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Gene: Pias3 (protein inhibitor of activated STAT 3) Mus musculus
Symbol: Pias3
Name: protein inhibitor of activated STAT 3
RGD ID: 1332134
Description: Exhibits SUMO transferase activity. Involved in several processes, including TNFSF11-mediated signaling pathway; negative regulation of osteoclast differentiation; and protein sumoylation. Localizes to cytoplasm and nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and hair follicle. Orthologous to human PIAS3 (protein inhibitor of activated STAT 3); PARTICIPATES IN interleukin-6 signaling pathway; Jak-Stat signaling pathway; sumoylation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; MGC27936; P; Pias3l; protein inhibitor of activated STAT protein 3
Homo sapiens (human) : PIAS3 (protein inhibitor of activated STAT 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pias3 (protein inhibitor of activated STAT, 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pias3 (protein inhibitor of activated STAT 3)
Pan paniscus (bonobo/pygmy chimpanzee) : PIAS3 (protein inhibitor of activated STAT 3)
Canis lupus familiaris (dog) : PIAS3 (protein inhibitor of activated STAT 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pias3 (protein inhibitor of activated STAT 3)
Sus scrofa (pig) : PIAS3 (protein inhibitor of activated STAT 3)
Chlorocebus sabaeus (African green monkey) : PIAS3 (protein inhibitor of activated STAT 3)
Heterocephalus glaber (naked mole-rat) : Pias3 (protein inhibitor of activated STAT 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm39396,603,679 - 96,613,386 (+)NCBI
GRCm38396,696,361 - 96,706,070 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl396,696,384 - 96,706,070 (+)EnsemblGRCm38mm10GRCm38
MGSCv37396,500,298 - 96,509,993 (+)NCBIGRCm37mm9NCBIm37
MGSCv36396,781,874 - 96,791,367 (+)NCBImm8
Celera398,105,407 - 98,115,104 (+)NCBICelera
Cytogenetic Map3F2.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pias3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1332134
Created: 2005-02-01
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.