Mir125b-2 (microRNA 125b-2) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mir125b-2 (microRNA 125b-2) Mus musculus
Analyze
Symbol: Mir125b-2
Name: microRNA 125b-2
RGD ID: 1607571
MGI Page MGI
Description: Enables RNA binding activity. Involved in miRNA-mediated gene silencing. Acts upstream of or within several processes, including cellular response to cytokine stimulus; cellular response to forskolin; and common myeloid progenitor cell proliferation. Is expressed in several structures, including brain; early conceptus; heart; and lung. Orthologous to human MIR125B2 (microRNA 125b-2).
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-125b; mir-125b-2; Mirn125; Mirn125b-2
RGD Orthologs
Human
Rat
Dog
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391677,443,161 - 77,443,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1677,443,161 - 77,443,231 (+)EnsemblGRCm39 Ensembl
GRCm381677,646,273 - 77,646,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1677,646,273 - 77,646,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv371677,646,518 - 77,646,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1677,873,203 - 77,873,273 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12007417   PMID:15634332   PMID:15845075   PMID:16247770   PMID:16369549   PMID:16381832   PMID:16766679   PMID:17369397   PMID:17505514   PMID:17604727   PMID:18311128   PMID:18347971  
PMID:18452032   PMID:19188425   PMID:19559694   PMID:19726871   PMID:20159450   PMID:20215419   PMID:20413612   PMID:20439489   PMID:20660734   PMID:21037258   PMID:21118986   PMID:21200031  
PMID:21267068   PMID:21347262   PMID:21368288   PMID:21643937   PMID:21806957   PMID:21822254   PMID:21935352   PMID:21993888   PMID:22144232   PMID:22164278   PMID:22366319   PMID:23646144  
PMID:24318812   PMID:24516121   PMID:24598163   PMID:24736844   PMID:25092555   PMID:25403182   PMID:25751060   PMID:25858512   PMID:26059631   PMID:26138442   PMID:26139524   PMID:26272872  
PMID:26681446   PMID:26794445   PMID:27835742   PMID:28281528   PMID:28432360   PMID:30286140   PMID:30609807   PMID:31080058   PMID:31949279   PMID:33319811   PMID:33386874   PMID:33475982  
PMID:34524260   PMID:34988755   PMID:36270980   PMID:36319063  


Genomics

Comparative Map Data
Mir125b-2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391677,443,161 - 77,443,231 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1677,443,161 - 77,443,231 (+)EnsemblGRCm39 Ensembl
GRCm381677,646,273 - 77,646,343 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1677,646,273 - 77,646,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv371677,646,518 - 77,646,588 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1677,873,203 - 77,873,273 (+)NCBICelera
Cytogenetic Map16C3.1NCBI
MIR125B2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382116,590,237 - 16,590,325 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl2116,590,237 - 16,590,325 (+)EnsemblGRCh38hg38GRCh38
GRCh372117,962,557 - 17,962,645 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362116,884,427 - 16,884,515 (+)NCBINCBI36Build 36hg18NCBI36
Celera213,132,744 - 3,132,832 (+)NCBICelera
Cytogenetic Map21q21.1NCBI
HuRef213,343,306 - 3,343,394 (+)NCBIHuRef
CHM1_12117,523,172 - 17,523,260 (+)NCBICHM1_1
T2T-CHM13v2.02114,945,711 - 14,945,799 (+)NCBIT2T-CHM13v2.0
Mir125b2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21116,245,620 - 16,245,707 (+)NCBImRatBN7.2mRatBN7.2
UTH_Rnor_SHR_Utx1124,899,593 - 24,899,680 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01117,614,454 - 17,614,541 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01116,775,310 - 16,775,397 (+)NCBIRnor_WKY
