Actn4 (actinin alpha 4) - Rat Genome Database

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Gene: Actn4 (actinin alpha 4) Mus musculus
Analyze
Symbol: Actn4
Name: actinin alpha 4
RGD ID: 62108
MGI Page MGI
Description: Enables actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Located in several cellular components, including Z disc; cytoskeleton; and pseudopodium. Is expressed in early conceptus and heart. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4); PARTICIPATES IN platelet-derived growth factor signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-actinin-4; C77391; F-actin cross-linking protein; MGC102374; non-muscle alpha-actinin 4
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Related Pseudogenes: Gm6101  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,592,673 - 28,661,799 (-)NCBIGRCm39mm39
GRCm39 Ensembl728,592,673 - 28,661,765 (-)Ensembl
GRCm38728,893,248 - 28,962,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,893,248 - 28,962,340 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,678,273 - 29,747,299 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,602,014 - 28,671,040 (-)NCBImm8
Celera723,454,694 - 23,523,720 (-)NCBICelera
Cytogenetic Map7B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal atrioventricular cushion morphology  (IEA)
abnormal blood urea nitrogen level  (IAGP)
abnormal coronary sinus connection  (IEA)
abnormal ductus venosus valve morphology  (IEA)
abnormal ductus venosus valve topology  (IEA)
abnormal eye muscle morphology  (IEA)
abnormal forebrain morphology  (IEA)
abnormal glomerular capillary morphology  (IAGP)
abnormal hypoglossal canal morphology  (IEA)
abnormal hypoglossal nerve topology  (IEA)
abnormal inferior vena cava morphology  (IEA)
abnormal infrahyoid muscle connection  (IEA)
abnormal intestine placement  (IEA)
abnormal lens epithelium morphology  (IEA)
abnormal lymphocyte chemotaxis  (IAGP)
abnormal Mullerian duct morphology  (IEA)
abnormal optic cup morphology  (IEA)
abnormal podocyte adhesion  (IAGP)
abnormal podocyte morphology  (IAGP)
abnormal renal glomerulus basement membrane morphology  (IAGP)
abnormal renal glomerulus morphology  (IAGP)
abnormal retina morphology  (IEA)
abnormal vein morphology  (IEA)
absent ductus venosus valve  (IEA)
absent hypoglossal canal  (IEA)
absent hypoglossal nerve  (IEA)
absent stapedial artery  (IEA)
absent superior cervical ganglion  (IEA)
albuminuria  (IAGP)
arteriovenous malformation  (IEA)
biliary cyst  (IEA)
blood in lymph vessels  (IEA)
cortical renal glomerulopathies  (IAGP)
decreased podocyte number  (IAGP)
detached podocyte  (IAGP)
dilated liver sinusoidal spaces  (IEA)
dilated renal tubules  (IAGP)
double outlet right ventricle  (IEA)
embryo tumor  (IEA)
glomerulosclerosis  (IAGP)
hemopericardium  (IEA)
heterochrony  (IEA)
increased trigeminal neuroma incidence  (IEA)
increased urine microalbumin level  (IAGP)
increased urine protein level  (IAGP)
kidney failure  (IAGP)
multiple persisting craniopharyngeal ducts  (IEA)
muscular ventricular septal defect  (IEA)
overriding aortic valve  (IEA)
pale kidney  (IAGP)
perimembraneous ventricular septal defect  (IEA)
perinatal lethality, incomplete penetrance  (IAGP)
persistent dorsal ophthalmic artery  (IEA)
podocyte foot process effacement  (IAGP)
postnatal growth retardation  (IAGP)
premature death  (IAGP)
preweaning lethality, incomplete penetrance  (IEA)
renal cast  (IAGP)
short snout  (IEA)
small hypoglossal canal  (IEA)
small kidney  (IAGP)
small superior cervical ganglion  (IEA)
subcutaneous edema  (IEA)
thin hypoglossal nerve  (IEA)
weight loss  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:10954430   PMID:10964513   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11440986   PMID:11544199   PMID:11724819   PMID:12217315  
PMID:12477932   PMID:12520002   PMID:12707390   PMID:12782671   PMID:12837758   PMID:12904583   PMID:12960352   PMID:14610273   PMID:15048094   PMID:15208719   PMID:15465019   PMID:15489334  
PMID:15633123   PMID:15782199   PMID:15841212   PMID:16141072   PMID:16141073   PMID:16196101   PMID:16319116   PMID:16751418   PMID:16837921   PMID:16944923   PMID:16998848   PMID:17082197  
PMID:17901210   PMID:17967808   PMID:18185509   PMID:18332111   PMID:18425115   PMID:18799693   PMID:19075228   PMID:19640905   PMID:20197409   PMID:20215401   PMID:20368620   PMID:21085685  
PMID:21267068   PMID:21565611   PMID:21677750   PMID:21725061   PMID:21784188   PMID:21873635   PMID:21940706   PMID:22114352   PMID:22673512   PMID:22693585   PMID:22804863   PMID:22929799  
PMID:23055941   PMID:23466492   PMID:23515331   PMID:23557398   PMID:23890175   PMID:24375477   PMID:24457600   PMID:24614889   PMID:24662305   PMID:24940801   PMID:25411248   PMID:25962121  
