Gps2 (G protein pathway suppressor 2) - Rat Genome Database
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Pathways
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Gene: Gps2 (G protein pathway suppressor 2) Mus musculus
Analyze
Symbol: Gps2
Name: G protein pathway suppressor 2
RGD ID: 1620861
MGI Page MGI
Description: Orthologous to human GPS2 (G protein pathway suppressor 2); INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI505953; GPS-2
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm5221  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,804,805 - 69,807,882 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,804,714 - 69,807,417 (+)Ensembl
GRCm381169,913,980 - 69,917,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,913,888 - 69,916,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,727,694 - 69,730,093 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,730,387 - 69,732,786 (+)NCBImm8
Celera1177,462,080 - 77,464,479 (+)NCBICelera
Cytogenetic Map11B3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IDA)
cytosol  (ISO)
mitochondrion  (IDA,ISO)
nucleoplasm  (TAS)
nucleus  (IDA,ISO)
transcription repressor complex  (IDA,ISO)

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
1. RGD automated import pipeline
2. RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15695367   PMID:15782199   PMID:16141072   PMID:16602821  
PMID:18218630   PMID:20159957   PMID:22424771   PMID:22666460   PMID:24953653   PMID:25519902   PMID:26070566   PMID:27270589   PMID:27480124   PMID:28039360   PMID:28123943   PMID:29499132  
PMID:29767559   PMID:30208320   PMID:30975991   PMID:32384137   PMID:32937117  


Genomics

Comparative Map Data
Gps2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391169,804,805 - 69,807,882 (+)NCBIGRCm39mm39
GRCm39 Ensembl1169,804,714 - 69,807,417 (+)Ensembl
GRCm381169,913,980 - 69,917,056 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1169,913,888 - 69,916,591 (+)EnsemblGRCm38mm10GRCm38
MGSCv371169,727,694 - 69,730,093 (+)NCBIGRCm37mm9NCBIm37
MGSCv361169,730,387 - 69,732,786 (+)NCBImm8
Celera1177,462,080 - 77,464,479 (+)NCBICelera
Cytogenetic Map11B3NCBI
GPS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl177,311,324 - 7,315,564 (-)EnsemblGRCh38hg38GRCh38
GRCh38177,312,661 - 7,315,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37177,215,980 - 7,218,679 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36177,156,702 - 7,159,382 (-)NCBINCBI36hg18NCBI36
Build 34177,156,701 - 7,159,382NCBI
Celera177,241,919 - 7,244,599 (-)NCBI
Cytogenetic Map17p13.1NCBI
HuRef177,110,027 - 7,112,707 (-)NCBIHuRef
CHM1_1177,224,746 - 7,227,426 (-)NCBICHM1_1
Gps2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21054,637,360 - 54,640,542 (+)NCBI
Rnor_6.0 Ensembl1056,524,468 - 56,526,987 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01056,524,327 - 56,527,447 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01056,269,440 - 56,272,538 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41056,757,674 - 56,760,194 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1053,791,431 - 53,793,951 (+)NCBICelera
Cytogenetic Map10q24NCBI
Gps2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554679,600,829 - 9,603,606 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554679,600,829 - 9,604,148 (+)NCBIChiLan1.0ChiLan1.0
GPS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1177,333,474 - 7,336,378 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl177,333,571 - 7,335,871 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0177,346,766 - 7,349,682 (-)NCBIMhudiblu_PPA_v0panPan3
GPS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl532,273,173 - 32,275,580 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1532,273,169 - 32,275,915 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Gps2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936595608,730 - 611,871 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1252,664,873 - 52,667,610 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11252,664,869 - 52,667,643 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23139,940,663 - 139,943,454 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPS2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,690,831 - 6,694,245 (-)NCBI
ChlSab1.1 Ensembl166,686,667 - 6,693,804 (-)Ensembl
Gps2
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247869,938,384 - 9,941,210 (-)NCBI

