Mir125b-1 (microRNA 125b-1) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mir125b-1 (microRNA 125b-1) Mus musculus
Analyze
Symbol: Mir125b-1
Name: microRNA 125b-1
RGD ID: 1607652
MGI Page MGI
Description: Enables RNA binding activity. Involved in miRNA-mediated gene silencing. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to estrogen stimulus; and cellular response to forskolin. Is expressed in several structures, including brain; early conceptus; heart; and lung. Orthologous to human MIR125B1 (microRNA 125b-1).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-125b-1; Mirn1; Mirn125; Mirn125b; Mirn125b-1
RGD Orthologs
Human
Rat
Dog
Pig
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,493,222 - 41,493,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,493,222 - 41,493,298 (+)EnsemblGRCm39 Ensembl
GRCm38941,581,926 - 41,582,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,390,009 - 41,390,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,821,699 - 38,821,775 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to estrogen stimulus  (IDA)
cellular response to forskolin  (IEP)
cellular response to inorganic substance  (IDA)
cellular response to interleukin-6  (ISO)
cellular response to leukemia inhibitory factor  (IEP)
cellular response to mechanical stimulus  (IDA)
cellular response to tumor necrosis factor  (IDA)
cellular response to vitamin D  (ISO)
cellular senescence  (IDA)
common myeloid progenitor cell proliferation  (IDA)
hematopoietic stem cell differentiation  (IDA)
juxtaglomerular apparatus development  (IDA)
long-term synaptic potentiation  (IEP)
miRNA-mediated gene silencing  (IMP)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated gene silencing by mRNA destabilization  (ISO)
negative regulation of angiogenesis  (ISO)
negative regulation of BMP signaling pathway  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of interleukin-6-mediated signaling pathway  (ISO)
negative regulation of keratinocyte proliferation  (ISO)
negative regulation of monocyte differentiation  (ISO)
negative regulation of osteoblast differentiation  (ISO)
negative regulation of receptor signaling pathway via STAT  (ISO)
negative regulation of tumor necrosis factor production  (ISO)
NIK/NF-kappaB signaling  (ISO)
positive regulation of gene expression  (IDA)
positive regulation of glial cell proliferation  (ISO)
positive regulation of keratinocyte differentiation  (ISO)
positive regulation of neuron apoptotic process  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of tau-protein kinase activity  (ISO)
positive regulation of vascular associated smooth muscle cell differentiation  (ISO)
sensory perception of sound  (IEP)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15634332   PMID:15845075   PMID:16247770   PMID:16369549   PMID:16381832   PMID:16766679   PMID:17369397   PMID:17505514   PMID:17604727   PMID:18311128   PMID:18347971  
PMID:18452032   PMID:18791161   PMID:19188425   PMID:19559694   PMID:19726871   PMID:20159450   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20660734   PMID:21037258   PMID:21118985  
PMID:21118986   PMID:21200031   PMID:21267068   PMID:21347262   PMID:21362569   PMID:21368288   PMID:21643937   PMID:21738213   PMID:21806957   PMID:21822254   PMID:21935352   PMID:21993888  
PMID:22003200   PMID:22144232   PMID:22164278   PMID:22366319   PMID:22512273   PMID:22693547   PMID:22797068   PMID:22843432   PMID:23646144   PMID:24318812   PMID:24477912   PMID:24560795  
PMID:24576954   PMID:24598163   PMID:25006123   PMID:25092555   PMID:25403182   PMID:25751060   PMID:25858512   PMID:25953743   PMID:25959411   PMID:26024858   PMID:26138442   PMID:26139524  
PMID:26272872   PMID:26585673   PMID:26634350   PMID:26681446   PMID:26794445   PMID:27020049   PMID:27235580   PMID:27304919   PMID:27336362   PMID:27426728   PMID:27683819   PMID:27835742  
PMID:28053194   PMID:28281528   PMID:28389358   PMID:28432360   PMID:28569771   PMID:28731435   PMID:28828398   PMID:29122578   PMID:29461585   PMID:29667275   PMID:30286140   PMID:30316051  
