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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:ursolic acid
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Accession:CHEBI:9908 term browser browse the term
Definition:A pentacyclic triterpenoid that is urs-12-en-28-oic acid substituted by a beta-hydroxy group at position 3.
Synonyms:exact_synonym: 3beta-hydroxyurs-12-en-28-oic acid
 related_synonym: (3beta)-3-hydroxyurs-12-en-28-oic acid;   Formula=C30H48O3;   InChI=1S/C30H48O3/c1-18-10-15-30(25(32)33)17-16-28(6)20(24(30)19(18)2)8-9-22-27(5)13-12-23(31)26(3,4)21(27)11-14-29(22,28)7/h8,18-19,21-24,31H,9-17H2,1-7H3,(H,32,33)/t18-,19+,21+,22-,23+,24+,27+,28-,29-,30+/m1/s1;   InChIKey=WCGUUGGRBIKTOS-GPOJBZKASA-N;   SMILES=[H][C@@]12[C@@H](C)[C@H](C)CC[C@@]1(CC[C@]1(C)C2=CC[C@]2([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])CC[C@@]12C)C(O)=O;   malol;   prunol;   urson
 xref: Beilstein:2228563;   CAS:77-52-1;   DrugBank:DB15588;   FooDB:FDB014373;   HMDB:HMDB0002395;   KEGG:C08988;   KNApSAcK:C00003558;   LIPID_MAPS_instance:LMPR0106180007
 xref_mesh: MESH:C005466
 xref: PDBeChem:6Q5;   PMID:17516089;   PMID:28493531;   PMID:30496629;   Reaxys:2228563;   Wikipedia:Ursolic_acid


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ursolic acid term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G ABCB1 ATP binding cassette subfamily B member 1 multiple interactions
decreases expression		 EXP ABCB1 protein inhibits the reaction [Ursolic Acid results in increased susceptibility to Doxorubicin]
Ursolic Acid results in decreased expression of ABCB1 mRNA; Ursolic Acid results in decreased expression of ABCB1 protein		 CTD PMID:33009882 NCBI chr 7:87,503,017...87,713,295
Ensembl chr 7:87,503,017...87,713,323 		JBrowse link
G ACACA acetyl-CoA carboxylase alpha increases phosphorylation EXP Ursolic Acid results in increased phosphorylation of ACACA protein CTD PMID:24802810 NCBI chr17:37,084,992...37,406,836
Ensembl chr17:37,084,992...37,406,836 		JBrowse link
G AIFM1 apoptosis inducing factor mitochondria associated 1 increases localization
decreases response to substance		 EXP Ursolic Acid results in increased localization of AIFM1 protein
AIFM1 mutant form results in decreased susceptibility to Ursolic Acid		 CTD PMID:20630652 NCBI chr  X:130,129,362...130,165,841
Ensembl chr  X:130,124,666...130,165,879 		JBrowse link
G AKT1 AKT serine/threonine kinase 1 decreases phosphorylation EXP Ursolic Acid results in decreased phosphorylation of AKT1 protein CTD PMID:19344998 PMID:24802810 NCBI chr14:104,769,349...104,795,748
Ensembl chr14:104,769,349...104,795,751 		JBrowse link
G APP amyloid beta precursor protein multiple interactions EXP Ursolic Acid inhibits the reaction [APP protein modified form results in decreased expression of RPT-3 protein]; Ursolic Acid inhibits the reaction [APP protein modified form results in increased susceptibility to Serotonin] CTD PMID:34902447 NCBI chr21:25,880,550...26,171,128
Ensembl chr21:25,880,535...26,171,128 		JBrowse link
G ARG1 arginase 1 multiple interactions ISO Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of ARG1 mRNA] CTD PMID:37019307 NCBI chr 6:131,573,226...131,584,329
Ensembl chr 6:131,470,832...131,584,332 		JBrowse link
G ASMTL-AS1 ASMTL antisense RNA 1 decreases expression EXP Ursolic Acid results in decreased expression of ASMTL-AS1 mRNA CTD PMID:37300450 NCBI chr  X:1,400,531...1,415,421
NCBI chr  Y:1,400,531...1,415,421
Ensembl chr  Y:1,401,769...1,414,028
Ensembl chr  X:1,401,769...1,414,028 		JBrowse link
G BAK1 BCL2 antagonist/killer 1 increases activity EXP Ursolic Acid results in increased activity of BAK1 protein CTD PMID:20630652 NCBI chr 6:33,572,552...33,580,276
Ensembl chr 6:33,572,547...33,580,293 		JBrowse link
G BAX BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 EXP
ISO		 Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of BAX protein]
Ursolic Acid results in increased expression of BAX protein		 CTD PMID:16012738 PMID:24051192 PMID:36587836 NCBI chr19:48,954,875...48,961,798
Ensembl chr19:48,954,815...48,961,798 		JBrowse link
G BCL2 BCL2 apoptosis regulator decreases expression
multiple interactions
increases phosphorylation		 EXP Ursolic Acid results in decreased expression of BCL2 mRNA; Ursolic Acid results in decreased expression of BCL2 protein