PMID:27160897   PMID:28190767   PMID:28378742   PMID:28706196   PMID:29111324   PMID:29114040   PMID:29378953   PMID:29459677   PMID:29539633   PMID:29873512   PMID:30196744   PMID:30333137  
PMID:30409884   PMID:30550785   PMID:30562941   PMID:30776251   PMID:30947518   PMID:31062503   PMID:32325033   PMID:32540856   PMID:32581705   PMID:33228246  


Genomics

Comparative Map Data
Actn4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39728,592,673 - 28,661,799 (-)NCBIGRCm39mm39
GRCm39 Ensembl728,592,673 - 28,661,765 (-)Ensembl
GRCm38728,893,248 - 28,962,351 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl728,893,248 - 28,962,340 (-)EnsemblGRCm38mm10GRCm38
MGSCv37729,678,273 - 29,747,299 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,602,014 - 28,671,040 (-)NCBImm8
Celera723,454,694 - 23,523,720 (-)NCBICelera
Cytogenetic Map7B1NCBI
ACTN4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1938,647,649 - 38,731,589 (+)EnsemblGRCh38hg38GRCh38
GRCh381938,647,649 - 38,731,589 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371939,138,289 - 39,222,229 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361943,830,167 - 43,913,010 (+)NCBINCBI36hg18NCBI36
Build 341943,830,166 - 43,913,010NCBI
Celera1935,940,352 - 36,023,163 (+)NCBI
Cytogenetic Map19q13.2NCBI
HuRef1935,584,836 - 35,667,954 (+)NCBIHuRef
CHM1_11939,139,090 - 39,221,979 (+)NCBICHM1_1
Actn4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2184,182,783 - 84,251,867 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl184,182,788 - 84,251,847 (-)Ensembl
Rnor_6.0187,078,012 - 87,147,347 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl187,078,020 - 87,147,333 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0188,258,630 - 88,327,965 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4184,000,723 - 84,073,767 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1184,079,711 - 84,151,876 (-)NCBI
Celera178,572,890 - 78,641,919 (-)NCBICelera
Cytogenetic Map1q21NCBI
Actn4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955468770,573 - 842,209 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955468770,573 - 841,859 (-)NCBIChiLan1.0ChiLan1.0
ACTN4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11944,313,569 - 44,395,508 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1944,313,569 - 44,395,508 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01935,742,758 - 35,825,321 (+)NCBIMhudiblu_PPA_v0panPan3
ACTN4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11114,354,993 - 114,427,997 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1114,309,693 - 114,427,991 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1113,759,618 - 113,832,649 (-)NCBI
ROS_Cfam_1.01114,956,867 - 115,029,926 (-)NCBI
UMICH_Zoey_3.11114,530,067 - 114,602,907 (-)NCBI
UNSW_CanFamBas_1.01114,147,609 - 114,220,650 (-)NCBI
UU_Cfam_GSD_1.01115,186,154 - 115,259,191 (-)NCBI
Actn4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934913,167,758 - 13,237,529 (+)NCBI
SpeTri2.0NW_0049368011,333,077 - 1,402,885 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ACTN4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl647,493,882 - 47,569,609 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1647,493,834 - 47,565,999 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2643,045,503 - 43,126,155 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ACTN4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1633,290,639 - 33,373,059 (+)NCBI
ChlSab1.1 Ensembl633,290,622 - 33,374,693 (+)Ensembl
Vero_WHO_p1.0NW_02366607311,240,578 - 11,323,802 (+)NCBI
Actn4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462479412,042,627 - 12,113,762 (+)NCBI

Position Markers
C77391  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,893,995 - 28,894,167UniSTSGRCm38
MGSCv37729,679,014 - 29,679,186UniSTSGRCm37
Celera723,455,435 - 23,455,607UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7396.52UniSTS
Actn4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS
RH126173  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,908,853 - 28,909,102UniSTSGRCm38
MGSCv37729,693,872 - 29,694,121UniSTSGRCm37
Celera723,470,293 - 23,470,542UniSTS
Cytogenetic Map7A3UniSTS
Whitehead/MRC_RH7405.09UniSTS
PMC343810P2  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,897,949 - 28,898,153UniSTSGRCm38
MGSCv37729,682,968 - 29,683,172UniSTSGRCm37
Celera723,459,389 - 23,459,593UniSTS
Cytogenetic Map7A3UniSTS
MARC_12245-12246:1008698037:1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm38728,911,509 - 28,912,290UniSTSGRCm38
MGSCv37729,696,528 - 29,697,309UniSTSGRCm37
Celera723,472,949 - 23,473,730UniSTS
Cytogenetic Map7A3UniSTS
Actn4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS
