Cd70 (CD70 antigen) - Rat Genome Database

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Gene: Cd70 (CD70 antigen) Mus musculus
Analyze
Symbol: Cd70
Name: CD70 antigen
RGD ID: 1557740
MGI Page MGI
Description: Predicted to enable cytokine activity and protease binding activity. Predicted to be involved in several processes, including B cell proliferation; T cell mediated immunity; and extrinsic apoptotic signaling pathway. Predicted to be located in extracellular space and membrane. Predicted to be active in plasma membrane. Is expressed in Meckel's cartilage; hip; and skeleton. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome. Orthologous to human CD70 (CD70 molecule).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: CD27 ligand; CD27-L; Cd27l; CD27LG; Ki-24 antigen; Tnfs; Tnfsf7; Tnlg8a; tumor necrosis factor (ligand) superfamily, member 7; tumor necrosis factor ligand 8a; tumor necrosis factor ligand superfamily member 7
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,452,997 - 57,456,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,452,997 - 57,456,777 (-)EnsemblGRCm39 Ensembl
GRCm381757,145,997 - 57,149,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,145,997 - 57,149,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,285,420 - 57,289,200 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,831,330 - 56,835,110 (-)NCBIMGSCv36mm8
Celera1761,495,459 - 61,499,239 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.69NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. MGDs mouse GO annotations MGD data from the GO Consortium
2. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
3. Mouse MP Annotation Import Pipeline RGD automated import pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9366422   PMID:9620608   PMID:11239407   PMID:11728341   PMID:11739537   PMID:12469117   PMID:12477932   PMID:12496380   PMID:12860530   PMID:15128787   PMID:15170228   PMID:15226368  
PMID:15557144   PMID:15634890   PMID:15661893   PMID:15937486   PMID:16217761   PMID:16920932   PMID:17237405   PMID:17295392   PMID:17311995   PMID:17438065   PMID:18292513   PMID:18354184  
PMID:19062317   PMID:19279334   PMID:19380782   PMID:19525396   PMID:19596991   PMID:19638429   PMID:19710474   PMID:19864607   PMID:19952354   PMID:20354106   PMID:20505312   PMID:20639485  
PMID:20699361   PMID:21267068   PMID:21304103   PMID:21490618   PMID:21507976   PMID:21873635   PMID:22450812   PMID:22499851   PMID:22781761   PMID:22798683   PMID:23137837   PMID:23159439  
PMID:23269247   PMID:23547099   PMID:23832783   PMID:23913967   PMID:24913981   PMID:25787857   PMID:26179759   PMID:26263500   PMID:26461455   PMID:26646413   PMID:26988069   PMID:27569212  
PMID:27786334   PMID:28341747   PMID:28495792   PMID:28550198   PMID:28651374   PMID:29046346   PMID:31263704   PMID:32868408   PMID:35856659   PMID:36271147   PMID:37024479   PMID:37160118  