[Ursolic Acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of BCL2 protein]		 CTD PMID:16012738 PMID:24802810 PMID:28868958 PMID:36587836 NCBI chr18:63,123,346...63,320,090
Ensembl chr18:63,123,346...63,320,128 		JBrowse link
G BECN1 beclin 1 multiple interactions EXP [Ursolic Acid results in increased phosphorylation of BCL2 protein] inhibits the reaction [BCL2 protein binds to BECN1 protein]; Ursolic Acid inhibits the reaction [BCL2 protein binds to BECN1 protein] CTD PMID:24802810 NCBI chr17:42,810,132...42,824,282
Ensembl chr17:42,810,134...42,833,350 		JBrowse link
G CASP3 caspase 3 increases expression
multiple interactions
increases activity		 ISO
EXP		 Ursolic Acid results in increased expression of CASP3 protein
acetyl-aspartyl-glutamyl-valyl-aspartal inhibits the reaction [Ursolic Acid results in increased cleavage of and results in increased activity of CASP3 protein]; Ursolic Acid results in increased cleavage of and results in increased activity of CASP3 protein
Ursolic Acid results in increased activity of CASP3 protein		 CTD PMID:16012738 PMID:19329757 PMID:20005942 PMID:24051192 NCBI chr 4:184,627,696...184,649,447
Ensembl chr 4:184,627,696...184,650,062 		JBrowse link
G CASP7 caspase 7 increases activity ISO Ursolic Acid results in increased activity of CASP7 protein CTD PMID:19329757 NCBI chr10:113,679,194...113,730,909
Ensembl chr10:113,679,162...113,730,907 		JBrowse link
G CASP8 caspase 8 increases activity EXP Ursolic Acid results in increased activity of CASP8 protein CTD PMID:20005942 NCBI chr 2:201,233,463...201,287,711
Ensembl chr 2:201,233,443...201,361,836 		JBrowse link
G CAT catalase increases activity ISO Ursolic Acid results in increased activity of CAT protein CTD PMID:24051192 NCBI chr11:34,438,934...34,472,060
Ensembl chr11:34,438,934...34,472,060 		JBrowse link
G CCND1 cyclin D1 decreases expression EXP Ursolic Acid results in decreased expression of CCND1 mRNA; Ursolic Acid results in decreased expression of CCND1 protein CTD PMID:24566423 PMID:24802810 NCBI chr11:69,641,156...69,654,474
Ensembl chr11:69,641,156...69,654,474 		JBrowse link
G CCND3 cyclin D3 decreases expression EXP Ursolic Acid results in decreased expression of CCND3 protein CTD PMID:24802810 NCBI chr 6:41,934,933...42,050,035
Ensembl chr 6:41,934,934...42,050,357 		JBrowse link
G CCNE1 cyclin E1 decreases expression EXP Ursolic Acid results in decreased expression of CCNE1 protein CTD PMID:24802810 NCBI chr19:29,811,991...29,824,312
Ensembl chr19:29,811,991...29,824,312 		JBrowse link
G CD86 CD86 molecule multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA] CTD PMID:37019307 NCBI chr 3:122,055,362...122,121,136
Ensembl chr 3:122,055,362...122,121,139 		JBrowse link
G CDK4 cyclin dependent kinase 4 decreases expression EXP Ursolic Acid results in decreased expression of CDK4 protein CTD PMID:24802810 NCBI chr12:57,747,727...57,752,310
Ensembl chr12:57,747,727...57,756,013 		JBrowse link
G CDKN1A cyclin dependent kinase inhibitor 1A increases expression EXP Ursolic Acid results in increased expression of CDKN1A protein CTD PMID:24802810 NCBI chr 6:36,676,463...36,687,332
Ensembl chr 6:36,676,460...36,687,337 		JBrowse link
G CDKN1B cyclin dependent kinase inhibitor 1B increases expression EXP Ursolic Acid results in increased expression of CDKN1B protein CTD PMID:24802810 NCBI chr12:12,717,368...12,722,369
Ensembl chr12:12,685,498...12,722,369 		JBrowse link
G CTNNB1 catenin beta 1 multiple interactions EXP Ursolic Acid results in increased phosphorylation of and results in increased degradation of CTNNB1 protein CTD PMID:24566423 NCBI chr 3:41,199,505...41,240,443
Ensembl chr 3:41,194,741...41,260,096 		JBrowse link
G CXCL2 C-X-C motif chemokine ligand 2 multiple interactions ISO Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of CXCL2 mRNA] CTD PMID:26513295 NCBI chr 4:74,097,040...74,099,195
Ensembl chr 4:74,097,040...74,099,196 		JBrowse link
G CYCS cytochrome c, somatic affects localization EXP Ursolic Acid affects the localization of CYCS protein CTD PMID:16012738 NCBI chr 7:25,118,656...25,125,260
Ensembl chr 7:25,118,656...25,125,260 		JBrowse link
G CYP2C19 cytochrome P450 family 2 subfamily C member 19 decreases activity
multiple interactions		 EXP Ursolic Acid results in decreased activity of CYP2C19 protein