cM Map7 UniSTS
Actn4  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map7A3UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1301572Sluc30_msusceptibility to lung cancer 30 (mouse)Not determined7269777136697919Mouse
1300722Sle3_msystemic lupus erythmatosus susceptibility 3 (mouse)Not determined7346321287493512Mouse
38501068Tip1_mtuberculosis immunophenotype 1, spleen CFU (mouse)7360000072900000Mouse
25314307Mlh1fc2_mMLH1 foci count 2 (mouse)76500000133900000Mouse
1357699Nhdlq6_mnon-HDL QTL 6 (mouse)Not determined71028944244289559Mouse
1558893Spir1_mStreptococcus pneumoniae infection resistance 1 (mouse)Not determined71060637344606511Mouse
10449139Eosn1_meosinophil differential 1 (mouse)71278145246781452Mouse
10449158Eosn3_meosinophil differential 3 (mouse)71278145246781452Mouse
4141566Femwf8_mfemur work to failure 8 (mouse)Not determined1333306047333196Mouse
11522751Cocia17_mcocaine-induced activity, QTL 17 (mouse)71343577947435779Mouse
25314314Sccor1_msynaptonemal complex length to mean MLH1 count ratio 1 (mouse)71360000047700000Mouse
1559016Drsi_mDCC-related Spp1 induction (mouse)Not determined71690336849509583Mouse
1301041Prnr2_mprion resistance 2 (mouse)Not determined71899486940024609Mouse
10412199Sst2_msusceptibility to tuberculosis 2 (mouse)Not determined718994869119886157Mouse
1301158Eae4_msusceptibility to experimental allergic encephalomyelitis 4 (mouse)Not determined719413473142366067Mouse
1301622Eae12_msusceptibility to experimental allergic encephalomyelitis 12 (mouse)Not determined71958059053580679Mouse
1301052Bhr6_mbronchial hyperresponsiveness 6 (mouse)Not determined72014282554142942Mouse
12904742Litsq2_mlitter size QTL 2 (mouse)72302446357024609Mouse
1301709Bdt4_mbone density traits 4 (mouse)Not determined72323914857239292Mouse
11354952Pdcc1_mplasmacytoid dentritic cell compartment 1 (mouse)72341710757417107Mouse
1301969Lbw5_mlupus NZB x NZW 5 (mouse)Not determined72719819161202351Mouse
7394747asp3_maudiogenic seizure prone 3 (mouse)Not determined72760637337142942Mouse
12790989Tgl6_mtriglyceride 6 (mouse)72789112561891125Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1692
Count of miRNA genes:613
Interacting mature miRNAs:775
Transcripts:ENSMUST00000068045, ENSMUST00000127210, ENSMUST00000129338, ENSMUST00000140622, ENSMUST00000143584, ENSMUST00000144909, ENSMUST00000148196, ENSMUST00000150493
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001360548 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360549 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001360550 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_021895 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006540257 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153311 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036153312 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_004934159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC166357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AI845456 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AJ289242 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK030237 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK077839 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK145322 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK150044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177173 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177458 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK180678 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182497 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK182840 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK183379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186041 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK186329 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK187645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK188747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189613 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189688 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK190205 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK191304 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK192806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193386 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK197401 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199718 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199777 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK199782 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK201509 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK202682 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK211546 