PMID:30340830   PMID:30484954   PMID:30537738   PMID:30613290   PMID:30684546   PMID:30686117   PMID:31080058   PMID:31782506   PMID:31945658   PMID:31949279   PMID:32016695   PMID:33319811  
PMID:33386874   PMID:33504864   PMID:33652034   PMID:33859745   PMID:34097926   PMID:34524260   PMID:34769281   PMID:34988755   PMID:35579934   PMID:36270980   PMID:36319063  


Genomics

Comparative Map Data
Mir125b-1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39941,493,222 - 41,493,298 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl941,493,222 - 41,493,298 (+)EnsemblGRCm39 Ensembl
GRCm38941,581,926 - 41,582,002 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)EnsemblGRCm38mm10GRCm38
MGSCv37941,390,009 - 41,390,085 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera938,821,699 - 38,821,775 (+)NCBICelera
Cytogenetic Map9A5.1NCBI
MIR125B1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811122,099,757 - 122,099,844 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl11122,099,757 - 122,099,844 (-)EnsemblGRCh38hg38GRCh38
GRCh3711121,970,465 - 121,970,552 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3611121,475,674 - 121,475,761 (-)NCBINCBI36Build 36hg18NCBI36
Celera11119,131,144 - 119,131,231 (-)NCBICelera
Cytogenetic Map11q24.1NCBI
HuRef11117,917,003 - 117,917,090 (-)NCBIHuRef
CHM1_111121,857,766 - 121,857,853 (-)NCBICHM1_1
T2T-CHM13v2.011122,128,759 - 122,128,846 (-)NCBIT2T-CHM13v2.0
Mir125b1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2841,952,966 - 41,953,052 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl841,952,966 - 41,953,052 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx847,445,457 - 47,445,543 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.0845,724,100 - 45,724,186 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.0843,591,670 - 43,591,756 (+)NCBIRnor_WKY
Rnor_6.0845,798,260 - 45,798,346 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl845,798,260 - 45,798,346 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0844,272,846 - 44,272,932 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera841,551,438 - 41,551,524 (+)NCBICelera
Cytogenetic Map8q22NCBI
MIR125B-1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1512,097,672 - 12,097,732 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl512,097,658 - 12,097,745 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha512,152,730 - 12,152,790 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0512,047,627 - 12,047,687 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl512,047,613 - 12,047,700 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1512,151,360 - 12,151,420 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0512,090,768 - 12,090,828 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0512,129,464 - 12,129,524 (+)NCBIUU_Cfam_GSD_1.0
MIR125B-1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl949,109,435 - 49,109,514 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1949,109,435 - 49,109,514 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2954,334,908 - 54,334,987 (-)NCBISscrofa10.2Sscrofa10.2susScr3

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Suv39h1mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20699419
Cbfbmmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22689670
Vsirmmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22751012
Snai1mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21945074
Erbb3mmu-miR-125b-5pOncomiRDBexternal_infoNANA23437196
Mmp13mmu-miR-125b-5pOncomiRDBexternal_infoNANA23425975
Tacstd2mmu-miR-125b-5pOncomiRDBexternal_infoNANA23416980
Pik3cdmmu-miR-125b-5pOncomiRDBexternal_infoNANA23160634
Sirt7mmu-miR-125b-5pOncomiRDBexternal_infoNANA23079745
E2f2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22999819
Mcl1mmu-miR-125b-5pOncomiRDBexternal_infoNANA22942733
Mcl1mmu-miR-125b-5pOncomiRDBexternal_infoNANA22824797
Junmmu-miR-125b-5pOncomiRDBexternal_infoNANA22797068
Mmp13mmu-miR-125b-5pOncomiRDBexternal_infoNANA22782903