Ursolic Acid inhibits the reaction [CYP2C19 protein results in increased metabolism of Mephenytoin]		 CTD PMID:15043991 NCBI chr10:94,762,681...94,855,547
Ensembl chr10:94,762,681...94,855,547 		JBrowse link
G DDIT3 DNA damage inducible transcript 3 increases expression
multiple interactions		 EXP Ursolic Acid results in increased expression of DDIT3 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A promotes the reaction [bardoxolone methyl results in increased expression of DDIT3 protein]]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of DDIT3 protein]		 CTD PMID:24802810 PMID:36587836 NCBI chr12:57,516,588...57,520,517
Ensembl chr12:57,516,588...57,521,737 		JBrowse link
G EDN1 endothelin 1 multiple interactions ISO Ursolic Acid inhibits the reaction [Choline results in increased expression of EDN1 protein] CTD PMID:27567547 NCBI chr 6:12,230,516...12,297,194
Ensembl chr 6:12,290,361...12,297,194 		JBrowse link
G EGFR epidermal growth factor receptor multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EGFR]] CTD PMID:26100520 NCBI chr 7:55,019,017...55,211,628
Ensembl chr 7:55,019,017...55,211,628 		JBrowse link
G EIF2AK3 eukaryotic translation initiation factor 2 alpha kinase 3 multiple interactions
increases phosphorylation		 EXP EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased expression of DDIT3 protein]; EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; Ursolic Acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased phosphorylation of EIF2AK3 protein]
Ursolic Acid results in increased phosphorylation of EIF2AK3 protein		 CTD PMID:24802810 PMID:36587836 NCBI chr 2:88,556,741...88,628,145
Ensembl chr 2:88,556,741...88,691,518 		JBrowse link
G EIF2S1 eukaryotic translation initiation factor 2 subunit alpha increases phosphorylation
multiple interactions		 EXP Ursolic Acid results in increased phosphorylation of EIF2S1 protein
EIF2AK3 mutant form inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased phosphorylation of EIF2S1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased phosphorylation of EIF2S1 protein]		 CTD PMID:24802810 PMID:36587836 NCBI chr14:67,360,328...67,386,516
Ensembl chr14:67,360,328...67,386,516 		JBrowse link
G EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 decreases expression EXP Ursolic Acid results in decreased expression of EIF4EBP1 protein CTD PMID:24802810 NCBI chr 8:38,030,534...38,060,365
Ensembl chr 8:38,030,534...38,060,365 		JBrowse link
G ERN1 endoplasmic reticulum to nucleus signaling 1 increases activity
multiple interactions		 EXP Ursolic Acid results in increased activity of ERN1 protein
Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of ERN1 protein]		 CTD PMID:24802810 PMID:36587836 NCBI chr17:64,039,142...64,130,144
Ensembl chr17:64,039,080...64,130,819 		JBrowse link
G FCGR2B Fc gamma receptor IIb multiple interactions ISO Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR2B mRNA] CTD PMID:37019307 NCBI chr 1:161,647,243...161,678,654
Ensembl chr 1:161,663,143...161,678,654 		JBrowse link
G GPT glutamic--pyruvic transaminase multiple interactions ISO Ursolic Acid inhibits the reaction [Choline results in increased activity of GPT protein] CTD PMID:27567547 NCBI chr 8:144,503,068...144,507,172
Ensembl chr 8:144,502,973...144,507,174 		JBrowse link
G HSPA5 heat shock protein family A (Hsp70) member 5 increases expression
multiple interactions		 EXP Ursolic Acid results in increased expression of HSPA5 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Acetylcysteine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in increased expression of HSPA5 protein]; Ursolic Acid inhibits the reaction [HSPA5 protein binds to EIF2AK3 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in increased expression of HSPA5 protein]		 CTD PMID:24802810 PMID:36587836 NCBI chr 9:125,234,853...125,241,343
Ensembl chr 9:125,234,853...125,241,382 		JBrowse link
G ICAM1 intercellular adhesion molecule 1 decreases expression EXP Ursolic Acid results in decreased expression of ICAM1 mRNA; Ursolic Acid results in decreased expression of ICAM1 protein CTD PMID:20005942 PMID:21539908 NCBI chr19:10,271,120...10,286,615
Ensembl chr19:10,271,093...10,286,615 		JBrowse link