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK212723 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK215382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK216383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK217326 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK219364 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC013616 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC027032 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC087554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ303410 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ303411 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U41415 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U41416 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000068045   ⟹   ENSMUSP00000066068
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,592,673 - 28,661,765 (-)Ensembl
GRCm38.p6 Ensembl728,893,248 - 28,962,340 (-)Ensembl
RefSeq Acc Id: ENSMUST00000127210   ⟹   ENSMUSP00000115436
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,598,045 - 28,661,648 (-)Ensembl
GRCm38.p6 Ensembl728,898,620 - 28,962,223 (-)Ensembl
RefSeq Acc Id: ENSMUST00000129338
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,593,657 - 28,594,277 (-)Ensembl
GRCm38.p6 Ensembl728,894,232 - 28,894,852 (-)Ensembl
RefSeq Acc Id: ENSMUST00000140622   ⟹   ENSMUSP00000123210
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,606,439 - 28,618,646 (-)Ensembl
GRCm38.p6 Ensembl728,907,014 - 28,919,221 (-)Ensembl
RefSeq Acc Id: ENSMUST00000143584
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,595,067 - 28,596,456 (-)Ensembl
GRCm38.p6 Ensembl728,895,642 - 28,897,031 (-)Ensembl
RefSeq Acc Id: ENSMUST00000144909
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,593,078 - 28,606,810 (-)Ensembl
GRCm38.p6 Ensembl728,893,653 - 28,907,385 (-)Ensembl
RefSeq Acc Id: ENSMUST00000148196   ⟹   ENSMUSP00000122268
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,612,803 - 28,649,184 (-)Ensembl
GRCm38.p6 Ensembl728,913,378 - 28,949,759 (-)Ensembl
RefSeq Acc Id: ENSMUST00000150493
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,601,340 - 28,607,111 (-)Ensembl
GRCm38.p6 Ensembl728,901,915 - 28,907,686 (-)Ensembl
RefSeq Acc Id: ENSMUST00000207765
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,594,834 - 28,596,723 (-)Ensembl
GRCm38.p6 Ensembl728,895,409 - 28,897,298 (-)Ensembl
RefSeq Acc Id: ENSMUST00000216863   ⟹   ENSMUSP00000151188
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,593,136 - 28,597,618 (-)Ensembl
GRCm38.p6 Ensembl728,893,711 - 28,898,193 (-)Ensembl
RefSeq Acc Id: ENSMUST00000217157   ⟹   ENSMUSP00000151028
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl728,593,080 - 28,661,765 (-)Ensembl
GRCm38.p6 Ensembl728,893,655 - 28,962,340 (-)Ensembl
RefSeq Acc Id: NM_001360548   ⟹   NP_001347477
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,757 (-)NCBI
GRCm38728,893,248 - 28,962,332 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360549   ⟹   NP_001347478
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,757 (-)NCBI
GRCm38728,893,248 - 28,962,332 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001360550   ⟹   NP_001347479
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,757 (-)NCBI
GRCm38728,893,248 - 28,962,332 (-)NCBI
Sequence:
RefSeq Acc Id: NM_021895   ⟹   NP_068695
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,757 (-)NCBI
GRCm38728,893,248 - 28,962,332 (-)NCBI
MGSCv37729,678,273 - 29,747,299 (-)RGD
Celera723,454,694 - 23,523,720 (-)RGD
cM Map7 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_006540255   ⟹   XP_006540318
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,799 (-)NCBI
GRCm38728,893,248 - 28,962,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006540257   ⟹   XP_006540320
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,799 (-)NCBI
GRCm38728,893,248 - 28,962,351 (-)NCBI
Sequence:
RefSeq Acc Id: XM_036153311   ⟹   XP_036009204
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,670 (-)NCBI
RefSeq Acc Id: XM_036153312   ⟹   XP_036009205
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,706 (-)NCBI
RefSeq Acc Id: XR_004934159
RefSeq Status:
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39728,592,673 - 28,661,706 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_068695   ⟸   NM_021895
- Peptide Label: isoform 1
- UniProtKB: P57780 (UniProtKB/Swiss-Prot),   Q3ULT2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006540320   ⟸   XM_006540257
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_006540318   ⟸   XM_006540255
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: NP_001347478   ⟸   NM_001360549
- Peptide Label: isoform 3
RefSeq Acc Id: NP_001347477   ⟸   NM_001360548