Stard13mmu-miR-125b-5pOncomiRDBexternal_infoNANA22693547
Tnfaip3mmu-miR-125b-5pOncomiRDBexternal_infoNANA22550173
Arid3ammu-miR-125b-5pOncomiRDBexternal_infoNANA22469780
Erbb2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22460089
Arid3bmmu-miR-125b-5pOncomiRDBexternal_infoNANA22307404
Bcl2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22293115
Bmfmmu-miR-125b-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21118986
Bcl2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22139839
Stat3mmu-miR-125b-5pOncomiRDBexternal_infoNANA22093834
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21880154
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21823019
Pgfmmu-miR-125b-5pOncomiRDBexternal_infoNANA21703189
Ets1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21444677
Muc1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21308711
Trp53mmu-miR-125b-5pOncomiRDBexternal_infoNANA20886540
Lin28bmmu-miR-125b-5pOncomiRDBexternal_infoNANA20827722
Muc1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20729973
Bcl3mmu-miR-125b-5pOncomiRDBexternal_infoNANA20658525
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20460378
Cyp24a1mmu-miR-125b-5pOncomiRDBexternal_infoNANA19570947
Bmfmmu-miR-125b-5pOncomiRDBexternal_infoNANA19471102
Cyp27b1mmu-miR-125b-5pOncomiRDBexternal_infoNANA19437538
Erbb2mmu-miR-125b-5pOncomiRDBexternal_infoNANA17110380
E2f3mmu-miR-125b-5pOncomiRDBexternal_infoNANA20549700
Smommu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Ddx19bmmu-miR-125b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16495412
Lin28ammu-miR-125b-5pMirtarbaseexternal_infoB-globin reporter assay//MicroarrayFunctional MTI16495412
Lin28ammu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI16227573
Tnfmmu-miR-125b-5pMirtarbaseexternal_infoGFP reporter assay//Luciferase reporter assayFunctional MTI17911593
Trim71mmu-miR-125b-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)19898466
Igf2mmu-miR-125b-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI21200031

Predicted Targets
Summary Value
Count of predictions:17102
Count of gene targets:8185
Count of transcripts:13335
Interacting mature miRNAs:mmu-miR-125b-1-3p, mmu-miR-125b-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13504833Bglu19_mblood glucose level 19 (mouse)9991076843910768Mouse
1300532Tbs2_mtuberculosis severity 2 (mouse)Not determined91236997046370114Mouse
10043917Obq37_mobesity QTL 37 (mouse)Not determined91339117547391175Mouse
1357637Si5lq2_mserum IGFBP-5 level QTL 2 (mouse)Not determined91541175149411890Mouse
4141591Cq4_mcholesterol QTL 4 (mouse)Not determined91541175149411890Mouse
1301421Lgth4_mbody length 4 (mouse)Not determined91541175149411890Mouse
4141447Cfmq2_mcystic fibrosis modifier QTL 2 (mouse)Not determined91541175149411890Mouse
12790993Adq1_maortic diameter QTL 1 (mouse)91574962749749627Mouse
11354951Pdcc3_mplasmacytoid dentritic cell compartment 3 (mouse)91574962749749627Mouse
12790997Adq2_maortic diameter QTL 2 (mouse)91574962749749627Mouse
12880415V125Dq7_mvitamin D active form serum level QTL 7 (mouse)91601129650011296Mouse
12880416V125Dq8_mvitamin D active form serum level QTL 8 (mouse)91601129650011296Mouse
13504834Hdlq109_mHDL QTL 109 (mouse)91670964150709641Mouse
1357465Vtbt6_mvertebral trabecular bone trait 6 (mouse)Not determined91697884050978943Mouse
1300643Pvcan2_mprotection against vaginal candidiasis 2 (mouse)Not determined91994340653943525Mouse
1301439Morph2_mmorphine antinociception 2 (mouse)Not determined92015336254153492Mouse
1301883Skull12_mskull morphology 12 (mouse)Not determined92030619754306370Mouse
1301045Sluc10_msusceptibility to lung cancer 10 (mouse)Not determined92030619754306370Mouse
10043950Pbft5_mpercent body fat 5 (mouse)Not determined92030619754306370Mouse
4142352Lmr17_mleishmaniasis resistance 17 (mouse)Not determined92030619754306370Mouse
12904939Edlmmq8_mextensor digitorum longus muscle mass QTL 8 (mouse)92085274054852740Mouse
13208563Bmiq8_mbody mass index QTL 8 (mouse)92491129668907282Mouse