G IFNG interferon gamma multiple interactions ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of CHIL3 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]]; [Ursolic Acid co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MRC1 mRNA; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of ARG1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of CHIL3 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of CD86 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR2B mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of FCGR3 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein] CTD PMID:37019307 NCBI chr12:68,154,768...68,159,740
Ensembl chr12:68,154,768...68,159,740 		JBrowse link
G IL6 interleukin 6 decreases expression
multiple interactions		 ISO Ursolic Acid results in decreased expression of IL6 protein
[Glucaric Acid co-treated with Ursolic Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of IL6 mRNA]		 CTD PMID:20869956 PMID:23835587 NCBI chr 7:22,727,200...22,731,998
Ensembl chr 7:22,725,884...22,732,002 		JBrowse link
G JUN Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO [Glucaric Acid co-treated with Ursolic Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of JUN protein]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of JUN]] CTD PMID:23835587 PMID:26100520 NCBI chr 1:58,780,791...58,784,047
Ensembl chr 1:58,776,845...58,784,048 		JBrowse link
G LEP leptin increases expression ISO Ursolic Acid results in increased expression of LEP protein CTD PMID:20869956 NCBI chr 7:128,241,278...128,257,629
Ensembl chr 7:128,241,278...128,257,629 		JBrowse link
G LONP1 lon peptidase 1, mitochondrial multiple interactions EXP Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of LONP1 protein] CTD PMID:36587836 NCBI chr19:5,691,834...5,720,452
Ensembl chr19:5,691,834...5,720,572 		JBrowse link
G MAPK1 mitogen-activated protein kinase 1 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK1 protein] CTD PMID:27274199 NCBI chr22:21,759,657...21,867,680
Ensembl chr22:21,759,657...21,867,680 		JBrowse link
G MAPK3 mitogen-activated protein kinase 3 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK3 protein] CTD PMID:27274199 NCBI chr16:30,114,105...30,123,220
Ensembl chr16:30,114,105...30,123,506 		JBrowse link
G MAPK8 mitogen-activated protein kinase 8 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK8 protein] CTD PMID:27274199 NCBI chr10:48,306,677...48,439,360
Ensembl chr10:48,306,639...48,439,360 		JBrowse link
G MAPK9 mitogen-activated protein kinase 9 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased phosphorylation of MAPK9 protein] CTD PMID:27274199 NCBI chr 5:180,233,143...180,292,083
Ensembl chr 5:180,233,143...180,292,099 		JBrowse link
G MMP2 matrix metallopeptidase 2 multiple interactions
decreases expression		 ISO
EXP		 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP2 protein]
[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein; Ursolic Acid results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP2 protein
Ursolic Acid results in decreased expression of MMP2 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP2 protein]		 CTD PMID:21539908 PMID:27274199 PMID:36191607 PMID:37019307 NCBI chr16:55,478,830...55,506,691
Ensembl chr16:55,389,700...55,506,691 		JBrowse link
G MMP9 matrix metallopeptidase 9 decreases expression
multiple interactions		 EXP
ISO		 Ursolic Acid results in decreased expression of MMP9 mRNA
2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of MMP9 protein]
[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of and results in decreased expression of MMP9 protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein; Ursolic Acid results in decreased secretion of and results in decreased activity of and results in decreased expression of MMP9 protein
2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]]; 2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MMP9 protein]		 CTD PMID:21539908 PMID:27274199 PMID:36191607 PMID:37019307 NCBI chr20:46,008,908...46,016,561
Ensembl chr20:46,008,908...46,016,561 		JBrowse link
G MRC1 mannose receptor C-type 1 multiple interactions ISO [Ursolic Acid co-treated with IFNG protein co-treated with Lipopolysaccharides] results in increased expression of MRC1 mRNA CTD PMID:37019307 NCBI chr10:17,809,348...17,911,164
Ensembl chr10:17,809,348...17,911,164 		JBrowse link
