Plvap (plasmalemma vesicle associated protein) - Rat Genome Database
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Gene: Plvap (plasmalemma vesicle associated protein) Mus musculus
Analyze
Symbol: Plvap
Name: plasmalemma vesicle associated protein
RGD ID: 733497
MGI Page MGI
Description: Predicted to have identical protein binding activity. Involved in developmental process and positive regulation of cellular extravasation. Predicted to localize to caveola; cell surface; and integral component of membrane. Is expressed in several structures, including cardiovascular system; liver; lung; spleen; and urinary system. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein); INTERACTS WITH 1,2-dimethylhydrazine; 2,3',4,4',5-Pentachlorobiphenyl; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MECA-32 antigen; MECA3; MECA32; plasmalemma vesicle protein 1; plasmalemma vesicle-associated protein; PV; Pv1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,950,397 - 71,964,446 (-)NCBIGRCm39mm39
GRCm38871,497,753 - 71,511,806 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,497,765 - 71,511,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,021,652 - 74,035,668 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,426,754 - 74,440,720 (-)NCBImm8
Celera874,008,038 - 74,022,136 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal capillary morphology  (IAGP)
abnormal circulating lipid level  (IAGP)
abnormal circulating protein level  (IAGP)
abnormal erythrocyte morphology  (IAGP)
abnormal intestine physiology  (IAGP)
abnormal kidney capillary morphology  (IAGP)
abnormal lipid level  (IAGP)
abnormal pancreas morphology  (IAGP)
abnormal peritubular capillary endothelium morphology  (IAGP)
abnormal pulmonary endothelial cell surface  (IAGP)
abnormal vascular endothelial cell morphology  (IAGP)
anemia  (IAGP)
ascites  (IAGP)
decreased abdominal adipose tissue amount  (IAGP)
decreased body length  (IAGP)
decreased body size  (IAGP)
decreased body weight  (IAGP)
decreased circulating calcium level  (IAGP)
decreased circulating HDL cholesterol level  (IAGP)
decreased circulating serum albumin level  (IAGP)
decreased circulating total protein level  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased retroperitoneal fat pad weight  (IAGP)
decreased white adipose tissue amount  (IAGP)
distended abdomen  (IAGP)
edema  (IAGP)
hemorrhage  (IAGP)
hyperchylomicronemia  (IAGP)
increased circulating cholesterol level  (IAGP)
increased circulating triglyceride level  (IAGP)
increased nucleated erythrocyte cell number  (IAGP)
increased vascular permeability  (IAGP)
intestinal edema  (IAGP)
kinked tail  (IAGP)
lethality throughout fetal growth and development, complete penetrance  (IAGP)
lethality, incomplete penetrance  (IAGP)
pale kidney  (IAGP)
pallor  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, complete penetrance  (IAGP)
skin edema  (IAGP)
small kidney  (IAGP)
small pancreas  (IAGP)
small spleen  (IAGP)
thin ventricular wall  (IAGP)
ventricular septal defect  (IAGP)
xanthoma  (IAGP)
References

Additional References at PubMed
PMID:7626790   PMID:8889548   PMID:10488149   PMID:12477932   PMID:12620989   PMID:14610273   PMID:15489334   PMID:16969073   PMID:16969078   PMID:17075074   PMID:18403646   PMID:18729210  
PMID:18799693   PMID:19060331   PMID:19380791   PMID:19420356   PMID:19837033   PMID:20208005   PMID:20562862   PMID:20590523   PMID:20730909   PMID:20944625   PMID:21119013   PMID:21421844  
PMID:21606205   PMID:21652679   PMID:21677750   PMID:21807945   PMID:22025255   PMID:22340501   PMID:22403691   PMID:22535667   PMID:22558309   PMID:22568538   PMID:22782339   PMID:23237953  
PMID:23362346   PMID:25083995   PMID:25139991   PMID:25271254   PMID:25541982   PMID:25665101   PMID:26416771   PMID:27050100   PMID:27113764   PMID:27732581   PMID:27742829   PMID:27810956  
PMID:27880905   PMID:27912058   PMID:28560318   PMID:29237738   PMID:30698992   PMID:30886418   PMID:31666588   PMID:31759628   PMID:31836710   PMID:32059772   PMID:32325033   PMID:32369449  
PMID:32369453   PMID:32663411  


