Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Actn4 (actinin alpha 4) Mus musculus
Symbol: Actn4
Name: actinin alpha 4
RGD ID: 62108
Description: Exhibits actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Localizes to several cellular components, including Z disc; cortical cytoskeleton; and pseudopodium. Colocalizes with stress fiber. Is expressed in early conceptus and heart. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4); PARTICIPATES IN platelet-derived growth factor signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; Entamoebiasis pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: alpha-actinin-4; C77391; F-actin cross-linking protein; MGC102374; non-muscle alpha-actinin 4
Homo sapiens (human) : ACTN4 (actinin alpha 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Actn4 (actinin alpha 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Actn4 (actinin alpha 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ACTN4 (actinin alpha 4)
Canis lupus familiaris (dog) : ACTN4 (actinin alpha 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Actn4 (actinin alpha 4)
Sus scrofa (pig) : ACTN4 (actinin alpha 4)
Chlorocebus sabaeus (African green monkey) : ACTN4 (actinin alpha 4)
Heterocephalus glaber (naked mole-rat) : Actn4 (actinin alpha 4)
more info ...
Related Pseudogenes: Gm6101  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl728,893,248 - 28,962,340 (-)EnsemblGRCm38mm10GRCm38
GRCm38728,893,248 - 28,962,351 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37729,678,273 - 29,747,299 (-)NCBIGRCm37mm9NCBIm37
MGSCv36728,602,014 - 28,671,040 (-)NCBImm8
Celera723,454,694 - 23,523,720 (-)NCBICelera
Cytogenetic Map7B1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Actn4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 62108
Created: 2001-04-11
Species: Mus musculus
Last Modified: 2020-09-23
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.