11532712Sluc39d_msusceptibility to lung cancer 39d (mouse)92558748559587581Mouse
11532696Sluc39c_msusceptibility to lung cancer 39c (mouse)92558748559587581Mouse
11532694Sluc39a_msusceptibility to lung cancer 39a (mouse)92558748559587581Mouse
11532695Sluc39b_msusceptibility to lung cancer 39b (mouse)92558748559587581Mouse
10043987Stheal13_msoft tissue heal 13 (mouse)Not determined92679642160796552Mouse
1300932Hdlq17_mHDL QTL 17 (mouse)Not determined92679642160796552Mouse
10043867Mtbcq9_mmultiple trait body composition QTL 9 (mouse)Not determined92679642160796552Mouse
10043878Adip20_madiposity 20 (mouse)Not determined92725119461251323Mouse
1301000Obq5_mobesity QTL 5 (mouse)Not determined92850333341799326Mouse
10043847Hdlq89_mHDL QTL 89 (mouse)Not determined92929292963293072Mouse
1301782Chol11_mcholesterol 11 (mouse)Not determined92929292963293072Mouse
1301365Ap5q_malcohol preference 5 QTL (mouse)Not determined93005316464053277Mouse
1357746Vtbt7_mvertebral trabecular bone trait 7 (mouse)Not determined93073991564740021Mouse
1302180Actd4_mactivity-distance traveled 4 (mouse)Not determined93243456366434857Mouse
4141148Cq5_mcholesterol QTL 5 (mouse)Not determined93245242166452546Mouse
1301692Hts_mhypothermia sensitivity (mouse)Not determined93251117266511421Mouse
4141323Ptnu3_mproteinuria 3 (mouse)Not determined93288970266889836Mouse
1357709Si5lq3_mserum IGFBP-5 level QTL 3 (mouse)Not determined93311102567111140Mouse
1558872Ibdq1_minflammatory bowel disease QTL 1 (mouse)Not determined93397884073439255Mouse
1357682Phdlc1_mplasma HDL cholesterol 1 (mouse)Not determined93410461942764866Mouse
1301252Etohc3_methanol consumption 3 (mouse)Not determined93503447869034599Mouse
1301972Cocrb8_mcocaine related behavior 8 (mouse)Not determined93503447869034599Mouse
1558968Tbdr1_mbody temperature response to dietary restriction, QTL 1 (mouse)Not determined93503447869034599Mouse
10045613Rapop7_mradiation-induced apoptosis 6 (mouse)Not determined93673624349420511Mouse
1301501Lmr2_mleishmaniasis resistance 2 (mouse)Not determined93694340650111140Mouse
1301007Pid2_mprion incubation determinant 2 (mouse)Not determined93715336244251323Mouse
4142042Alpq3_malcohol preference QTL 3 (mouse)Not determined93730619798701707Mouse
10043971Obq32_mobesity QTL 32 (mouse)Not determined93781952871819528Mouse
12790986Pcho9_mplasma cholesterol 9 (mouse)93809957572099575Mouse
12790992Arlsq1_maortic root lesion size QTL 1 (mouse)93809957572099575Mouse
12791002Arlsq2_maortic root lesion size QTL 2 (mouse)93809957572099575Mouse
12738449Spcq2_msperm count QTL 2 (mouse)93939988573399885Mouse
1558993Tdmq1_mtype 2 diabetes modifying QTL 1 (mouse)Not determined94041959451808670Mouse
4141071Ath29_matherosclerosis 29 (mouse)Not determined94041959474607925Mouse
11532693Sluc39_msusceptibility to lung cancer 39 (mouse)94064537448351476Mouse
1301702Brm1_mbrachyury modifier 1 (mouse)Not determined94080504774805204Mouse
12738415Lfibq8_mliver fibrosis QTL 8 (mouse)94140216245343743Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000175613
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl941,493,222 - 41,493,298 (+)Ensembl
GRCm38.p6 Ensembl941,581,926 - 41,582,002 (+)Ensembl
RefSeq Acc Id: NR_029822
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39941,493,222 - 41,493,298 (+)NCBI
GRCm38941,581,926 - 41,582,002 (+)ENTREZGENE
MGSCv37941,390,009 - 41,390,085 (+)RGD
Celera938,821,699 - 38,821,775 (+)RGD
cM Map9 ENTREZGENE
Sequence:
Promoters
RGD ID:8669316
Promoter ID:EPDNEW_M12689
Type:single initiation site
Name:Mir125b-1_1
Description:Mus musculus microRNA 125b-1 (Mir125b-1), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38941,582,003 - 41,582,063EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2676810 AgrOrtholog
Ensembl Genes ENSMUSG00000093354 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000175613 ENTREZGENE
MGD MGI:2676810 ENTREZGENE
miRBase MI0000725 ENTREZGENE
NCBI Gene 387236 ENTREZGENE
PhenoGen Mir125b-1 PhenoGen
RNAcentral URS0000209905 RNACentral
  URS00002DABEA RNACentral
  URS000075F06E RNACentral