Rnor_6.01116,097,346 - 16,097,433 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01119,752,280 - 19,752,367 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1116,251,853 - 16,251,940 (+)NCBICelera
Cytogenetic Map11q11NCBI
MIR125B-2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13113,304,980 - 13,305,040 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3113,304,964 - 13,305,052 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3113,318,783 - 13,318,843 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.03113,334,446 - 13,334,506 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3113,334,430 - 13,334,518 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13113,303,634 - 13,303,694 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03113,342,383 - 13,342,443 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03113,742,924 - 13,742,984 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Smommu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20216554
Ddx19bmmu-miR-125b-5pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)16495412
Lin28ammu-miR-125b-5pMirtarbaseexternal_infoB-globin reporter assay//MicroarrayFunctional MTI16495412
Lin28ammu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI16227573
Tnfmmu-miR-125b-5pMirtarbaseexternal_infoGFP reporter assay//Luciferase reporter assayFunctional MTI17911593
Trim71mmu-miR-125b-5pMirtarbaseexternal_infoqRT-PCRNon-Functional MTI (Weak)19898466
Igf2mmu-miR-125b-5pMirtarbaseexternal_infoNorthern blot//qRT-PCR//Western blotFunctional MTI21200031
Suv39h1mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI20699419
Cbfbmmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22689670
Vsirmmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI22751012
Snai1mmu-miR-125b-5pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI21945074
Erbb3mmu-miR-125b-5pOncomiRDBexternal_infoNANA23437196
Mmp13mmu-miR-125b-5pOncomiRDBexternal_infoNANA23425975
Tacstd2mmu-miR-125b-5pOncomiRDBexternal_infoNANA23416980
Bmfmmu-miR-125b-5pMirtarbaseexternal_infoqRT-PCRFunctional MTI (Weak)21118986
Pik3cdmmu-miR-125b-5pOncomiRDBexternal_infoNANA23160634
Sirt7mmu-miR-125b-5pOncomiRDBexternal_infoNANA23079745
E2f2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22999819
Mcl1mmu-miR-125b-5pOncomiRDBexternal_infoNANA22942733
Mcl1mmu-miR-125b-5pOncomiRDBexternal_infoNANA22824797
Junmmu-miR-125b-5pOncomiRDBexternal_infoNANA22797068
Mmp13mmu-miR-125b-5pOncomiRDBexternal_infoNANA22782903
Stard13mmu-miR-125b-5pOncomiRDBexternal_infoNANA22693547
Tnfaip3mmu-miR-125b-5pOncomiRDBexternal_infoNANA22550173
Arid3ammu-miR-125b-5pOncomiRDBexternal_infoNANA22469780
Erbb2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22460089
Arid3bmmu-miR-125b-5pOncomiRDBexternal_infoNANA22307404
Bcl2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22293115
Bcl2mmu-miR-125b-5pOncomiRDBexternal_infoNANA22139839
Stat3mmu-miR-125b-5pOncomiRDBexternal_infoNANA22093834
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21880154
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21823019
Pgfmmu-miR-125b-5pOncomiRDBexternal_infoNANA21703189
Ets1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21444677
Muc1mmu-miR-125b-5pOncomiRDBexternal_infoNANA21308711
Trp53mmu-miR-125b-5pOncomiRDBexternal_infoNANA20886540
Lin28bmmu-miR-125b-5pOncomiRDBexternal_infoNANA20827722
Muc1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20729973
Bcl3mmu-miR-125b-5pOncomiRDBexternal_infoNANA20658525
E2f3mmu-miR-125b-5pOncomiRDBexternal_infoNANA20549700