Genomics

Comparative Map Data
Plvap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,950,397 - 71,964,446 (-)NCBIGRCm39mm39
GRCm38871,497,753 - 71,511,806 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,497,765 - 71,511,752 (-)EnsemblGRCm38mm10GRCm38
MGSCv37874,021,652 - 74,035,668 (-)NCBIGRCm37mm9NCBIm37
MGSCv36874,426,754 - 74,440,720 (-)NCBImm8
Celera874,008,038 - 74,022,136 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
PLVAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1917,351,450 - 17,377,342 (-)EnsemblGRCh38hg38GRCh38
GRCh381917,351,455 - 17,377,342 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371917,462,264 - 17,488,137 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,323,264 - 17,349,137 (-)NCBINCBI36hg18NCBI36
Build 341917,323,263 - 17,349,137NCBI
Celera1917,364,020 - 17,389,889 (-)NCBI
Cytogenetic Map19p13.11NCBI
HuRef1917,028,734 - 17,054,390 (-)NCBIHuRef
CHM1_11917,461,531 - 17,487,440 (-)NCBICHM1_1
Plvap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01619,906,354 - 19,918,668 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,906,318 - 19,918,689 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01619,767,918 - 19,780,232 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41618,668,569 - 18,678,431 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11618,668,567 - 18,678,429 (-)NCBI
Celera1618,389,929 - 18,402,243 (-)NCBICelera
Cytogenetic Map16p14NCBI
Plvap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955524885,276 - 893,044 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955524885,245 - 895,552 (+)NCBIChiLan1.0ChiLan1.0
PLVAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11917,813,665 - 17,838,331 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,814,574 - 17,838,271 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01916,840,151 - 16,864,334 (-)NCBIMhudiblu_PPA_v0panPan3
PLVAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2045,351,091 - 45,416,477 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12045,405,295 - 45,417,093 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Plvap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365963,511,235 - 3,523,164 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PLVAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,324,560 - 60,344,448 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1260,324,565 - 60,344,450 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LOC103234138
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl615,857,947 - 15,879,058 (-)Ensembl
ChlSab1.1615,857,945 - 15,879,022 (-)NCBI
Plvap
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908602,388 - 613,445 (+)NCBI