- Peptide Label: isoform 2
RefSeq Acc Id: NP_001347479   ⟸   NM_001360550
- Peptide Label: isoform 4
RefSeq Acc Id: ENSMUSP00000151028   ⟸   ENSMUST00000217157
RefSeq Acc Id: ENSMUSP00000151188   ⟸   ENSMUST00000216863
RefSeq Acc Id: ENSMUSP00000066068   ⟸   ENSMUST00000068045
RefSeq Acc Id: ENSMUSP00000115436   ⟸   ENSMUST00000127210
RefSeq Acc Id: ENSMUSP00000123210   ⟸   ENSMUST00000140622
RefSeq Acc Id: ENSMUSP00000122268   ⟸   ENSMUST00000148196
RefSeq Acc Id: XP_036009205   ⟸   XM_036153312
- Peptide Label: isoform X3
RefSeq Acc Id: XP_036009204   ⟸   XM_036153311
- Peptide Label: isoform X2
Protein Domains
Calponin-homology (CH)   EF-hand

Promoters
RGD ID:6892504
Promoter ID:EPDNEW_M9703
Type:initiation region
Name:Actn4_1
Description:Mus musculus actinin alpha 4 , transcript variant 1, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38728,962,281 - 28,962,341EPDNEW
RGD ID:6840492
Promoter ID:MM_KWN:49684
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   Brain,   Kidney,   Liver,   Lung,   MEF_B6
Transcripts:OTTMUST00000041195
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,679,481 - 29,680,522 (-)MPROMDB
RGD ID:6840491
Promoter ID:MM_KWN:49685
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000041194
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,681,631 - 29,683,007 (-)MPROMDB
RGD ID:6840485
Promoter ID:MM_KWN:49686
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   Kidney,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000041189,   OTTMUST00000041193
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,692,206 - 29,693,687 (-)MPROMDB
RGD ID:6840487
Promoter ID:MM_KWN:49687
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:OTTMUST00000041191
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,703,821 - 29,705,232 (-)MPROMDB
RGD ID:6840486
Promoter ID:MM_KWN:49688
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Brain,   Kidney,   Lung,   MEF_B6
Transcripts:OTTMUST00000041190
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,734,736 - 29,735,722 (-)MPROMDB
RGD ID:6840488
Promoter ID:MM_KWN:49689
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:OTTMUST00000041188,   OTTMUST00000041192
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv36729,747,171 - 29,748,322 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1890773 AgrOrtholog
Ensembl Genes ENSMUSG00000054808 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000066068 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000115436 UniProtKB/TrEMBL
  ENSMUSP00000122268 UniProtKB/TrEMBL
  ENSMUSP00000123210 UniProtKB/TrEMBL
  ENSMUSP00000151028 ENTREZGENE, UniProtKB/TrEMBL
  ENSMUSP00000151188 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000068045 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000127210 UniProtKB/TrEMBL
  ENSMUST00000140622 UniProtKB/TrEMBL
  ENSMUST00000148196 UniProtKB/TrEMBL
  ENSMUST00000216863 UniProtKB/TrEMBL
  ENSMUST00000217157 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 1.10.418.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Actinin_actin-bd_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CH_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand-dom_pair UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF-hand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_hand_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin/alpha-actinin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:60595 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1890773 ENTREZGENE
NCBI Gene 60595 ENTREZGENE
Pfam EF-hand_7 UniProtKB/TrEMBL
  EF-hand_8 UniProtKB/TrEMBL
  EFhand_Ca_insen UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PF00307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Spectrin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Actn4 PhenoGen
PROSITE ACTININ_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACTININ_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EF_HAND_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50021 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART EFh UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00033 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPEC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF47576 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1L1SV25_MOUSE UniProtKB/TrEMBL
  A0A1L1SVJ6_MOUSE UniProtKB/TrEMBL
  ACTN4_MOUSE UniProtKB/Swiss-Prot
  D3Z0L8_MOUSE UniProtKB/TrEMBL
  D3Z761_MOUSE UniProtKB/TrEMBL
  E9Q2W9_MOUSE UniProtKB/TrEMBL
  P57780 ENTREZGENE
  Q1A602_MOUSE UniProtKB/TrEMBL
  Q3UDJ7_MOUSE UniProtKB/TrEMBL
  Q3ULT2 ENTREZGENE, UniProtKB/TrEMBL
  Q61063_MOUSE UniProtKB/TrEMBL
  Q61064_MOUSE UniProtKB/TrEMBL
  Q8BP35_MOUSE UniProtKB/TrEMBL