Genomics

Comparative Map Data
Cd70
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391757,452,997 - 57,456,777 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1757,452,997 - 57,456,777 (-)EnsemblGRCm39 Ensembl
GRCm381757,145,997 - 57,149,777 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1757,145,997 - 57,149,777 (-)EnsemblGRCm38mm10GRCm38
MGSCv371757,285,420 - 57,289,200 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361756,831,330 - 56,835,110 (-)NCBIMGSCv36mm8
Celera1761,495,459 - 61,499,239 (-)NCBICelera
Cytogenetic Map17DNCBI
cM Map1729.69NCBI
CD70
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38196,581,648 - 6,591,150 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl196,583,183 - 6,604,103 (-)EnsemblGRCh38hg38GRCh38
GRCh37196,581,659 - 6,591,161 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36196,536,850 - 6,542,163 (-)NCBINCBI36Build 36hg18NCBI36
Build 34196,536,850 - 6,542,163NCBI
Celera196,525,685 - 6,531,003 (-)NCBICelera
Cytogenetic Map19p13.3NCBI
HuRef196,346,587 - 6,351,902 (-)NCBIHuRef
CHM1_1196,585,772 - 6,591,088 (-)NCBICHM1_1
T2T-CHM13v2.0196,571,316 - 6,593,751 (-)NCBIT2T-CHM13v2.0
Cd70
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr892,093,540 - 2,096,692 (-)NCBIGRCr8
mRatBN7.292,006,563 - 2,009,715 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl92,006,563 - 2,009,715 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx92,440,782 - 2,443,934 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.097,790,156 - 7,793,308 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.096,746,009 - 6,749,161 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.099,842,585 - 9,845,728 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl99,842,585 - 9,845,728 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.098,844,883 - 8,848,026 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera96,508,540 - 6,511,692 (+)NCBICelera
Cytogenetic Map9q11NCBI
CD70
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22010,993,584 - 11,003,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11910,218,951 - 10,229,120 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0195,615,056 - 5,621,055 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1196,535,559 - 6,542,310 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl196,535,559 - 6,542,310 (-)Ensemblpanpan1.1panPan2
CD70
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12053,639,315 - 53,642,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2053,639,436 - 53,642,319 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2053,386,663 - 53,389,596 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02054,293,471 - 54,296,448 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2054,293,040 - 54,296,476 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12053,360,273 - 53,363,248 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02053,808,582 - 53,811,556 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02054,037,542 - 54,040,520 (+)NCBIUU_Cfam_GSD_1.0
Cd70
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118213,913,063 - 213,916,307 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365883,918,965 - 3,921,720 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365883,918,944 - 3,921,720 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CD70
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl272,528,400 - 72,532,951 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1272,528,988 - 72,531,950 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2273,154,180 - 73,157,142 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CD70
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.166,188,720 - 6,202,212 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl66,188,897 - 6,193,652 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660811,796,679 - 1,810,205 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cd70
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248283,720,808 - 3,724,337 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cd70
127 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:52
Count of miRNA genes:51
Interacting mature miRNAs:52
Transcripts:ENSMUST00000019633
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4141272Tfv1_mtotal food volume 1 (mouse)Not determined485475265637357Mouse
1301338Lmr1_mleishmaniasis resistance 1 (mouse)Not determined171008134086996400Mouse
4142150Stheal11_msoft tissue heal 11 (mouse)Not determined171228621183361768Mouse
1301454Eae5_msusceptibility to experimental allergic encephalomyelitis 5 (mouse)Not determined172461275058612864Mouse
10412204Bbaa29_mB.burgdorferi-associated arthritis 29 (mouse)Not determined172605118560051352Mouse
1302005Loco2_mlocomotor activity 2 (mouse)Not determined172688497260885114Mouse
15039348Nmrs37_mNAFLD-associated magnetic resonance shift 37 (mouse)172781520961815209Mouse
1300703Uvbi2_mUVB induced immunosuppression 2 (mouse)Not determined172862240662622654Mouse
1300589Myaa2_mmodifier of Yaa 2 (mouse)Not determined173013255564132666Mouse
4140955Plgr1_mplague resistance locus 1 (mouse)Not determined3103350065033630Mouse
1300885Mbis4_mMycobacterium bovis-induced systemic lupus erythematosus 4 (mouse)Not determined173517581770165926Mouse
10755514Amzn2_manatomical modifier of Zfp423 2 (mouse)173596629469966424Mouse
12904951Smmq2_msoleus muscle mass QTL 2 (mouse)173678974370789743Mouse
1300592Pcyts5_mplasmacytoma susceptibility 5 (mouse)Not determined173871288772712970Mouse
10755525Lymph2_mlymphocyte differential 2 (mouse)173880562672805626Mouse
10755534Lymph4_mlymphocyte differential 4 (mouse)173880562672805626Mouse
4141319Hmtb8_mhemostasis and thrombosis rebleeding time 8 (mouse)Not determined4053444774534623Mouse
15039324Nmrs48_mNAFLD-associated magnetic resonance shift 48 (mouse)174093918774939187Mouse
26884390Skwq9_mskull length QTL 9, 10 week (mouse)174371089167806995Mouse
26884428Cvht3_mcranial vault height 3, 5 week (mouse)174651092682407429Mouse
14700692Cihvtq1_mcoxsackieviral infection heart viral titre QTL 1 (mouse)175000702870006995Mouse
1357754Ahl3_mage related hearing loss 3 (mouse)Not determined175020395784204103Mouse
4142243Lfnq5_mlung function QTL 5 (mouse)Not determined5173897957534623Mouse
4141879Chlq9_mcirculating hormone level QTL 9 (mouse)Not determined175175842585758612Mouse
1357532Bmch7_mbone mechanical trait 7 (mouse)Not determined175175842585758612Mouse
1357447Heal13_mwound healing/regeneration 13 (mouse)Not determined175710765191107803Mouse
4141758Pstc5_mperiosteal circumference 5 (mouse)Not determined175710765191107803Mouse
4141011Bmd26_mbone mineral density 26 (mouse)Not determined175710765191107803Mouse
1300735Pgia20_mproteoglycan induced arthritis 20 (mouse)Not determined175710765191107803Mouse
12910536Nrq8a_mnoise-induced hearing loss resistant QTL 8a (mouse)175710765191107803Mouse
12910537Nrq8_mnoise-induced hearing loss resistant QTL 8 (mouse)175710765191107803Mouse


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000019633   ⟹   ENSMUSP00000019633
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1757,452,997 - 57,456,777 (-)Ensembl
GRCm38.p6 Ensembl1757,145,997 - 57,149,777 (-)Ensembl
RefSeq Acc Id: NM_011617   ⟹   NP_035747
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391757,452,997 - 57,456,777 (-)NCBI
GRCm381757,145,997 - 57,149,777 (-)ENTREZGENE
MGSCv371757,285,420 - 57,289,200 (-)RGD
Celera1761,495,459 - 61,499,239 (-)RGD
cM Map17 ENTREZGENE
Sequence:
Reference Protein Sequences
RefSeq Acc Id: NP_035747   ⟸   NM_011617
- UniProtKB: O55237 (UniProtKB/Swiss-Prot),   Q05A52 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000019633   ⟸   ENSMUST00000019633
Protein Domains
TNF family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O55237-F1-model_v2 AlphaFold O55237 1-195 view protein structure


Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1195273 AgrOrtholog
Ensembl Genes ENSMUSG00000019489 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019633 ENTREZGENE
  ENSMUST00000019633.8 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.120.40 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CD70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TNF_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tumour_necrosis_fac-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:21948 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1195273 ENTREZGENE
NCBI Gene 21948 ENTREZGENE
PANTHER CD70 ANTIGEN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR15152 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cd70 PhenoGen
PROSITE TNF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART TNF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CD70_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q05A52 ENTREZGENE, UniProtKB/TrEMBL