Position Markers
AI607903  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,499,342 - 71,499,488UniSTSGRCm38
MGSCv37874,023,241 - 74,023,387UniSTSGRCm37
Celera874,009,627 - 74,009,773UniSTS
Cytogenetic Map8B3.3UniSTS
Whitehead/MRC_RH8766.18UniSTS
UniSTS:235922  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,510,802 - 71,511,104UniSTSGRCm38
MGSCv37874,034,701 - 74,035,003UniSTSGRCm37
Celera874,021,169 - 74,021,471UniSTS
Cytogenetic Map8B3.3UniSTS
Plvap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv37874,032,313 - 74,032,965UniSTSGRCm37
MGSCv37874,032,312 - 74,032,787UniSTSGRCm37
Celera874,018,780 - 74,019,255UniSTS
Celera874,018,781 - 74,019,433UniSTS
cM Map833.5UniSTS
Plvap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,508,414 - 71,509,066UniSTSGRCm38
MGSCv37874,032,313 - 74,032,965UniSTSGRCm37
Celera874,018,781 - 74,019,433UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS
Plvap  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38871,508,413 - 71,508,888UniSTSGRCm38
MGSCv37874,032,312 - 74,032,787UniSTSGRCm37
Celera874,018,780 - 74,019,255UniSTS
Cytogenetic Map8B3.3UniSTS
cM Map833.5UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4140967Bmd39_mbone mineral density 39 (mouse)Not determined832016544117238700Mouse
1558875Eae31_mexperimental allergic encephalomyelitis susceptibility 31 (mouse)Not determined834642776114837007Mouse
1301013Capsq4_mcapsaicin sensitivity related QTL 4 (mouse)Not determined83616300092728652Mouse
27226754Femd6_mfemur midshaft diameter 6, 10 week (mouse)837400000109600000Mouse
12904744Carcdq1_mcardiac collagen deposition QTL 1 (mouse)83970925694689598Mouse
1301544Iba3_minduction of brown adipocytes 3 (mouse)Not determined84429488078295025Mouse
1301717Adip4_madiposity 4 (mouse)Not determined84763703081637146Mouse
10766453Char11_mP. chabaudi malaria resistance QTL 11 (mouse)84763703081637146Mouse
1301441Skull11_mskull morphology 11 (mouse)Not determined84773713481737254Mouse
1357715Alaa3_malopecia areata 3 (mouse)Not determined84879293982793021Mouse
14746987Manh64_mmandible shape 64 (mouse)85005330684053306Mouse
14747005Mancz7_mmandible centroid size 7 (mouse)85005330684053306Mouse
14700686Civq3_mcerebral infarct volume QTL 3 (mouse)85188219185882191Mouse
1301506Aevm1_mautoimmune extremity vasculitis in MRL mice 1 (mouse)Not determined85428781788287993Mouse
1301952Im3_mimmunoregulatory 3 (mouse)Not determined85470661488706763Mouse
10412287Carg3_mCandida albicans resistance gene 3 (mouse)Not determined85554502889545028Mouse
11353828Gf7_mgonadal fat pad weight 7 (mouse)85820147992201479Mouse
10043975Obq31_mobesity QTL 31 (mouse)Not determined85840977692409776Mouse
1301688Orch6_mautoimmune orchitis resistance 6 (mouse)Not determined86078685094786976Mouse
4141285Tgq18_mtriglyceride QTL 18 (mouse)Not determined6346010797460107Mouse
4141797Skmw16_mskeletal muscle weight 16 (mouse)Not determined86393954797939696Mouse
1357787Vtbt5_mvertebral trabecular bone trait 5 (mouse)Not determined86535776899357920Mouse
10043992Hbnr11_mHeligmosomoides bakeri nematode resistance 11 (mouse)Not determined86560020799600347Mouse
10766466Char12_mP. chabaudi malaria resistance QTL 12 (mouse)86826982782600347Mouse
1301767Fcsa2_mfemoral cross-sectional area 2 (mouse)Not determined870305375104305495Mouse
4142283Imraq2_mimmune response to AAV2 QTL 2 (mouse)Not determined870305375104305495Mouse
1558780Idd22_minsulin dependent diabetes susceptibility 22 (mouse)Not determined871102903105103009Mouse
4141395Char2a_mP. chabaudi malaria resistance QTL 2a (mouse)Not determined7113678390202598Mouse
4142023W3q5_mweight 3 weeks QTL 5 (mouse)Not determined71287817123895615Mouse
1357708Orq1_movulation rate QTL 1 (mouse)Not determined871287817123895615Mouse
1301872Cd4ts3_mCD4 T cell subset 3 (mouse)Not determined871396181105396393Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:272
Count of miRNA genes:220
Interacting mature miRNAs:231
Transcripts:ENSMUST00000048452
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000048452   ⟹   ENSMUSP00000035404
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl871,497,765 - 71,511,752 (-)Ensembl
RefSeq Acc Id: NM_032398   ⟹   NP_115774
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,950,397 - 71,964,413 (-)NCBI
GRCm38871,497,753 - 71,511,769 (-)NCBI
MGSCv37874,021,652 - 74,035,668 (-)RGD
Celera874,008,038 - 74,022,136 (-)RGD
cM Map8 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_011242342   ⟹   XP_011240644
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39871,950,404 - 71,964,446 (-)NCBI
GRCm38871,497,760 - 71,511,806 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_115774   ⟸   NM_032398
- UniProtKB: Q91VC4 (UniProtKB/Swiss-Prot),   G3X924 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_011240644   ⟸   XM_011242342
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: ENSMUSP00000035404   ⟸   ENSMUST00000048452

Promoters
RGD ID:8667403
Promoter ID:EPDNEW_M11733
Type:initiation region
Name:Plvap_1
Description:Mus musculus plasmalemma vesicle associated protein , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38871,511,769 - 71,511,829EPDNEW
RGD ID:6848335
Promoter ID:MM_ACW:47897
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Spleen
Transcripts:PLVAP.CSEP07-UNSPLICED
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,022,276 - 74,023,137 (-)MPROMDB
RGD ID:6843621
Promoter ID:MM_KWN:54790
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Lung
Transcripts:ENSMUST00000110041,   NM_032398
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36874,035,286 - 74,035,786 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890497 AgrOrtholog
Ensembl Genes ENSMUSG00000034845 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000035404 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000048452 ENTREZGENE, UniProtKB/TrEMBL
InterPro PV-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:84094 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1890497 ENTREZGENE
NCBI Gene 84094 ENTREZGENE
PANTHER PTHR21687 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PV-1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Plvap PhenoGen
UniGene Mm.260768 ENTREZGENE
UniProt G3X924 ENTREZGENE, UniProtKB/TrEMBL
  PLVAP_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary Q99JB1 UniProtKB/Swiss-Prot