G MTOR mechanistic target of rapamycin kinase decreases phosphorylation
multiple interactions		 EXP Ursolic Acid results in decreased phosphorylation of MTOR protein
ursodoxicoltaurine inhibits the reaction [Ursolic Acid results in decreased phosphorylation of MTOR protein]		 CTD PMID:24802810 NCBI chr 1:11,106,535...11,262,551
Ensembl chr 1:11,106,535...11,262,556 		JBrowse link
G NFKB1 nuclear factor kappa B subunit 1 multiple interactions ISO [Ursolic Acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of NFKB1 protein] CTD PMID:23835587 NCBI chr 4:102,501,359...102,617,302
Ensembl chr 4:102,501,330...102,617,302 		JBrowse link
G NFKBIA NFKB inhibitor alpha multiple interactions EXP Ursolic Acid analog results in decreased phosphorylation of and results in increased expression of NFKBIA protein CTD PMID:26134000 NCBI chr14:35,401,513...35,404,749
Ensembl chr14:35,401,079...35,404,749 		JBrowse link
G NOS2 nitric oxide synthase 2 decreases expression ISO Ursolic Acid results in decreased expression of NOS2 protein CTD PMID:24051192 NCBI chr17:27,756,766...27,800,529
Ensembl chr17:27,756,766...27,800,529 		JBrowse link
G NOS3 nitric oxide synthase 3 multiple interactions ISO Ursolic Acid inhibits the reaction [Choline results in increased expression of NOS3 protein] CTD PMID:27567547 NCBI chr 7:150,991,017...151,014,588
Ensembl chr 7:150,991,017...151,014,588 		JBrowse link
G PARP1 poly(ADP-ribose) polymerase 1 increases cleavage EXP Ursolic Acid results in increased cleavage of PARP1 protein CTD PMID:16012738 NCBI chr 1:226,360,691...226,408,093
Ensembl chr 1:226,360,210...226,408,154 		JBrowse link
G PLAU plasminogen activator, urokinase decreases secretion
multiple interactions		 EXP Ursolic Acid results in decreased secretion of PLAU protein
[Ursolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in decreased secretion of PLAU protein; [Ursolic Acid co-treated with Oleanolic Acid] results in decreased secretion of PLAU protein		 CTD PMID:36191607 NCBI chr10:73,909,164...73,917,494
Ensembl chr10:73,909,177...73,917,496 		JBrowse link
G PLAUR plasminogen activator, urokinase receptor decreases expression
multiple interactions		 EXP Ursolic Acid results in decreased expression of PLAUR protein
[Ursolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid co-treated with Irinotecan] results in increased secretion of and results in decreased expression of PLAUR protein; [Ursolic Acid co-treated with Oleanolic Acid] results in increased secretion of and results in decreased expression of PLAUR protein		 CTD PMID:36191607 NCBI chr19:43,646,095...43,670,169
Ensembl chr19:43,646,095...43,670,547 		JBrowse link
G PPARG peroxisome proliferator activated receptor gamma multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of PPARG protein]
2-chloro-5-nitrobenzanilide inhibits the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of PPARG protein]		 CTD PMID:27274199 PMID:37019307 NCBI chr 3:12,287,368...12,434,344
Ensembl chr 3:12,287,368...12,434,356 		JBrowse link
G PTGS2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO [Ursolic Acid co-treated with Glucaric Acid] inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]]; Ursolic Acid inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with 9,10-Dimethyl-1,2-benzanthracene] results in increased expression of PTGS2 mRNA]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 mRNA]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2]] CTD PMID:23835587 PMID:26100520 PMID:26513295 NCBI chr 1:186,671,791...186,680,423
Ensembl chr 1:186,671,791...186,680,922 		JBrowse link
G PTPN1 protein tyrosine phosphatase non-receptor type 1 decreases activity EXP Ursolic Acid results in decreased activity of PTPN1 protein CTD PMID:27085377 PMID:29175190 PMID:30160205 PMID:36933777 NCBI chr20:50,510,383...50,585,241
Ensembl chr20:50,510,321...50,585,241 		JBrowse link
G RELA RELA proto-oncogene, NF-kB subunit decreases expression EXP Ursolic Acid analog results in decreased expression of RELA mRNA; Ursolic Acid analog results in decreased expression of RELA protein CTD PMID:26134000 NCBI chr11:65,653,601...65,663,857
Ensembl chr11:65,653,599...65,663,090 		JBrowse link
G RPS6KB1 ribosomal protein S6 kinase B1 decreases expression EXP Ursolic Acid results in decreased expression of RPS6KB1 protein CTD PMID:24802810 NCBI chr17:59,893,121...59,950,574