Position Markers
AI505953  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381169,916,472 - 69,916,554UniSTSGRCm38
MGSCv371169,729,974 - 69,730,056UniSTSGRCm37
Celera1177,464,360 - 77,464,442UniSTS
Cytogenetic Map11B3UniSTS
Cytogenetic Map11B4UniSTS
Whitehead/MRC_RH11912.86UniSTS
RH126545  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381917,693,264 - 17,693,509UniSTSGRCm38
GRCm381169,916,745 - 69,916,994UniSTSGRCm38
MGSCv371917,767,754 - 17,767,999UniSTSGRCm37
MGSCv371169,730,247 - 69,730,496UniSTSGRCm37
Celera1177,464,633 - 77,464,882UniSTS
Celera1918,373,033 - 18,373,278UniSTS
Cytogenetic Map11B4UniSTS
Cytogenetic Map19BUniSTS
Cytogenetic Map11B3UniSTS
cM Map1915.0UniSTS
cM Map11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11330000072800000Mouse
13208559Wght10_mweight 10 (mouse)11400000089000000Mouse
13208558Lgth12_mbody length 12 (mouse)11400000095000000Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11693027789128908Mouse
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1917420497007000Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112185736495990405Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113600000085000000Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113639175083590530Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113661246070618665Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113672273870723028Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113719011571190238Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113812528972125383Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114236579176365904Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114236579176365904Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114473921176963931Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4141000Nidd3_mnon-insulin-dependent diabetes mellitus 3 (mouse)Not determined4515120179151308Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114527504680087498Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114581775489927907Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114629434180294436Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114642858180428696Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115018736584187585Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115260355986603559Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115349976287499911Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115423592683842826Mouse
4141875Etax9_methanol induced ataxia 9 (mouse)Not determined5539415972319101Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
1300664Etohcta9_methanol conditioned taste aversion 9 (mouse)Not determined115786383491863932Mouse
10053682Eae45_mexperimental allergic encephalomyelitis susceptibility 45 (mouse)Not determined115859972974863932Mouse
1300924Ity2_mimmunity to S. typhimurium 2 (mouse)Not determined15861720487804412Mouse
4141982Skts-fp2_mskin tumor susceptibility in FVB and PWK 2 (mouse)Not determined5882844085175703Mouse
1301987Pid3_mprior incubation determinant 3 (mouse)Not determined116179599488808902Mouse
1301319Dautb4_mdopamine uptake transporter binding 4 (mouse)Not determined116226517996265327Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301999Lmr15_mleishmaniasis resistance 15 (mouse)Not determined116342858181939647Mouse
10044004Stzid3_mstreptozotocin induced diabetes susceptibility 3 (mouse)Not determined116342858194173092Mouse
11039501Ltpr6a_mLeishmania tropica response 6a (mouse)116493951098939647Mouse
11039502Ltpr6b_mLeishmania tropica response 6b (mouse)116493951098939647Mouse
11039515Ltpr6_mLeishmania tropica response 6 (mouse)116493951098939647Mouse
1301546Pcir2_mperiosteal circumference 2 (mouse)Not determined1166842594100842826Mouse
1357766Si5lq6_mserum IGFBP-5 level QTL 6 (mouse)Not determined1166842594100842826Mouse
4141012Femwf6_mfemur work to failure 6 (mouse)Not determined66842594100842826Mouse
1301833Tbbmd5_mtotal body bone mineral density 5 (mouse)Not determined1166842594100842826Mouse
1300784Prdt3_mprion disease incubation time 3 (mouse)Not determined1166842594100842826Mouse
1300628Lgth6_mbody length 6 (mouse)Not determined1166842594100842826Mouse
4142316Ity2b_mimmunity to S. typhimurium 2b (mouse)Not determined116718736579923086Mouse
27226783Tibl5_mtibia length 5, 5 week (mouse)1168300000102000000Mouse
36049778Ars6_mantibody response to SARS-CoV 6, day 15, IgM (mouse)116910000072600000Mouse
36049779Ars7_mantibody response to SARS-CoV 7, day 29, IgG1 (mouse)116910000072600000Mouse
36049784Ars8_mantibody response to SARS-CoV 8, day 29, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049785Ars9_mantibody response to SARS-CoV 9, day 29, IgM (mouse)116910000072600000Mouse
36049786Ars10_mantibody response to SARS-CoV 10, 4 days post-rechallenge, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049787Ars11_mantibody response to SARS-CoV 11, 4 days post-rechallenge, IgM (mouse)116910000072600000Mouse
36049788Ars1_mantibody response to SARS-CoV 1, day 7, IgG1 (mouse)116910000072600000Mouse
36049789Ars2_mantibody response to SARS-CoV 2, day 7, IgG2a+IgG2c (mouse)116910000072600000Mouse
36049790Ars3_mantibody response to SARS-CoV 3, day 7, IgG2b (mouse)116910000072600000Mouse
36049791Ars4_mantibody response to SARS-CoV 4, day 7, IgG3 (mouse)116910000072600000Mouse
36049792Ars5_mantibody response to SARS-CoV 5, day 7, IgM (mouse)116910000072600000Mouse
35673314Ari2_mantibody response to influenza 2, day 10, IgG3 (mouse)116910000072600000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1026
Count of miRNA genes:370
Interacting mature miRNAs:410
Transcripts:ENSMUST00000057884, ENSMUST00000072581, ENSMUST00000116358, ENSMUST00000124596, ENSMUST00000134581
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000057884   ⟹   ENSMUSP00000054072
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,914,192 - 69,916,591 (+)Ensembl
RefSeq Acc Id: ENSMUST00000072581   ⟹   ENSMUSP00000072389
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,913,888 - 69,916,576 (+)Ensembl
RefSeq Acc Id: ENSMUST00000116358   ⟹   ENSMUSP00000112062
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,914,050 - 69,916,590 (+)Ensembl
RefSeq Acc Id: ENSMUST00000124596
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,914,845 - 69,915,880 (+)Ensembl
RefSeq Acc Id: ENSMUST00000134581   ⟹   ENSMUSP00000136921
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl1169,916,041 - 69,916,556 (+)Ensembl
RefSeq Acc Id: NM_001357906   ⟹   NP_001344835
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,804,846 - 69,807,420 (+)NCBI
GRCm381169,914,020 - 69,916,594 (+)NCBI
Sequence:
RefSeq Acc Id: NM_019726   ⟹   NP_062700
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,804,846 - 69,807,420 (+)NCBI
GRCm381169,914,020 - 69,916,594 (+)NCBI
MGSCv371169,727,694 - 69,730,093 (+)RGD
Celera1177,462,080 - 77,464,479 (+)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_030246187   ⟹   XP_030102047
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391169,804,805 - 69,807,882 (+)NCBI
GRCm381169,913,980 - 69,917,056 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_062700   ⟸   NM_019726
- UniProtKB: Q921N8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_030102047   ⟸   XM_030246187
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001344835   ⟸   NM_001357906
RefSeq Acc Id: ENSMUSP00000072389   ⟸   ENSMUST00000072581
RefSeq Acc Id: ENSMUSP00000136921   ⟸   ENSMUST00000134581
RefSeq Acc Id: ENSMUSP00000054072   ⟸   ENSMUST00000057884
RefSeq Acc Id: ENSMUSP00000112062   ⟸   ENSMUST00000116358

