152644838460448484Mouse
27226800Scvln20_msacral vertebrae length 2, 16 week (mouse)152660000066500000Mouse
1301450Bpq6_mblood pressure QTL 6 (mouse)Not determined152841925062419343Mouse
1357512Bsbob5_mBSB obesity 5 (mouse)Not determined152841925062419343Mouse
26884425Cvht2_mcranial vault height 2, 5 week (mouse)1528800000102100000Mouse
26884392Humsd8_mhumerus midshaft diameter 8, 16 week (mouse)152930000076200000Mouse
26884452Sklq17_mskull length QTL 17, 16 week (mouse)153020000058100000Mouse
1558985Eae32_mexperimental allergic encephalomyelitis susceptibility 32 (mouse)Not determined1532578270103517472Mouse
1300578Cd8ts3_mCD8 T cell subset 3 (mouse)Not determined153414129868141408Mouse
1301324Cdif_mcolor difference (mouse)Not determined153611251070112623Mouse
27226729Tibmd2_mtibia midshaft diameter 2, 5 week (mouse)153800000086800000Mouse
1301580Hrq2_mheart rate quantitative locus 2 (mouse)Not determined153923699973237197Mouse
1300949Lore5_mloss of righting induced by ethanol 5 (mouse)Not determined154015604558158901Mouse
4142459Lfnq3_mlung function QTL 3 (mouse)Not determined4031362672500731Mouse
26884402Cvht9_mcranial vault height 9, 16 week (mouse)154230000095600000Mouse
1300644Fob3_mF-line obesity QTL 3 (mouse)11.3Not determined154414443889377036Mouse
1357703Vtbt17_mvertebral trabecular bone trait 17 (mouse)Not determined154468146478681588Mouse
1301568Tria2_mT-cell receptor induced activation 2 (mouse)Not determined154498729278987432Mouse
26884420Cvht6_mcranial vault height 6, 10 week (mouse)154570000069300000Mouse
1357756Alaa4_malopecia areata 4 (mouse)Not determined154651779780517996Mouse
10755515Amzn3_manatomical modifier of Zfp423 3 (mouse)154651779780517996Mouse
1301006Hfib1_mhepatic fibrogenesis 1 (mouse)Not determined154743448581434630Mouse
1301860Gct3_mgranulosa cell tumorigenesis 3 (mouse)Not determined154753774781537842Mouse
26884397Humsd5_mhumerus midshaft diameter 5, 10 week (mouse)154850000098500000Mouse
26884399Humsd1_mhumerus midshaft diameter 1, 5 week (mouse)1548500000101800000Mouse
1301429Pcir3_mperiosteal circumference 3 (mouse)Not determined154859351382593647Mouse
25394541Skmw81_mskeletal muscle weight 81, EDL (mouse)155079567653285678Mouse
1357661Eae2b_msusceptibility to experimental allergic encephalomyelitis 2b (mouse)Not determined155114129865072459Mouse
1301779Dpml_mdopamine loss (mouse)Not determined155114129876910293Mouse
4142198Hbtq_mhabituation QTL (mouse)Not determined155128885985288984Mouse
10045637Heal27_mwound healing/regeneration 29 (mouse)Not determined155154651285546662Mouse
35673313Ari8_mantibody response to influenza 8, day 15-45, TotalG (mouse)155160000055000000Mouse
10412067Pain2_mpain 2 (mouse)Not determined155177349085773777Mouse
1302080Szs13_mseizure susceptibility 13 (mouse)Not determined155181398385822600Mouse
1301708Cocrb14_mcocaine related behavior 14 (mouse)Not determined155193466685934802Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:2686
Count of miRNA genes:880
Interacting mature miRNAs:1240
Transcripts:ENSMUST00000077273, ENSMUST00000110244, ENSMUST00000133362, ENSMUST00000140798
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000077273   ⟹   ENSMUSP00000076505
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1553,064,038 - 53,346,159 (-)Ensembl
RefSeq Acc Id: ENSMUST00000110244
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1553,083,146 - 53,196,255 (-)Ensembl
RefSeq Acc Id: ENSMUST00000133362   ⟹   ENSMUSP00000117921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1553,068,664 - 53,345,659 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140798
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1553,089,931 - 53,107,868 (-)Ensembl
RefSeq Acc Id: NM_010162   ⟹   NP_034292
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391552,931,657 - 53,209,579 (-)NCBI
GRCm381553,068,261 - 53,346,183 (-)ENTREZGENE
MGSCv371552,899,816 - 53,177,738 (-)RGD
Celera1554,621,498 - 54,903,011 (-)RGD
cM Map15 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034292   ⟸   NM_010162
- UniProtKB: P97464 (UniProtKB/Swiss-Prot),   Q3V1P4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000117921   ⟸   ENSMUST00000133362
RefSeq Acc Id: ENSMUSP00000076505   ⟸   ENSMUST00000077273

Promoters
RGD ID:6825991
Promoter ID:MM_KWN:18429
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   MEF_B6
Transcripts:OTTMUST00000046536
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361552,939,191 - 52,939,822 (-)MPROMDB
RGD ID:6825990
Promoter ID:MM_KWN:18430
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_4Hour,   Liver
Transcripts:ENSMUST00000110244
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361553,027,701 - 53,028,201 (-)MPROMDB
RGD ID:6825989
Promoter ID:MM_KWN:18431
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000077273,   OTTMUST00000056056
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361553,175,971 - 53,178,172 (-)MPROMDB
RGD ID:8683728
Promoter ID:EPDNEW_M19894
Type:initiation region
Name:Ext1_1
Description:Mus musculus exostoses 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381553,346,132 - 53,346,192EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:894663 AgrOrtholog
Ensembl Genes ENSMUSG00000061731 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000076505 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000117921 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000077273 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000133362 UniProtKB/TrEMBL
Gene3D-CATH 3.90.550.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Exostosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exostosin-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Exostosin_GT47 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GT64 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Nucleotide-diphossugar_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:14042 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:894663 ENTREZGENE
NCBI Gene 14042 ENTREZGENE
PANTHER PTHR11062 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR11062:SF97 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Exostosin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Glyco_transf_64 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ext1 PhenoGen
Superfamily-SCOP SSF53448 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt D6RE56_MOUSE UniProtKB/TrEMBL
  EXT1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V1P4 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary Q61546 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-09-03 Ext1  exostosin glycosyltransferase 1  Ext1  exostoses (multiple) 1  Symbol and/or name change 5135510 APPROVED