Ensembl chr17:59,893,046...59,950,574 		JBrowse link
G SIGMAR1 sigma non-opioid intracellular receptor 1 multiple interactions
increases expression		 EXP Ursolic Acid inhibits the reaction [bardoxolone methyl results in decreased expression of SIGMAR1 protein]; Ursolic Acid inhibits the reaction [ochratoxin A results in decreased expression of SIGMAR1 protein]
Ursolic Acid results in increased expression of SIGMAR1 protein		 CTD PMID:36587836 NCBI chr 9:34,634,722...34,637,787
Ensembl chr 9:34,634,722...34,637,844 		JBrowse link
G SRC SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SRC]] CTD PMID:26100520 NCBI chr20:37,344,699...37,406,050
Ensembl chr20:37,344,685...37,406,050 		JBrowse link
G STAT3 signal transducer and activator of transcription 3 multiple interactions ISO Resveratrol promotes the reaction [Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]]; Ursolic Acid inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]; Ursolic Acid promotes the reaction [Resveratrol inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of STAT3]] CTD PMID:26100520 NCBI chr17:42,313,324...42,388,442
Ensembl chr17:42,313,324...42,388,568 		JBrowse link
G TGFB1 transforming growth factor beta 1 decreases expression EXP Ursolic Acid results in decreased expression of TGFB1 protein CTD PMID:21539908 NCBI chr19:41,330,323...41,353,922
Ensembl chr19:41,301,587...41,353,922 		JBrowse link
G TIMP1 TIMP metallopeptidase inhibitor 1 multiple interactions ISO 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]]; Ursolic Acid inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of TIMP1 protein]
2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]]; 2-chloro-5-nitrobenzanilide promotes the reaction [Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 mRNA]; Ursolic Acid inhibits the reaction [[IFNG protein co-treated with Lipopolysaccharides] results in decreased expression of TIMP1 protein]		 CTD PMID:27274199 PMID:37019307 NCBI chr  X:47,582,436...47,586,789
Ensembl chr  X:47,582,408...47,586,789 		JBrowse link
G TNF tumor necrosis factor decreases expression ISO Ursolic Acid results in decreased expression of TNF protein CTD PMID:24051192 NCBI chr 6:31,575,565...31,578,336
Ensembl chr 6:31,575,565...31,578,336 		JBrowse link
G TOP1 DNA topoisomerase I decreases activity EXP Ursolic Acid results in decreased activity of TOP1 protein CTD PMID:10860928 NCBI chr20:41,028,822...41,124,487
Ensembl chr20:41,028,822...41,124,487 		JBrowse link
G TOP2A DNA topoisomerase II alpha decreases activity EXP Ursolic Acid results in decreased activity of TOP2A protein CTD PMID:10860928 NCBI chr17:40,388,525...40,417,896
Ensembl chr17:40,388,525...40,417,896 		JBrowse link
G VEGFA vascular endothelial growth factor A decreases expression ISO Ursolic Acid results in decreased expression of VEGFA protein CTD PMID:24051192 NCBI chr 6:43,770,211...43,786,487
Ensembl chr 6:43,770,184...43,786,487 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 26034
    role 25961
      application 25172
        pharmaceutical 24558
          drug 24544
            protective agent 20758
              geroprotector 19047
                ursolic acid 71
                  23-hydroxyursolic acid + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 26034
    subatomic particle 26009
      composite particle 26009
        hadron 26020
          baryon 26009
            nucleon 26009
              atomic nucleus 26009
                atom 26009
                  main group element atom 25834
                    main group molecular entity 25834
                      s-block molecular entity 25166
                        hydrogen molecular entity 24765
                          hydrides 22965
                            organic hydride 21924
                              organic fundamental parent 21924
                                hydrocarbon 21350
                                  terpene 14657
                                    terpenoid 14293
                                      triterpenoid 890
                                        pentacyclic triterpenoid 474
                                          ursolic acid 71
                                            23-hydroxyursolic acid + 0
paths to the root