Promoters
RGD ID:6821012
Promoter ID:MM_KWN:8147
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000072581,   ENSMUST00000116358,   NM_019726,   OTTMUST00000013529,   UC007JSO.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,726,686 - 69,728,457 (+)MPROMDB
RGD ID:6821011
Promoter ID:MM_KWN:8148
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000013530
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361169,728,606 - 69,729,887 (+)MPROMDB
RGD ID:8675248
Promoter ID:EPDNEW_M15654
Type:initiation region
Name:Gps2_1
Description:Mus musculus G protein pathway suppressor 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15655  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,914,034 - 69,914,094EPDNEW
RGD ID:8675250
Promoter ID:EPDNEW_M15655
Type:initiation region
Name:Gps2_2
Description:Mus musculus G protein pathway suppressor 2 , transcript variant1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M15654  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381169,914,261 - 69,914,321EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1891751 AgrOrtholog
Ensembl Genes ENSMUSG00000023170 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000054072 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000072389 UniProtKB/Swiss-Prot
  ENSMUSP00000112062 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000136921 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000057884 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000072581 UniProtKB/Swiss-Prot
  ENSMUST00000116358 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000134581 UniProtKB/TrEMBL
InterPro GPS2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:56310 UniProtKB/Swiss-Prot
MGD MGI:1891751 ENTREZGENE
NCBI Gene 56310 ENTREZGENE
PANTHER PTHR22654 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam G_path_suppress UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Gps2 PhenoGen
UniProt GPS2_MOUSE UniProtKB/Swiss-Prot
  J3QNR4_MOUSE UniProtKB/TrEMBL
  Q921N8 ENTREZGENE
  Q9WV81_MOUSE UniProtKB/TrEMBL