Bak1mmu-miR-125b-5pOncomiRDBexternal_infoNANA20460378
Cyp24a1mmu-miR-125b-5pOncomiRDBexternal_infoNANA19570947
Bmfmmu-miR-125b-5pOncomiRDBexternal_infoNANA19471102
Cyp27b1mmu-miR-125b-5pOncomiRDBexternal_infoNANA19437538
Erbb2mmu-miR-125b-5pOncomiRDBexternal_infoNANA17110380

Predicted Targets
Summary Value
Count of predictions:9947
Count of gene targets:5190
Count of transcripts:8162
Interacting mature miRNAs:mmu-miR-125b-2-3p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
26884376Skwq4_mskull length QTL 4, 5 week (mouse)16841786490896888Mouse
1357517Bwtn1_mbody weight at necropsy 1 (mouse)Not determined162001932985600826Mouse
1302096Aod1a_mautoimmune ovarian dysgenesis 1a (mouse)Not determined163544664392573008Mouse
26884416Bzwq5_mbi-zygomatic width QTL 5, 5 week (mouse)163732036284696888Mouse
11522747Eae41_mexperimental allergic encephalomyelitis susceptibility 41 (mouse)164039913478015472Mouse
1357778Diobq_mdiet-induced obesity QTL (mouse)Not determined164219781782331174Mouse
4141212Imraq3_mimmune response to AAV2 QTL 3 (mouse)Not determined164438335078383506Mouse
1301719Remslp3_mrapid eye movement sleep 3 (mouse)Not determined164438335078383506Mouse
14928310Manh80_mmandible shape 80 (mouse)164821984182219841Mouse
1301394Eae11_msusceptibility to experimental allergic encephalomyelitis 11 (mouse)Not determined165356189187562035Mouse
1301364Lith14_mlithogenic gene 14 (mouse)Not determined165566184689661961Mouse
1301125Sluc27_msusceptibility to lung cancer 27 (mouse)Not determined166160864495608764Mouse
4141113Tgq28_mtriglyceride QTL 28 (mouse)Not determined6298664696986646Mouse
1300928Etia_methanol induced activation (mouse)Not determined166331390797314016Mouse
1558740Bpq9_mblood pressure QTL 9 (mouse)Not determined166332733697327472Mouse
1302194Pgia10_mproteoglycan induced arthritis 10 (mouse)Not determined166860072298008968Mouse
1301032Tauph_mtau phosphorylation (mouse)Not determined166907613298008968Mouse
11049573Lmr18b_mleishmaniasis resistance 18b (mouse)166912761198008968Mouse
11049574Lmr18a_mleishmaniasis resistance 18a (mouse)166912761198008968Mouse
4142262Lmr18_mleishmaniasis resistance 18 (mouse)Not determined166912761198008968Mouse
11522753Cocia19_mcocaine-induced activity, QTL 19 (mouse)166925448298008968Mouse
1301598Renf2_mrenal failure 2 (mouse)Not determined167038025298008968Mouse
10412076Pod_mplasticity of ocular dominance (mouse)Not determined167354484584350326Mouse
12880403Sefq1_mstress effect QTL 1 (mouse)167469664378896643Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000083538
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1677,443,161 - 77,443,231 (+)Ensembl
GRCm38.p6 Ensembl1677,646,273 - 77,646,343 (+)Ensembl
RefSeq Acc Id: NR_029540
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391677,443,161 - 77,443,231 (+)NCBI
GRCm381677,646,273 - 77,646,343 (+)ENTREZGENE
MGSCv371677,646,518 - 77,646,588 (+)RGD
Celera1677,873,203 - 77,873,273 (+)RGD
cM Map16 ENTREZGENE
Sequence:
Promoters
RGD ID:13674262
Promoter ID:EPDNEW_M21280
Type:single initiation site
Name:Mir125b-2_1
Description:Mus musculus microRNA 125b-2 (Mir125b-2), microRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381677,646,341 - 77,646,401EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:3618706 AgrOrtholog
Ensembl Genes ENSMUSG00000065472 Ensembl, ENTREZGENE
Ensembl Transcript ENSMUST00000083538 ENTREZGENE
MGD MGI:3618706 ENTREZGENE
miRBase MI0000152 ENTREZGENE
NCBI Gene 723952 ENTREZGENE
PhenoGen Mir125b-2 PhenoGen
RNAcentral URS0000209905 RNACentral
  URS000030A921 RNACentral
  URS000075DBD1 RNACentral